Article
Pharmacology & Pharmacy
Afsana Sheikh, Shadab Md, Nabil A. Alhakamy, Prashant Kesharwani
Summary: There is a growing demand for safe and targeted cancer therapies as conventional treatments often fail to reach the intended site. Nanocarriers enable targeted delivery, increasing drug concentration at the tumor site while reducing toxicity to healthy cells and overcoming drug resistance. Aptamers, with their ability to recognize and interact with biomarkers overexpressed by cancer cells, play a crucial role in cancer immunotherapy and drug delivery. This review highlights the use of aptamer-chitosan nanoparticles in cancer therapy and their potential for reducing toxic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Applied
Fatemeh Khatami, Maryam M. Matin, Noor Mohammad Danesh, Ahmad Reza Bahrami, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: The novel AACS nanocomplex was developed for targeted co-delivery of DOX and antimiR-21, showing promising results in inhibiting cancer cell growth through cellular uptake and cytotoxicity assessments.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Environmental
Meishen Ren, Jiaojiao Zhou, Zhiyong Song, Hong Mei, Ming Zhou, Zhen F. Fu, Heyou Han, Ling Zhao
Summary: Rabies, a lethal disease caused by a neurotropic virus, currently lacks effective clinical therapy. A photothermal therapy using aptamer conjugated RVG-Apt-PEG-Silica gold nanorods showed promising results in reducing viral load and increasing survival rate in a mouse model.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Nanoscience & Nanotechnology
Jincong Yan, Tian Gao, Zhongzhong Lu, Jingbo Yin, Ye Zhang, Renjun Pei
Summary: Aptamers, short oligonucleotide sequences with selective binding abilities, have shown promise in improving controlled and accurate delivery of photosensitizers into tumor sites for enhanced photodynamic therapy. Modification of aptamers onto PSs or nanocarriers enables specific recognition and binding to tumor cells, resulting in superior therapeutic efficiency. The development of aptamer-targeted platforms for tumor therapy holds potential for synergistic treatment modalities like PDT, photothermal therapy, and chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Thomas Abraham, Christopher O. McGovern, Samuel S. Linton, Zachary Wilczynski, James H. Adair, Gail L. Matters
Summary: Aptamer-targeted nanoparticles loaded with imaging agents showed enhanced detection of pancreatic and prostate tumors in vivo and ex vivo. The specific interaction with CCK-B receptors allows for well-distributed distribution of the tumor-targeted nanoparticles in the tumor matrix, improving early cancer detection.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Zhiqiang Bai, Lu Zhao, Haidi Feng, Hui Xu, Nianping Zhang, Yanjun Li, Jinping Song, Yunfeng Bai, Ronghua Yang, Feng Feng
Summary: A novel DOX/Ti3C2/Apt-M therapeutic nanoplatform was successfully fabricated, which specifically targeted MCF-7 tumor cells and suppressed tumor growth significantly through combination therapy of multimodal stimuli-responsive drug release and photothermal effect. This work provides a new idea of targeted tumor therapy based on Ti3C2 nanosheets.
