Signaling mechanisms in red blood cells: A view through the protein phosphorylation and deformability

Interspecies Diversity of Osmotic Gradient Deformability of Red Blood Cells in Human and Seven Vertebrate Animal Species

(2022) Adam Varga et al.   Cells

Proteomic Analysis of the Role of the Adenylyl Cyclase–cAMP Pathway in Red Blood Cell Mechanical Responses

(2022) Elif Ugurel et al.   Cells

Voxelotor for the treatment of sickle cell disease in pediatric patients

(2022) Clark Brown et al.   Expert Review of Hematology

Circulating Wnt Ligands Activate the Wnt Signaling Pathway in Mature Erythrocytes

(2021) Ronen Siman-Tov et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Haemoglobin response to senicapoc in patients with sickle cell disease: a re‐analysis of the Phase III trial

(2021) Kenneth I. Ataga et al.   BRITISH JOURNAL OF HAEMATOLOGY

Up-down biphasic volume response of human red blood cells to PIEZO1 activation during capillary transits

(2021) Simon Rogers et al.   PLoS Computational Biology

PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells

(2021) Simon Rogers et al.   PLoS Computational Biology

Calcium/protein kinase C signaling mechanisms in shear-induced mechanical responses of red blood cells

(2021) Elif Ugurel et al.   MICROVASCULAR RESEARCH

Voxelotor in adolescents and adults with sickle cell disease (HOPE): long-term follow-up results of an international, randomised, double-blind, placebo-controlled, phase 3 trial

(2021) Jo Howard et al.   Lancet Haematology

From Experiments to Simulation: Shear-Induced Responses of Red Blood Cells to Different Oxygen Saturation Levels

(2020) Elif Ugurel et al.   Frontiers in Physiology

Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease

(2020) Panae Noomuna et al.   BRITISH JOURNAL OF HAEMATOLOGY

Active modulation of human erythrocyte mechanics

(2020) Lennart Kuck et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis

(2020) Mehrdad Ghashghaeinia et al.   APOPTOSIS

Red Cell Membrane Disorders: Structure meets Function

(2020) Mary Risinger et al.   BLOOD

Coronavirus disease 2019 (COVID-19), human erythrocytes and the PKC-alpha/-beta inhibitor chelerythrine –possible therapeutic implication

(2020) Mehrdad Ghashghaeinia et al.   CELL CYCLE

Concealed role of red blood cells in pathogenesis of pulmonary arterial hypertension: Decreased red blood cell nitric oxide generation and effect of Rho-Kinase inhibitor fasudil

(2020) Ibrahim Basarici et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

Shear Stress Ameliorates Superoxide Impairment to Erythrocyte Deformability With Concurrent Nitric Oxide Synthase Activation

(2019) Lennart Kuck et al.   Frontiers in Physiology

Rho-kinase is a negative regulator of red blood cell eNOS under basal conditions

(2019) Pinar Ulker et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease

(2019) Elliott Vichinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability

(2019) Alexey N. Semenov et al.   Frontiers in Physiology

Sublethal mechanical trauma alters the electrochemical properties and increases aggregation of erythrocytes

(2018) Antony P. McNamee et al.   MICROVASCULAR RESEARCH

Squeezing for Life – Properties of Red Blood Cell Deformability

(2018) Rick Huisjes et al.   Frontiers in Physiology

Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease

(2018) Joames K. F. Leal et al.   Frontiers in Physiology

Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease

(2018) Miriam M. Cortese-Krott et al.   Redox Biology

Sickle cell disease

(2018) Gregory J. Kato et al.   Nature Reviews Disease Primers

The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

(2017) Fatima Ardito et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sickle Cell Disease

(2017) Frédéric B. Piel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

(2017) Brian Metcalf et al.   ACS Medicinal Chemistry Letters

Red Blood Cell Passage of Small Capillaries Is Associated with Transient Ca2+-mediated Adaptations

(2017) Jens G. Danielczok et al.   Frontiers in Physiology

‘Gardos Channelopathy’: a variant of hereditary Stomatocytosis with complex molecular regulation

(2017) Elisa Fermo et al.   Scientific Reports

Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties

(2016) H. Chu et al.   BLOOD

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease

(2016) Donna Oksenberg et al.   BRITISH JOURNAL OF HAEMATOLOGY

Regulation of red blood cell deformability is independent of red blood cell-nitric oxide synthase under hypoxia

(2016) Marijke Grau et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

Interspecies diversity of erythrocyte mechanical stability at various combinations in magnitude and duration of shear stress, and osmolality

(2016) Norbert Nemeth et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

(2016) Helen Shinru Wei et al.   NEURON

Band 3 Erythrocyte Membrane Protein Acts as Redox Stress Sensor Leading to Its Phosphorylation by p72Syk

(2016) Antonella Pantaleo et al.   Oxidative Medicine and Cellular Longevity

Global transformation of erythrocyte properties via engagement of an SH2-like sequence in band 3

(2016) Estela Puchulu-Campanella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical perturbations trigger endothelial nitric oxide synthase activity in human red blood cells

(2016) Shunmugan Nagarajan et al.   Scientific Reports

“Oxygen Sensing” by Na,K-ATPase: These Miraculous Thiols

(2016) Anna Bogdanova et al.   Frontiers in Physiology

Mutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis

(2015) E. Glogowska et al.   BLOOD

Protein kinase C mediates caspase 3 activation: A role for erythrocyte morphology changes

(2015) Cristiana Carelli-Alinovi et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

Decrease in red blood cell deformability is associated with a reduction in RBC-NOS activation during storage

(2015) Marijke Grau et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

Activation of protein kinase C by phorbol ester increases red blood cell scramblase activity and external phosphatidylserine

