标题
Clinical Trial Design for Lipoprotein(a)-Lowering Therapies
作者
关键词
-
出版物
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 81, Issue 16, Pages 1633-1645
出版商
Elsevier BV
发表日期
2023-04-18
DOI
10.1016/j.jacc.2023.02.033
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Association of Lipoprotein(a) With Atherosclerotic Plaque Progression
- (2022) Yannick Kaiser et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a)
- (2022) Michael J. Koren et al. NATURE MEDICINE
- Lipoprotein(a) beyond the kringle IV repeat polymorphism: The complexity of genetic variation in the LPA gene
- (2022) Stefan Coassin et al. ATHEROSCLEROSIS
- Single Ascending Dose Study of a Short Interfering RNA Targeting Lipoprotein(a) Production in Individuals With Elevated Plasma Lipoprotein(a) Levels
- (2022) Steven E. Nissen et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol
- (2022) Calvin Yeang et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction
- (2022) Stephen J. Nicholls et al. JACC-Cardiovascular Imaging
- Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement
- (2022) Florian Kronenberg et al. EUROPEAN HEART JOURNAL
- Ancestry, Lipoprotein(a), and Cardiovascular Risk Thresholds
- (2022) Sotirios Tsimikas et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes
- (2022) Paul Lacaze et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Quantification of LDL-Cholesterol Corrected for Molar Concentration of Lipoprotein(a)
- (2022) Robert S. Rosenson et al. CARDIOVASCULAR DRUGS AND THERAPY
- Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease
- (2022) Michelle L. O’Donoghue et al. NEW ENGLAND JOURNAL OF MEDICINE
- Progression of whole-heart Atherosclerosis by coronary CT and major adverse cardiovascular events
- (2021) Alexander R. van Rosendael et al. Journal of Cardiovascular Computed Tomography
- Emerging RNA Therapeutics to Lower Blood Levels of Lp(a)
- (2021) Sotirios Tsimikas et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial
- (2021) Paul M Ridker et al. LANCET
- In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
- (2021) Kiran Musunuru et al. NATURE
- 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
- (2021) Frank L J Visseren et al. EUROPEAN HEART JOURNAL
- High-Sensitivity C-Reactive Protein Modifies the Cardiovascular Risk of Lipoprotein(a)
- (2021) Wei Zhang et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease
- (2021) Johanna F. Schachtl-Riess et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol
- (2021) Gregory G. Schwartz et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association
- (2021) Gissette Reyes-Soffer et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome
- (2020) Vera A. Bittner et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The promise and challenge of therapeutic genome editing
- (2020) Jennifer A. Doudna NATURE
- Lipoprotein(a) Reduction in Persons with Cardiovascular Disease
- (2020) Sotirios Tsimikas et al. NEW ENGLAND JOURNAL OF MEDICINE
- Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome
- (2020) Gregory G. Schwartz et al. CIRCULATION
- Effect of C-Reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients With High-Risk Vascular Disease
- (2020) Rishi Puri et al. JAMA Cardiology
- Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial
- (2020) Michael Szarek et al. EUROPEAN HEART JOURNAL
- Lipoprotein(a), PCSK9 Inhibition and Cardiovascular Risk: Insights from the FOURIER Trial
- (2019) Michelle L. O'Donoghue et al. CIRCULATION
- 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease
- (2019) Donna K. Arnett et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Lipoprotein(a) and Risk of Ischemic Stroke in the REGARDS Study
- (2019) Pankaj Arora et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Statin therapy increases lipoprotein(a) levels
- (2019) Sotirios Tsimikas et al. EUROPEAN HEART JOURNAL
- Use of lipoprotein(a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association. Don P. Wilson, MD, on behalf of the Writing group
- (2019) Don P. Wilson et al. Journal of Clinical Lipidology
- Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis
- (2019) Kang H. Zheng et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outcomes
- (2019) Claudia Lamina et al. JAMA Cardiology
- Lipoprotein Apheresis for Lipoprotein(a) and Cardiovascular Disease
- (2019) Patrick M. Moriarty et al. Journal of Clinical Lipidology
- Lipoprotein(a)-Lowering by 50 mg/dL (105 nmol/L) May Be Needed to Reduce Cardiovascular Disease 20% in Secondary Prevention
- (2019) Christian M. Madsen et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis
- (2018) Sotirios Tsimikas et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies
- (2018) Stephen Burgess et al. JAMA Cardiology
- High lipoprotein(a) and high risk of mortality
- (2018) Anne Langsted et al. EUROPEAN HEART JOURNAL
- Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials
- (2018) Peter Willeit et al. LANCET
- How to use Mendelian randomization to anticipate the results of randomized trials
- (2017) Brian A Ference EUROPEAN HEART JOURNAL
- LPA Gene, Ethnicity, and Cardiovascular EventsClinical Perspective
- (2016) Sang-Rok Lee et al. CIRCULATION
- Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in HumansClinical Perspective
- (2016) Fleur M. van der Valk et al. CIRCULATION
- Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients
- (2016) Stephen J. Nicholls et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor’s role
- (2016) Frederick J. Raal et al. JOURNAL OF LIPID RESEARCH
- Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials
- (2016) Nicholas J Viney et al. LANCET
- Mechanistic insights into Lp(a)-induced IL-8 expression: a role for oxidized phospholipid modification of apo(a)
- (2015) Corey A. Scipione et al. JOURNAL OF LIPID RESEARCH
- IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans
- (2015) Nike Müller et al. JOURNAL OF LIPID RESEARCH
- Plaque Characterization by Coronary Computed Tomography Angiography and the Likelihood of Acute Coronary Events in Mid-Term Follow-Up
- (2015) Sadako Motoyama et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Pro-Inflammatory Interleukin-1 Genotypes Potentiate the Risk of Coronary Artery Disease and Cardiovascular Events Mediated by Oxidized Phospholipids and Lipoprotein(a)
- (2014) Sotirios Tsimikas et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Coronary atheroma volume and cardiovascular events during maximally intensive statin therapy
- (2013) R. Puri et al. EUROPEAN HEART JOURNAL
- Lipoprotein(a): resurrected by genetics
- (2013) F. Kronenberg et al. JOURNAL OF INTERNAL MEDICINE
- MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma
- (2013) Philipp Wiesner et al. JOURNAL OF LIPID RESEARCH
- Relationship of Apolipoproteins A-1 and B, and Lipoprotein(a) to Cardiovascular Outcomes
- (2013) John J. Albers et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- High-Risk Coronary Atheroma
- (2013) Rishi Puri et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions
- (2012) Rogier A. van Dijk et al. JOURNAL OF LIPID RESEARCH
- Intravascular Ultrasound-Derived Measures of Coronary Atherosclerotic Plaque Burden and Clinical Outcome
- (2010) Stephen J. Nicholls et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction
- (2009) Pia R. Kamstrup JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Lipoprotein(a) Concentration and the Risk of Coronary Heart Disease, Stroke, and Nonvascular Mortality
- (2009) JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
- (2009) Robert Clarke et al. NEW ENGLAND JOURNAL OF MEDICINE
- A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma
- (2008) Claes Bergmark et al. JOURNAL OF LIPID RESEARCH
- Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
- (2008) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started