Toxicity dose descriptors from animal inhalation studies of 13 nanomaterials and their bulk and ionic counterparts and variation with primary particle characteristics

Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study

(2022) Dina Mourad Saleh et al.   Particle and Fibre Toxicology

Time course of pulmonary inflammation and trace element biodistribution during and after sub-acute inhalation exposure to copper oxide nanoparticles in a murine model

(2022) Sudartip Areecheewakul et al.   Particle and Fibre Toxicology

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

(2022) Shotaro Yamano et al.   Particle and Fibre Toxicology

No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

(2022) Shotaro Yamano et al.   Scientific Reports

Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats

(2021) Boris A. Katsnelson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Retained particle surface area dose drives inflammation in rat lungs following acute, subacute, and subchronic inhalation of nanomaterials

(2021) Frédéric Cosnier et al.   Particle and Fibre Toxicology

Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO2 NM)

(2021) Fátima Brandão et al.   Nanomaterials

Variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity

(2021) Johannes G. Keller et al.   NanoImpact

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

(2020) Sabina Halappanavar et al.   Particle and Fibre Toxicology

Dissolution behavior of metal oxide nanomaterials in cell culture medium versus distilled water

(2020) Mary-Luyza Avramescu et al.   JOURNAL OF NANOPARTICLE RESEARCH

In vitro assessment of cobalt oxide particle dissolution in simulated lung fluids for identification of new decorporating agents

(2020) Anne Van Der Meeren et al.   TOXICOLOGY IN VITRO

Health effects after inhalation of micro- and nano-sized zinc oxide particles in human volunteers

(2020) Christian Monsé et al.   ARCHIVES OF TOXICOLOGY

Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat

(2020) Dina Mourad Saleh et al.   Particle and Fibre Toxicology

Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

(2019) Sutunkova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effect of the inhalation of and topical exposure to zinc oxide nanoparticles on airway inflammation in mice

(2019) Kuo-Liang Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Multi-walled carbon nanotube-induced inhalation toxicity: Recognizing nano bis-demethoxy curcumin analog as an ameliorating candidate

(2018) Arul Prakash Francis et al.   Nanomedicine-Nanotechnology Biology and Medicine

Short-term inhalation study of graphene oxide nanoplates

(2018) Young Hun Kim et al.   Nanotoxicology

Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers

(2018) Christian Monsé et al.   Particle and Fibre Toxicology

Physicochemical predictors of Multi-Walled Carbon Nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different Multi-Walled Carbon Nanotubes in mice

(2018) Kristina Bram Knudsen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

In vivo-induced size transformation of cerium oxide nanoparticles in both lung and liver does not affect long-term hepatic accumulation following pulmonary exposure

(2018) Justyna Modrzynska et al.   PLoS One

Subacute inhalation toxicity study of synthetic amorphous silica nanoparticles in Sprague-Dawley rats

(2017) Jae Hoon Shin et al.   INHALATION TOXICOLOGY

Solubility of nano-sized metal oxides evaluated by using in vitro simulated lung and gastrointestinal fluids: implication for health risks

(2017) Laijin Zhong et al.   JOURNAL OF NANOPARTICLE RESEARCH

Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in rats

(2017) Christina Umbright et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

(2017) Daniela Schwotzer et al.   Particle and Fibre Toxicology

Surface area is the biologically most effective dose metric for acute nanoparticle toxicity in the lung

(2016) Otmar Schmid et al.   JOURNAL OF AEROSOL SCIENCE

No genotoxicity in rat blood cells upon 3- or 6-month inhalation exposure to CeO2or BaSO4nanomaterials

(2016) Eugenia Cordelli et al.   MUTAGENESIS

In vitroandin vivogenotoxic effects of straight versus tangled multi-walled carbon nanotubes

(2016) Julia Catalán et al.   Nanotoxicology

Airway irritation, inflammation, and toxicity in mice following inhalation of metal oxide nanoparticles

(2016) Søren T. Larsen et al.   Nanotoxicology

Simplein vitromodels can predict pulmonary toxicity of silver nanoparticles

(2016) Hedwig M. Braakhuis et al.   Nanotoxicology

On the contribution of the phagocytosis and the solubilization to the iron oxide nanoparticles retention in and elimination from lungs under long-term inhalation exposure

(2016) M.P. Sutunkova et al.   TOXICOLOGY

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

(2016) Niels Hadrup et al.   PLoS One

Perfluorononanoic acid in combination with 14 chemicals exerts low-dose mixture effects in rats

(2015) Niels Hadrup et al.   ARCHIVES OF TOXICOLOGY

Negligible respiratory irritation and inflammation potency of pigmentary TiO2in mice

(2015) Maija Leppänen et al.   INHALATION TOXICOLOGY

5-Day repeated inhalation and 28-day post-exposure study of graphene

(2015) Jae Hoon Shin et al.   Nanotoxicology

Effects of prenatal inhalation exposure to copper nanoparticles on murine dams and offspring

(2015) Andrea Adamcakova-Dodd et al.   Particle and Fibre Toxicology

Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

(2015) Daniela Pothmann et al.   Particle and Fibre Toxicology

Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice

(2015) Jennifer D. Sisler et al.   Particle and Fibre Toxicology

Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats

(2015) Tatsuya Kasai et al.   Particle and Fibre Toxicology

Comparative toxicity and carcinogenicity of soluble and insoluble cobalt compounds

(2015) Mamta Behl et al.   TOXICOLOGY

MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

(2015) Sarah S. Poulsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pulmonary Responses of Sprague-Dawley Rats in Single Inhalation Exposure to Graphene Oxide Nanomaterials

