Article
Biochemistry & Molecular Biology
Yana Yang, Wenhui Qi, Yanyan Zhang, Ruining Wang, Mingyue Bao, Mengyuan Tian, Xing Li, Yuan Zhang
Summary: ROR gamma t is a crucial transcription factor for the differentiation of pro-inflammatory Th17 cells. In this study, a natural compound called 2,2',4'-trihydroxychalcone (TDC) was found to directly bind to the ligand binding domain of ROR gamma t and inhibit its transcriptional activation activity. TDC administration effectively alleviated the disease development in three different mouse models of Th17-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anna Tosi, Lavinia Nardinocchi, Maria Luigia Carbone, Lorena Capriotti, Elena Pagani, Simona Mastroeni, Cristina Fortes, Fernanda Scopelliti, Caterina Cattani, Francesca Passarelli, Antonio Rosato, Stefania D'Atri, Cristina Maria Failla, Andrea Cavani
Summary: The study found that in cutaneous melanoma, there is a lower percentage of Th17 lymphocytes compared to basal cell carcinomas, and TIL clones could not differentiate into the Th17 phenotype in vitro. The presence of Th17 cells did not correlate with patient characteristics, but a lower amount was observed in samples from female donors. The expression of placenta growth factor by melanoma cells may be associated with the presence of Th17 lymphocytes.
Article
Immunology
Rosanne D. Reitsema, William F. Jiemy, Lieske Wekema, Annemieke M. H. Boots, Peter Heeringa, Minke G. Huitema, Wayel H. Abdulahad, Yannick van Sleen, Maria Sandovici, Caroline Roozendaal, Arjan Diepstra, Thomas Kwee, Bhaskar Dasgupta, Elisabeth Brouwer, Kornelis S. M. van der Geest
Summary: This study investigated the T helper 1 (T-H1) and T helper 17 (T-H17) cell responses in blood, synovial fluid, and bursa tissue of patients with polymyalgia rheumatica (PMR). The findings suggest that T-H1 cells are involved in the inflammation of bursae and tendon sheaths in PMR, indicating the T-H1 cell pathway as a potential therapeutic target for PMR.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xiaoxue Ma, Shingo Nakayamada
Summary: T follicular helper (Tfh) cells participate in humoral immune responses by promoting inflammation and aiding B cells survival, proliferation, maturation, and generation of autoantibodies. The plasticity of Tfh cells allows for adjustment of differentiation direction based on immune response level, regulated by various signaling factors such as cytokines, receptors, transcription factors, and genes. The STAT family signaling pathways play a crucial role in Tfh formation, with each member contributing to Tfh differentiation through mutual restraint and cooperation among cytokine-STAT signals.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xinzou Fan, Panyin Shu, Ying Wang, Ning Ji, Dunfang Zhang
Summary: Neutrophils are the predominant immune cells in human peripheral circulation that play a crucial role in fighting infections, autoimmune diseases, and cancer. This review discusses the physiological roles of Th17 cells and neutrophils, their interactions, and their involvement in pathological processes. The study also provides a summary of drugs targeting IL-17A and their clinical trials.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hanan E. Alrashidi, Amna A. Alotiby
Summary: This study found that zinc supplementation can increase the number of T regulatory cells (Tregs) and slightly decrease the number of T helper 17 cells (Th17). Zinc can reduce the production of IFN gamma, but its effect on IL10 is not significant. In mixed lymphocyte cultures, zinc supplementation significantly increases the expression of Tregs-specific transcription factors.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Lixing Zhou, Meiling Ge, Yan Zhang, Xiaochu Wu, Mi Leng, Chunmei Gan, Yi Mou, Jiao Zhou, C. Alexander Valencia, Qiukui Hao, Bin Zhu, Biao Dong, Birong Dong
Summary: The distribution of CD4(+) T cell subsets changes in centenarians, with a decrease in the Th17/Treg cell ratio and a shift towards anti-inflammatory secretory phenotypes, suggesting an alleviation of inflammaging.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Eleonore Beurel, Eva M. Medina-Rodriguez, Richard S. Jope
Summary: Understanding the mechanisms contributing to susceptibility to depression is crucial for improving treatments for depressed patients. The adaptive immune system, specifically T and B cells, has emerged as a potential factor in depression. There are various abnormalities in the immune system of depressed patients, with the strongest evidence found for changes in Th17 cells. Th17 cells are associated with inflammatory responses, and targeting them with neutralizing antibodies shows promise as a therapeutic approach for depression.
