Review
Immunology
Emmanuelle Rochette, Oussama Saidi, Etienne Merlin, Pascale Duche
Summary: Juvenile idiopathic arthritis (JIA) is a common rheumatic disease in young people. The physical activity of children and adolescents with JIA is lower than their healthy counterparts, which may be due to joint pain and decreased physical capacities. Increased physical activity and exercise have shown potential benefits in improving various health outcomes in JIA. However, more research is needed to establish evidence-based guidelines for physical activity and exercise prescription in this population.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Cecile Torregrosa, Frederic Chorin, Eva Ester Molina Beltran, Cindy Neuzillet, Victoire Cardot-Ruffino
Summary: This literature review focuses on adapted physical exercise in the management of cancer patients, aiming to raise awareness among medical staff about its importance. The benefits of exercise are summarized from physiological, pathophysiological, and cellular perspectives, as well as the interactions between individuals and their environment. Integration of exercise dimensions with oncological treatments in multidisciplinary supportive care is considered a new paradigm to improve patient survival and quality of life. This emerging field of exercise oncology aims to understand the biological mechanisms by which aerobic exercise affects cancer incidence, progression, and metastases. The article provides an overview of current physical exercise interventions in cancer patient management, as well as discussing potential clinical applications and the importance of personalized, integrated, patient-centered, and multidisciplinary approaches.
Review
Oncology
Annabelle Emery, Sally Moore, James E. Turner, John P. Campbell
Summary: Undertaking a high volume of physical activity is associated with a reduced risk of cancer and can suppress tumor growth. Physical activity may alter T-cell regulation to prevent cancer development.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Chunping Liu, Huiqi Chen, Yanjiao Liu, Haiding Huang, Wanling Yu, Tingting Du, Xinyao Long, Xinming Chen, Zhijun Chen, Sien Guo, Jinxin Li, Zebo Jiang, Lei Wang, Chuanjian Lu
Summary: Psoriasis is a persistent inflammatory disease with a genetic predisposition, and it is often associated with the involvement of multiple organs. Atherosclerosis is a common complication in severe psoriasis patients. The specific pathogenesis of psoriasis is still unclear, but it is believed to be a polygenic genetic disease influenced by factors such as heredity and environment. Immune-mediated inflammatory pathways are involved in the proliferation of keratinocytes and the release of inflammatory factors. Psoriasis and atherosclerosis are closely related, and systemic inflammation may be a common feature of both conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Sport Sciences
Dan Lin, Cheryl L. Thompson, Djibril M. Ba, Joshua E. Muscat, Shouhao Zhou, Connie J. Rogers, Kathleen M. Sturgeon
Summary: The study revealed an inverse association between leisure-time physical activity level and white blood cell count, as well as neutrophil-to-lymphocyte ratio, suggesting that higher levels of physical activity may lead to lower levels of inflammation, which could be important for future chronic disease outcomes.
SPORTS MEDICINE-OPEN
(2023)
Review
Cardiac & Cardiovascular Systems
Gabrielle Fredman, Katherine C. MacNamara
Summary: Inflammation-resolution is a highly coordinated process governed by endogenous factors, with imbalances potentially leading to non-resolving inflammation and diseases. Recent studies emphasize the importance of balanced ratios of specialized pro-resolving mediators and pro-inflammatory lipids in timely inflammation resolution. Future research aims to address therapeutic strategies and mechanisms of disease related to these imbalances in order to tackle important human diseases such as atherosclerosis.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mathilde Mura, Michele Weiss-Gayet, Nellie Della-Schiava, Erica Chirico, Patrick Lermusiaux, Marie Chambion-Diaz, Camille Faes, Anaelle Boreau, Benedicte Chazaud, Antoine Millon, Vincent Pialoux
Summary: Atherosclerosis is associated with chronic inflammation involving circulating monocytes. Physical activity has been shown to decrease inflammation and the risk of stroke. This study found that moderately active patients had a lower percentage of classical and intermediate monocytes compared to non-active and highly active patients. In contrast, the percentage of non-classical monocytes increased in moderately active patients. These findings suggest that physical activity can be beneficial for patients by reducing the risk of ischemic stroke and promoting lesion healing.
Article
Geriatrics & Gerontology
Jeremy Raffin, Davide Angioni, Kelly Giudici, Philippe Valet, Geetika Aggarwal, Andrew D. Nguyen, John E. Morley, Sophie Guyonnet, Yves Rolland, Bruno Vellas, Philipe de Souto Barreto
Summary: This study aimed to investigate the associations between body mass index (BMI), physical activity (PA), and the adipokine progranulin (PGRN) in older adults. The results showed that higher PA levels were associated with lower PGRN concentrations in individuals without obesity, while the opposite pattern was found in obese individuals. In addition, BMI was positively associated with PGRN levels in highly active individuals.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Rosangela A. Hoshi, Yanyan Liu, Heike Luttmann-Gibson, Saumya Tiwari, Franco Giulianini, Allen M. Andres, Jeramie D. Watrous, Nancy R. Cook, Karen H. Costenbader, Olivia Okereke, Paul M. Ridker, JoAnn E. Manson, I-Min Lee, Manickavasagar Vinayagamoorthy, Susan Cheng, Trisha Copeland, Mohit Jain, Daniel Chasman, Olga Demler, Samia Mora
Summary: This study identified a profile of bioactive lipids associated with physical activity, and 12 of these lipids were found to have opposite associations with incident cardiovascular disease events.
CIRCULATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Byunghun So, Li Li Ji, Saba Imdad, Chounghun Kang
Summary: This study aimed to investigate the effect of voluntary wheel running (VWR) on the metabolic changes in the livers of high-fat diet (HFD)-induced NAFLD mice. LC-MS/MS was used to determine whether the tested intervention affected the protein expression profiles of the mouse livers. The results showed that VWR counteracted the adverse effects of HFD on the livers of the mice and affected the expression of proteins involved in ketogenesis, lipid metabolism, and the metabolism of drugs and xenobiotics.
Article
Cardiac & Cardiovascular Systems
Wende Tian, Tai Zhang, Xinyi Wang, Jie Zhang, Jianqing Ju, Hao Xu
Summary: This study provides a comprehensive view of the scientific literature on atherosclerosis through bibliometric analysis. The results show that research on atherosclerosis is mainly driven by North America and Europe, with a focus on the link between inflammation and atherosclerosis, as well as its complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander Maier, Yohana C. Toner, Jazz Munitz, Nathaniel A. T. Sullivan, Ken Sakurai, Anu E. Meerwaldt, Eliane E. S. Brechbuhl, Geoffrey Prevot, Yuri van Elsas, Rianne J. F. Maas, Anna Ranzenigo, Georgios Soultanidis, Mohammad Rashidian, Carlos Perez-Medina, Gyu Seong Heo, Robert J. Gropler, Yongjian Liu, Thomas Reiner, Matthias Nahrendorf, Filip K. Swirski, Gustav J. Strijkers, Abraham J. P. Teunissen, Claudia Calcagno, Zahi A. Fayad, Willem J. M. Mulder, Mandy M. T. van Leent
Summary: Research on atherosclerotic cardiovascular disease in the past 2 decades has identified inflammation as a major contributor to the disease process. This study developed and applied multiparametric imaging methods to investigate the immune response after myocardial infarction. The results demonstrated the strengths and capabilities of these imaging techniques in detecting inflammatory activity in cardiovascular disease.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Review
Oncology
Vicente Javier Clemente-Suarez, Alexandra Martin-Rodriguez, Laura Redondo-Florez, Pablo Ruisoto, Eduardo Navarro-Jimenez, Domingo Jesus Ramos-Campo, Jose Francisco Tornero-Aguilera
Summary: Recent research suggests a strong link between the functioning of mitochondria and the development of cancer. Healthy mitochondria play a vital role in maintaining metabolic processes and controlling cell death, but inflammation can harm their function and lead to tissue damage. Engaging in both endurance and resistance exercises, in addition to maintaining an active lifestyle, can help improve mitochondrial functioning and reduce the risk of cancer.
Article
Clinical Neurology
Mauro F. F. Mediano, Yejin Mok, Josef Coresh, Anna Kucharska-Newton, Priya Palta, Kamakshi Lakshminarayan, Wayne D. Rosamond, Kunihiro Matsushita, Silvia Koton
Summary: Higher levels of total prestroke physical activity, as well as work and leisure activities, are associated with a lower risk of mortality after incident stroke. It is suggested that promoting physical activity throughout life could be beneficial in reducing long-term mortality post-stroke.
