Biomimetic hematoma delivers an ultra-low dose of rhBMP-2 to successfully regenerate large femoral bone defects in rats

Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep

(2020) Lovorka Grgurevic et al.   BONE

Recombinant Human BMP6 Applied Within Autologous Blood Coagulum Accelerates Bone Healing: Randomized Controlled Trial in High Tibial Osteotomy Patients

(2020) Catharina Chiari et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fibrin-VLDL Receptor-Dependent Pathway Promotes Leukocyte Transmigration by Inhibiting Src Kinase Fyn and is a Target for Fibrin β15-42 Peptide

(2019) Sergiy Yakovlev et al.   THROMBOSIS AND HAEMOSTASIS

Expanded skeletal stem and progenitor cells promote and participate in induced bone regeneration at subcritical BMP-2 dose

(2019) Panagiota Papageorgiou et al.   BIOMATERIALS

Extracellular calcium stimulates osteogenic differentiation of human adipose-derived stem cells by enhancing bone morphogenetic protein-2 expression

(2019) Risa Yanai et al.   CELL CALCIUM

The roles of cellular and molecular components of a hematoma at early stage of bone healing

(2018) Hoi Ting Shiu et al.   Journal of Tissue Engineering and Regenerative Medicine

Osteogenic differentiation of equine adipose tissue derived mesenchymal stem cells using CaCl 2

(2018) Mohamed I. Elashry et al.   RESEARCH IN VETERINARY SCIENCE

Effect of fibrinogen, fibrin, and fibrin degradation products on transendothelial migration of leukocytes

(2018) Sergiy Yakovlev et al.   THROMBOSIS RESEARCH

Biomaterials for the Delivery of Growth Factors and Other Therapeutic Agents in Tissue Engineering Approaches to Bone Regeneration

(2018) Christine J. Kowalczewski et al.   Frontiers in Pharmacology

Cellular biology of fracture healing

(2018) Chelsea S. Bahney et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Circulating osteogenic precursor cells: Building bone from blood

(2018) Jack Feehan et al.   EBioMedicine

Low-dose BMP-2 and MSC dual delivery onto coral scaffold for critical-size bone defect regeneration in sheep

(2017) Adeline Decambron et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Calvarial Bone Regeneration Is Enhanced by Sequential Delivery of FGF-2 and BMP-2 from Layer-by-Layer Coatings with a Biomimetic Calcium Phosphate Barrier Layer

(2017) Gloria Gronowicz et al.   TISSUE ENGINEERING PART A

A Concert between Biology and Biomechanics: The Influence of the Mechanical Environment on Bone Healing

(2017) Vaida Glatt et al.   Frontiers in Physiology

Inflammation, fracture and bone repair

(2016) Florence Loi et al.   BONE

Reverse Dynamization

(2016) Vaida Glatt et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Structural properties of fracture haematoma: current status and future clinical implications

(2016) Xin Wang et al.   Journal of Tissue Engineering and Regenerative Medicine

A composited PEG-silk hydrogel combining with polymeric particles delivering rhBMP-2 for bone regeneration

(2016) Dakun Ma et al.   Materials Science & Engineering C-Materials for Biological Applications

A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2

(2016) Aaron W. James et al.   TISSUE ENGINEERING PART B-REVIEWS

Templated Repair of Long Bone Defects in Rats with Bioactive Spiral-Wrapped Electrospun Amphiphilic Polymer/Hydroxyapatite Scaffolds

(2015) Artem B. Kutikov et al.   ACS Applied Materials & Interfaces

Effects of low dose FGF-2 and BMP-2 on healing of calvarial defects in old mice

(2015) Lyndon F. Charles et al.   EXPERIMENTAL GERONTOLOGY

Biological aspects of segmental bone defects management

(2015) Ivo Dumic-Cule et al.   INTERNATIONAL ORTHOPAEDICS

Mechanisms of fibrin polymerization and clinical implications

(2013) J. W. Weisel et al.   BLOOD

The optimal carrier for BMP-2: a comparison of collagen versus fibrin matrix

(2012) Sebastian Schützenberger et al.   ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY

Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds

(2012) Sungsoo S. Lee et al.   BIOMATERIALS

The Human Serum Metabolome

(2011) Nikolaos Psychogios et al.   PLoS One

A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned

(2011) Eugene J. Carragee et al.   Spine Journal

High Doses of Bone Morphogenetic Protein 2 Induce Structurally Abnormal Bone and Inflammation In Vivo

(2011) Janette N. Zara et al.   TISSUE ENGINEERING PART A

Thrombin generation, fibrin clot formation and hemostasis

(2008) Alisa S. Wolberg et al.   TRANSFUSION AND APHERESIS SCIENCE