Article
Pharmacology & Pharmacy
Dekang Yan, Xiuwu Qu, Muhan Chen, Jiahua Wang, Xiuying Li, Zixu Zhang, Yang Liu, Liang Kong, Yang Yu, Ruijun Ju, Xuetao Li
Summary: In this study, Mannose (MAN)-modified co-loaded Curcumin (CUR) and ginsenoside Rb1 (Rb1) liposomes were prepared to treat Alzheimer's disease (AD) by crossing the blood-brain barrier (BBB). The resulting liposomes showed good stability and were able to accumulate in N2a cells/bEnd.3 cells. Furthermore, in vivo animal experiments demonstrated that MAN-CUR/Rb1 liposomes improved AD-related pathological features, inhibited oxidative stress and neuroinflammation, and enhanced learning and cognition in APP/PS-1 mice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Miseon Sung, Yohan Yoon, Jeeyeon Lee
Summary: The study found that the immune enhancement effects of ginsenoside Rb1 (G-Rb1) were more significant when a high proportion of Lactobacillus already existed in the intestines of mice. Additionally, the intake of G-Rb1 increased the abundance of the genus Akkermansia in the intestine, which is beneficial for the immune system.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Medicine, General & Internal
Laia Montoliu-Gaya, Daniel Alcolea, Nicholas J. Ashton, Jordi Pegueroles, Johannes Levin, Beatriz Bosch, Juan Lantero-Rodriguez, Maria Carmona-Iragui, Olivia Wagemann, Mircea Balasa, Przemyslaw Radoslaw Kac, Isabel Barroeta, Albert Llado, Wagner S. Brum, Laura Videla, Fernando Gonzalez-Ortiz, Bessy Benejam, Javier Jose Arranz Martinez, Thomas K. Karikari, Georg Nuebling, Alexandre Bejanin, Andrea L. Benedet, Rafael Blesa, Alberto Lleo, Kaj Blennow, Raquel Sanchez-Valle, Henrik Zetterberg, Juan Fortea
Summary: This study found that plasma GFAP levels are associated with the diagnosis and progression of Alzheimer's disease in adults with Down syndrome, indicating its potential as a biomarker. This biomarker may have applications in clinical practice and clinical trials.
Article
Immunology
Marco Antonio De Bastiani, Bruna Bellaver, Wagner S. Brum, Debora G. Souza, Pamela C. L. Ferreira, Andreia S. Rocha, Guilherme Povala, Joao Pedro Ferrari-Souza, Andrea L. Benedet, Nicholas J. Ashton, Thomas K. Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A. Pascoal, Eduardo R. Zimmer
Summary: Our study investigated the association between plasma GFAP and Aβ and tau pathology, and conducted transcriptomic analysis on hippocampal GFAP-positive astrocytes in mouse models. The findings suggest unique signatures in GFAP-positive astrocytes associated with Aβ and tau pathologies.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Chemistry, Multidisciplinary
Jia-yi He, Quan Hong, Bi-xia Chen, Shao-yuan Cui, Ran Liu, Guang-yan Cai, Jiao Guo, Xiang-mei Chen
Summary: Panax notoginseng, a traditional Chinese medicine, has beneficial effects on diabetic kidney disease (DKD) by alleviating podocyte injury through inhibiting apoptosis and mitochondrial damage. Rb1, the main active ingredient of Panax notoginseng, combines with aldose reductase to effectively mitigate the progression of diabetic kidney disease.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Pharmacology & Pharmacy
Yuqi Lai, Qinxiang Tan, Shu Xv, Sha Huang, Yuhua Wang, Yunjia Li, Ting Zeng, Chan Mo, Yuyao Chen, Shaohui Huang, Chuying Zhou, Lei Gao, Zhiping Lv
Summary: GRb1 has a protective effect on alcohol-induced liver injury by reducing lipid deposition, exhibiting antioxidant and anti-inflammatory actions, which suggest its potential as a promising candidate against ALD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Naixin Kang, Hongwei Gao, Luan He, Yanli Liu, Handong Fan, Qiongming Xu, Shilin Yang
Summary: The study found that Rb1 exhibits strong antiviral activities against EV71 infection in both in vitro and in vivo models, reducing viral damage and enhancing immune responses.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xinyu Zhang, Lei Wang, Rong Guo, Jie Xiao, Xiaoling Liu, Mei Dong, Xiaorong Luan, Xiaoping Ji, Huixia Lu
Summary: Rb1 has shown promising results in alleviating arterial stiffness induced by diabetes, improving aortic compliance and endothelium-dependent vasodilation. Additionally, Rb1 can ameliorate aortic remodeling in diabetes by influencing MMP2, MMP9, and TGF beta 1/Smad2/3 pathways. It is also suggested that Rb1 may inhibit oxidative stress and enhance AMPK phosphorylation as potential mechanisms for improving arterial stiffness in diabetes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Goksu Ozcelikay, Maria Gamella, Mehmet Altay Unal, Kivilcim Gucuyener, Ana Montero-Calle, Rodrigo Barderas, Jose M. Pingarron, Susana Campuzano, Sibel A. Ozkan
Summary: This study presents a magnetic microbeads-based electrochemical immunoplatform for the detection of GFAP, which has potential clinical applications in the diagnosis and prognosis of neurodegenerative diseases. The platform demonstrates low detection limit, good selectivity, and the ability to differentiate between healthy individuals and patients with VD and AD.