Review
Medicine, General & Internal
Toru Tanaka, Naoto Sasaki, Yoshiyuki Rikitake
Summary: Tregs play a protective role in atherosclerosis by regulating immune responses to prevent and treat the development of the disease. Enhancing regulatory immune responses may be an attractive approach to treating atherosclerotic diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Gehlen, Anja Stundl, Radoslaw Debiec, Federica Fontana, Markus Krane, Dinara Sharipova, Christopher P. Nelson, Baravan Al-Kassou, Ann Sophie Giel, Jan Malte Sinning, Christopher M. H. Bruenger, Carolin F. Zelck, Laura L. Koebbe, Peter S. Braund, Thomas R. Webb, Simon Hetherington, Stephan Ensminger, Buntaro Fujita, Salah A. Mohamed, Malakh Shrestha, Heike Krueger, Matthias Siepe, Fabian Alexander Kari, Peter Nordbeck, Larissa Buravezky, Malte Kelm, Verena Veulemans, Matti Adam, Stephan Baldus, Karl Ludwig Laugwitz, Yannick Haas, Matthias Karck, Uwe Mehlhorn, Lars Oliver Conzelmann, Ingo Breitenbach, Corinna Lebherz, Paul Urbanski, Won Keun Kim, Joscha Kandels, David Ellinghaus, Ulrike Nowak-Goettl, Per Hoffmann, Felix Wirth, Stefanie Doppler, Harald Lahm, Martina Dressen, Moritz von Scheidt, Katharina Knoll, Thorsten Kessler, Christian Hengstenberg, Heribert Schunkert, Georg Nickenig, Markus M. Noethen, Aidan P. Bolger, Salim Abdelilah-Seyfried, Nilesh J. Samani, Jeanette Erdmann, Teresa Trenkwalder, Johannes Schumacher
Summary: This study provides deeper insights into the genetic risk architecture of bicuspid aortic valve (BAV) disease, including both single-marker and polygenic levels. The study identified a new risk locus and confirmed previously reported risk loci. Additionally, the study revealed that the transcriptome profile in endothelial cells plays a major role in the pathology of BAV.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Behnes, Shqipdona Lahu, Gjin Ndrepepa, Maurizio Menichelli, Katharina Mayer, Jochen Woehrle, Isabell Bernlochner, Senta Gewalt, Bernhard Witzenbichler, Willibald Hochholzer, Dirk Sibbing, Salvatore Cassese, Dominick J. Angiolillo, Rayyan Hemetsberger, Christian Valina, Arne Mueller, Sebastian Kufner, Christian W. Hamm, Erion Xhepa, Alexander Hapfelmeier, Hendrik B. Sager, Michael Joner, Massimiliano Fusaro, Gert Richardt, Karl-Ludwig Laugwitz, Franz-Josef Neumann, Heribert Schunkert, Stefanie Schupke, Adnan Kastrati, Ibrahim Akin
Summary: This analysis compared the efficacy and safety of ticagrelor and prasugrel in patients with acute coronary syndrome (ACS) presenting during different time periods.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thorsten Kessler, Heribert Schunkert
Editorial Material
Cardiac & Cardiovascular Systems
Thorsten Kessler, Hendrik B. Sager, Matthias Mann
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Daniele Giacoppo, Hector A. Alvarez-Covarrubias, Tobias Koch, Salvatore Cassese, Erion Xhepa, Thorsten Kessler, Jens Wiebe, Michael Joner, Willibald Hochholzer, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Sebastian Kufner
Summary: This study aims to compare the interventional strategies for the treatment of drug-eluting stent (DES) in-stent restenosis (ISR). The comparative efficacy and safety of plain balloon (PB), paclitaxel-coated balloon (PCB), and paclitaxel-eluting stent (PES) for percutaneous coronary intervention (PCI) of DES-ISR were evaluated for a 10-year follow-up. The results showed no significant difference among the treatments in clinical follow-up and primary endpoints, but PES and PCB were significantly superior to PB in target lesion revascularization.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
S. L. Andrews, M. Ghaderi-Najafabadi, P. Gong, N. Shamkhi, L. Carleton, C. Schofield, T. Kessler, N. J. Samani, T. R. Webb, G. E. Morris
Summary: The large extracellular matrix protein SVEP1 plays a crucial role in cell adhesion through integrin α9β1. This study reveals the significant involvement of SVEP1 in the pathogenesis of coronary artery disease (CAD). It shows that SVEP1 plays a critical role in monocyte recruitment and differentiation into macrophages.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
M. Amin Sharifi, Michael Wierer, Tan An Dang, Jelena Milic, Aldo Moggio, Nadja Sachs, Moritz von Scheidt, Julia Hinterdobler, Philipp Mueller, Julia Werner, Barbara Stiller, Zouhair Aherrahrou, Jeanette Erdmann, Andrea Zaliani, Mira Graettinger, Jeanette Reinshagen, Sheraz Gul, Philip Gribbon, Lars Maegdefessel, Juergen Bernhagen, Hendrik B. Sager, Matthias Mann, Heribert Schunkert, Thorsten Kessler
Summary: ADAMTS-7 plays a role in the development of atherosclerotic plaques by reducing the stability of TIMP-1, which in turn promotes the activity of MMP-9 and the degradation of collagen. Disrupting the interaction between ADAMTS-7 and TIMP-1 may be a strategy to increase plaque stability and reduce the risk of atherosclerosis-related events.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Ingo Hilgendorf, Johannes Backs, Stephan Baldus, Jessy Chen, David Duncker, Ali El-Armouche, Norbert Frey, Denise Hilfiker-Kleiner, Victoria Johnson, Stephan Kuenzel, Kai C. Wollert, Andreas Zeiher, Hendrik B. Sager
Summary: Policy makers in various sectors recognize that clinician scientists play a crucial role in translating innovative therapies into clinical practice. Research on cardiovascular diseases, the leading cause of death worldwide, should be prioritized. Based on internal discussions and surveys, the German Cardiac Society has thoroughly analyzed the situation and role of clinician scientists in cardiovascular medicine, with a focus on improving their working conditions and career prospects.
Meeting Abstract
Medicine, Research & Experimental
Thorsten Kessler
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
