Article
Neurosciences
Ping Xiao, Kelei Hua, Feng Chen, Yi Yin, Jurong Wang, Xiangjun Fu, Jiasheng Yang, Qingfeng Liu, Queenie Chan, Guihua Jiang
Summary: In this study, blood perfusion and morphological changes were investigated in patients with obstructive sleep apnea (OSA) using pseudo-continuous arterial spin labeling (pCASL) and voxel-based morphometry (VBM) methods. Increased cerebral blood flow (CBF) values and decreased gray matter volume (GMV) were observed in specific brain regions of OSA patients compared to healthy controls. These changes were closely associated with the pathophysiological mechanism of OSA and abnormal behavior, psychology, and cognitive function.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Otorhinolaryngology
Carol Li, Yann-Fuu Kou, Michael A. DeMarcantonio, Christine H. Heubi, Robert Fleck, Ali Kandil, David F. Smith, Stacey L. Ishman
Summary: This study compared the findings of same-day cine MRI and DISE in evaluating persistent obstructive sleep apnea following adenotonsillectomy. The results showed that DISE provided better examination of nasal and supraglottic obstruction, while cine MRI offered better soft tissue resolution for lymphoid tissue hypertrophy and a global view of airway obstruction. Both techniques are complementary in evaluating children with persistent obstructive sleep apnea.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Clinical Neurology
Jing Gao, Jiancang Cao, Jieyu Chen, Dan Wu, Ke Luo, Guo Shen, Yanyan Fang, Wenwen Zhang, Gang Huang, Xiaoyan Su, Lianping Zhao
Summary: This study found that patients with obstructive sleep apnea (OSA) exhibited structural atrophy in the brainstem and frontotemporal lobe, as well as altered functional connectivity. These findings provide insights into the neurobiological mechanisms underlying cognitive impairment in OSA patients, particularly the association between brainstem atrophy and cognitive impairment.
Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Jin Tan, Huifang Xing, Sha Sha, Jinwen Li, Yuyang Miao, Qiang Zhang
Summary: Circulating microvesicles (MVs) concentrations in elderly patients with obstructive sleep apnea appear to be elevated, with levels correlated with OSA severity and obesity. Age and comorbidities may also play a role in MV concentrations, although the associations were not significant. Further research with a larger sample size is needed for verification.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Pei-Kang Liu, Tzu-Yu Chiu, Nan-Kai Wang, Sarah R. Levi, Ming-Ju Tsai
Summary: Obstructive sleep apnea (OSA) is a common sleep disorder that can lead to ocular consequences, clinicians should understand the eye diseases in patients with OSA and provide comprehensive care.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Elisabetta Zinellu, Sara S. Fois, Barbara Piras, Gianfranco Pintus, Ciriaco Carru, Arduino A. Mangoni, Alessandro G. Fois, Angelo Zinellu, Pietro Pirina
Summary: The study found that the MDA concentrations were significantly higher in patients with obstructive sleep apnea (OSA) compared to controls, indicating that MDA may be involved in the pathogenesis of OSA and providing insights for future research on its potential clinical use.
Review
Biochemistry & Molecular Biology
Piero Giuseppe Meliante, Federica Zoccali, Francesca Cascone, Vanessa Di Stefano, Antonio Greco, Marco de Vincentiis, Carla Petrella, Marco Fiore, Antonio Minni, Christian Barbato
Summary: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by intermittent hypoxia (IH) during sleep due to recurrent upper airway obstruction. The associated oxidative stress (OS) leads to various complications that affect both sleep-wake rhythm and systemic functions. This literature review investigates the molecular changes, diagnostic markers, and potential medical therapies for OSAS. The findings suggest that IH increases oxygen free radicals (ROS) and impairs antioxidant capacities, resulting in endothelial dysfunction, osteoporosis, systemic inflammation, increased cardiovascular risk, pulmonary remodeling, and neurological alterations in OSAS patients. The most promising pharmacological therapies include N-acetylcysteine (NAC), Vitamin C, Leptin, Dronabinol, or Atomoxetine + Oxybutynin, but further research is needed. Continuous positive airway pressure (CPAP) remains the approved therapy for reversing most molecular changes, while future drugs may target the remaining dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shin Koike, Haruka Sudo, Satori Turudome, Masako Ueyama, Yoshiaki Tanaka, Hiroshi Kimura, Yo-Ichi Ishida, Yuki Ogasawara
Summary: This study analyzed Prx2-SO2/3 levels in clinical samples and found a positive correlation between the oxidation state of Prx2 in red blood cells and the severity of obstructive sleep apnea (OSA). Prx2-SO2/3 may serve as a promising biomarker for OSA.
Review
Clinical Neurology
Gintare Paulekiene, Milda Pajarskiene, Evelina Pajediene, Andrius Radziunas
Summary: The purpose of this review is to explore how voxel-based morphometry can help identify correlations between neuroanatomical grey matter structures and sleep disorders. Recent findings have shown that the effect of grey matter volume changes on the pathogenesis of sleep disturbances is still not fully understood. Inconsistent results from VBM studies raise new debates on the spatiotemporal complexity of whole-brain networks and their role in sleep.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Philipp Hegner, Simon Lebek, Benedikt Schaner, Florian Ofner, Mathias Gugg, Lars Siegfried Maier, Michael Arzt, Stefan Wagner
Summary: Left ventricular contractile dysfunction and arrhythmias frequently occur in patients with sleep-disordered breathing. This study examined a mouse model of obstructive sleep apnea (OSA) and found that inhibition of the oxidative activation of CaMKII provided cardioprotection, suggesting therapeutic implications. The study demonstrated the association between OSA and contractile dysfunction as well as pro-arrhythmic activity, and shed light on the underlying mechanisms.
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Hiwa Mohammadi, Ardalan Aarabi, Mohammad Rezaei, Habibolah Khazaie, Serge Brand
Summary: The study found that individuals with OSAS have significantly lower spindle density in N3 and shorter spindle duration in N2 compared to healthy controls. Furthermore, individuals with mild OSAS showed sleep spindle characteristics more similar to healthy controls, unlike those with moderate and severe OSAS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Engineering, Biomedical
Xin-Xue Lin, Phone Lin, En-Hau Yeh, Gi-Ren Liu, Wan-Ching Lien, Yuguang Fang
Summary: In this paper, an AI-based framework called RAPIDEST is proposed to detect OSA. The framework only requires EEG signals, simplifying the signal collection process and reducing the complexity of severity determination for apnea and hypopnea.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Peripheral Vascular Disease
Liyue Xu, Brendan T. Keenan, David Maislin, Thorarinn Gislason, Bryndis Benediktsdottir, Sigrun Gudmundsdottir, Marianna Gardarsdottir, Bethany Staley, Frances M. Pack, Xiaofeng Guo, Yuan Feng, Jugal Chahwala, Pritika Manaktala, Anila Hussein, Maheshwara Reddy-Koppula, Zeba Hashmath, Jonathan Lee, Raymond R. Townsend, Richard J. Schwab, Allan Pack, Samuel T. Kuna, Julio A. Chirinos
Summary: This study investigated the impact of obesity on the effectiveness of PAP therapy and the levels of NT-proBNP in adults with and without OSA. The results indicated that obesity modified the effects of PAP treatment on NT-proBNP and left atrial volume index, suggesting potential differences in cardiac remodeling in obese individuals with OSA.