MATERIALS & DESIGN
(2023)
Article
Pharmacology & Pharmacy
Jamileh Kadkhoda, Ayuob Aghanejad, Banafsheh Safari, Jaleh Barar, Seyed Hossien Rasta, Soodabeh Davaran
Summary: This study successfully developed a targeted photothermal therapy with a multifunctional drug delivery platform. The Mucin1 (MUC1) aptamer-modified poly (ethylene glycol)-gold nanoparticle system loaded with Paclitaxel (PTX) showed selective cytotoxicity towards MUC1-positive breast cancer cells and exhibited excellent cellular uptake ability when combined with near-infrared (NIR) irradiation. The synergistic effect of PTX/PEG-AuNPs@antiMUC1 was observed, leading to increased cell death compared to either photothermal therapy or chemotherapy alone. Protein expression analysis confirmed the potential of this synergistic combinational system in cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yan Zhang, Hai-Yun Zhang, Zhengping Jiang, Yuan-Lu Cui, Qiang-Song Wang
Summary: Targeted delivery of glutamine-decorated nanoparticles achieved efficient tumor treatment. The combination of tetrandrine and doxorubicin showed a synergistic effect for tumor treatment. The method demonstrated promising efficacy and reduced toxicity in an animal model.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Analytical
Maroua Hamami, Meryem Bouaziz, Noureddine Raouafi, Azzedine Bendounan, Hafsa Korri-Youssoufi
Summary: The study introduces an electrochemical aptasensor for the detection of ampicillin, utilizing a nanostructure composed of MoS2 nanosheets and conductive polypyrrole nanoparticles. By studying the structural and morphological properties of the nanocomposite, it was found that the material formed a synergetic effect on the electrochemical redox process. The biosensor demonstrated high sensitivity and selectivity, with a limit of detection of 10 pg/L for ampicillin, making it a promising device for environmental antibiotic detection.
Article
Pharmacology & Pharmacy
Dilyana Georgieva, Denitsa Nikolova, Elena Vassileva, Bistra Kostova
Summary: This study explores chitosan-based nanoparticles as potential delivery vehicles for galantamine hydrobromide (GH) via intranasal administration. The nanoparticles showed high loading efficiency and prolonged release of the drug. After 1 year of storage, the stability of the GH-loaded nanoparticles was also demonstrated.
Review
Biochemistry & Molecular Biology
Shiming He, Yue Du, Hongyu Tao, Huaiyu Duan
Summary: This review paper summarizes recent advances in aptamer-mediated drug delivery systems in cancer therapy, including aptamer-drug conjugates, aptamer-siRNA, and aptamer-functionalized nanoparticle systems. The article discusses the application prospects and existing challenges of these innovative approaches, highlighting their potential to reduce toxicity and improve therapeutic efficacy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biotechnology & Applied Microbiology
Fei Gao, Jianhui Yin, Yan Chen, Changyong Guo, Honggang Hu, Jiacan Su
Summary: Aptamer-embedded drug delivery systems have shown great potential in cancer therapy, as they can specifically bind to a variety of target molecules. They offer numerous advantages, including high biostability, versatile chemical modification, low immunogenicity, and strong tissue penetration. Therefore, they have attracted extensive interest in the field of precision medicine and hold significant importance for cancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Shafiei, Reyhaneh Sadat Saberi, Masoud A. Mehrgardi
Summary: The study developed a graphene-based aptasensor for sensitive detection of human breast cancer cells, showing high selectivity and sensitivity. The aptamer played a key role in improving the properties of the composite for cell capture.
BIOELECTROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Qiuxia Yang, Yongbo Peng, Zhengyu Deng, Dailiang Zhang, Cheng-Yu Long, Guo-Rong Zhang, Juan Li, Xue-Qiang Wang, Weihong Tan
Summary: The phosphorothioate backbone modification strategy was used to regulate the biomedical properties of pancreatic cancer cell-targeting aptamer, enhancing its stability and cell uptake capacity, leading to increased drug accumulation at the tumor site, improved therapeutic efficacy, and reduced side effects. The fully thio-substituted aptamer and its functionalized form with mitomycin C showed prolonged plasma half-life and higher binding and uptake capacities. The modified aptamer demonstrated specific cytotoxicity against targeted cancer cells and lower toxicity to non-targeted cells, indicating its specificity and biosafety.
NATIONAL SCIENCE REVIEW
(2023)
Article
Biotechnology & Applied Microbiology
Maryamsadat Shahidi, Omid Abazari, Parisa Dayati, Javad Zavar Reza, Mohammad Hossein Modarressi, Davood Tofighi, Bibi Fatemeh Haghiralsadat, Fatemeh Oroojalian
Summary: This study developed a nanoparticle-based delivery system consisting of selenium nanoparticles modified by chitosan and hyaluronic acid, which successfully delivered PLK1 siRNAs to bladder cancer cells. These findings suggest that hyaluronic acid-chitosan-selenium nanoparticles may provide a good vehicle for targeted gene therapy for bladder cancer.
