Review
Clinical Neurology
Zhiqing Tang, Kaiyue Han, Rongrong Wang, Yue Zhang, Hao Zhang
Summary: Excitatory rTMS over the ipsilesional hemisphere significantly improves upper limb motor function, hand strength, and hand dexterity in stroke patients. Both iTBS and HF-rTMS can significantly promote upper limb motor function and hand dexterity, with excitatory rTMS being most beneficial when applied within the first 3 months after stroke.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Suzana Bleckmann Reis, Wanderley Marques Bernardo, Carlos Andre Oshiro, Hermano Igo Krebs, Adriana Bastos Conforto
Summary: According to this systematic review and meta-analysis, there is currently insufficient data to support the benefits of NIBS as an add-on intervention to robot-assisted therapy for upper-limb motor function or activity in individuals with stroke.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Review
Clinical Neurology
Gengbin Chen, Tuo Lin, Manfeng Wu, Guiyuan Cai, Qian Ding, Jiayue Xu, Wanqi Li, Cheng Wu, Hongying Chen, Yue Lan
Summary: This updated meta-analysis provides robust evidence of the efficacy of rTMS treatment in improving upper extremity and fine function during various phases of stroke.
FRONTIERS IN NEUROLOGY
(2022)
Review
Engineering, Biomedical
Natalia Comino-Suarez, Juan C. Moreno, Julio Gomez-Soriano, Alvaro Megia-Garcia, Diego Serrano-Munoz, Julian Taylor, Monica Alcobendas-Maestro, Angel Gil-Agudo, Antonio J. del-Ama, Juan Avendano-Coy
Summary: The systematic review found that the combination of tDCS with RT did not improve upper limb function, strength, spasticity, functional independence, or velocity of movement after stroke. However, tDCS may enhance the effects of RT alone for lower limb function.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Review
Clinical Neurology
Qingqing Zhao, Hong Li, Yu Liu, Haonan Mei, Liying Guo, Xianying Liu, Xiaolin Tao, Jiang Ma
Summary: In stroke patients, the combined treatment of MT and NIBS shows significant improvements in the recovery of upper limb motor function, as reflected in body structure and function, activity levels, and cortical excitability.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Afifa Safdar, Marie-Claire Smith, Winston D. Byblow, Cathy M. Stinear
Summary: This review assessed the application of rTMS protocols for improving upper limb motor performance after stroke. The majority of studies still follow the interhemispheric competition model and do not consider the bimodal balance recovery model. Future studies should select patients and apply rTMS protocols based on ipsilesional corticomotor function.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Review
Physiology
Kun Hu, Yu Chen, Feng Guo, Xin Wang
Summary: The use of transcranial direct current stimulation (tDCS) to improve upper limb muscle strength and endurance in healthy individuals is still debated. This article reviews relevant literature and finds that tDCS has no significant effect on upper limb muscle strength but significantly improves upper limb muscle endurance.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Clinical Neurology
Peng Xu, Yan Huang, Jie Wang, Xu An, Tianyou Zhang, Yuechun Li, Jun Zhang, Baojun Wang
Summary: The meta-analysis did not find a significant reduction in the Modified Ashworth Scale (MAS) for post-stroke spasticity patients with repetitive transcranial magnetic stimulation (rTMS) compared to sham treatment. However, a significant effect of rTMS was observed in the change score analysis within the treatment groups, indicating potential benefits. No significant placebo effect was observed in the sham treatment groups.
JOURNAL OF NEUROLOGY
(2021)
Review
Neurosciences
Wataru Kuwahara, Shun Sasaki, Rieko Yamamoto, Michiyuki Kawakami, Fuminari Kaneko
Summary: This study found that robot-assisted gait training combined with non-invasive brain stimulation (NIBS) significantly improved lower limb function in patients with stroke and spinal cord injury (SCI). However, there was no significant improvement in lower limb activities. The use of transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) did not show superior effectiveness in improving lower limb function compared to sham stimulation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Neurosciences
Weiwei Yang, Xiongbin Cao, Xiaoyun Zhang, Xuebing Wang, Xiaowen Li, Yaping Huai
Summary: This study systematically evaluated the effect of repetitive transcranial magnetic stimulation (rTMS) on dysphagia recovery after stroke and found that rTMS therapy may be more effective than conventional therapy, with no significant differences between low-frequency and high-frequency groups or between rTMS groups and conventional training group. The study suggests that rTMS might be an effective treatment for dysphagia in stroke patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Huiliu Fan, Yang Song, Xuanzhen Cen, Peimin Yu, Istvan Biro, Yaodong Gu
Summary: This study aimed to evaluate the value of rTMS in the treatment of lower-limb motor dysfunction in stroke patients via gait characteristics. It confirmed the enhancing effects of rTMS on the lower-limb motor ability of stroke patients, but more rigorous studies in this field are much warranted. The most common setting was found to be a 15- to 20-min course of rTMS for 2 to 3 weeks, with 1 Hz and 10 Hz being the most commonly used low and high frequencies.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Joyce L. Chen, Ashley Schipani, Clarissa Pedrini Schuch, Henry Lam, Walter Swardfager, Alexander Thiel, Jodi D. Edwards
Summary: Cathodal tDCS on contralesional M1 may enhance motor recovery post-stroke, but the effects are small and consistent. Further research with larger cohorts is necessary to explore potential sub-populations that may respond to this approach.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Onika Banduni, Megha Saini, Neha Singh, Debasish Nath, S. Senthil Kumaran, Nand Kumar, M. V. Padma Srivastava, Amit Mehndiratta
Summary: Upper extremity motor impairment is common in stroke patients, and traditional rehabilitation methods have limitations. Virtual reality and rTMS provide technology-driven solutions for better post-stroke upper limb motor improvement. Interactive games in a VR environment can provide novel and motivating customized training, while rTMS can facilitate neuroplasticity and promote recovery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Psychiatry
Jeffrey D. Voigt, Andrew F. Leuchter, Linda L. Carpenter
Summary: Through analyzing data from multiple randomized controlled trials, this study found that theta burst stimulation (TBS) is superior to sham treatment in treating major depressive disorder, and is noninferior to standard rTMS therapy (high frequency stimulation over the left prefrontal cortex). These results support the continued development of TBS as a treatment for depression.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Neurosciences
Xin Wen, Zicai Liu, Lida Zhong, Yang Peng, Jing Wang, Huiyu Liu, Xiaoqian Gong
Summary: This study conducted a meta-analysis on the efficacy of repetitive transcranial magnetic stimulation (rTMS) for post-stroke dysphagia. The results showed that rTMS, when combined with traditional swallowing exercises, effectively improved swallowing function in patients. Additionally, stimulation frequency had a significant impact on the efficacy, while stimulation site did not show a significant difference.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Rehabilitation
Miriam Allein Zago Marcolino, Melina Hauck, Cinara Stein, Jociane Schardong, Aline de Souza Pagnussat, Rodrigo Della Mea Plentz
DISABILITY AND REHABILITATION
(2020)
Article
Rehabilitation
Ana Paula Salazar, Veronica Cimolin, Giulia Palermo Schifino, Katia Daniele Rech, Ritchele Redivo Marchese, Aline Souza Pagnussat
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2020)
Review
Rehabilitation
Jociane Schardong, Cinara Stein, Rodrigo Della Mea Plentz
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2020)
