Article
Clinical Neurology
Abhilasha Tripathi, Mritunjai Kumar, Jayantee Kalita, Surya Kant, Usha K. Misra
Summary: This study evaluated the levels of serum antidiuretic hormone (ADH), its receptors, and renin in patients with cerebral salt wasting (CSW) in tuberculous meningitis (TBM). The study found that CSW is the most common cause of hyponatremia in TBM patients and correlates with disease severity.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Qinglin Ye, Xi Peng, Xiaogang Zhang, Qingqing Cao, Kaiyan Tao, Liang Wang
Summary: Tuberculous meningitis (TBM) with hyponatremia is common and can affect the prognosis of patients if not treated properly. This study found that serum sodium levels and the severity of TBM were independent predictors of poor outcomes. Hyponatremia was mainly caused by syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and correcting hyponatremia in TBM patients had an impact on their prognosis.
NEUROLOGICAL SCIENCES
(2022)
Review
Medicine, General & Internal
John K. Maesaka, Louis J. Imbriano, Candace Grant, Nobuyuki Miyawaki
Summary: Our understanding of hyponatremic conditions has undergone significant changes, leading to a new approach for diagnosis and differentiation of various causes and syndromes. Fractional excretion of urate and isotonic saline infusions have shown promise in distinguishing SIADH from C/RSW, and a natriuretic protein called HPRWSP has been identified in patients with hyponatremia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Jyotsna Kubre, Vigya Goyal, Saurabh Saigal, J. P. Sharma, Rajnish Joshi
Summary: Hyponatremia is common in neurocritical care patients and is often due to either syndrome of inappropriate ADH secretion or cerebral salt wasting. Proper differentiation between SIADH and CSW is crucial for determining the appropriate treatment strategy.
Article
Immunology
Wen Li, Shu Teng, Shi-Yong Zhao, Zheng-Hong Qi
Summary: This article reports a case of SIADH secondary to varicella in a 9-year-old girl with remarkable hyponatremia. The patient's serum sodium returned to the normal level under appropriate treatment and no evidence of hyponatremia was found at a 3-month follow-up. The authors suggest that the existence of SIADH should be considered when treating patients with varicella who present with severe hyponatremia.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Pediatrics
Ankit Kumar Meena, Pamali Mahasweta Nanda, Rajni Sharma, Biswaroop Chakrabarty, Sheffali Gulati
Summary: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of euvolemic hyponatremia in hospitalized children. It is characterized by increased serum ADH, leading to water retention through V2 receptors in the distal renal tubules. The conventional treatment for SIADH includes fluid restriction and salt supplementation, but pharmacological therapy may be required in some cases. Limited experience exists with the use of V2-receptor antagonists in the pediatric population. In this case report, a girl with corpus callosum agenesis and severe symptomatic hyponatremia due to SIADH was successfully managed with the V2-receptor antagonist tolvaptan.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Neurosciences
Abhilasha Tripathi, Ravindra Singh Thakur, Jayantee Kalita, Devendra Kumar Patel, Usha K. Misra
Summary: This study found that in TBM patients, those with CSW had significantly higher levels of catecholamines, especially norepinephrine. Sequential studies revealed that dopamine and epinephrine increased at the time of hyponatremia and declined on its correction. The severity of TBM was related to dopamine levels, while the severity of CSW was related to epinephrine levels.
NEUROSCIENCE LETTERS
(2021)
Review
Medicine, General & Internal
Esteban Poch, Alicia Molina, Gaston Pineiro
Summary: Hyponatremia is a common electrolyte disorder in hospitalized patients, with SIADH being a frequent cause that is mainly induced by factors such as cancer, pulmonary illnesses, central nervous system disorders, and various drugs. Diagnosis of SIADH by professionals often does not align with established criteria, potentially affecting therapeutic outcomes.
Article
Medicine, General & Internal
Mari Mori, Satoru Takeshita, Nami Nakamura, Yuki Mizuno, Akiko Tomita, Mineyoshi Aoyama, Hiroki Kakita, Yasumasa Yamada
Summary: This report demonstrates the safety and efficacy of tolvaptan in an infant with HPE-associated SIADH.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Endocrinology & Metabolism
Jamala Mammadova, Cengiz Kara, Eda Celebi Bitkin, Elif Izci Gullu, Murat Aydin
Summary: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is an X-linked disease caused by activating mutations in the arginine vasopressin receptor-2 (AVPR2) gene. Patients excrete concentrated urine despite very low levels of AVP, and consequently develop euvolemic hyponatremia. Due to its low frequency, patients may be misdiagnosed and treated incorrectly.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Rashid Salih, Ronald van Toorn, James A. Seddon, Regan S. Solomons
Summary: Hyponatremia and hypoglycorrhachia are common in children with acute tuberculous meningitis (TBM), and they are associated with the staging of TBM disease, stroke, brainstem dysfunction, cranial nerve palsies, and non-communicating hydrocephalus.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Tomoaki Takao, Kentaro Tanaka, Yoshimasa Shiraishi, Keiichi Ota, Yasuto Yoneshima, Eiji Iwama, Isamu Okamoto
Summary: A case of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient treated with osimertinib was described. The patient's condition improved after discontinuation of osimertinib treatment, and she was able to continue treatment with gefitinib without developing hyponatremia.
CLINICAL LUNG CANCER
(2021)
Article
Medicine, General & Internal
Toru Hamada, Katsuyuki Matsuki, Seiji Kondou, Shinya Furukawa, Morikazu Onji
Summary: Duloxetine can cause syndrome of inappropriate secretion of antidiuretic hormone (SIADH), leading to hyponatremia. Elderly patients are more susceptible, with lower doses and earlier onset. Duloxetine-induced SIADH should be considered in high-risk elderly patients when hyponatremia occurs.