Article
Environmental Sciences
L. Fei, F. Ali, A. Said, N. Tariq, F. Raziq, N. Ali, U. Arif, M. S. Akhter, A. Rahdar, M. Bilal
Summary: Three types of zinc ferrite nanoparticles were synthesized successfully and characterized for their structure and photocatalytic performance. The results showed that these nanoparticles exhibited excellent photocatalytic properties and could be reused.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Leili Mohammadi, Amin Mohammadpour, Mohammad Reza Hosseini, Ebrahim Shahsavani, Reza Abbasi Rayeni, Mohammad Golaki, Abbas Rahdar, Sadanand Pandey
Summary: This study investigated the photocatalytic degradation of BOD from wastewater using copper oxide nanoparticles. The study found that factors such as UV intensity, pH, time, and copper oxide dose significantly influenced the removal efficiency. The Langmuir isotherm provided the best fit for the experimental data.
ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY
(2023)
Review
Chemistry, Applied
Mehrab Pourmadadi, Shima Ostovar, Mohammad Mahdi Eshaghi, Maryam Rajabzadeh-Khosroshahi, Sara Safakhah, Suresh Ghotekar, Abbas Rahdar, Ana M. Diez-Pascual
Summary: Metal-organic frameworks (MOFs) have attracted attention for their flexibility, tunable porosity, and easy functionalization, and have been investigated as carriers for therapeutics delivery to cancerous organs due to their high encapsulating capacity, controlled cargo release, biodegradability, and biocompatibility. Various methods have been used to fabricate MOFs, and post-synthetic modification is commonly employed to functionalize them. This literature review focuses on drug-loaded MOFs for cancer detection and treatment, as well as bacterial, fungal, and viral infections, describing different types of MOFs as drug carriers and biosensing platforms. The review also discusses future perspectives and challenges, particularly in cancer therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biophysics
Laura Ferreira, Filipa Mascarenhas-Melo, Sofia Rabaca, Ankita Mathur, Ankur Sharma, Prabhanjan S. Giram, Kiran D. Pawar, Abbas Rahdar, Faisal Raza, Francisco Veiga, Priscila Gava Mazzola, Ana Claudia Paiva-Santos
Summary: The progress in new delivery systems for active ingredients in dermopharmaceutical and cosmetic fields has been boosted by the use of cyclodextrins (CDs) as versatile carriers. CDs are able to form host-guest inclusion complexes with guest active molecules, improving their physicochemical properties. The advantages of CDs in dermopharmaceutical and cosmetic applications include improved solubility and stability of active ingredients, as well as the ability to mask unpleasant odors, making them promising for skin disease treatment and cosmetic formulation improvement.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Medicinal
Anai A. Valencia-Lazcano, Dilawar Hassan, Mehrab Pourmadadi, Amin Shamsabadipour, Razieh Behzadmehr, Abbas Rahdar, Dora I. Medina, Ana M. Diez-Pascual
Summary: This study reviews the applications of 5-Fluorouracil (5-FU) as an anticancer drug for various types of cancers. Different approaches, such as nanoparticles loaded with 5-FU, co-delivery systems with other drugs, have been described to overcome the limitations of 5-FU therapy. This review provides the latest progress on 5-FU-loaded nanocarriers and their potential as an advanced tool for cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Maryam Rajabzadeh-Khosroshahi, Mohammad Mahdi Eshaghi, Erfan Rahmani, Hamidreza Motasadizadeh, Rabia Arshad, Abbas Rahdar, Sadanand Pandey
Summary: In biomedical engineering, researchers are studying the modification of TiO2 (titania) to enhance its physiochemical properties. This comprehensive review focuses on the potential applications of nanoscale TiO2 and its nanocomposites in biomedical research, specifically in cancer therapeutics. The use of titania-based nanomaterials in biosensors, particularly in the electrochemical field, has been widely explored. Various bioimaging techniques, such as FL, PA, CT, PET, MR, and multi-mode imaging, have been evaluated for their applicability. Nanoscale titania has also emerged as a popular candidate for cancer treatment methods including phototherapy, chemotherapy, and microwave hyperthermia. Finally, a multifunctional nanoplatform combining different treatment methods has been developed for cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mahmood Barani, Mohammad Reza Hajinezhad, Sheida Shahraki, Shekoufeh Mirinejad, Mahtab Razlansari, Saman Sargazi, Abbas Rahdar, Ana M. Diez-Pascual
Summary: The introduction of innovative medications such as proteasome inhibitors (PIs) has significantly increased the response rate and overall survival of cancer patients. In this study, novel nickel-based metal-organic frameworks (Ni-MOFs) loaded with the second-generation PI carfilzomib (CFZ) were developed and demonstrated to have high loading efficiency and controlled release behavior. The CFZ-loaded Ni-MOFs exhibited higher cytotoxic effects against cancer cells compared to free CFZ and showed potential as promising carriers for targeted drug delivery. Rating: 9 out of 10.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sepehr Darvishan, Mehrab Pourmadadi, Majid Abdouss, Saeedeh Mazinani, Fatemeh Yazdian, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A novel PAA-based hydrogel coated with ?-alumina modified with PVP was synthesized for the delivery of quercetin to cancer cells. The addition of Al2O3 increased pH-sensitivity, and the use of Span 80 surfactant led to a nano niosomal emulsion that improved stability and retention of quercetin. The microemulsion's physical interactions, crystalline structure, and morphology were analyzed, and drug loading efficiency was significantly improved with the double emulsion method. The developed ?-alumina-PAA/PVP nanoemulsion shows promise as a pH-sensitive drug delivery system.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mahmood Barani, Mohammad Reza Hajinezhad, Farshid Zargari, Sheida Shahraki, Fatemeh Davodabadi, Shekoufeh Mirinejad, Saman Sargazi, Abbas Rahdar, Ana M. Diez-Pascual
Summary: Novel niosomes containing cholesterol, Span (60), Tween (60), and gemcitabine (GEM) were developed and characterized. They showed a nanometric size, controlled drug release, and higher effectiveness in cancer cell lines compared to free GEM. The main mechanism of cell-killing effects was apoptosis, with some cells undergoing necrosis. However, intravenous treatment with niosomal GEM caused severe side effects in rats, while free GEM did not. Molecular dynamics simulations demonstrated the interactions between GEM and niosome components, suggesting their potential as drug carriers with reduced side effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Amirhossein Ghaemi, Meysam Shaghaghi, Abbas Rahdar, Sadanand Pandey
Summary: Cabazitaxel has shown superior anticancer efficacy compared to docetaxel and paclitaxel in resistant cancer models and has a high ability to penetrate the blood-brain barrier for brain tumor treatment. However, its clinical application is limited due to low solubility and tumor cell uptake. Various nanocarriers, including albumin and lipid-based nanoparticles, prodrugs, and polymeric nanoparticles, have been explored to overcome these limitations and improve the therapeutic efficacy of Cabazitaxel. Chemical modifications, such as acid-sensitivity, active targeting, and PEGylation, have also been utilized to enhance the carrier's properties.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Amir Hossein Khodabandehloo, Mehrab Pourmadadi, Amin Shamsabadipour, Hadis Langari, Amanda-Lee Manicum, Abbas Rahdar, Francesco Baino
