Article
Environmental Sciences
Weili Mao, Lingling Mao, Nan Zhao, Yingying Zhang, Meirong Zhao, Hangbiao Jin
Summary: This study investigated the occurrence of free Bisphenol S (BPS) and its conjugated metabolites in rat internal tissues, blood, and excreta after continuous BPS dosage. The results showed that concentrations of free BPS and its metabolites reached steady state after 9 days of continuous dosage. The study also found that analyzing human blood and urine may not accurately reflect the contamination of BPS metabolites in human internal tissues.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Medicinal
Lingling Mao, Shuhong Fang, Meirong Zhao, Weiping Liu, Hangbiao Jin
Summary: This study utilized metabolomics to examine the metabolic changes in rat plasma following exposure to BPA or BPS, revealing distinct alterations in metabolome and the up-regulation/down-regulation of specific metabolites in the different exposure groups. Pathway analysis also highlighted significant disruptions in metabolic pathways associated with BPA and BPS exposure.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Environmental Sciences
Josephine Bou Dagher, Coral K. Hahn-Townsend, Amrita Kaimal, Maryam Al Mansi, Joseph E. Henriquez, Diane G. Tran, Christian R. Laurent, Caleb J. Bacak, Hannah E. Buechter, Celexis Cambric, Jared Spivey, Yen-Jun Chuang, Elyssa J. Campbell, Abhyuday Mandal, Puliyur S. Mohankumar, Sheba M. J. MohanKumar
Summary: The study found that a mixture of BPA and DEHP significantly affected pregnancy outcomes, with male offspring appearing more susceptible to the programming effects of these chemicals or their mixture. The results emphasize the need to reconsider the possible additive, antagonistic, or synergistic effects of EDC mixtures.
Article
Environmental Sciences
Archana Molangiri, Saikanth Varma, Kota Sri Naga Hridayanka, Myadara Srinivas, Suryam Reddy Kona, Ahamed Ibrahim, Asim K. Duttaroy, Sanjay Basak
Summary: Prenatal exposure to bisphenol A (BPA) and bisphenol S (BPS) can have long-lasting effects on offspring, increasing the risk of metabolic diseases. The study suggests that BPS has a greater impact on the body compared to BPA, including obesity, liver fat, inflammation, and predisposition to fatty liver in adult offspring.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Madelyn C. Huang, Johnathan R. Furr, Veronica G. Robinson, Laura Betz, Keith Shockley, Helen Cunny, Kristine Witt, Suramya Waidyanatha, Dori Germolec
Summary: The study found that doses of DON up to 3 mg/kg/day did not affect maternal survival or body weight, but resulted in slight toxicity manifested as decreased body weight in the offspring. The no-observed effect level was 1 mg/kg/day.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Farah Hanan Fathihah Jaffar, Khairul Osman, Chua Kien Hui, Aini Farzana Zulkefli, Siti Fatimah Ibrahim
Summary: The study found that supplementation with 250 mg/kg BW/d of EBN showed a significant increase in sperm concentration, sperm motility, FSH, and LH levels compared to the group receiving 10 mg/kg BW/d. There was a dose-dependent increase in testosterone level, but it was not significant between groups. In conclusion, EBN was found to have significant effects on male reproductive parameters.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sandra Concepcion Das, Kavitha Varadharajan, Muralitharan Shanmugakonar, Hamda A. Al-Naemi
Summary: The study reveals the impact of chronic cadmium exposure on the MMP-TIMP system in cardiac tissue, which may contribute to the pathogenesis of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Santokh Gill, V. M. Ruvin Kumara
Summary: The study compared the neurodevelopmental effects of BPA and its major replacement BPF on rat fetal neural stem cells, revealing that both compounds increase cell proliferation and impact differentiation rates of oligodendrocytes and neurons. There were concentration-dependent decreases in the maturation of oligodendrocytes and neurons, with a concomitant increase in immature cells.
Article
Environmental Sciences
Marta Sendra, Martina Stampar, Katarina Fras, Beatriz Novoa, Antonio Figueras, Bojana Zegura
Summary: BPA is a widely used chemical compound in the manufacturing of human products, but it has been found to have endocrine disrupting and genotoxic effects. The industry has started developing BPA analogues, but there is insufficient data to determine their safety. Further research is needed to evaluate the risks of these analogues and ensure their safety for humans.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Maarten C. Bosland, Michael J. Schlicht, Nicole Acevedo, Ana M. Soto, Gail Prins
Summary: This study aimed to determine the effects of perinatal exposure to bisphenol A (BPA) on induction of prostate cancer in rats. The results showed that perinatal BPA exposure did not significantly affect the incidence of prostate carcinomas but significantly reduced the occurrence of malignant tumors at any site in the body in rats.
Article
Multidisciplinary Sciences
Michael T. Williams, Chiho Sugimoto, Samantha L. Regan, Emily M. Pitzer, Adam L. Fritz, Mathieu Sertorio, Anthony E. Mascia, Ralph E. Vatner, John P. Perentesis, Charles V. Vorhees
Summary: Recent studies suggest that ultra-high dose rates of proton radiation confer less toxicity to exposed healthy tissue and reduce cognitive decline compared with conventional radiation dose rates. However, further preclinical data are required to demonstrate this sparing effect.
Article
Plant Sciences
Nan Hu, Fang-yin Jin, Miao-miao Gao, Lian-jie Liu, Jin-hui Wang, Bao-feng Yang, Chun-li Li
Summary: This study demonstrates that BAI can effectively reduce the opacity of the lens in Na2SeO3-induced cataract rats. This effect may be achieved through the modulation of the MAPK and PI3K/AKT signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Subramaniam Jayanthi, Bruce Ladenheim, Patricia Sullivan, Michael T. McCoy, Irina N. Krasnova, David S. Goldstein, Jean Lud Cadet
Summary: Perturbations in striatal dopamine homeostasis may contribute to METH use disorder. Rats exposed to footshocks after long-term METH intake showed decreased intake when given a DA D1 receptor antagonist. Compulsive METH takers exhibited abnormal DA metabolism and decreased protein levels. These findings are consistent with studies on human METH users.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Suhayla Hamad Shareef, Ameena S. M. Juma, Derin N. F. Agha, Abdullah R. Alzahrani, Ibrahim Abdel Aziz Ibrahim, Mahmood Ameen Abdulla
Summary: The present study investigated the hepatoprotective effects of Alpinetin against TAA-induced liver cirrhosis in rats. The results showed that Alpinetin can alleviate TAA-induced liver injury, reduce liver enzyme activity, increase total protein and albumin levels, enhance SOD and CAT levels, decrease MDA levels, modulate inflammatory cytokines, inhibit cell proliferation, and exhibit a good safety profile. Therefore, Alpinetin could be a potential therapeutic agent for TAA-induced liver damage.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Qian Yang, Zhenzhu Zhu, Qin Liu, Lihong Chen
Summary: The study found that exposure to BPB in zebrafish larvae led to abnormal thyroid hormone levels and inhibited neuronal development, potentially causing neurotoxicity and thyroid disruption.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)