期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 363, 期 -, 页码 207-216出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2016.02.038
关键词
Pineal cysts; Symptomatic; MRI; Central venous hypertension; Clinical outcome
资金
- Dept. of Neurosurgery, Oslo University Hospital Rikshospitalet
Background: While most pineal cysts (PCs) are asymptomatic, some PCs are accompanied with symptoms of variable severity. We suggested that symptom severity in symptomatic patients with non-hydrocephalic PCs relates to venous compression causing central venous hypertension. This study explored whether possible magnetic resonance imaging (MRI) biomarkers of central venous hypertension could differentiate the severity of symptoms in individuals with non-hydrocephalic PCs. Methods: The study included all individuals with PCs and MRI available for analysis followed conservatively within the department from 2003 to 2014. Severity of symptoms at follow-up were assessed from a questionnaire. Suggested MRI biomarkers indicative of central venous hypertension were explored, in addition to MRI measures of cyst size, aqueduct stenosis, and tectal compression. Results: The study included 66 patients. As compared to the 27/66 patients (41%) with None-Moderate symptoms at follow-up, the 39/66 patients (59%) with Much-Severe symptoms presented with significantly altered indices of central venous hypertension (tectum-splenium-cyst ratio and indices of thalamic and periventricular edema). PC grading based on MRI biomarkers of central venous hypertension differentiated the severity of symptoms. Conclusion: The results indicate an association between severity of symptoms and MRI biomarkers of central venous hypertension in symptomatic individuals with non-hydrocephalic PCs. (C) 2016 Elsevier B.V. All rights reserved.
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