Summary: Various diseases during cancer surgery, including infections, trauma, and tumor resections, can lead to bone damage or skeletal defects. These defects cannot heal spontaneously due to medical conditions such as diabetes, hormone-related problems, and autoimmune disorders. Bone-tissue engineering has emerged as a solution to these challenges, utilizing strategies like studying bone structures, employing growth factors, scaffolds, and biomaterial-centered regenerative approaches. This study reviews recent bone-tissue-engineering strategies using 2D materials such as graphene and its derivatives, black phosphorus, and MXenes, which show great potential in regenerative medicine.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Biotechnology & Applied Microbiology
Larissa Renata Santos Andrade, Ianny Andrade Cruz, Lucas Tadeu Fuess, Hafiz M. N. Iqbal, Ram Naresh Bharagava, Ana Claudia de Melo Oliveira, Renan Tavares Figueiredo, Ranyere Lucena de Souza, Abbas Rahdar, Luiz Fernando Romanholo Ferreira
Summary: Anaerobic digestion (AD) is widely used for efficient treatment of effluents to recover energy and value-added chemical products. The addition of nanoparticles (NPs) with reactive surface area, such as TiO2 nanoplates, can enhance microbial metabolism and promote rapid conversion of organic matter into bioenergy. This study examined the interrelationship between the addition of TiO2 nanoplates impregnated on Luffa Cylindrica (LufTiO2) and the reuse of this nanocatalyst (LufTiO2R) in biogas production from cassava wastewater. The results showed that both LufTiO2 and LufTiO2R improved the system performance by reducing delay time and increasing biogas production, indicating their potential application in stimulating biogas production.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mehrab Pourmadadi, Erfan Rahmani, Amin Shamsabadipour, Amirmasoud Samadi, Javad Esmaeili, Rabia Arshad, Abbas Rahdar, Fariborz Tavangarian, Sadanand Pandey
Summary: Cellulose derivatives have gained significant attention in the field of biomedical applications due to their biocompatibility and favorable physical and mechanical features. This study discusses the potential of carboxymethyl cellulose (CMC) in biomedical applications, and reviews different methods for producing CMC hydrogels. Literature review shows that CMC exhibits strong anti-bacterial and anti-tumor properties, and has widespread applications in tissue engineering, wound dressing, and drug delivery.
PROCESS BIOCHEMISTRY
(2023)
Article
Cell Biology
Zahra Keramati, Gholamreza Motalleb, Abbas Rahdar, Mohammad Amin Kerachian
Summary: This study investigated the effect of co-incubation of 5-FU and gum-based cerium oxide nanoparticles (Ceo-2-XG) on the apoptosis and IC50 of Caco-2 cancer cells. The synthesized Ceo-2-XG nanoparticles were characterized using various techniques. The results showed that co-incubation of 5-FU and Ceo-2-XG nanoparticles significantly increased apoptosis and had a higher antiproliferative activity compared to 5-FU alone.
Review
Materials Science, Multidisciplinary
Saman Sargazi, Mahtab Ghasemi Toudeshkchouei, Abbas Rahdar, Aisha Rauf, Soheil Amani, Muhammad Bilal, Razieh Behzadmehr, Ana M. Diez-Pascual, Francesco Baino
Summary: As a major global cause of liver damage, non-alcoholic fatty liver disease (NAFLD) is associated with excessive hepatocellular lipid accumulation, elevated hepatic enzymes, and fibrotic evidence. Nanotechnology has revolutionized the synthesis of nanostructures for imaging, diagnosis, and treatment of diseases, including NAFLD. Loading drugs into nanocarriers is a promising strategy for extending their circulating time and treating NAFLD. Various nanostructures, such as inorganic nanoparticles, organic-based nanoparticles, metallic nanocarriers, and lipid-based nanocarriers, have been designed and shown significant effects on glucose/lipid levels and liver function indices in NAFLD treatment. However, limitations exist for their use as diagnostic agents. This review aims to discuss recent advancements in nanomedicine for the early diagnosis, treatment, and prognosis of NAFLD.
IRANIAN JOURNAL OF MATERIALS SCIENCE AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
