Article
Multidisciplinary Sciences
Manijeh Goldberg, Aaron Manzi, Amritpreet Birdi, Brandon Laporte, Peter Conway, Stefanie Cantin, Vasudha Mishra, Alka Singh, Alexander T. Pearson, Eric R. Goldberg, Sam Goldberger, Benjamin Flaum, Rifat Hasina, Nyall R. London, Gary L. Gallia, Chetan Bettegowda, Simon Young, Vlad Sandulache, James Melville, Jonathan Shum, Sonya E. O'Neill, Erkin Aydin, Alex Zhavoronkov, Anxo Vidal, Atenea Soto, Maria Jose Alonso, Ari J. Rosenberg, Mark W. Lingen, Anil D'Cruz, Nishant Agrawal, Evgeny Izumchenko
Summary: This study evaluates the use of PRV111, a nanotechnology-based system for local delivery of cisplatin, in animal models of oral cancer and in a clinical trial with OCSCC patients. The results show that PRV111 leads to increased cisplatin retention in tumors and avoids systemic toxicity. It also produces robust anti-tumor responses and complete regression of premalignant lesions. The clinical trial demonstrates efficacy and safety, with significant tumor reduction and no serious adverse events reported.
NATURE COMMUNICATIONS
(2022)
Review
Nanoscience & Nanotechnology
Siyan Liu, Jing Li, Lin Gu, Kunzhe Wu, Hua Xing
Summary: Chemoimmunotherapy shows promise for treating TNBC, but challenges remain in improving efficacy and reducing side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Sabrina Valetti, Azra Riaz, Anemona Doko, Kaiser Sultana, Mahboubeh Eskandari, Zdenka Prgomet, Adam Feiler, Robert Ronn, Bengt Dahlstrom, Johan Engblom, Sebastian Bjorklund
Summary: This article presents a study on the oral transmucosal delivery of eletriptan for the treatment of migraines. The study proposes the conditions required for transmucosal delivery and demonstrates the effectiveness and safety of this method through in vitro and cellular experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Yundi Chen, Lixue Wang, Mingfeng Zheng, Chuandong Zhu, Guosheng Wang, Yiqiu Xia, Ethan J. Blumenthal, Wenjun Mao, Yuan Wan
Summary: Research shows that engineered universal EVs carrying PD-1 proteins are effective in reducing cancer cell proliferation, inducing apoptosis, and blocking PD-L1 mediated T cell suppression. These EVs demonstrate strong anti-tumor activity in tumor models, with efficacy comparable to clinical anti-PD1 monoclonal antibodies.
BIOACTIVE MATERIALS
(2022)
Article
Geochemistry & Geophysics
Zhangjuan Xie, Jie Xia, Mengxia Jiao, Pengyuan Zhao, Zhiqiang Wang, Shengli Lin, Yun Xing, Yifan Li, Zhou Lu, Ziwen Zhong, Changhong Miao, Pinghong Zhou, Jiawen Qian, Luman Wang, Dan Zhang, Jie Gu, Yiwei Chu, Ronghua Liu
Summary: Tumor-derived exosomes drive Bregs to suppress anti-tumor immunity by delivering lncRNA HOTAIR, which activates the STAT3 pathway and induces PDL1 expression in B cells. The presence of exosomal HOTAIR is positively correlated with tumor-infiltrating PDL1+ B cells in CRC patients.
ORGANIC GEOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Wenjun Zhu, Yu Chao, Qiutong Jin, Linfu Chen, Jing-jing Shen, Jiafei Zhu, Yu Chai, Panhao Lu, Nailin Yang, Muchao Chen, Yang Yang, Qian Chen, Zhuang Liu
Summary: Researchers have developed a drug delivery system for therapeutic proteins that can be orally administered, enabling the proteins to enter the bloodstream and show promising efficacy in cancer treatment with reduced immune-related adverse events.