Article
Pharmacology & Pharmacy
Zhaobin Zeng, Haibin Wang, Renhui Yi, Jianyun Lou, Shuting Wen, Zheng Hu
Summary: This study investigated the effects of ginsenosides on blood pressure and intracranial arteries using a rat model. Comparative analysis and 16S rRNA sequencing were conducted to identify marker genera in the gut microbiota, and metabolites were analyzed to uncover potential mediators of blood pressure regulation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zhihui Fu, Xiaohui Wang, Xuan Lu, Ying Yang, Lingling Zhao, Lin Zhou, Kaikai Wang, Hanlin Fu
Summary: In this study, a modified bovine serum albumin carrier was successfully developed to improve the therapeutic efficacy of Ginsenoside Rb1. By enhancing the solubility and cellular uptake of Rb1, the anti-inflammatory effects were significantly enhanced. The results indicate that the developed carrier plays a crucial role in inhibiting inflammatory reactions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qian Zhang, Jinping Hu, Ankang Mao, Meitong Liu, Shuang Guan, Jing Lu
Summary: Ginsenoside Rb1 can alleviate hepatocyte pyroptosis by activating mitophagy, which may provide a basis for formulating effective dietary therapy or dietary recommendation.
Article
Biochemistry & Molecular Biology
Zhuoqun Meng, Jianing Lu, Guangcai Ge, Guang Wang, Ran Zhang, Yuhan Li, Shuang Guan, Jing Lu
Summary: The study found that ginsenoside Rb1 can reduce lipid accumulation in animals and cells induced by high-fat diet and palmitic acid. In addition, ginsenoside Rb1 also promotes autophagic flux and exerts its effects by regulating the transcription factor EB and miR-128, further promoting autophagic lipid degradation.
Article
Cell Biology
Shan Wen, Zhi-Ru Zou, Shuai Cheng, Hui Guo, Heng-Shuo Hu, Fan-Zhuo Zeng, Xi-Fan Mei
Summary: Ginsenoside Rb1 can promote metabolic reprogramming, enhance glycolytic activity and ATP production, and improve the survival of motor neurons and motor function recovery in mouse and cell models of spinal cord injury by inhibiting neuronal oxidative stress and protecting mitochondria. The therapeutic effects of ginsenoside Rb1 on spinal cord injury are closely related to sirtuin 3, as its suppression can remarkably weaken these effects.
NEURAL REGENERATION RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Liang Gong, Jiayi Yin, Yu Zhang, Ren Huang, Yuxuan Lou, Haojie Jiang, Liyan Sun, Jinjing Jia, Xiansi Zeng
Summary: Panax ginseng and Panax notoginseng are two well-known herbs used for medical purposes in Asian countries. This review highlights the neuroprotective roles of ginsenoside Rb1, an important active ingredient found in these herbs, in various central nervous system diseases. The potential mechanisms of ginsenoside Rb1's neuroprotection are also discussed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Mona E. M. Younis, Fatima A. Jaber, Kamlah Ali Majrashi, Hanan A. Ghoneim, Mustafa Shukry, Manal E. Shafi, Najah M. Albaqami, Mohamed E. Abd El-Hack, Mahmoud M. Abo Ghanima
Summary: This experiment estimated the effects of synthetic androgen and estrogenic antagonists on body characteristics and immune response of male and female broilers, as well as the correlation between sex hormone levels. Androgen treatment group showed the highest feed intake, while TAM20 treatment group showed the lowest. Early androgen injection significantly increased breast percentage, while TAM20 treatment particularly decreased comb percentage.
