Article
Oncology
Eddy S. Yang, Eric Deutsch, Altan Mehmet, Jerome Fayette, Yungan Tao, Lisle Nabell, Sharon A. Spencer, Xuejing A. Wang, Elizabeth A. Spoljoric, Wei Zhang, Scott M. Hynes, Rodney L. Decker, Aimee K. Bence Lin, William N. William
Summary: This study aimed to investigate the feasibility of combining prexasertib with cisplatin-radiotherapy or cetuximab-radiotherapy in treating HNSCC, and concluded that prexasertib could be safely combined with cetuximab-radiotherapy, although a safe dose for cisplatin-radiotherapy was not established.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Oncology
Elena Muraro, Giuseppe Fanetti, Valentina Lupato, Vittorio Giacomarra, Agostino Steffan, Carlo Gobitti, Emanuela Vaccher, Giovanni Franchin
Summary: Cetuximab in combination with radiotherapy is limited to locally advanced HNSCC patients unfit for cisplatin. Reliable biomarkers for cetuximab efficacy in this cancer setting are lacking. Adverse events like skin rash are associated with efficacy, while acquired resistance is linked to microenvironment plasticity.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Otorhinolaryngology
Mei-Kim Ang, Jose Enrique Montoya, Ekkasit Tharavichitkul, Cindy Lim, Terence Tan, Lan Ying Wang, Joseph Wee, Yoke-Lim Soong, Kam-Weng Fong, Quan Sing Ng, Daniel Shao-Weng Tan, Chee-Keong Toh, Eng-Huat Tan, Wan-Teck Lim
Summary: In this study, the combination of nimotuzumab with cisplatin and radiotherapy was found to be safe and effective in treating locally advanced head and neck squamous cell carcinoma, with high response rates observed in patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
S. Mollnar, P. Pondorfer, A-K Kasparek, S. Reinisch, F. Moik, M. Stotz, M. Halm, J. Szkandera, A. Terbuch, F. Eisner, A. Gerger, K. S. Kapp, R. Partl, S. Vasicek, T. Weiland, M. Pichler, H. Stoeger, D. Thurnher, F. Posch
Summary: In locally advanced head and neck squamous cell carcinoma patients, radiochemotherapy often leads to toxicities requiring treatment modifications, which can impact outcomes. While chemotherapy modifications did not significantly impact treatment outcomes, reductions in radiotherapy dose were associated with impaired long-term results.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Biology
Tsung-Jang Yeh, Leong-Perng Chan, Hui-Ting Tsai, Chin-Mu Hsu, Shih-Feng Cho, Mei-Ren Pan, Yi-Chang Liu, Chih-Jen Huang, Che-Wei Wu, Jeng-Shiun Du, Hui-Ching Wang
Summary: Metronomic chemotherapy with tegafur-uracil as a maintenance therapy significantly improved overall survival, disease-free survival, and distant metastasis-free survival in patients with locally advanced head and neck squamous cell carcinoma (LA HNSCC), with tolerable adverse events.
Review
Biochemistry & Molecular Biology
Yingming Sun, Zhe Wang, Sufang Qiu, Ruoyu Wang
Summary: HNSCC, the 9th most common malignant tumor worldwide, can be divided into HPV-related and HPV-unrelated subtypes based on etiology. HPV-positive HNSCC is more sensitive to treatment with better survival rates, requiring individualized therapy. EGFR amplification and PI3K/AKT/mTOR pathway aberrant activation are common in HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhenxing Zhang, Haoran Zhu, Chifeng Zhao, Dong Liu, Jun Luo, Yukang Ying, Yuan Zhong
Summary: This study investigated the cancer-promoting effect of DDIT4 in Head and Neck Squamous Cell Carcinoma (HNSCC) and its mechanisms. DDIT4 overexpression was found to be associated with worse tumor characteristics, while DDIT4 knockdown inhibited the proliferation, invasion, and migration of HNSCC cells, as well as the expression of HIF-1a, VEGF, and vimentin. Additionally, DDIT4 expression was negatively correlated with immune infiltrations and played a crucial role in the differentiation of CAFs and T cells.
