Ion Mobility Mass Spectrometry Unveils Global Protein Conformations in Response to Conditions that Promote and Reverse Liquid–Liquid Phase Separation

Salt-Induced Transitions in the Conformational Ensembles of Intrinsically Disordered Proteins

(2022) Hiranmay Maity et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Direct Observation of “Elongated” Conformational States in α‐Synuclein upon Liquid‐Liquid Phase Separation

(2022) Daniele Ubbiali et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native mass spectrometry for the investigation of protein structural (dis)order

(2022) Carlo Santambrogio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α-Synuclein

(2022) Neeleema Seetaloo et al.   Analytical Chemistry

An Improved Calibration Approach for Traveling Wave Ion Mobility Spectrometry: Robust, High-Precision Collision Cross Sections

(2021) K. Richardson et al.   ANALYTICAL CHEMISTRY

Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins

(2021) Rebecca Beveridge et al.   Frontiers in Chemistry

Cyclic Ion Mobility–Collision Activation Experiments Elucidate Protein Behavior in the Gas Phase

(2021) Charles Eldrid et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

ALS‐linked mutations impair UBQLN2 stress‐induced biomolecular condensate assembly in cells

(2021) Julia F. Riley et al.   JOURNAL OF NEUROCHEMISTRY

Salt-Dependent Conformational Changes of Intrinsically Disordered Proteins

(2021) Samuel Wohl et al.   Journal of Physical Chemistry Letters

Previously uncharacterized interactions between the folded and intrinsically disordered domains impart asymmetric effects on UBQLN2 phase separation

(2021) Tongyin Zheng et al.   PROTEIN SCIENCE

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Mass Spectrometry Analysis of Intact Proteins from Crude Samples

(2020) Shay Vimer et al.   ANALYTICAL CHEMISTRY

Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

(2020) Rani Moons et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metal ions shape α-synuclein

(2020) Rani Moons et al.   Scientific Reports

Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins

(2019) Rebecca Beveridge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner

(2019) Thuy P. Dao et al.   STRUCTURE

Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia

(2019) Laurence Renaud et al.   Acta Neuropathologica Communications

Fundamentals of ion mobility spectrometry

(2018) Valérie Gabelica et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions

(2018) Thuy P. Dao et al.   MOLECULAR CELL

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability

(2017) Pascal Leuenberger et al.   SCIENCE

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

(2016) Roland Hjerpe et al.   CELL

The recognition of ubiquitinated proteins by the proteasome

(2016) Guinevere L. Grice et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Consequences of point mutations in melanoma-associated antigen 4 (MAGE-A4) protein: Insights from structural and biophysical studies

(2016) Yoshio Hagiwara et al.   Scientific Reports

ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1

(2015) Kathleen M. Gilpin et al.   HUMAN MOLECULAR GENETICS

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Mass-Spectrometry-Based Framework To Define the Extent of Disorder in Proteins

(2014) Rebecca Beveridge et al.   ANALYTICAL CHEMISTRY

DISOPRED3: precise disordered region predictions with annotated protein-binding activity

(2014) David T. Jones et al.   BIOINFORMATICS

Effects of Polarity on the Structures and Charge States of Native-Like Proteins and Protein Complexes in the Gas Phase

(2013) Samuel J. Allen et al.   ANALYTICAL CHEMISTRY

Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: Characterization of inhibition by nucleic acids and 4-aminoquinolines

(2013) Joel A. Cassel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology

(2010) Matthew F. Bush et al.   ANALYTICAL CHEMISTRY

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Effects of buffer loading for electrospray ionization mass spectrometry of a noncovalent protein complex that requires high concentrations of essential salts

(2010) Harry J. Sterling et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Affinity Makes the Difference: Nonselective Interaction of the UBA Domain of Ubiquilin-1 with Monomeric Ubiquitin and Polyubiquitin Chains

(2007) Daoning Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY