Article
Obstetrics & Gynecology
Dana R. Siegel, Laura Grau, Mary Sammel, Liesl Nel-Themaaat, Nanette Santoro, Alex J. Polotsky
Summary: This study aimed to examine whether AMH and FSH can predict live birth. By analyzing a large number of pregnancy records, it was found that AMH and FSH were not associated with the probability of live birth, and the only significant factor associated with live birth was age.
REPRODUCTIVE SCIENCES
(2023)
Review
Endocrinology & Metabolism
Casper P. P. Hagen, Margit Bistrup Fischer, Gylli Mola, Theis Bech Mikkelsen, Line Hartvig Cleemann, Claus Hojbjerg Gravholt, Mette H. H. Viuff, Anders Juul, Anette Tonnes Pedersen, Katharina Maria Main
Summary: Turner syndrome (TS) is a chromosomal disorder characterized by the absence of the second X chromosome, affecting about 1 in 2500 female births. TS is associated with primary ovarian insufficiency (POI), with only a small percentage of women achieving pregnancy without egg donation. This review evaluates the clinical use of ovarian function markers in TS patients and reports on the transition from pediatric to gynecological and adult endocrinological care in a Danish center.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Geriatrics & Gerontology
Panagiotis Anagnostis, Panagiota Florou, Julia K. Bosdou, Grigorios F. Grimbizis, Ioannis Iakovou, Efstratios M. Kolibianakis, Dimitrios G. Goulis
Summary: This study reviewed the effect of RAI on ovarian reserve in premenopausal women with DTC, finding that AMH concentrations decreased at 3 months post-treatment and remained low at 6 and 12 months. FSH concentrations showed no difference at these time points.
Article
Endocrinology & Metabolism
Lu Li, Bo Sun, Fang Wang, Yile Zhang, Yingpu Sun
Summary: AMH is associated with oocyte collection rate and TE rate in women with diminished ovarian reserve. An AMH level of 0.355 ng/ml is a cutoff value for predicting TE. For patients undergoing embryo transfer, AMH is not associated with clinical pregnancy while female age is an independent risk factor.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Jose Buratini, Mariabeatrice Dal Canto, Elena De Ponti, Fausta Brambillasca, Claudio Brigante, Silvana Gippone, Mario Mignini Renzini, Antonio La Marca
Summary: The study found that the association of basal FSH and AMH with IVF/ICSI success changes with maternal age, with basal FSH better reflecting clinical outcomes in pre-AMA patients and AMH better suiting AMA patients.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Dang Kien Nguyen, Sean O'Leary, Moustafa Abdelhafez Gadalla, Bronnie Roberts, Helen Alvino, Kelton P. Tremellen
Summary: This study found that serum AMH levels can predict cumulative live birth rates to some extent following IVF/ICSI treatment. Women with higher AMH levels had higher CLBR, while those with lower AMH levels may take longer to achieve a successful pregnancy.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Hsiao-Wen Tsai, Pei-Fen Liao, Chia -Jung Li, Li -Te Lin, Zhi-Hong Wen, Kuan-Hao Tsui
Summary: The study found that high serum AMH concentrations have a negative impact on fertilization and embryo development among infertile women undergoing ART, potentially due to a hyperandrogenic environment leading to decreased oocyte developmental competence.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Multidisciplinary Sciences
Mara Simopoulou, Dionysios Galatis, Evangelos Maziotis, Agni Pantou, Polina Giannelou, Sokratis Grigoriadis, Panagiotis Tzonis, Theodora Griva, Athanasios Zikopoulos, Anastasios Philippou, Michael Koutsilieris, Konstantinos Pantos, Konstantinos Sfakianoudis
Summary: The aim of this study is to develop a prediction model for successful application of Oocyte Retrieval during the Luteal Phase (LuPOR) in poor responders. The model uses predictive factors to define the population benefiting from LuPOR. The results show that the combined characteristics in the prediction model have a high accuracy.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Y. Zhou, S. Richard, N. J. Batchelor, D. E. Oorschot, G. M. Anderson, M. W. Pankhurst
Summary: The present findings suggest that AMH-mediated follicle atresia only occurs in early follicles before they become sensitive to FSH. Additionally, the study found that AMH overexpression leads to increased apoptosis rates of granulosa cells and oocytes in the ovaries. This indicates that the role of AMH is not to preserve ovarian reserve, but to prevent excessive follicle accumulation.