PHARMACOLOGICAL REVIEWS
(2022)
Article
Immunology
Tsunghan Hsieh, Daiki Sasaki, Naoyuki Taira, Hsiaochiao Chien, Shukla Sarkar, Yu Seto, Mio Miyagi, Hiroki Ishikawa
Summary: JunB plays a critical role in the clonal expansion of T helper cells by inhibiting apoptosis, thereby regulating the generation of Th1, Th2, and Th17 cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kouhei Koshida, Mitsuki Ito, Kyosuke Yakabe, Yoshimitsu Takahashi, Yuki Tai, Ryouhei Akasako, Tatsuki Kimizuka, Shunsuke Takano, Natsumi Sakamoto, Kei Haniuda, Shuhei Ogawa, Shunsuke Kimura, Yun-Gi Kim, Koji Hase, Yohsuke Harada
Summary: In this study, Foxp3 conditional knockout mice were used to investigate the relationship between Treg cells and intestinal bacterial communities. Deletion of Foxp3 reduced the relative abundance of Clostridia, suggesting the role of Treg cells in maintaining Treg-inducing microbes. Additionally, the knockout increased the levels of fecal immunoglobulins and immunoglobulin-coated bacteria due to immunoglobulin leakage into the gut lumen as a result of loss of mucosal integrity, which is dependent on the gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Miranda L. Curtiss, Alexander F. Rosenberg, Christopher D. Scharer, Betty Mousseau, Natalia A. Ballesteros Benavides, John E. Bradley, Beatriz Leon, Chad Steele, Troy D. Randall, Frances E. Lund
Summary: CHI3L1 is found to play a significant role in allergic diseases based on data from patient cohorts and mouse models. In this study, Chi3l1 was shown to modulate T(H)2 and IL-4-producing T-FH cells, which are crucial for IgE responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jinqiu Jiang, Shi Yan, Xiaoying Zhou, Jinghua Zhou, Xiaoming Bai, Qi Tan, Yunqiu Xia, Hua Wang, Xiaoyan Luo
Summary: The study found that the percentage of IL-10-producing Breg cells is significantly lower in children with extrinsic AD, and it correlates negatively with increased Tfh cell responses and disease activity. Co-culture experiments showed that Breg cells from patients with extrinsic AD cannot effectively inhibit the differentiation of Tfh cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yusuke Endo, Toshio Kanno, Takahiro Nakajima, Kazutaka Ikeda, Yoshitaka Taketomi, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. K. Asou, Keisuke Miyako, Yoshinori Hasegawa, Yusuke Kawashima, Osamu Ohara, Makoto Murakami, Toshinori Nakayama
Summary: Metabolic fluxes involving fatty acid biosynthesis play critical roles in differentiating T helper 17 (T(H)17) cells. Through a CRISPR-based screen and lipidomics analyses, researchers identified that 1-oleoyl-lysophosphatidylethanolamine acts as a lipid modulator promoting the activity of retinoid-related orphan receptor gamma t (ROR?t) in T(H)17 cells. Additionally, the study identified specific enzymes and lipid metabolites required for the transcription and differentiation of T(H)17 cells. Overall, the findings highlight the importance of lipid metabolism in T(H)17 cell differentiation and pathogenicity.
SCIENCE IMMUNOLOGY
(2023)
Review
Allergy
Yin Yao, Cai-Ling Chen, Di Yu, Zheng Liu
Summary: Allergic diseases are characterized by overactive type 2 immune responses to allergens and IgE-mediated hypersensitivity. Follicular helper T cells and follicular regulatory T cells play crucial roles in controlling IgE production and the immunopathogenesis of allergic diseases.
Article
Immunology
Mehdi Shahbazi, Mohammad Jafari, Zahra Moulana, Mahdi Sepidarkish, Mojgan Bagherzadeh, Maryam Rezanejad, Mohammad Mirzakhani, Mostafa Javanian, Masomeh Bayani, Mahmoud Sadeghi-Haddad-Zavareh, Hamed Mehdinezhad, Reza Ghadimi, Mostafa Ghasemzadeh, Ali Shokuhi Rad, Mousa Mohammadnia-Afrouzi
Summary: This study found a dysregulated balance of Th1 and Th17 cells in COVID-19 patients, which is associated with the severity of the disease. Critical patients showed significantly decreased frequencies of Th1 and Th17 cells, while there was no significant change in the frequency of Treg cells.
Article
Biochemistry & Molecular Biology
Xinyan Li, Fahong Li, Yao Zhang, Yaoyue Kang, Jie Yu, Feifei Yang, Hongyan Liu, Yanli Qin, Yuxian Huang, Richeng Mao, Jiming Zhang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Infectious Diseases
Y. Zhang, P. Hu, X. Qi, H. Ren, R. -C. Mao, J. -M. Zhang
CLINICAL MICROBIOLOGY AND INFECTION
(2016)
Article
Gastroenterology & Hepatology
Yao Zhang, Jing Li, Fahong Li, Xun Qi, Jiming Zhang
HEPATOLOGY RESEARCH
(2018)
Article
Medicine, General & Internal
Xueyun Zhang, Jiajia Han, Xun Qi, Yao Zhang, Pu Zhou, Xiaoqin Liu, Yue Ying, Wenhong Zhang, Jiming Zhang, Yuxian Huang
Summary: This study aimed to investigate the role of disseminated intravascular coagulation (DIC) scores in predicting the prognosis of HBV-ACLF patients. The results showed that a high DIC score is associated with poor prognosis in HBV-ACLF patients and can be used in combination with CLIF-C OFs to improve the accuracy of prognosis prediction.
