Article
Gastroenterology & Hepatology
Jia-Feng Wu, Steven Shinn-Forng Peng, Chi-San Tai, Wen-Hsi Lin, Yung-Ming Jeng, Wen-Ming Hsu, Huey-Ling Chen, Yen-Hsuan Ni, Mei-Hwei Chang
Summary: This study investigated the utility of liver-to-psoas apparent diffusion coefficient ratios (LTPAR) and age-adjusted serum matrix metalloproteinase-7 (MMP-7) for diagnosing biliary atresia (BA) in cholestatic infants. The results showed that LTPAR was significantly lower in BA infants, while age-adjusted MMP7 ratio was significantly higher. Considering both serum and imaging parameters may improve the diagnostic performance of BA in cholestatic infants.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pediatrics
Zongrong Gong, Lin Lin, Gen Lu, Chaomin Wan
Summary: By combining clinical, laboratory, and abdominal ultrasonographic features, we have developed a simple prediction model to estimate the risk of biliary atresia (BA) in neonatal cholestasis (NC) patients.
Article
Medicine, General & Internal
Consolato M. Sergi, Susan Gilmour
Summary: The diagnosis of biliary atresia remains challenging, and the focus of research is to identify the etiology and shift from symptomatic to curative treatment. Genetic factors may play a role in the occurrence of this hepatobiliary disease. This review highlights the complexities of the disease.
Article
Surgery
Xuexin Lu, Jingying Jiang, Zhen Shen, Gong Chen, Ying Wu, Xianmin Xiao, Weili Yan, Shan Zheng
Summary: This study evaluated the efficacy and side effects of steroid therapy for postoperative treatment of type 3 biliary atresia (BA). The results showed that additional steroid therapy improved postoperative bile drainage and native liver survival, without increasing early-stage serious adverse events (SAEs).
Article
Gastroenterology & Hepatology
Chee-Seng Lee, Yen-Hsuan Ni, Huey-Ling Chen, Jia-Feng Wu, Hong-Yuan Hsu, Yin-Hsiu Chien, Ni-Chung Lee, Wuh-Liang Hwu, Ting-An Yen, Huey-Huey Chua, Yu-Ju Chen, Yu-Lin Wang, Mei-Hwei Chang
Summary: This study aimed to evaluate the potential of matrix metalloproteinase-7 (MMP-7) levels measured using the dried blood spot (DBS) method within 3 days of birth as a screening tool for biliary atresia (BA) patients. MMP-7 levels were significantly higher in BA patients compared to non-BA patients. DBS MMP-7 analysis can be used to distinguish BA from other conditions as early as 3 days of age.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Pediatrics
Bo Wu, Ying Zhou, Xinbei Tian, Wei Cai, Yongtao Xiao
Summary: This study evaluated the diagnostic values of matrix metalloprotease-7 (MMP-7), interleukin-8 (IL-8), and gamma-glutamyl transferase (GGT) in children with biliary atresia (BA). The results showed that these biomarkers have good accuracy in differentiating BA from non-BA and diagnosing cholic stool in infants.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Chiyoe Shirota, Akinari Hinoki, Takao Togawa, Shogo Ito, Wataru Sumida, Satoshi Makita, Hizuru Amano, Aitaro Takimoto, Shunya Takada, Masamune Okamoto, Yoichi Nakagawa, Daiki Kato, Hiroo Uchida
Summary: This study conducted a preliminary investigation into the exclusion of biliary atresia (BA) and confirmed the usefulness of intravenous indocyanine green (ICG) fluorescence cholangiography. The results showed that ICG fluorescence cholangiography may be a useful and less invasive diagnostic procedure for ruling out BA in infants.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pediatrics
Scott C. Fligor, Thomas I. Hirsch, Savas T. Tsikis, Andrew Adeola, Mark Puder
Summary: This review discusses the importance of adjuvant therapies and evolving management strategies in improving long-term outcomes for patients with biliary atresia.
