标题
FDA-Approved Fluorinated Heterocyclic Drugs from 2016 to 2022
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 9, Pages 7728
出版商
MDPI AG
发表日期
2023-04-24
DOI
10.3390/ijms24097728
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- The Pharmaceutical Industry in 2022: An Analysis of FDA Drug Approvals from the Perspective of Molecules
- (2023) Beatriz G. de la Torre et al. MOLECULES
- New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use
- (2022) Davide Benedetto Tiz et al. MOLECULES
- Capsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 Infection
- (2022) Sorana Segal-Maurer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Atogepant (Qulipta®) for migraine prevention
- (2022) Debbie L. Hay et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Oteseconazole: First Approval
- (2022) Sheridan M. Hoy DRUGS
- Lenacapavir: First Approval
- (2022) Julia Paik DRUGS
- Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
- (2022) Liang Zhang et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer’s Disease
- (2021) Caitlin Jie et al. Pharmaceuticals
- New drug approvals for 2020: Synthesis and clinical applications
- (2021) Shuo Yuan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Piflufolastat F 18: Diagnostic First Approval
- (2021) Susan J. Keam Molecular Diagnosis & Therapy
- Atogepant: First Approval
- (2021) Emma D. Deeks DRUGS
- Oteseconazole: an advance in treatment of recurrent vulvovaginal candidiasis
- (2021) Jack D Sobel et al. Future Microbiology
- Review of Synthetic Routes and Crystalline Forms of the Antiandrogen Oncology Drugs Enzalutamide, Apalutamide, and Darolutamide
- (2020) David L. Hughes ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Fluorine-containing drugs approved by the FDA in 2019
- (2020) Haibo Mei et al. CHINESE CHEMICAL LETTERS
- Fluorinated scaffolds for antimalarial drug discovery
- (2020) Charu Upadhyay et al. Expert Opinion on Drug Discovery
- Metabolic and Pharmaceutical Aspects of Fluorinated Compounds
- (2020) Benjamin M. Johnson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthetic Approaches to New Drugs Approved during 2018
- (2020) Andrew C. Flick et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications
- (2020) Nagaraju Kerru et al. MOLECULES
- Contribution of Organofluorine Compounds to Pharmaceuticals
- (2020) Munenori Inoue et al. ACS Omega
- Selumetinib: First Approval
- (2020) Anthony Markham et al. DRUGS
- New Drug Approvals for 2019: Synthesis and Clinical Applications
- (2020) Shuo Yuan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Abemaciclib, a CDK4 and CDK6 inhibitor for the treatment of metastatic breast cancer
- (2020) Miguel Martin et al. Future Oncology
- Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification
- (2020) Jeffrey M. Kallemeyn et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Decitabine/Cedazuridine: First Approval
- (2020) Sohita Dhillon DRUGS
- Polypharmacological Drug Actions of Recently FDA Approved Antibiotics
- (2020) Carlie Wetzel et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Oral berotralstat for the prophylaxis of hereditary angioedema attacks in patients in Japan: A phase 3 randomized trial
- (2020) Isao Ohsawa et al. ALLERGY
- Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations
- (2020) V. Subbiah et al. ANNALS OF ONCOLOGY
- Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation
- (2019) Carsten Theodor Beuckmann et al. SLEEP
- Fluorine‐Containing Drugs Approved by the FDA in 2018
- (2019) Haibo Mei et al. CHEMISTRY-A EUROPEAN JOURNAL
- Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer
- (2019) Fabrice André et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alpelisib: First Global Approval
- (2019) Anthony Markham DRUGS
- Ublituximab and Umbralisib in Relapsed/ Refractory B-cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia
- (2019) Matthew Lunning et al. BLOOD
- Synthesis of a Hominal Bis(difluoromethyl) Fragment
- (2019) Viktor Ivasyshyn et al. ACS Omega
- Pexidartinib: First Approval
- (2019) Yvette N. Lamb DRUGS
- Role of sulphur-heterocycles in medicinal chemistry: An update
- (2019) Shelly Pathania et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
- (2019) Jude Canon et al. NATURE
- Patent Review of Synthetic Routes and Crystalline Forms of the CFTR-Modulator Drugs Ivacaftor, Lumacaftor, Tezacaftor, and Elexacaftor
- (2019) David L. Hughes ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
- (2019) Brian A. Lanman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Ubrogepant for the Treatment of Migraine
- (2019) David W. Dodick et al. NEW ENGLAND JOURNAL OF MEDICINE
- Development of the Enabling Route for Glecaprevir via Ring-Closing Metathesis
- (2019) Russell D. Cink et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Tezacaftor/Ivacaftor in Subjects with Cystic Fibrosis and F508del/F508del-CFTR or F508del/G551D-CFTR
- (2018) Scott H. Donaldson et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Rucaparib: An emerging parp inhibitor for treatment of recurrent ovarian cancer
- (2018) Angela Musella et al. CANCER TREATMENT REVIEWS
- Apalutamide: First Global Approval
- (2018) Zaina T. Al-Salama DRUGS
- Baloxavir: First Global Approval
- (2018) Young-A Heo DRUGS
- Sofosbuvir/Velpatasvir/Voxilaprevir: A Review in Chronic Hepatitis C
- (2018) Young-A Heo et al. DRUGS
- Fostamatinib: First Global Approval