Article
Biochemistry & Molecular Biology
Amira Mostafa Elshamy, Doaa Shatat, Norhan Ahmed AbuoHashish, Mohamed Abd Elmotaal Safa, Nashwa Elgharbawy, Hoda Ali Ibrahim, Ramez Abd Elmoneim Barhoma, Eman Fawzy Eltabaa, Ahmed S. Ahmed, Amany Mohamed Shalaby, Mohamed Ali Alabiad, Mohammed Alorini, Rowida Raafat Ibrahim
Summary: This study investigates the ameliorative effect of sesame oil on experimentally induced PCOS and elucidates the possible molecular mechanisms. The results suggest that sesame oil can significantly improve hormonal, metabolic, inflammatory, and ER stress status in PCOS rats, and it regulates the regulatory proteins through the PI3K/PKA and MAPK/ERK2 signaling cascades.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Materials Science, Multidisciplinary
Amany Mohamed Shalaby, Abdulfatah Mohammed Albakkosh, Rania H. Shalaby, Mohamed Ali Alabiad, Amira Mostafa Elshamy, Mohammed Alorini, Fatima A. Jaber, Shereen Elsayed Tawfeek
Summary: This study investigated the impact of PFOS on the mucosa of the jejunum of rats and evaluated the protective impact of LGEO. The results showed that PFOS significantly increased oxidative stress, pro-inflammatory cytokines, caspase-3, and gene expression related to inflammation and oxidative stress. LGEO treatment significantly reduced these harmful effects.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Toxicology
Arwa A. Elsheikh, Sulaiman Mohammed Alnasser, Amany Mohamed Shalaby, Mohamed Ali Alabiad, Noha Ali Abd-Almotaleb, Mohammed Alorini, Fatima A. Jaber, Eman El-Sayed Khayal
Summary: Microplastics are a worldwide concern due to their harmful effects on marine organisms, accumulation in food chains, and human exposure. Silymarin, a therapeutic agent, has shown potential in treating liver damage caused by polystyrene microplastic particles (PS-MPs), particularly in the size range of 1-5 μm.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Microscopy
Amany Mohamed Shalaby, Rania H. H. Shalaby, Mohamed Ali Alabiad, Doaa I. I. Abdelrahman, Mohammed Alorini, Fatima A. A. Jaber, Shaimaa Mohamed Abdelfattah Hassan
Summary: This study investigated the impact of Myl on the liver structure and function of rats and evaluated the protective effect of EPO. The results showed that Myl significantly increased liver enzymes, oxidative stress parameters, and pro-inflammatory cytokines. EPO administration reduced these harmful effects and protected the liver against Myl toxicity due to its anti-inflammatory and anti-oxidant activities.
ULTRASTRUCTURAL PATHOLOGY
(2023)
Article
Cell & Tissue Engineering
Asmaa Gaber, Ahlam M. Elbakry, Rabab M. Aljarari, Fatima A. Jaber, Yasser A. Khadrawy, Dina Sabry, Rasha E. Abo-ELeneen, Osama M. Ahmed
Summary: Alzheimer's disease is the most common cause of age-related neurodegeneration and cognitive impairment. This study found that intravenous injection of bone marrow-derived mesenchymal stem cells (BM-MSCs) and oral administration of gamma-secretase inhibitor-953 (GSI-953) during pregnancy can protect rat dams from cognitive impairment and neurodegeneration induced by amyloid beta and Tau protein, as well as reverse brain developmental disruptions. These treatments also suppress neural inflammation and promote neurotrophic signaling. These findings demonstrate the broad-spectrum effects of BM-MSCs and GSI-953 in the treatment of Alzheimer's disease.
STEM CELLS INTERNATIONAL
(2023)
Article
Materials Science, Multidisciplinary
Maha Abdelhamid Fathy, Amal Anbaig, Raja Aljafil, Sherein F. El-Sayed, Hanim Magdy Abdelnour, Mona Mostafa Ahmed, Eman M. A. Abdelghany, Sulaiman Mohammed Alnasser, Shaimaa Mohamed Abdelfattah Hassan, Amany Mohamed Shalaby
Summary: Liraglutide can prevent diabetic osteoporosis by increasing bone growth and inhibiting bone resorption. The study also suggests that the vitamin D receptor Bsm1 polymorphism may have an impact on the therapeutic outcomes of liraglutide.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Agriculture, Dairy & Animal Science
Mahmoud Kamal, Nesreen Aljahdali, Fatima A. Jaber, Kamlah A. Majrashi, Waleid H. Kishk, Hassan A. Khalil, Ahmed M. Abdel-Khalek, Mostafa A. Ayoub, Mohamed E. Abd El-Hack
Summary: This study aimed to investigate the effect of dietary chitosan supplementation on the productive and reproductive performance of New Zealand White rabbits. The results showed that adding 0.2 g/kg chitosan to the diet improved ovarian diameter and the number of mature follicles, and significantly increased conception rate, kindling interval, and litter size. However, adding more than 0.4 g/kg chitosan had negative effects on reproductive parameters.
ANNALS OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Rasha M. Sherif, Dalia Talat, Bothaina A. Alaidaroos, Reem M. Farsi, Shahira A. Hassoubah, Fatima A. Jaber, Treza M. Azer, Reham M. El-Masry, Mohamed E. Abd El-Hack, Madiha S. Ibrahim, Ahmed Elbestawy
Summary: This study evaluated the antimicrobial effect of zinc oxide nanoparticles (ZnO NPs) against Escherichia coli O26 and its Shiga toxin type 2 (Stx2). The results showed a significant decrease in Stx2 level and protein content in response to ZnO NPs treatment, indicating the strong antibacterial activities of ZnO NPs against E. coli O26.
ANNALS OF ANIMAL SCIENCE
(2023)