(2015) Sung Gu Han et al.   Biomed Research International

Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria

(2014) Jana Keller et al.   ARCHIVES OF TOXICOLOGY

Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line

(2014) Petra Jackson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Particulate nature of inhaled zinc oxide nanoparticles determines systemic effects and mechanisms of pulmonary inflammation in mice

(2014) Jen-Kun Chen et al.   Nanotoxicology

Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats

(2014) Tatsuya Kasai et al.   Nanotoxicology

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

(2014) Elina M Rydman et al.   Particle and Fibre Toxicology

The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats

(2014) Susanne Rittinghausen et al.   Particle and Fibre Toxicology

Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes

(2014) Linda M Sargent et al.   Particle and Fibre Toxicology

Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation

(2014) Brittany L Baisch et al.   Particle and Fibre Toxicology

Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles

(2014) Hedwig M Braakhuis et al.   Particle and Fibre Toxicology

Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

(2014) Andrea Adamcakova-Dodd et al.   Particle and Fibre Toxicology

Evidence from pharmacology and pathophysiology suggests that chemicals with dissimilar mechanisms of action could be of bigger concern in the toxicological risk assessment of chemical mixtures than chemicals with a similar mechanism of action

(2014) Niels Hadrup   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free-Radical Scavenging Activity and Oxidative Stress

(2014) Uschi M. Graham et al.   ChemPlusChem

The dissolution and biological effects of silver nanoparticles in biological media

(2014) K. Loza et al.   Journal of Materials Chemistry B

Advancing human health risk assessment: Integrating recent advisory committee recommendations

(2013) Michael Dourson et al.   CRITICAL REVIEWS IN TOXICOLOGY

Pulmonary and Cardiovascular Responses of Rats to Inhalation of Silver Nanoparticles

(2013) Jenny R. Roberts et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Toxicity and bio-accumulation of inhaled cerium oxide nanoparticles in CD1 mice

(2013) Srinivas Aalapati et al.   Nanotoxicology

Cardiopulmonary toxicity of pulmonary exposure to occupationally relevant zinc oxide nanoparticles

(2013) Hsiao-Chi Chuang et al.   Nanotoxicology

Comparative hazard identification of nano- and micro-sized cerium oxide particles based on 28-day inhalation studies in rats

(2013) Ilse Gosens et al.   Nanotoxicology

Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes

(2013) Robert R Mercer et al.   Particle and Fibre Toxicology

Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

(2013) Lan Ma-Hock et al.   Particle and Fibre Toxicology

Oxidative stress and inflammatory responses of rat following acute inhalation exposure to iron oxide nanoparticles

(2012) A Srinivas et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Anin vivoandin vitrotoxicological characterisation of realistic nanoscale CeO2inhalation exposures

(2012) Philip Demokritou et al.   Nanotoxicology

Acute pulmonary dose–responses to inhaled multi-walled carbon nanotubes

(2012) Dale W. Porter et al.   Nanotoxicology

Persistent DNA Damage Measured by Comet Assay of Sprague Dawley Rat Lung Cells after Five Days of Inhalation Exposure and 1 Month Post-Exposure to Dispersed Multi-Wall Carbon Nanotubes (MWCNTs) Generated by New MWCNT Aerosol Generation System

(2012) Jin Sik Kim et al.   TOXICOLOGICAL SCIENCES

Zeta Potential and Solubility to Toxic Ions as Mechanisms of Lung Inflammation Caused by Metal/Metal Oxide Nanoparticles

(2012) Wan-Seob Cho et al.   TOXICOLOGICAL SCIENCES

Effects of inhaled nano-TiO2 aerosols showing two distinct agglomeration states on rat lungs

(2012) A. Noël et al.   TOXICOLOGY LETTERS

Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: Mass and surface area as an exposure metric

(2011) Meng Ho et al.   INHALATION TOXICOLOGY

Genotoxicity of inhaled nanosized TiO2 in mice

(2011) Hanna K. Lindberg et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring

(2011) Petra Jackson et al.   Nanotoxicology

Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity

(2011) Craig A. Poland et al.   Nanotoxicology

Acute inhalation toxicity of cerium oxide nanoparticles in rats

(2011) A. Srinivas et al.   TOXICOLOGY LETTERS

Inhalation exposure to nanosized and fine TiO2 particles inhibits features of allergic asthma in a murine model

(2010) Elina M Rossi et al.   Particle and Fibre Toxicology

Changing the dose metric for inhalation toxicity studies: Short-term study in rats with engineered aerosolized amorphous silica nanoparticles

(2009) Christie M. Sayes et al.   INHALATION TOXICOLOGY

Subchronic 13-Week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects Are Determined by Density of Agglomerate Structures, Not Fibrillar Structures

(2009) Jürgen Pauluhn   TOXICOLOGICAL SCIENCES

Airway Exposure to Silica-Coated TiO2 Nanoparticles Induces Pulmonary Neutrophilia in Mice

(2009) Elina M. Rossi et al.   TOXICOLOGICAL SCIENCES

Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): The key metric of dose is particle mass and not particle surface area

(2009) Jürgen Pauluhn   TOXICOLOGY

Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis

(2008) A. A. Shvedova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO2Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population

(2008) Zhen Chen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Lung Function Changes in Sprague-Dawley Rats After Prolonged Inhalation Exposure to Silver Nanoparticles

(2008) Jae Hyuck Sung et al.   INHALATION TOXICOLOGY

Development of a Short-Term Inhalation Test in the Rat Using Nano-Titanium Dioxide as a Model Substance

(2008) Lan Ma-Hock et al.   INHALATION TOXICOLOGY

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Inhalation carcinogenicity study with nickel metal powder in Wistar rats

(2008) Adriana R. Oller et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY