Article
Genetics & Heredity
Ling Zhu, Xi Zeng, Weiwei Liu, Wei Han, Guoning Huang, Jingyu Li
Summary: This study compared the DNA methylation profiles of human embryos cultured in uninterrupted or interrupted incubators. The results showed that eight-cell embryos cultured in TLI and SI had similar genome-wide methylation patterns. Although 198 differentially methylated genes were identified, only five of them had significantly different transcription levels between the two groups.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Obstetrics & Gynecology
Xiao-Dong Zhang, Qi Zhang, Wei Han, Wei -Wei Liu, Xiao- Li Shen, Gui-Dong Yao, Sen-Lin Shi, Lin -Li Hu, Shan -Shan Wang, Jun-Xia Wang, Jian-Jun Zhou, Wei -Wei Kang, Heng-De Zhang, Chen Luo, Qi Yu, Rui-Zhi Liu, Ying-Pu Sun, Hai-Xiang Sun, Xiao-Hong Wang, Song Quan, Guo-Ning Huang
Summary: The study found that using a time-lapse incubator for embryo culture and assessment led to a significantly higher number of successfully implanted embryos in the first transfer cycle and a higher implantation rate compared to using a standard incubator with static assessment. This suggests that time-lapse technology may have potential clinical benefits in assisted reproduction.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Aisling Ahlstrom, Kersti Lundin, Anna-Karin Lind, Kristina Gunnarsson, Goran Westlander, Hannah Park, Anna Thurin-Kjellberg, Steinunn A. Thorsteinsdottir, Snorri Einarsson, Mari Astrom, Kristina Lofdahl, Judith Menezes, Susanne Callender, Cina Nyberg, Jens Winerdal, Camilla Stenfelt, Brit-Randi Jonassen, Nan Oldereid, Lisa Nolte, Malin Sundler, Thorir Hardarson
Summary: The use of a commercially available time-lapse algorithm for Day 5 blastocyst selection did not improve ongoing pregnancy rates compared with morphology alone.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Chandra C. C. Shenoy, Alexandra Bader, David L. L. Walker, Jolene R. R. Fredrickson, Amy L. L. Weaver, Yulian Zhao
Summary: This study examined blastomere exclusion during embryo development and its association with aneuploidy. Results showed that embryos with blastomere exclusion had a higher rate of aneuploidy compared to those without exclusion. Late blastomere exclusion or a combination of early and late exclusion was particularly associated with an increased risk of aneuploid embryo genetics. These findings should be considered in embryo selection using time-lapse culture systems.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yuqiong Wang, Sheng Wang, Xilin Qian, Yanrong Kuai, Yang Xu
Summary: A single-center, large-cohort, retrospective study compared embryonic development in group culture systems with or without G4 embryos, revealing that multiple G4 embryos have a negative impact on neighboring embryos, while polypronuclear embryos contribute positively. LC-MS/MS analysis of G1-G4 embryo secretome showed that certain proteins secreted by G4 embryos may harm nearby embryos, emphasizing the importance of limiting the number of G4 embryos in group culture settings.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Obstetrics & Gynecology
Romualdo Sciorio, Marcos Meseguer
Summary: The main aim of assisted reproductive technology is to achieve a healthy singleton live birth, and the introduction of time-lapse monitoring technology has enabled embryologists to more accurately assess embryo status and implantation potential.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Infectious Diseases
Eric P. F. Chow, Deborah A. Williamson, Jane S. Hocking, Matthew G. Law, Kate Maddaford, Catriona S. Bradshaw, Anna McNulty, David J. Templeton, Richard Moore, Gerald L. Murray, Jennifer A. Danielewski, Rebecca Wigan, Marcus Y. Chen, Rebecca J. Guy, Lei Zhang, Basil Donovan, Andrew E. Grulich, John M. Kaldor, David M. Whiley, Vincent J. Cornelisse, Benjamin P. Howden, David A. Lewis, Tim R. H. Read, Christopher K. Fairley
Summary: The study compared the efficacy of Listerine and Biotene mouthwashes in preventing gonorrhea among men who have sex with men. The results showed that there was no significant difference between the two mouthwashes in preventing oropharyngeal gonorrhea. Further studies are warranted to determine the potential role of mouthwash in preventing gonorrhea transmission.
LANCET INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Raymond Hang Wun Li, Sue Seen Tsing Lo, Kristina Gemzell-Danielsson, Carol Ho Yi Fong, Pak Chung Ho, Ernest Hung Yu Ng
Summary: This study found that co-administration of oral piroxicam 40 mg with levonorgestrel improved the efficacy of emergency contraception. The use of piroxicam could be considered in clinical settings where levonorgestrel emergency contraception is the chosen option.
Article
Oncology
Juan W. Valle, Arndt Vogel, Crystal S. Denlinger, Aiwu Ruth He, Li-Yuan Bai, Rashida Orlova, Eric Van Cutsem, Jorge Adeva, Li-Tzong Chen, Radka Obermannova, Thomas J. Ettrich, Jen-Shi Chen, Harpreet Wasan, Allicia C. Girvan, Wei Zhang, Jiangang Liu, Chunlao Tang, Philip J. Ebert, Amit Aggarwal, Samuel C. McNeely, Brian A. Moser, Joana M. Oliveira, Roberto Carlesi, Richard A. Walgren, Do-Youn Oh
Summary: This study investigated the efficacy and safety of adding ramucirumab or merestinib to first-line cisplatin-gemcitabine in patients with biliary tract cancer. The results showed that these treatment regimens were well tolerated but did not improve progression-free survival in patients with this type of cancer.
Article
Rheumatology
Pascal Richette, Augustin Latourte, Jeremie Sellam, Daniel Wendling, Muriel Piperno, Philippe Goupille, Yves-Marie Pers, Florent Eymard, Sebastien Ottaviani, Paul Ornetti, Rene-Marc Flipo, Bruno Fautrel, Olivier Peyr, Jean Pierre Bertola, Eric Vicaut, Xavier Chevalier
Summary: The study found that tocilizumab was not more effective than placebo in relieving pain in patients with hand osteoarthritis. Apart from the primary endpoint, there were no significant differences in secondary outcomes between the tocilizumab group and the placebo group.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Gastroenterology & Hepatology
Jeroen M. Schuitenmaker, Froukje B. van Hoeij, Marlies P. Schijven, Jan Tack, Jose M. Conchillo, Eric J. Hazebroek, Andre J. P. M. Smout, Albert J. Bredenoord
Summary: The study results indicate that pneumatic dilation with a 35 mm balloon is not superior to sham dilation for the treatment of persistent dysphagia after fundoplication.
Article
Medicine, General & Internal
Andrew W. Horne, Stephen Tong, Catherine A. Moakes, Lee J. Middleton, W. Colin Duncan, Ben W. Mol, Lucy H. R. Whitaker, Davor Jurkovic, Arri Coomarasamy, Natalie Nunes, Tom Holland, Fiona Clarke, Ann M. Doust, Jane P. Daniels
Summary: This study evaluated whether oral gefitinib in combination with methotrexate is more effective than methotrexate alone in the treatment of tubal ectopic pregnancy. The results showed that oral gefitinib does not offer clinical benefit over methotrexate and increases minor adverse reactions.