Article
Oncology
Haiyan Bai, Alvaro S. Padron, Yilun Deng, Yiji J. Liao, Clare J. Murray, Carlos Ontiveros, Suresh J. Kari, Aravind Kancharla, Anand V. R. Kornepati, Myrna Garcia, Ryan Michael Reyes, Harshita B. Gupta, Jose R. Conejo-Garcia, Tyler Curiel
Summary: This study identified chlorambucil as a drug that can deplete tumor cell PDL1 levels, which has potential therapeutic effects in tumors that are resistant to alpha PDL1 immune checkpoint blockade therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Engineering, Biomedical
Siyu Wang, Yue Song, Kunxia Cao, Lingxiao Zhang, Xuedong Fang, Fangfang Chen, Shouhua Feng, Fei Yan
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Nanomedicine-based photothermal therapy (PTT) has shown promising results for solid tumor ablation, providing a potential therapeutic strategy for CRC.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Qi-Song Tong, Wei-Min Miao, Hua Huang, Jia-Qi Luo, Rong Liu, Yong-Cong Huang, Dong-Kun Zhao, Song Shen, Jin-Zhi Du, Jun Wang
Summary: A newly developed tumor-penetrating nanoparticle can modulate the deep microenvironment of PDAC, facilitating the effectiveness of chemoimmunotherapy.
Article
Chemistry, Multidisciplinary
Jiamin Wu, Natalie Jones, Nojoud A. L. Fayez, Po-Han Chao, Angeline Wu, Daniele Ribeiro de Araujo, Elham Rouhollahi, Analisa Jia, Shyh-Dar Li
Summary: We propose a non-parenteral delivery method for proteins using protamine, an FDA-approved peptide. Protamine promotes actin tubulation and rearrangement, enhancing intracellular protein delivery compared to poly(arginine)(8) (R8). Protamine directs proteins to the nuclei with minimal lysosomal uptake, in contrast to R8-mediated delivery. Intranasal delivery of insulin mixed with protamine effectively reduces blood glucose levels in diabetic mice for up to 6 hours, similar to subcutaneously injected insulin.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Bharti Mangla, Shamama Javed, Muhammad H. Sultan, Waquar Ahsan, Geeta Aggarwal, Kanchan Kohli
Summary: Drug delivery via the oral route is popular due to its convenience, safety, and cost-effectiveness. Transmucosal delivery, especially through the oral mucosa, is being investigated for efficient administration of bioactive compounds, including vaccines. Needle-free devices have been developed to improve patient compliance by reducing anxiety and pain. Nanocarriers enhance vaccine bioavailability and immune response, leading to increased efficacy. This review summarizes recent research on needle-free and non-invasive approaches for oral transmucosal vaccine delivery, highlighting their strengths and challenges.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Haifeng Ni, Sunxiang Qian, Jie Lu, Jie Feng, Xiao-zhou Mou, Jing Zhang
Summary: This study utilized dextran microgels as modular drug libraries, which were integrated with granulocyte-macrophage colony-stimulating factor (GM-CSF) into cryogels for combined anti-cancer treatment. The multiscale delivery platform improved the synergistic effect of various medications on tumor treatment.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Samaneh Alaei, Hamid Omidian
Summary: Mucoadhesive oral thin films are a focus of current drug development, offering advantages such as higher bioavailability and faster onset of action through transmucosal drug delivery. Buccal and sublingual strips or patches are preferred transmucosal delivery platforms due to flexibility, ease of use, and fast dissolution.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hyunkyu Lee, Hye Su Min, Mingyu Jang, Geonwoo Kang, Seongdae Gong, Chisong Lee, Young Woo Song, Ui-Won Jung, Somin Lee, Hyeon Yeol Ryu, Huisuk Yang, Hyungil Jung
Summary: Lidocaine is commonly used as a local anesthetic to reduce pain. Dissolving microneedles can effectively deliver lidocaine by overcoming the oral mucosal barrier, providing local anesthesia with lower doses and without mucosal irritation.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Nanoscience & Nanotechnology
Hazem Choukaife, Salma Seyam, Batoul Alallam, Abd Almonem Doolaanea, Mulham Alfatama
Summary: This article summarizes the pathology and therapy of colorectal cancer (CRC), as well as the challenges faced by oral drug delivery. It emphasizes the role of nanotechnology in oral drug targeted delivery systems and the significance of chitosan and its derivatives.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Xintong Zhang, Yanhong Liu, Wei Liu, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang
Summary: This study developed a macrophage-hitchhiking gene delivery system for the treatment of rheumatoid arthritis. The system demonstrated excellent targeting ability and nuclear entry ability, leading to efficient transfection of interleukin-10 in macrophages and alleviation of inflammation symptoms. This research provides a novel strategy for gene therapy and gene delivery system design for rheumatoid arthritis and other similar inflammatory diseases.