Review
Clinical Neurology
Fengyu Yang, Zhigang Cao, Xiaoyu Wang, Zhenwen Cui, Dekui Cheng, Ziji Li, Bingke Lv, Hongliang Zhang, Pin Guo, Yugong Feng, Wei Liu
Summary: This study analyzed the differences between cerebral salt-wasting syndrome (CSWS) and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in patients with hyponatremia after hypothalamic tumor surgery, finding that plasma BNP, urinary sodium excretion, urine volume, and IVCD are important indicators for identifying CSWS and SIADH.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Oncology
Marcus Skribek, Benedek Bozoky, Georgios Tsakonas
Summary: Asian patients with EGFR-mutated NSCLC have a higher prevalence and may develop SIADH with osimertinib treatment, which can be significantly improved after discontinuation. Further studies are needed to evaluate the potential mechanisms of osimertinib-induced SIADH.
Article
Medicine, General & Internal
Nikhil Dongre, Varun Kumar Singh, Jayantee Kalita, Usha Kant Misra
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Jayantee Kalita, Vijay Kumar, Usha K. Misra, Sunil Kumar
Summary: Movement disorders are common neurological symptoms in Wilson disease. They include dystonia, chorea, tremor, and are associated with MRI lesions, oxidative stress, glutamate, and cytokine levels.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Jayantee Kalita, Usha K. Misra, Robin Bansal
Summary: The study found that phonophobia in migraineurs may be related to lower hearing threshold and higher brainstem neuronal excitability, presenting characteristics such as lower hearing threshold, higher headache frequency, and multiple sensory triggers. Additionally, higher amplitudes of BAEP waves in migraineurs and their relationship with the frequency of headache and hearing threshold suggest the sensitization of brainstem auditory neurons.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Letter
Clinical Neurology
Jayantee Kalita, Nikhil Dongre, Usha Kant Misra
Article
Public, Environmental & Occupational Health
Usha Kant Misra, Mritunjai Kumar, Jayantee Kalita
Summary: Through a randomized controlled trial on patients with tuberculous meningitis, it was found that sequential anti-tubercular treatment was associated with a lower frequency of drug-induced hepatitis, lower in-hospital mortality, and better 6-month outcomes compared to the standard regimen.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Clinical Neurology
Jayantee Kalita, Usha K. Misra, Mritunjai Kumar, Robin Bansal, Ravi Uniyal
Summary: In this study, it was found that palinopsia is more frequent in migraineurs and is associated with neuronal dysexcitability. The impaired habituation of N75 and P100 waveforms is a biomarker for palinopsia in migraine, with N75 showing more pronounced impairment than P100.
CLINICAL EEG AND NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jayantee Kalita, Abhilasha Tripathi, Nikhil Dongre, Usha K. Misra
Summary: The COVID-19 pandemic and lockdown measures have worsened symptoms, mental health, and sleep quality in myasthenia gravis patients.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Neurosciences
Abhilasha Tripathi, Ravindra Singh Thakur, Jayantee Kalita, Devendra Kumar Patel, Usha K. Misra
Summary: This study found that in TBM patients, those with CSW had significantly higher levels of catecholamines, especially norepinephrine. Sequential studies revealed that dopamine and epinephrine increased at the time of hyponatremia and declined on its correction. The severity of TBM was related to dopamine levels, while the severity of CSW was related to epinephrine levels.
NEUROSCIENCE LETTERS
(2021)
Article
Public, Environmental & Occupational Health
Jayantee Kalita, Mahesh S. Jadhav, Varun K. Singh, Usha K. Misra
Summary: This report describes a patient with scrub typhus who presented with non-convulsive status epilepticus (NCSE) and recovered after treatment with antiepileptic medications. The study indicates that scrub typhus patients have the potential for recovery even after experiencing prolonged NCSE.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Clinical Neurology
Ashish K. Dubey, Jayantee Kalita, Sarvesh K. Chaudhary, Usha K. Misra
Summary: This study investigated the impact of anticoagulation status on recanalization and outcome in patients with cerebral venous thrombosis. The results showed that at 3 months, recanalization and outcome were not dependent on the patients' coagulation status. Further prospective studies are needed to determine the effects of anticoagulant duration on recanalization and outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Jayantee Kalita, Prakash C. Pandey, Ruchi Shukla, Usha K. Misra
Summary: Telephonic follow-up is feasible and beneficial for patients with tuberculous meningitis, with most patients able to manage medical issues through phone calls and reducing the need for physical visits. It is cost effective, helps in treatment modifications, and overcomes the barrier of distance.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Clinical Neurology
Usha K. Misra, Jayantee Kalita, Varun K. Singh, Aditya Kapoor, Abhilasha Tripathi, Prabhakar Mishra
Summary: The study found that regular exercise for 30 minutes in patients with mild to moderate MG improves their quality of life and walking distance compared to rest, without any adverse events.
EUROPEAN NEUROLOGY
(2021)
Meeting Abstract
Clinical Neurology
J. Kalita, U. K. Misra, V. K. Singh, P. Pandey, J. Thomas
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Meeting Abstract
Clinical Neurology
U. K. Misra, J. Kalita, V. K. Singh, A. Kapoor, A. Tripathi, P. Mishra
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Meeting Abstract
Critical Care Medicine
Anil Gulati, Nilesh Agrawal, Deepti Vibha, U. K. Misra, Birinder Paul, Rajnish Kumar, Jeyaraj Pandian, Shweta Varshney, Manish Lavhale
CRITICAL CARE MEDICINE
(2020)
