Article
Radiology, Nuclear Medicine & Medical Imaging
Guan-Yeu Chen, Teh-Fu Hsu, I-San Chan, Chia-Hao Liu, Wei-Ting Chao, Ying-Chu Shih, Ling-Yu Jiang, Yen-Hou Chang, Peng-Hui Wang, Yi-Jen Chen
Summary: This study compared the ability of the O-RADS and ADNEX models to classify benign or malignant adnexal lesions. The results showed that the O-RADS classification was comparable to the ADNEX model and had higher sensitivity at the 10% cutoff value. Additionally, the quick-access O-RADS flowchart was found to be helpful in categorization and could shorten the analysis time.
EUROPEAN RADIOLOGY
(2022)
Article
Mathematical & Computational Biology
Larry L. Tang, Zhen Meng, Qizhai Li
Summary: This article introduces a powerful method for comparing two samples by drawing inference from ROC curve model parameters and using a comprehensive statistic based on Cauchy combination. The method is particularly useful for non-normal continuous biomarker results and performs well in various scenarios.
STATISTICS IN MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Zhenzhen Li, Xiang Tong, Sitong Liu, Jirong Yue, Hong Fan
Summary: The Fujifilm SILVAMP TB LAM test shows high sensitivity and specificity for diagnosing adults with TB, especially in patients with HIV infection or low CD4 cell counts. However, its performance in diagnosing children with TB is slightly less satisfactory compared to adults.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Jinling Xie, Yinzhong Chen, Shihao Chen, Huaquan Long, Weijian Zhang, Guoan Liu
Summary: The study suggests that Notch signaling molecules and Th1-type factors have the potential to serve as biomarkers for tracking the progression of active tuberculosis (TB) at different stages. Specifically, Notch1, DLL1, and Hes1 were upregulated in TB patients, while T-bet and IFN-gamma were downregulated. The combiROC model of IFN-gamma and the percentage of lymphocytes (L%) showed superior discriminatory ability in identifying individuals with active TB. Notch pathway molecules were more effective than Th1-type factors in differentiating mild and moderate/severe cases of active TB.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Cleo Anastassopoulou, Athanasios Tsakris, George P. Patrinos, Yiannis Manoussopoulos
Summary: Serological methods, like Dot-ELISA, are commonly used for pathogen infection diagnosis, but the qualitative output can be uncertain due to overlapping dot colorations. This study introduces a novel approach using machine learning to evaluate Dot-ELISA output, providing a more accurate and reliable diagnosis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biology
M. Amico, I Van Keilegom, B. Han
Summary: This article introduces a cure model for handling cure fractions in survival data, and proposes a ROC curve estimator to evaluate the classification performance of cured/noncured status. Through simulations and comparisons, the good performance of the proposed method is demonstrated, applied to a breast cancer dataset.
Article
Microbiology
Aurelie Schnuriger, Sophie Vimont, Alexandre Godmer, Joel Gozlan, Salah Gallah, Muriel Mace, Valerie Lalande, Kenda Saloum, Marine Perrier, Nicolas Veziris, Laurence Morand-Joubert
Summary: Based on our comparative analysis, we propose an algorithm for the use of both syndromic and specific assays, for an optimal care of the meningitis/encephalitis threat in adult and pediatric patients.