FRONTIERS IN MEDICINE
(2022)
Article
Virology
Xun Qi, Fahong Li, Yao Zhang, Haoxiang Zhu, Feifei Yang, Xinyan Li, Xuhua Jiang, Liang Chen, Yuxian Huang, Jiming Zhang
Summary: This prospective cohort study confirmed the association between STAT4 rs7574865 gene polymorphism and HBeAg seroconversion and HBsAg loss, showing that the GT/TT group had better treatment response in treatment-naive patients and also performed well in NA-experienced patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Immunology
Yifei Guo, Jiajia Han, Yao Zhang, Jingjing He, Weien Yu, Xueyun Zhang, Jingwen Wu, Shenyan Zhang, Yide Kong, Yue Guo, Yanxue Lin, Jiming Zhang
Summary: The Omicron variant of SARS-CoV-2, designated as a variant of concern by WHO, has rapidly spread worldwide, possibly due to mutations in its spike protein that reduce the protective effects of neutralizing antibodies. However, compared to previous variants, the Omicron variant has lower hospitalization and mortality rates, and the effectiveness of vaccination and antiviral drugs has not been significantly affected. Both Fc-mediated and T-cell immunity functions have been well retained.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Yifei Guo, Yue Guo, Yongmei Zhang, Fahong Li, Jie Yu, Yao Zhang, Zhongliang Shen, Richeng Mao, Haoxiang Zhu, Jiming Zhang
Summary: This study developed and validated predictive models based on readily available variables of preadmission and after-admission for predicting prolonged SARS-CoV-2 infection of patients with COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Gastroenterology & Hepatology
Yao Zhang, Jiajia Han, Xueyun Zhang, Fahong Li, Yifei Guo, Jingjing He, Richeng Mao, Haoxiang Zhu, Jie Yu, Yuxian Huang, Feifei Yang, Jiming Zhang
Summary: This study investigated the contribution of monocytic MDSCs (mMDSCs) and CD4(+) Tregs to functional cure after PegIFN alpha-2a therapy in chronic hepatitis B (CHB) patients. The results showed that the frequencies of immune suppressive cells were related to the response to PegIFN alpha-2a treatment, suggesting that therapeutic targeting of these cells may be effective in boosting anti-HBV immunity.
LIVER INTERNATIONAL
(2023)
Article
Microbiology
Yao Zhang, Jiajia Han, Feng Sun, Yue Guo, Yifei Guo, Haoxiang Zhu, Feng Long, Zhijie Xia, Shanlin Mao, Hui Zhao, Zi Ge, Jie Yu, Yongmei Zhang, Lunxiu Qin, Ke Ma, Richeng Mao, Jiming Zhang
Summary: This study developed a risk scoring model based on the characteristics of patients at the time of admission to help medical practitioners identify critically ill patients and take prompt measures.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Yifei Guo, Jiajia Han, Yongmei Zhang, Chengmeng Jin, Yao Zhang, Jingjing He, Shiqi Chen, Yue Guo, Yanxue Lin, Fahong Li, Feifei Yang, Zhongliang Shen, Richeng Mao, Haoxiang Zhu, Jiming Zhang
Summary: Pegylated interferon (PEG-IFN) therapy can lead to hepatitis B surface antigen (HBsAg) loss, also known as functional cure. However, a small proportion of patients who achieve functional cure may experience HBsAg reversion (HRV), and the factors involved are not well understood.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Jingjing He, Yifei Guo, Yao Zhang, Jiajia Han, Jingwen Chen, Yidi Jia, Zhenxuan Ma, Jingwen Wu, Shenyan Zhang, Fahong Li, Richeng Mao, Jiming Zhang
Summary: The study compares the effectiveness of TAF and PegIFN-α regimen with TDF and PegIFN-α therapy in CHB patients. The results show that TAF plus PegIFN-α treatment has a higher HBsAg loss rate, quicker virological response, and better ALT normalization compared to TDF plus PegIFN-α treatment.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Gastroenterology & Hepatology
Jiajia Han, Yifei Guo, Xueyun Zhang, Yao Zhang, Jian Sun, Jingjing He, Richeng Mao, Yuxian Huang, Jiming Zhang
Summary: This study aimed to clarify the factors associated with low-level viremia in patients during long-term monotherapy with tenofovir disoproxil fumarate or entecavir. The study found that hepatitis e antigen-positivity, entecavir treatment, and duration of therapy were independently associated with low-level viremia.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2023)