Article
Chemistry, Multidisciplinary
Richard K. Cross, Dave Spurgeon, Claus Svendsen, Elma Lahive, Simon Little, Frank von der Kammer, Frederic Loosli, Marianne Matzke, Teresa F. Fernandes, Vicki Stone, Willie J. G. M. Peijnenburg, Eric A. J. Bleeker
Summary: Even small changes in physicochemical properties of nanoforms (NFs) can influence their environmental fate and hazard. Testing and characterizing each individual NF will not be feasible due to the large number of new materials being developed. Targeting the most relevant form of the NF for a given exposure is important for efficient risk assessment. In aquatic systems, functional fate processes play a key role in determining the exposure relevant form of NFs. Grouping of NFs and read-across based on functional fate pathways can be justified by considering the shared fate and hazard profile. A new Integrated Approaches to Testing and Assessment (IATA) is presented, focusing on dissolution, dispersion stability, chemical transformations, and the contribution to toxicity from particles and dissolved components. This IATA can be used as a template for future in vivo kinetic assessments.
Article
Chemistry, Multidisciplinary
Minhui Lu, Xiaoxuan Zhang, Lijun Cai, Jingjing Gan, Jinglin Wang, Yu Wang, Yuanjin Zhao
Summary: Researchers have proposed a novel black phosphorus-loaded hydrogel inverse opal microneedle patch that exhibits photothermal responsive capacity and vivid structural color screening for psoriasis treatment. With improved materials, structures, and functions, the microneedle patch enables intelligent drug delivery and enhances drug loading and controllable release.
Article
Chemistry, Multidisciplinary
Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han, Mingzhe Gan, Peifeng Liu
Summary: This study presents a novel microfluidic platform for precise and flexible control of oxygen concentrations in microbial suspension culture. The platform demonstrates unique capabilities for spatiotemporal gas control and detection, allowing for applications in screening, studying, and culturing industrial or niche-specific environmental microbiomes.
Review
Chemistry, Multidisciplinary
Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu, Ying Liu
Summary: This review categorizes the potential health risks of microplastic pollution by focusing on the three primary pollution sources. It provides an in-depth analysis of the pharmacokinetics, toxicity potential, and biological mechanism of microplastics in the human body. The review aims to fill knowledge gaps about the toxicity of microplastics on human health and provide ideas for repairing the damage caused by microplastics.
Article
Chemistry, Multidisciplinary
Fanshu Ma, Yi Cao, Jincong Yan, Zhongzhong Lu, Lina Sun, Zahid Hussain, Zheng Wang, Li Wang, Renjun Pei
Summary: This study proposes a simple yet powerful method to create multifunctional hybrid nanovesicles that combine the characteristics of oncolytic viruses and pyroptosis, leading to enhanced tumor targeting and improved immune response. The results demonstrate excellent tumor inhibition efficacy against melanoma and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang, Xing-Can Shen, Liangnian Ji, Hui Chao
Summary: This study presents the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy. The conjugates were found with strong two-photon absorption and could generate reactive oxygen species (ROS) to induce cell death and inhibit tumor growth through immune system activation.
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Chemistry, Multidisciplinary
Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.
Article
Chemistry, Multidisciplinary
Xu Zhang, Kejian Shi, Jiahui Mao, Kerou Mao, Yangrui Jia, Jiakun Zhang, Qingzhen Wang, Ru Bai, Fene Gao, Shihui Liu, Mengyu Guo, Fenglan Qin, Shengmin Li, Chunying Chen, Huige Zhou, Jing Liu, Fulin Chen
Summary: Compared with vein injection, oral administration is a preferred non-invasive and self-help treatment option for cancer therapy. However, the harsh gastrointestinal tract and biological barriers limit the stability and efficiency of oral drug delivery systems. To overcome these challenges, researchers have developed Cyssome, a drug delivery platform that can maintain stability in harsh environments, penetrate biological barriers, and improve drug release and bioavailability.