(2015) Latorya A. Barber et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease

(2015) Igor A Altman et al.   International Wound Journal

Piezo1 links mechanical forces to red blood cell volume

(2015) Stuart M Cahalan et al.   eLife

Rho GTPases in erythroid maturation

(2014) Theodosia A. Kalfa et al.   CURRENT OPINION IN HEMATOLOGY

Regulation of cAMP by phosphodiesterases in erythrocytes

(2014) Shaquria P. Adderley et al.   Pharmacological Reports

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Functional Significance of the Rho/Rho-Kinase Pathway in Human Erythrocytes

(2014) R. Nalan Tiftik et al.   Turkish Journal of Hematology

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

(2013) A. George et al.   BLOOD

Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1

(2013) I. Andolfo et al.   BLOOD

Protein Kinase Ca and P-Type Ca2+Channel CaV2.1 in Red Blood Cell Calcium Signalling

(2013) Lisa Wagner-Britz et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Disorders of red cell volume regulation

(2013) Patrick G. Gallagher   CURRENT OPINION IN HEMATOLOGY

Synergistic effects of prostacyclin analogs and phosphodiesterase inhibitors on cyclic adenosine 3′,5′ monophosphate accumulation and adenosine 3′5′ triphosphate release from human erythrocytes

(2013) Stephanie M Knebel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Thalassemic erythrocytes release microparticles loaded with hemichromes by redox activation of p72Syk kinase

(2013) E. Ferru et al.   HAEMATOLOGICA

Calcium in Red Blood Cells—A Perilous Balance

(2013) Anna Bogdanova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Allosteric Mechanism Induced by Protein Kinase A (PKA) Phosphorylation of Dematin (Band 4.9)

(2013) Lin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of cytosolic phosphodiesterases in the erythrocyte: A possible role for PDE5

(2013) Shaquria P. Adderley et al.   MEDICAL SCIENCE MONITOR

RBC-NOS-Dependent S-Nitrosylation of Cytoskeletal Proteins Improves RBC Deformability

(2013) Marijke Grau et al.   PLoS One

Nitroprusside inhibits calcium-induced impairment of red blood cell deformability

(2013) Viachaslau Barodka et al.   TRANSFUSION

Oxygen regulates the band 3–ankyrin bridge in the human erythrocyte membrane

(2012) Marko Stefanovic et al.   BIOCHEMICAL JOURNAL

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease

(2012) M. M. Cortese-Krott et al.   BLOOD

Comparative studies of water permeability of red blood cells from humans and over 30 animal species: an overview of 20 years of collaboration with Philip Kuchel

(2012) Gheorghe Benga   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Identification of a Novel Role for Dematin in Regulating Red Cell Membrane Function by Modulating Spectrin-Actin Interaction

(2012) Ichiro Koshino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iatrogenic Hyperviscosity and Thrombosis

(2012) Herbert Meiselman et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

The Cyclic AMP Pathway

(2012) P. Sassone-Corsi   Cold Spring Harbor Perspectives in Biology

The Rho kinase inhibitor Y-27632 increases erythrocyte deformability and low oxygen tension-induced ATP release

(2011) K. M. Thuet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phosphorylation-Dependent Perturbations of the 4.1R-Associated Multiprotein Complex of the Erythrocyte Membrane

(2011) Emilie Gauthier et al.   BIOCHEMISTRY

Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium

(2011) R. Zennadi et al.   BLOOD

Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity

(2011) L. De Franceschi et al.   BLOOD

Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte band 3

(2011) E. Ferru et al.   BLOOD

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapo

(2011) Kenneth I. Ataga et al.   BRITISH JOURNAL OF HAEMATOLOGY

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways

(2011) Na Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Shear stress activation of nitric oxide synthase and increased nitric oxide levels in human red blood cells

(2011) Pinar Ulker et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

MCP-1 Upregulates Amylin Expression in Murine Pancreatic β Cells through ERK/JNK-AP1 and NF-κB Related Signaling Pathways Independent of CCR2

(2011) Kun Cai et al.   PLoS One

Control of Erythrocyte Membrane-Skeletal Cohesion by the Spectrin-Membrane Linkage

(2010) Lionel Blanc et al.   BIOCHEMISTRY

The sensing of poorly deformable red blood cells by the human spleen can be mimicked in vitro

(2010) G. Deplaine et al.   BLOOD

Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: The role of protein kinase C, Rac GTPases, and reactive oxygen species

(2010) Alex George et al.   BLOOD CELLS MOLECULES AND DISEASES

Hypoxia Activates a Ca2+-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes

(2010) David H. Vandorpe et al.   PLoS One

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Red blood cell proteomics

(2010) E.M. Pasini et al.   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes

(2009) Shaquria P. Adderley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The dual roles of red blood cells in tissue oxygen delivery: oxygen carriers and regulators of local blood flow

(2009) F. B. Jensen   JOURNAL OF EXPERIMENTAL BIOLOGY

Current knowledge about the functional roles of phosphorylative changes of membrane proteins in normal and diseased red cells

(2009) Antonella Pantaleo et al.   Journal of Proteomics

Oxygen-dependent ion transport in erythrocytes

(2008) A. Bogdanova et al.   Acta Physiologica

Oxidized and poorly glycosylated band 3 is selectively phosphorylated by Syk kinase to form large membrane clusters in normal and G6PD-deficient red blood cells

(2008) Antonella Pantaleo et al.   BIOCHEMICAL JOURNAL

Molecular biology of the cell, 5th edition by B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter

(2008) John Boyle   BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

Red cell membrane: past, present, and future

(2008) N. Mohandas et al.   BLOOD