HUMAN REPRODUCTION
(2022)
Article
Agriculture, Dairy & Animal Science
Xue Yu, Zan Li, Xinzhe Zhao, Liping Hua, Shuanghang Liu, Changjiu He, Liguo Yang, John S. Davis, Aixin Liang
Summary: This study found that anti-Mullerian hormone has no effect on oocyte maturation, but inhibits the maturation and expansion of cumulus oocyte complexes stimulated by follicle-stimulating hormone. These findings expand our understanding of the functional role of anti-Mullerian hormone in regulating folliculogenesis.
Article
Endocrinology & Metabolism
Tian Tian, Lixue Chen, Rui Yang, Xiaoyu Long, Qin Li, Yongxiu Hao, Fei Kong, Rong Li, Yuanyuan Wang, Jie Qiao
Summary: This study aimed to develop a risk prediction model for fertilization disorders during in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and identified biological and clinical factors associated with low fertilization rate and total fertilization failure. By constructing prediction models, we can accurately predict the risk of fertilization disorders in patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Qiumin Wang, Dan Qi, Lixia Zhang, Jingru Wang, Yanbo Du, Hong Lv, Lei Yan
Summary: This study retrospectively analyzed 16,583 patients undergoing the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to determine the dose-response relationships and optimal ranges of age, AMH, basal FSH, number of cryopreserved embryos, and number of total transferred embryos associated with a higher cumulative live birth rate (CLBR). The study proposed the optimal ranges of these five factors that were correlated with a higher CLBR in the first oocyte retrieval cycle.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Yan Tang, Yanning Li
Summary: This study analyzed the value of measuring serum AMH, INHB, and bFSH levels in assessing postoperative ovarian reserve function in patients with endometrioma undergoing laparoscopic cystectomy. The results showed that AMH and INHB levels decreased while bFSH levels increased after surgery. Serum AMH and INHB levels were positively correlated with AFC and negatively correlated with bFSH levels. The combination of serum AMH, bFSH, and INHB tests had a high diagnostic value for postoperative abnormal ovarian reserve function.
FRONTIERS IN SURGERY
(2022)
Article
Endocrinology & Metabolism
Kyle Dymanus, Lauren E. Howard, Taofik Oyekunle, Amanda M. De Hoedt, Artak Labadzhyan, Thomas Polascik, Stephen J. Freedland, Zachary Klaassen
Summary: This population-level study among male veterans found inconsistent associations between FSH levels and risk of prostate cancer (PC), possibly influenced by selection bias and confounding variables. Future studies should consider different study designs.
Article
Endocrinology & Metabolism
Jingyi Wen, Kecheng Huang, Xiaofang Du, Hanwang Zhang, Ting Ding, Cuilian Zhang, Wenmin Ma, Ying Zhong, Wenyu Qu, Yi Liu, Zhiying Li, Song Deng, Aiyue Luo, Yan Jin, Jinjin Zhang, Shixuan Wang
Summary: The study found that inhibin B levels rapidly decrease with age in healthy reproductive age women. Inhibin B is positively correlated with AMH, AFC, and other ovarian reserve markers, and has a slightly higher predictive value for AFC compared to FSH.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Andrea Weghofer, David H. Barad, Sarah K. Darmon, Vitaly A. Kushnir, David F. Albertini, Norbert Gleicher
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2020)
Article
Cell Biology
Aritro Sen, Hanne M. Hoffmann
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Editorial Material
Genetics & Heredity
David F. Albertini
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Editorial Material
Genetics & Heredity
David F. Albertini
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Editorial Material
Genetics & Heredity
David F. Albertini
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Editorial Material
Genetics & Heredity
David F. Albertini
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Genetics & Heredity
Sambit Roy, Binbin Huang, Niharika Sinha, Jianrong Wang, Aritro Sen
Summary: Traditionally seen as a male hormone, androgens are now recognized as essential regulators of fertility and female health. Research has shown that androgens directly influence the expression of key ovarian genes critical for female fertility through epigenetic changes. Understanding these mechanisms may have potential implications for improving female fertility and treating conditions like polycystic ovary syndrome.