- (2018) Anthony Markham DRUGS
- Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
- (2018) Nicholas A. Meanwell JOURNAL OF MEDICINAL CHEMISTRY
- The Pharmaceutical Industry in 2017. An Analysis of FDA Drug Approvals from the Perspective of Molecules
- (2018) Beatriz de la Torre et al. MOLECULES
- 2017 FDA drug approvals
- (2018) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer
- (2018) Matthew R. Smith et al. NEW ENGLAND JOURNAL OF MEDICINE
- Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
- (2018) Janeta Popovici-Muller et al. ACS Medicinal Chemistry Letters
- Doravirine
- (2018) Marie-Alice Colombier et al. Current Opinion in HIV and AIDS
- Ivosidenib: First Global Approval
- (2018) Sohita Dhillon DRUGS
- In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit
- (2018) Takeshi Noshi et al. ANTIVIRAL RESEARCH
- Talazoparib: First Global Approval
- (2018) Sheridan M. Hoy DRUGS
- A Survey of the Structures of US FDA Approved Combination Drugs
- (2018) Pradipta Das et al. JOURNAL OF MEDICINAL CHEMISTRY
- Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil
- (2018) Emi Takashita et al. Frontiers in Microbiology
- A review of binimetinib for the treatment of mutant cutaneous melanoma
- (2017) Peter Koelblinger et al. Future Oncology
- Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure
- (2017) Markus Follmann et al. JOURNAL OF MEDICINAL CHEMISTRY
- In Vitro and In Silico Characterization of Lemborexant (E2006), a Novel Dual Orexin Receptor Antagonist
- (2017) Carsten Theodor Beuckmann et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-Containing Antiviral, Letermovir
- (2017) Cheol K. Chung et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- 2016 FDA drug approvals
- (2017) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Development of a Leuckart–Wallach Reaction in Flow for the Synthesis of Abemaciclib
- (2017) Michael O. Frederick et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease
- (2016) Annamaria Martorana et al. CURRENT PHARMACEUTICAL DESIGN
- An analysis of FDA-approved drugs: natural products and their derivatives
- (2016) Eric Patridge et al. DRUG DISCOVERY TODAY
- Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction
- (2016) Guy R. Humphrey et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Potent Antiviral Activities of the Direct-Acting Antivirals ABT-493 and ABT-530 with Three-Day Monotherapy for Hepatitis C Virus Genotype 1 Infection
- (2015) Eric J. Lawitz et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent
- (2015) Bing Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist
- (2015) Yu Yoshida et al. JOURNAL OF MEDICINAL CHEMISTRY
- A synthesis of abemaciclib utilizing a Leuckart–Wallach reaction
- (2015) Michael O. Frederick et al. TETRAHEDRON LETTERS
- The synthesis of gemcitabine
- (2014) Kylie Brown et al. CARBOHYDRATE RESEARCH
- Sofosbuvir: First Global Approval
- (2014) Gillian M. Keating et al. DRUGS
- Design, Synthesis, and Pharmacological Evaluation of Fluorinated Tetrahydrouridine Derivatives as Inhibitors of Cytidine Deaminase
- (2014) Dana Ferraris et al. JOURNAL OF MEDICINAL CHEMISTRY
- [18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease
- (2013) Chun-Fang Xia et al. Alzheimers & Dementia
- Introduction of Fluorine and Fluorine-Containing Functional Groups
- (2013) Theresa Liang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation
- (2013) Pascal Furet et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
- (2013) Bernard Côté et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Sofosbuvir for the treatment of hepatitis C virus
- (2013) Tarik Asselah EXPERT OPINION ON PHARMACOTHERAPY
- Trifluoroacetic acid: Uses and recent applications in organic synthesis
- (2013) Simón E. López et al. JOURNAL OF FLUORINE CHEMISTRY
- MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
- (2013) Paolo A Ascierto et al. LANCET ONCOLOGY
- ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
- (2012) N. J. Clegg et al. CANCER RESEARCH
- 2-(3- -Ureido)-Pentanedioic Acid, [18F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer
- (2011) Y. Chen et al. CLINICAL CANCER RESEARCH
- The Novel Anticytomegalovirus Compound AIC246 (Letermovir) Inhibits Human Cytomegalovirus Replication through a Specific Antiviral Mechanism That Involves the Viral Terminase
- (2011) T. Goldner et al. JOURNAL OF VIROLOGY
- Fluorinated contrast agents for magnetic resonance imaging; a review of recent developments
- (2011) James C. Knight et al. RSC Advances
- Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective
- (2010) Norio Shibata et al. Beilstein Journal of Organic Chemistry
- Fluorine in health care: Organofluorine containing blockbuster drugs
- (2010) David O’Hagan JOURNAL OF FLUORINE CHEMISTRY
- One Step Radiosynthesis of 6-[18F]Fluoronicotinic Acid 2,3,5,6-Tetrafluorophenyl Ester ([18F]F-Py-TFP): A New Prosthetic Group for Efficient Labeling of Biomolecules with Fluorine-18
- (2010) Dag E. Olberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
- (2010) Michael J. Sofia et al. JOURNAL OF MEDICINAL CHEMISTRY
- An Efficient and Diastereoselective Synthesis of PSI-6130: A Clinically Efficacious Inhibitor of HCV NS5B Polymerase
- (2009) Peiyuan Wang et al. JOURNAL OF ORGANIC CHEMISTRY
- Fluorine in medicinal chemistry
- (2007) Sophie Purser et al. CHEMICAL SOCIETY REVIEWS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now