FRONTIERS IN PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Manpreet K. Virk, Muhammad Umair M. Mian, Dalia A. Bashir, John K. Wilkes, Tobias Schlingman, Saul Flores, Curtis Kennedy, Fong Lam, Ayse A. Arikan, Trung Nguyen, Krupa Mysore, Nhu Thao Nguyen Galvan, Jorge Coss-Bu, Saul J. Karpen, Sanjiv Harpavat, Moreshwar S. Desai
Summary: In children with biliary atresia, elevated serum bile acid levels are associated with abnormal left ventricular geometry, suggesting that bile acid excess may be a potential trigger for myocardial structural changes.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Pediatrics
Abdulrahman Al-Hussaini, Mohammed Abanemai, Homoud Alhebbi, Omar Saadah, Razan Bader, Ahmed Al Sarkhy, Maher Alhatlani, Hana Halabi, Ahmed Aladsani, Mohammed AlEdreesi, Sami Wali, Talal Alguofi, Khalid Al-drees, Zahid Arain, Badr Al Saleem, Ali Asery, Sinan Holdar, Sami Alrashidi, Fahad Alsayed, Sulaiman Aldhalan, Amira NasserAllah, Rawabi Alghamdi, Faisal Alhaffaf, Ahmed AlAwfi, Abdulrahman AlSweed, Ali Alshamrani, Manal AlShaikh, Anjum Saeed, Heba Assiri, Muhammed Salman Bashir
Summary: This study is the first nationwide study of biliary atresia (BA) in Saudi Arabia, showing a lower incidence rate compared to other regions and a problem of late referral. Therefore, national policies should be implemented to improve timely referrals and earlier surgery.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Wing Ki Chan, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong
Summary: This study evaluated the accuracy of EHIDA in distinguishing between BA and other causes of cholestatic jaundice. The results showed that EHIDA has limited accuracy in both diagnosing and excluding BA. Surgical exploration remains the gold standard for diagnosing BA.
FRONTIERS IN PEDIATRICS
(2022)
Review
Gastroenterology & Hepatology
Vandana Jain, Emma C. Alexander, Charlotte Burford, Anita Verma, Anil Dhawan
Summary: Biliary atresia (BA) is a fibro-obliterative condition affecting infants, with surgery achieving bile flow restoration in some cases but cirrhosis and associated complications remaining common. Liver transplantation remains a frequent outcome, and advances in molecular technology have enabled characterization of gut microbiota genes. The gut microbiome plays a crucial role in host metabolism, nutrition, and immune function.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Pediatrics
Sindhu Pandurangi, Seung Kim, Akihiro Asai, Alexander Bondoc, William Balistreri, Kathleen Campbell, Alexander Miethke, Anna Peters, Michael Rogers, Amy Taylor, Suzanna Labib Attia, Troy Gibbons, Bhargava Mullapudi, Rachel Sheridan, Greg Tiao, Jorge A. Bezerra
Summary: This study aimed to evaluate the efficacy of personalized use of antibiotics and corticosteroids in patients with biliary atresia after surgery. The results showed that the personalized medication group had a significantly higher success rate of bile drainage compared to the conventional treatment group, and also maintained more native livers at 2 years. Therefore, personalized medication may help improve postoperative bile drainage.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
Hirotaka Sakaguchi, Ken-ichiro Konishi, Ryosuke Yasuda, Hideyuki Sasaki, Koichiro Yoshimaru, Takahisa Tainaka, Suguru Fukahori, Yukihiro Sanada, Itaru Iwama, Hiromichi Shoji, Masahiro Kinoshita, Toshiharu Matsuura, Jun Fujishiro, Hiroo Uchida, Masaki Nio, Yushiro Yamashita, Tatsuki Mizuochi
Summary: This study found that serum MMP-7 concentration is a useful marker for diagnosing BA in Japanese infants, but it cannot predict the need for liver transplantation within a year.
HEPATOLOGY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Wanli Yang, Xingyong Chen, Zhengquan Liu, Yutong Zhao, Yufei Chen, Zhaoyu Geng
Summary: The cell cycle plays a crucial role in the regulation of follicular atresia, and sodium outflow and high expression of MMP3 and MMP9 may be responsible for the structural destruction and apoptosis of follicular cells.