Article
Agriculture, Dairy & Animal Science
Valentina Lodde, Alberto Maria Luciano, Giulia Musmeci, Ileana Miclea, Irene Tessaro, Mariella Aru, David F. Albertini, Federica Franciosi
Summary: Women's reproductive performance declines starting in midlife, with a very low possibility of pregnancy by age 40-45. Premature ovarian failure and early ovarian aging can lead to low-quality eggs, impacting fertility. Understanding cellular mechanisms is essential for finding solutions to reproductive aging issues.
Review
Endocrinology & Metabolism
Niharika Sinha, Gretchen Lydia Walker, Aritro Sen
Summary: Exposure to adverse conditions during fetal development can lead to epigenetic changes that predispose offspring to diseases later in life. For example, offspring exposed to gestational diabetes have an increased risk of developing obesity and metabolic disorders in adulthood. Reproductive dysfunction and infertility later in life may be linked to epigenetic reprogramming of genes.
Article
Agriculture, Dairy & Animal Science
Miguel Chirivi, C. Javier Rendon, Madison N. Myers, Crystal M. Prom, Sambit Roy, Aritro Sen, Adam L. Lock, G. Andres Contreras
Summary: The exposure to endotoxin can enhance lipolysis and reduce insulin sensitivity in adipose tissue, leading to decreased sensitivity of adipocytes to the antilipolytic action of insulin.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Sambit Roy, Niharika Sinha, Binbin Huang, Holly Cline-Fedewa, Norbert Gleicher, Jianrong Wang, Aritro Sen
Summary: In females, the expression of particular genes is regulated through epigenetic modifications, and one of these modifications, called H3K27me3, is involved in gene repression. The enzyme JMJD3 can remove the H3K27me3 modification and promote gene expression. This study shows that JMJD3 specifically expressed in ovarian granulosa cells (GCs) is necessary for maintaining normal fertility in females. The deletion of JMJD3 in GCs leads to decreased healthy follicles, disrupted estrous cycle, and subfertility. Furthermore, JMJD3 is important for mitochondrial function, and its reduction results in decreased mitochondrial DNA content in GCs. The expression of JMJD3 also decreases with age in mice and humans. Overall, this study highlights the critical role of JMJD3 in maintaining normal ovarian function and female fertility, and suggests a potential involvement of JMJD3 in female reproductive aging.
Article
Obstetrics & Gynecology
D. H. Barad, D. F. Albertini, E. Molinari, N. Gleicher
Summary: This study aimed to investigate the effects of intraovarian injection of platelet-rich plasma (PRP) on ovarian function in patients with extremely low functional ovarian reserve (LFOR). The results showed that PRP treatment did not have clinically significant effects on ovarian function over a 1-year follow-up period. However, two patients with poor prognosis achieved pregnancy after PRP treatment. The study suggests that sporadic pregnancies are possible even in extremely poor prognosis patients due to LFOR, but further research is needed to determine the role of PRP treatments in these pregnancies.
HUMAN REPRODUCTION OPEN
(2022)
Article
Endocrinology & Metabolism
Norbert Gleicher, Sarah Darmon, Emanuela Molinari, Lin Zhang, Jianjun Hu, David F. Albertini, David H. Barad
Summary: This study found that young women under the age of 41 with adrenal hypoandrogenism may actually suffer from secondary ovarian insufficiency (SOI) rather than primary ovarian insufficiency (POI). In some cases, this condition could be treated with androgen supplementation.
Article
Obstetrics & Gynecology
A. Weghofer, D. H. Barad, S. K. Darmon, V. A. Kushnir, D. F. Albertini, N. Gleicher
HUMAN REPRODUCTION OPEN
(2020)
Meeting Abstract
Obstetrics & Gynecology
David H. Barad, David F. Albertini, Norbert Gleicher
FERTILITY AND STERILITY
(2020)