MOLECULAR CARCINOGENESIS
(2023)
Article
Cell Biology
Huan Li, Jun Wang, Lei He, Fengrui Zhang, Qingzhe Meng, Junhong Huang, Yahui Li, Rong Liu, Xinjie Yang, Jianhua Wei
Summary: A new scoring system based on EMT and hypoxia, named CIEH, has been developed for predicting prognosis and guiding treatment planning in HNSCC patients. The CIEH model, containing 14 characteristic factors, shows potential as biomarkers for HNSCC and is correlated with tumor immune infiltration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Zhaomeng Guo, Kang Li, Peng Liu, Xiangmin Zhang, Jie Lv, Xianhai Zeng, Peng Zhang
Summary: Head and neck squamous cell carcinoma (HNSCC) originates from different parts of the head and neck, and the causes and molecular basis can vary. The tumor microenvironment (TME) consisting of various cells and molecules is crucial for the survival and spread of cancer cells. Understanding the interaction between tumor cells and the TME is essential for developing effective anti-cancer therapies.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jing Li, Tao Yang, Qihong Wang, Yuedan Li, Haiyan Wu, Mei Zhang, Hong Qi, Hongxin Zhang, Jinfeng Li
Summary: This study demonstrates that SQLE plays a vital role in the progression of head and neck squamous cell carcinoma (HNSCC). High expression of SQLE is associated with aggressive tumor features and poor prognosis. Additionally, overexpression of SQLE enhances the proliferation, migration, and invasion abilities of HNSCC cells. The PI3K/Akt signaling pathway is implicated in the SQLE-mediated progression of HNSCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Oncology
Morena Fasano, Ida D'Onofrio, Maria Paola Belfiore, Antonio Angrisani, Valentina Caliendo, Carminia Maria Della Corte, Mario Pirozzi, Sergio Facchini, Marianna Caterino, Cesare Guida, Valerio Nardone, Alfonso Reginelli, Salvatore Cappabianca
Summary: This review discusses the role of clinical management, geriatric evaluation, and therapeutic approaches in elderly patients with head and neck squamous cell carcinoma (HNSCC). Elderly HNSCC patients are often frail with multiple comorbidities and may receive suboptimal treatment. The review summarizes different strategies for the clinical management of elderly HNSCC patients.
Article
Biochemistry & Molecular Biology
Nadege Kindt, Fabrice Journe, Stephane Carlier, Anne Trelcat, Alessandro Scalia, Sven Saussez
Summary: The study suggests that oxLDL may decrease the migration of HNC cell lines by regulating the CD36/beta-catenin pathway.
Article
Genetics & Heredity
Xiaobo Cui, Yali Zhang, Le Zhang, Jiayi Liu, Yunfei Bai, Yanru Cui, Boqian Wang, Shu Zhang, Xin Li
Summary: In this study, researchers found that Lon Peptidase 2, Peroxisomal (LONP2) was upregulated in head and neck squamous cell carcinoma (HNSCC) and its overexpression promoted cell growth and migration. Silencing of LONP2 inhibited tumor growth and improved apoptosis rate in HNSCC cells. Knockdown of LONP2 also downregulated the expression of plastin 3 (PLS3) and inhibited cell proliferation induced by LONP2 overexpression, suggesting that LONP2 exerts its oncogenic effect in HNSCC cells by positively regulating PLS3 expression.
Article
Oncology
Sara Varatanovic, Stefan Stoiber, Markus Haas, Alexander Lein, Lorenz Kadletz-Wanke, Faris F. Brkic
Summary: MK0752 shows potential as a therapeutic agent for HPV-positive HNSCC by exhibiting antineoplastic effects and inducing apoptosis. Further investigation is needed to validate these findings and understand the underlying mechanisms.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Sharon Changshan Wu, Karl Munger
Summary: Cancer/testis antigens show potential as therapeutic targets and prognostic biomarkers in head and neck squamous cell carcinoma, warranting further study to elucidate their role in the pathogenesis of these cancers. Their differential expression in HPV-positive HNSCC may mechanistically contribute to the genesis and clinical characteristics of these cancers, making them attractive targets for immunotherapies. These antigens, historically linked to diverse cancers, are increasingly implicated in various hallmarks of cancer, suggesting potential as cancer drivers.