MICROBIOLOGY SPECTRUM
(2022)
Article
Veterinary Sciences
Adrian-Valentin Potarniche, Michal Czopowicz, Olga Szalus-Jordanow, Agata Moroz, Marcin Mickiewicz, Lucjan Witkowski, Iwona Markowska-Daniel, Emilia Bagnicka, Constantin Cerbu, Diana Olah, Marina Spinu, Jaroslaw Kaba
Summary: This study aimed to evaluate the performance of different commercial ELISAs in testing milk samples for CAE. The results show that both wELISA and TM/CA-ELISA can be interchangeably used for individual goat milk samples.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Regina Koenig, Angela Heine
Summary: The present study aimed to evaluate the effectiveness of a brief intervention using an educational video on recognizing subtle sexism. It also investigated the use of signal detection theory (SDT) to measure participants' ability to detect subtle sexist content. The results showed that the intervention improved participants' ability to identify subtle sexism but also led to more false accusations of sexism in non-sexist statements.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Geriatrics & Gerontology
Yingni Sun, Jin Hua, Gen Chen, Jianjie Li, Jiateng Yang, Hongwei Gao
Summary: Alzheimer's disease is a common neurodegenerative disease, and a study found that decreased levels of Alix in brain tissues and serum were significantly associated with cognitive decline and A beta levels in AD patients. Serum Alix may be a potential novel and non-invasive biomarker for AD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Statistics & Probability
ShengLi Tzeng, Chun-Shu Chen, Yu-Fen Li, Jin-Hua Chen
Summary: In a systematic review of diagnostic performance, summarizing performance metrics is crucial. This article investigates existing methods and proposes a more robust method for model selection in a meta-analysis of diagnostic studies with small sample sizes. Simulation studies show that existing criteria fail to consistently choose appropriate models under limited numbers of studies. Our suggestion performs best in scenarios with a small number of studies, as demonstrated using an example of chemiluminescence immunoassay (CLIA) for COVID-19 diagnosis.
JOURNAL OF APPLIED STATISTICS
(2023)
Article
Medicine, General & Internal
Patricia F. R. Siqueira, Marcos K. Fleury, Roberia M. Pontes, Renata S. P. Silva, Elaine S. Costa, Marcelo G. P. Land
Summary: A new decision tool has been developed and validated to predict the presence of multiple deletions in alpha-thalassemia, improving the efficiency of molecular analysis. The model uses variables such as HbA(2) percentage, serum ferritin, and mean corpuscular volume to increase the pre-test probability. The tool aims to assist physicians in determining when to perform molecular studies for the diagnosis of alpha-thalassemia.
Article
Infectious Diseases
Xingwu Zou, Yanling Zhu, Yao Qin, Fan Fei, Yuanyuan Chen, Pengcheng Wang, Lihong Zhou, Yazhen Lang
Summary: The study aimed to assess the value of combining NGS with Xpert MTB/RIF for the early diagnosis of pulmonary tuberculosis (PTB). Retrospective analysis of 85 patients with suspected PTB was conducted. Xpert MTB/RIF, TBseq Ultra, TB-DNA, and TB-RNA showed significantly higher positive detection rates for PTB compared to acid-fast staining. These methods also demonstrated higher sensitivity and accuracy than acid-fast stained smears. Kappa agreement analysis indicated good agreement between Xpert MTB/RIF and TBseq Ultra. Combined diagnosis improved detection sensitivity compared to single methods. ROC curve analysis showed that the combination of Xpert MTB/RIF and TBseq Ultra had the highest area under the curve (0.886). In conclusion, the combined diagnosis of TBseq Ultra and Xpert MTB/RIF offers a promising application in the early diagnosis of PTB with characteristics of short cycle, high specificity, and accuracy.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Li, Tamara Ruegamer, Christoph Brochhausen, Karin Menhart, Andreas Hiergeist, Lukas Kraemer, Dirk Hellwig, Lars S. Maier, Christof Schmid, Jonathan Jantsch, Christian Schach
Summary: This study investigated diagnostic tools for infective endocarditis and their correlation with mortality outcomes. Positive blood cultures and transesophageal echocardiography were found to be the most sensitive for diagnosing IE, while vegetation size showed high predictive power. Systemic embolism and NT-proBNP levels were associated with mortality.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Veterinary Sciences