Article
Rheumatology
Renaud Felten, Valerie Devauchelle-Pensec, Raphaele Seror, Pierre Duffau, David Saadoun, Eric Hachulla, Hatron Pierre Yves, Carine Salliot, Aleth Perdriger, Jacques Morel, Arsene Mekinian, Olivier Vittecoq, Jean-Marie Berthelot, Emanuelle Dernis, Veronique Le Guern, Philippe Dieude, Claire Larroche, Christophe Richez, Thierry Martin, Charles Zarnitsky, Gilles Blaison, Pierre Kieffer, Francois Maurier, Azeddine Dellal, Stephanie Rist, Emmanuel Andres, Anne Contis, Emmanuel Chatelus, Christelle Sordet, Jean Sibilia, Cecile Arnold, Mira Y. Tawk, Ouafaa Aberkane, Lise Holterbach, Patrice Cacoub, Alain Saraux, Xavier Mariette, Nicolas Meyer, Jacques-Eric Gottenberg
Summary: This study aimed to demonstrate the efficacy of targeting interleukin 6 receptor in patients with primary Sjogren's syndrome-related systemic complications. However, the results showed that over 24 weeks of treatment, tocilizumab did not improve systemic involvement and symptoms in patients with primary Sjogren's syndrome.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Genetics & Heredity
Alessandro Bartolacci, Andrea Borini, Danilo Cimadomo, Gemma Fabozzi, Roberta Maggiulli, Cristina Lagalla, Daniela Pignataro, Miriam dell'Aquila, Federica Parodi, Gilda Patria, Carlotta Zaca, Filippo Maria Ubaldi, Laura Rienzi, Giovanni Coticchio
Summary: This study investigated whether high relative humidity conditions, when using a time-lapse system and sequential culture media, are beneficial to embryo culture and improve ongoing pregnancy rates. The results suggest that high relative humidity conditions do not improve the rate of ongoing pregnancy and several embryological outcomes, under the conditions used in this study.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Oncology
Dean A. Fennell, Sean Ewings, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Kayleigh Hill, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Aarti Gaba, Liz Darlison, Peter Wells-Jordan, Cathy Richards, Charlotte Poile, Jason F. Lester, Gareth Griffiths
Summary: The study evaluated the efficacy and safety of nivolumab in patients with pleural or peritoneal malignant mesothelioma who had progressed following platinum-based chemotherapy. Nivolumab showed improved progression-free survival and overall survival compared to placebo in these patients, with manageable treatment-related adverse events. The results suggest that nivolumab might be a beneficial treatment for patients with malignant mesothelioma who have progressed on first-line therapy.
Article
Obstetrics & Gynecology
Yizhen Liu, Jim G. Thornton, Wentao Li, Madelon van Wely, Ben W. Mol
Summary: The analysis of 22 RCTs by Dr. Maged suggests potential data integrity issues, and it is recommended that journals investigate according to the guidelines of the Committee on Publication Ethics. The procedures demonstrated in this paper may help assess data integrity for future attempts to verify the authenticity of published RCTs.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Jennifer A. Wessel, Sarah Hunt, Madelon van Wely, Femke Mol, Rui Wang
Summary: This article reviews the concerns and considerations surrounding the overuse of in vitro fertilization (IVF), as well as the underappreciation of alternatives to IVF in clinical practice and research. It summarizes the current evidence on the effectiveness, safety, and cost-effectiveness of various alternatives to IVF, such as expectant management, intrauterine insemination, tubal flushing, in vitro maturation, and intravaginal culture. The article also discusses the trend of IVF use over the last decade and the roles of different alternatives to IVF in modern reproductive medicine.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Krystle Y. Chong, Sarah Solangon, Kurt Barnhart, Pamela Causa-Andrieu, Perrine Capmas, George Condous, Liesl de Waard, James M. N. Duffy, Andrew W. Horne, Maria Memtsa, Femke Mol, Munira Oza, Romina Pesce, Annika Strandell, Madelon van Wely, Janneke van't Hooft, Lan N. Vuong, Jian Zhang, Davor Jurkovic, Ben W. Mol
Summary: This study developed a core outcome set for ectopic pregnancy (EP) to address methodological deficiencies in published randomized controlled trials and systematic reviews. The core outcome set consists of 6 outcomes, including treatment success, resolution time, the number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
E. M. Bordewijk, T. Jannink, N. S. Weiss, T. de Vries, M. Nahuis, A. Hoek, M. Goddijn, B. W. Mol, M. van Wely, M-Ovin Study Grp
