Article
Cell Biology
Michiko Yamane, Nanako Takaoka, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M. Hoffman, Yasuyuki Amoh
Summary: Hair-follicle-associated pluripotent (HAP) stem cells, located in hair follicles, can differentiate into multiple cell types, including neurons and cardiomyocytes. Studies have shown that HAP stem cells treated with neural-induction medium can differentiate into dopaminergic neurons, which may potentially help improve symptoms of Parkinson's disease in the future.
Article
Biochemistry & Molecular Biology
Mariko Kato Hayashi, Kaoru Sato, Yuko Sekino
Summary: Neurons induce astrocyte branches and make them avoid each other, potentially contributing to the tiling of astrocytes' territories.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Mafalda Correia, Joana Lopes, Daniela Lopes, Ana Melero, Pooyan Makvandi, Francisco Veiga, Jorge F. J. Coelho, Ana C. Fonseca, Ana Claudia Paiva-Santos
Summary: This review discusses nanotechnology-based strategies for hair follicle (HF) regeneration, including controlled drug release and HF-specific targeting. In addition to traditional hair repair methods, wound-induced hair neogenesis (WIHN) has gained attention as a research focus. HF regeneration involves various modalities and technologies, including modulation of the hair cycle, stimulation of progenitor cells and signaling pathways, tissue engineering, WIHN, and gene therapy.
Review
Cell Biology
Sangbum Park
Summary: Hair follicles undergo continuous growth and regression cycles driven by the regulation of stem cells and niche components. Complex morphogenesis is required to build the structure of hair follicles during embryonic development. Understanding the formation and maintenance of hair follicles, as well as the mechanisms for hair follicle generation and skin regeneration, is crucial.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Wei Tu, Yu-Wei Cao, Mang Sun, Qian Liu, Heng-Guang Zhao
Summary: This review examines the function of mTOR signaling in hair follicles and hair diseases, and discusses the underlying molecular mechanisms that mTOR signaling regulates.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Carla M. Abreu, Mariana T. Cerqueira, Rogerio P. Pirraco, Luca Gasperini, Rui L. Reis, Alexandra P. Marques
Summary: The conditioned medium from interfollicular keratinocytes (KCs-CM) has been shown to improve the hair inductive ability of DP cells, with significant effects on DP cell growth and restoration of activity. Additionally, DP cells cultured with KCs-CM in spheroids demonstrated superior activity and supported the formation of hair follicle- and sebaceous gland-like structures in mice when co-grafted with human keratinocytes.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Cell Biology
Min Yang, Tingting Weng, Wei Zhang, Manjia Zhang, Xiaojie He, Chunmao Han, Xingang Wang
Summary: Alopecia is a commonly seen issue affecting various age groups, with hair follicle regeneration considered as a strategy to address this problem. Non-coding RNAs, particularly microRNAs and long ncRNAs, play crucial regulatory roles in hair follicle development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Allen W. Lynch, Christina Theodoris, Henry Long, Myles Brown, X. Shirley Liu, Clifford A. Meyer
Summary: MIRA is a comprehensive methodology that compares gene expression and chromatin accessibility in single cells to infer regulatory mechanisms driving cell fate transitions. It models cell states and regulatory potential of gene loci to represent cell states in an efficient and interpretable latent space, and reveals the variable influence of local accessibility on transcription at different gene loci.
Review
Biochemistry & Molecular Biology
Matej Znidaric, Zan Michel Zurga, Uros Maver
Summary: The field of hair research has advanced significantly in recent decades, particularly in the development of in vitro hair follicle models. The focus has been on manipulating cellular and molecular features to grow functional in vitro hair follicles. Challenges still remain in fully understanding follicle behavior and successfully creating different types of hair through in vitro methods.
Article
Cell & Tissue Engineering
Yuyang Gan, Hailin Wang, Lijuan Du, Zhexiang Fan, Pingping Sun, Kaitao Li, Qian Qu, Jin Wang, Ruosi Chen, Zhiqi Hu, Yong Miao
Summary: A large number of pelage HF-MSCs can be quickly and conveniently isolated from adult mice using a two-step Ficoll density gradient sedimentation method. These cells possess similar characteristics and functions as whisker HF-MSCs and can promote hair growth by secreting exosomes.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Sunil S. Adav, Kee Woei Ng
Summary: Aging is a complex process that affects physiological functions, including hair graying, thinning, and loss. These changes in hair can have a significant impact on an individual's self-esteem and mental health. Omics technologies have helped lead to the discovery of hair aging biomarkers and potential therapies.
AGEING RESEARCH REVIEWS
(2023)
Article
Veterinary Sciences
Wei Yan, Fei Hao, Xiaoshu Zhe, Yingmin Wang, Dongjun Liu
Summary: This study confirmed the biological characteristics and differentiation potential of PHFSCs and SHFSCs from Arbas Cashmere goats, expanding and refining our knowledge of adult stem cell types and characteristics.
BMC VETERINARY RESEARCH
(2022)
Article
Oncology
Hui Cheng, Fei Liu, Manqian Zhou, Shang Chen, Haoyan Huang, Yue Liu, Xiaotong Zhao, Qiaonan Zhang, Xinrun Zhou, Zongjin Li, Hong Cai
Summary: The study found that the PGE2 matrix can promote early stage hair follicle development and improve the condition of hair follicle stem cells. In addition, the PGE2 delivery system may be a new strategy for treating hair disorders.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yoshihiro Oaku, Akinari Abe, Yohei Sasano, Fuka Sasaki, Chika Kubota, Naoki Yamamoto, Tohru Nagahama, Noriaki Nagai
Summary: In this study, we found that MXD-NPs prepared using the bead mill method demonstrated better hair follicle delivery and hair growth promotion compared to commercially available CA-MXD solution. MXD-NPs enabled the accumulation of MXD in the upper hair follicles more efficiently and activated HFSC, leading to hair growth.
Article
Biochemistry & Molecular Biology
Jiali Li, Bohao Zhao, Shuyu Yao, Yingying Dai, Xiyu Zhang, Naisu Yang, Zhiyuan Bao, Jiawei Cai, Yang Chen, Xinsheng Wu
Summary: This study found that exosomes derived from dermal papilla cells regulate hair follicle stem cell proliferation by stimulating LEF1, providing new insights into the regulatory mechanisms of hair follicle growth and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Rebecca A. Barnard, Matthew B. Pomaville, Brian J. O'Roak
FRONTIERS IN NEUROSCIENCE
(2015)
Article
Cell Biology
Anke Vermehren-Schmaedick, Jeffrey Y. Huang, Madison Levinson, Matthew B. Pomaville, Sarah Reed, Gary A. Bellus, Fred Gilbert, Boris Keren, Delphine Heron, Damien Haye, Christine Janello, Christine Makowski, Katharina Danhauser, Lev M. Fedorov, Tobias B. Haack, Kevin M. Wright, Michael S. Cohen
Summary: PARP6, a neuronally enriched member of the poly-ADP-ribose polymerase family, plays a crucial role in dendrite morphogenesis in rat hippocampal neurons. A Parp6 loss-of-function mouse model was generated using CRISPR-Cas9 mutagenesis, revealing the importance of Parp6 catalytic activity for postnatal survival. Additionally, mutations in PARP6 were found in patients with neurodevelopmental disorders, highlighting the significance of PARP6 in human neuronal function.
Article
Psychology, Multidisciplinary
Matthew B. Pomaville, David D. Lent
FRONTIERS IN PSYCHOLOGY
(2018)