Tarun Kumar, Mahavir Singh, Babu Lal Jangir, Devan Arora, Sreenidhi Srinivasan, Devender Bidhan, Dipin Chander Yadav, Maroudam Veerasami, Douwe Bakker, Vivek Kapur, Naresh Jindal
Summary: The study evaluated a defined-antigen skin test for diagnosing bTB in water buffaloes, showing that the 20 μg DST cocktail had the same diagnostic sensitivity as the SIT, indicating potential utility in routine surveillance programs for BCG vaccination of water buffaloes.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Critical Care Medicine
Alexandros L. Georgiadis, Yuko Y. Palesch, David Zygun, J. Claude Hemphill, Claudia S. Robertson, Peter D. Leroux, Jose I. Suarez
NEUROCRITICAL CARE
(2015)
Review
Critical Care Medicine
Jennifer Frontera, Wendy Ziai, Kristine O'Phelan, Peter D. Leroux, Peter J. Kirkpatrick, Michael N. Diringer, Jose I. Suarez
NEUROCRITICAL CARE
(2015)
Review
Critical Care Medicine
Giuseppe Citerio, Soojin Park, J. Michael Schmidt, Richard Moberg, Jose I. Suarez, Peter D. Le Roux
NEUROCRITICAL CARE
(2015)
Article
Clinical Neurology
P. Gonzalez, X. Garcia, A. Guerra, J. C. Arango, H. Delgado, C. S. Uribe, J. Sara, J. C. Lopez de Mesa, O. Hernandez
Article
Clinical Neurology
Olga Helena Hernandez Ortiz, Hector Ivan Garcia Garcia, Fabian Munoz Ramirez, Juan Sebastian Cardona Florez, Bladimir Alejandro Gil Valencia, Salvador Ernesto Medina Mantilla, Maria Juliana Moreno Ochoa, Jorge Eliecer Sara Ochoa, Fabian Jaimes
JOURNAL OF NEUROSURGERY
(2018)
Article
Clinical Neurology
Juan Pablo Millan Sandoval, Luisa Maria Escobar del Rio, Edison Augusto Gomez, Lady Diana Ladino, Lina Maria Lopez Ospina, Diana Marcela Diaz, Jose Fernando Zapata, Olga Helena Hernandez
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2020)
Article
Neurosciences
Claudia Ramos, Camilo Villalba, Jenny Garcia, Serggio Lanata, Hugo Lopez, David Aguillon, Christian Cordano, Lucia Madrigal, Daniel C. Aguirre-Acevedo, Francisco Lopera
Summary: A study found that smoking and alcohol consumption were associated with improvements in certain cognitive assessments in carriers of the PSEN1-E280A genetic variant, possibly due to a survival bias. Coffee was also related to improvements in executive function and language, suggesting potential short-term neuroprotective effects.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Psychology, Clinical
Juan Pablo Zapata-Ospina, Jenny Garcia-Valencia
Summary: Content-based validity is the evidence of whether the items of an instrument represent the construct to be inferred. It is often overlooked in the development of health measurement scales. This narrative review aims to revise the concept of content as evidence of validity and synthesize evaluation methods.
JOURNAL OF HEALTH PSYCHOLOGY
(2022)
Article
Urology & Nephrology
Lesly Roxana Suaza-Martinez, Jenny Garcia-Valencia, Daniela Estrada Gomez, Alina Giraldo-Arismendi
Summary: The study aimed to determine the complications rate and risk factors associated with bipolar transurethral resection of the prostate at a complex care institution in Colombia. The overall complication rate was less than 20%, with the most frequent complications being grade I and II according to the Clavien Dindo classification. Modifiable risk factors were identified, which could potentially reduce postoperative morbidity.
ARCHIVOS ESPANOLES DE UROLOGIA
(2021)
Article
Medicine, General & Internal
Breitner Arteaga-Rubiano, Jenny Garcia-Valencia
Summary: A study conducted in a specialized clinic for hemophilia patients in Colombia found that the quality of life in adult patients with hemophilia is associated with factors such as age, number of comorbidities, socioeconomic level, joint disease, and mobility. The study showed high scores in quality of life, but further longitudinal studies with larger samples are needed to establish causal associations.
Article
Medicine, General & Internal
Lesly Roxana Suaza-Martinez, Jenny Garcia-Valencia, Alina Maria Giraldo-Arismendi
Review
Medicine, General & Internal
Francisco Luis Caro-Zapata, Andrea Vasquez-Franco, Edgar David Correa-Galeano, Jenny Garcia-Valencia
Article
Anesthesiology
Jorge Eliecer Sara-Ochoa, Olga Helena Hernandez Ortiz, Fabian Alberto Jaimes
TRENDS IN ANAESTHESIA AND CRITICAL CARE
(2017)