Summary: This study aimed to investigate the long-term outcomes of using gonadotrophins versus clomiphene citrate (CC) in women with normogonadotropic anovulation and clomiphene failure. The results showed that about four in five women were able to have a live birth after experiencing clomiphene failure, with no significant difference in pregnancy outcomes among the allocated groups.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Sarah Annie Solangon, Madelon Van Wely, Norah Van Mello, Ben W. Mol, Jackie A. Ross, Davor Jurkovic
Summary: Ectopic pregnancy is a common health condition affecting 1 in 100 women. Methotrexate (MTX) and expectant management are both viable treatment options for women with mild symptoms and low hCG levels. A systematic review and meta-analysis of randomized controlled trials showed no statistically significant difference in treatment efficacy between MTX and expectant management, suggesting that initial expectant management may be preferred due to fewer side-effects.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Noor E. Simons, Annemijn A. de Ruigh, Janneke van't Hooft, Cornelieke S. H. Aarnoudse-Moens, Madelon van Wely, David P. van der Ham, Augustinus S. P. van Teeffelen, Tessa J. Roseboom, Ben W. Mol, Aleid G. Leemhuis, Eva Pajkrt
Summary: Management of late preterm prelabor rupture of membranes between 34+0 and 36+6 weeks' gestation shows similar risks between induction of labor and expectant management. However, children at 2 years of age show more neurodevelopmental delay with expectant management. Long-term outcomes in child development after 2 years are still unknown.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Joanne Aalberts, Madelon van Wely
FERTILITY AND STERILITY
(2023)
Review
Obstetrics & Gynecology
T. R. Zaat, E. B. Kostova, P. Korsen, M. G. Showell, F. Mol, M. van Wely
Summary: Based on a systematic review and meta-analysis, natural cycle frozen embryo transfer (NC-FET) appears to be associated with a lower risk of adverse obstetric and neonatal outcomes compared to artificial cycle frozen embryo transfer (AC-FET). Furthermore, NC-FET with luteal phase support (LPS) may reduce the risk of preterm birth. Therefore, NC-FET should be the preferred treatment for women undergoing frozen embryo transfer. The use of LPS in NC-FET may decrease the risk of preterm birth, but more research is needed to determine its efficacy and safety.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Obstetrics & Gynecology
Jitske Eliveld, Ilias van der Bles, Madelon van Wely, Andreas Meissner, Alexandre T. Soufan, Annemieke C. Heijboer, Sjoerd Repping, Fulco van der Veen, Ans M. M. van Pelt
Summary: This study investigates the risk of hypogonadism in men with obstructive azoospermia, non-obstructive azoospermia (NOA) or Klinefelter syndrome after testicular sperm extraction (TESE). The results show that 36% of men with Klinefelter syndrome, 4% of men with obstructive azoospermia, and 3% of men with NOA required testosterone replacement therapy (TRT). Klinefelter syndrome is strongly associated with the need for TRT, while no association is found for obstructive azoospermia or NOA. Additionally, higher testosterone concentrations before TESE are linked to a lower chance of needing TRT.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Aafke Bruinsma, Judit K. J. Keulen, Rik Van Eekelen, Madelon Van Wely, Joep C. Kortekaas, Jeroen Van Dillen, Joris A. M. Van de Post, Ben W. Mol, Esteriek de Miranda
Summary: This study assessed the cost-effectiveness of elective induction of labour (IOL) at 41 weeks compared to expectant management (EM) until 42 weeks for late-term pregnancies. The results showed that IOL has an 80% chance of being cost-effective for preventing adverse perinatal outcomes at a certain willingness-to-pay threshold. Subgroup analysis suggested that IOL may be cost-effective for nulliparous women, but unlikely to be cost-effective for multiparous women. The cost-effectiveness in other settings will depend on the baseline characteristics of the population and the organization and funding of the healthcare system.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X
(2023)
Letter
Obstetrics & Gynecology
T. R. Zaat, F. Mol, M. van Wely
HUMAN REPRODUCTION UPDATE
(2023)
Editorial Material
Obstetrics & Gynecology
Madelon van Wely, Julie M. Hastings, Basil Tarlatzis, Arne Sunde
HUMAN REPRODUCTION UPDATE
(2023)
Review
Obstetrics & Gynecology
Janneke A. C. van Baar, Elena B. Kostova, John Allotey, Shakila Thangaratinam, Javier R. Zamora, Mercedes Bonet, Caron Rahn Kim, Lynne M. Mofenson, Heinke Kunst, Asma Khalil, Elisabeth van Leeuwen, Julia Keijzer, Marije Strikwerda, Bethany Clark, Maxime Verschuuren, Arri Coomarasamy, Mariette Goddijn, Madelon van Wely
Summary: This systematic review aims to determine the prevalence of early pregnancy loss in women with SARS-Cov-2 infection and compare the risk to pregnant women without SARS-CoV-2 infection.
HUMAN REPRODUCTION UPDATE
(2023)