Article
Engineering, Biomedical
Elren Passos-Monteiro, Leonardo A. Peyre-Tartaruga, Ana P. J. Zanardi, Edson S. da Silva, Pedro Jimenez-Reyes, Jean-Benoit Morin, Aline S. Pagnussat
CLINICAL BIOMECHANICS
(2020)
Article
Neurosciences
Katia Daniele Rech, Ana Paula Salazar, Ritchele Redivo Marchese, Giulia Schifino, Veronica Cimolin, Aline Souza Pagnussat
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Clinical Neurology
Aline Souza Pagnussat, Ana Paula Salazar, Camila Pinto, Ritchele Redivo Marchese, Carlos R. M. Rieder, Jose Osmar Alves Filho, Alexandre R. Franco, Ana Francisca Rozin Kleiner
ACTA NEUROLOGICA SCANDINAVICA
(2020)
Article
Health Care Sciences & Services
Celina Borges Migliavaca, Cinara Stein, Veronica Colpani, Timothy Hugh Barker, Zachary Munn, Maicon Falavigna
BMC MEDICAL RESEARCH METHODOLOGY
(2020)
Review
Rehabilitation
Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
Summary: FES has limited impact on gait speed for patients with foot drop, but shows better improvement when combined with supervised exercises. It is effective in enhancing ankle dorsiflexion, balance, and functional mobility, although with some uncertainties in the results due to high heterogeneity.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Physiology
Anelise Ineu Figueiredo, Gustavo Balbinot, Fabiane Oliveira Brauner, Aniuska Schiavo, Rafael Reimann Baptista, Aline Souza Pagnussat, Kristen Hollands, Regis Gemerasca Mestriner
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Endocrinology & Metabolism
Giovana F. Piccoli, Leonardo A. Mesquita, Cinara Stein, Marina Aziz, Maira Zoldan, Nathalia A. H. Degobi, Bernardo F. Spiazzi, Gilberto L. Lopes Junior, Veronica Colpani, Fernando Gerchman
Summary: The study aimed to evaluate if patients treated with GLP-1RAs had a higher risk of breast neoplasms. The findings revealed that treatment with GLP-1RAs for obesity and diabetes does not increase the risk of breast neoplasms.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Camila Pinto, Ana Paula Salazar, Ewald Max Hennig, Graham Kerr, Aline Souza Pagnussat
Article
Chemistry, Analytical
Giulia Schifino, Veronica Cimolin, Massimiliano Pau, Maira Jaqueline da Cunha, Bruno Leban, Micaela Porta, Manuela Galli, Aline Souza Pagnussat
Summary: The study assessed the effects of foot drop stimulators (FDS) in stroke patients using spatio-temporal parameters and harmonic ratio (HR) obtained from trunk accelerations. Results indicated that FDS treatment led to increased gait speed and improved step symmetry, with further research needed to advance understanding of FDS device effects on stroke patients.
Article
Infectious Diseases
Maicon Falavigna, Karlyse Claudino Belli, Alexandre Naime Barbosa, Alexandre Prehn Zavascki, Ana Catharina de Seixas Santos Nastri, Christiane Machado Santana, Cinara Stein, Debora Dalmas Graf, Flavio Adsuara Cadegiani, Helio Penna Guimaraes, Jose Tadeu Monteiro, Juliana Carvalho Ferreira, Luciano Cesar Pontes de Azevedo, Marcelo Mihailenko Chaves Magri, Marcone Lima Sobreira, Maria Beatriz Gandra de Souza Dias, Maura Salaroli de Oliveira, Mirian de Freitas Dal Ben Corradi, Regis Rosa, Ricardo Souza Heinzelmann, Rosemeri Maurici da Silva, Rubens Belfort Junior, Sergio Cimerman, Veronica Colpani, Viviane Cordeiro Veiga, Carlos Roberto Ribeiro de Carvalho
Summary: Few therapies have demonstrated effectiveness in the treatment of outpatients with COVID-19. Recommendations are against the use of several drugs, focusing on avoiding ineffective treatments based on evidence-based medicine principles.
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Nutrition & Dietetics
Cinara Stein, Lucas Helal, Celina Borges Migliavaca, Caroline Nicola Sangalli, Veronica Colpani, Priscila Raupp da Rosa, Luis Beck-da-Silva, Luis E. Rohde, Carisi Anne Polanczyk, Maicon Falavigna
Summary: This study evaluated the effects of sodium and fluid restriction in patients with heart failure. The results showed that sodium restriction increased mortality and hospitalization, while fluid restriction reduced mortality and hospitalization. The combination of sodium and fluid restriction did not significantly affect mortality or hospitalization.
CLINICAL NUTRITION ESPEN
(2022)
Review
Cardiac & Cardiovascular Systems
Celina Borges Migliavaca, Cinara Stein, Veronica Colpani, Bruna Eibel, Roberta Bgeginski, Marcus Vinicius Simoes, Luiz Eduardo Rohde, Maicon Falavigna