Article
Obstetrics & Gynecology
K. Gemzell-Danielsson, D. Apter, J. Zatik, S. Weyers, T. Piltonen, L. Suturina, I Apolikhina, M. Jost, M. D. Creinin, J-M Foidart
Summary: The study confirmed that E4/DRSP provides effective contraception, a predictable bleeding pattern, and a favorable safety profile. The proportion of participants who discontinued the study was relatively low, with overall satisfactory results.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Medicine, General & Internal
David F. Archer, Diana Mansour, Jean-Michel Foidart
Summary: Bleeding irregularities are a common reason for discontinuation of oral contraceptives. Different types of contraceptives have different bleeding patterns, and the use of different bleeding definitions makes comparisons between products difficult. The balance between estrogen and progestin is important for a regular bleeding pattern, and a too low dose of ethinylestradiol may disrupt this balance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Jill E. Long, Min S. Lee, Diana L. Blithe
Summary: New methods of male contraception are being developed, including both hormonal and nonhormonal options. The NICHD is supporting the development of reversible male contraceptive agents, but industry involvement remains limited.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Rakhee Sachdeva, Narender Kumar, Vivian Brache, Barbara A. Friedland, Marlena Plagianos, Shimin Zhang, Larisa Kizima, Leila Cochon, Ana Sofia Tejada Tabar, Ann Blanc, Ruth B. Merkatz
Summary: In a pilot study, 30 women were given levonorgestrel (LNG) oral contraceptives or depot medroxyprogesterone acetate (DMPA) injections to identify biomarkers of hormonal contraceptive use. Serum and urine samples were collected at different time points, and liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to measure LNG and MPA levels. The results suggest that urine samples can be used to identify biomarkers of LNG and MPA use.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Obstetrics & Gynecology
Mitchell D. Creinin, Carolina Sales Vieira, Carolyn L. Westhoff, Diana J. A. Mansour
Summary: This study aims to address limitations in existing definitions of menstrual bleeding changes associated with contraceptive methods and proposes new recommendations for standardized bleeding data analyses. The study suggests three criteria for assessing bleeding outcomes: pattern, flow, and duration, and provides descriptors for each criterion based on the predictability of bleeding patterns. Standardizing outcomes allows for better comparison between studies and improved understanding of differences between contraceptive products for both clinicians and patients.
Article
Obstetrics & Gynecology
M. H. Kangasniemi, R. K. Arffman, S. Joenvaara, A. Haverinen, K. Luiro, T. Tohmola, R. Renkonen, O. Heikinheimo, J. S. Tapanainen, T. T. Piltonen
Summary: This study compares the effects of an estradiol-based combined oral contraceptive (COC) with an ethinylestradiol-based COC and a dienogest-only preparation on the serum proteome. The results demonstrate that the synthetic COC has a wider range of effects on the serum proteome compared to the natural estrogen COC and the progestin-only preparation, involving multiple biological functions.
HUMAN REPRODUCTION
(2023)
Article
Sport Sciences
Essi K. Ahokas, Helen G. Hanstock, Ida Lofberg, Mari Nyman, Piia Wenning, Heikki Kyrolainen, Ritva S. Mikkonen, Johanna K. Ihalainen
Summary: The aim of this study was to investigate within-cycle differences in nocturnal heart rate (HR) and heart rate variability (HRV) in naturally menstruating women (NM) and women using combined hormonal contraceptives (CU) or progestin-only hormonal contraceptives (PU). The results showed that the menstrual cycle and hormonal cycle phases influence autonomic nervous system balance, which is reflected in measurements of nocturnal HR and HRV.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Sport Sciences
Lynita White, Justin M. Losciale, Kipling Squier, Sarah Guy, Alex Scott, Jerilynn C. Prior, Jackie L. Whittaker
Summary: This systematic review assessed the association between combined hormonal contraceptives (CHC) use and musculoskeletal tissue pathophysiology, injuries, or conditions. The results indicate low certainty evidence for the effect of CHC use on bone health and suggest against advocating or prescribing CHC for musculoskeletal purposes.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Jeffrey T. Jensen, David F. Archer, Carolyn L. Westhoff, Anita L. Nelson, Shelli Graham, Brian Bernick
Summary: This study evaluated the satisfaction of women who had recently used a monthly contraceptive ring or contraceptive pills with a segesterone acetate and ethinyl estradiol contraceptive vaginal system. The results showed high satisfaction with the vaginal system, and most women liked it as much or better than any previous contraceptive method. The ease of use and one-year duration were the most liked features, while ring insertion and feeling it coming out were the most disliked features. The majority of participants had no concerns about using the system for a year and had recommended it to others.
JOURNAL OF WOMENS HEALTH
(2023)
Review
Endocrinology & Metabolism
Valerie L. Jentsch, Lisa Poetzl, Oliver T. Wolf, Christian J. Merz
Summary: Men and women respond differently to stress and the impact of stress on their cognition and emotion is also different. However, the effects of hormonal contraceptives on this interaction have been overlooked. This selective review highlights how hormonal contraceptives can modulate the effects of stress hormones on cognition and emotion. Several studies have shown that women using hormonal contraceptives may experience reduced or even absent stress effects on cognitive-emotional processes, compared to men or naturally cycling women. The findings suggest that hormonal contraceptives may affect the neuroendocrine stress response and central glucocorticoid sensitivity.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Lia A. Bernardi, Marissa Steinberg Weiss, Anne Waldo, Quaker Harmon, Mercedes R. Carnethon, Donna D. Baird, Lauren A. Wise, Erica E. Marsh
Summary: The study found that current users of hormonal contraceptives among African American women had significantly lower mean AMH levels. There was little difference in AMH levels between former users and non-users of hormonal contraceptives. Different types of hormonal contraceptives also had varying effects on AMH levels.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Mitchell D. Creinin, Jeffrey T. Jensen, Melissa J. Chen, Amanda Black, Dustin Costescu, Jean-Michel Foidart
Summary: This study aims to evaluate the relationship between adherence and pregnancy in users of an estetrol and drospirenone combined oral contraceptive. A secondary analysis was conducted using data from two parallel phase 3 trials. The results showed a significant correlation between adherence to the oral contraceptive and the rate of unintended pregnancies.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Zongliang Chang, Weibing Qin, Huili Zheng, Kathleen Schegg, Lu Han, Xiaohua Liu, Yue Wang, Zhuqing Wang, Hayden McSwiggin, Hongying Peng, Shuiqiao Yuan, Jiabao Wu, Yongxia Wang, Shenghui Zhu, Yanjia Jiang, Hua Nie, Yuan Tang, Yu Zhou, Michael J. M. Hitchcock, Yunge Tang, Wei Yan
Summary: Triptonide, a natural compound from the Chinese herb Tripterygium Wilfordii Hook F, displays reversible male contraceptive effects by inducing deformed sperm in mice and monkeys. Male infertility is achieved within weeks of treatment, but fertility is regained after cessation of triptonide intake. Triptonide targets late spermiogenesis without causing discernable toxic side effects on vital organs and blood in both species.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Belinda Pletzer, Carmen Lang, Birgit Derntl, Ramune Griksiene
Summary: Prospective randomized controlled trials on hormonal contraceptive effects on the brain are rare, so most evidence comes from cross-sectional studies. Personality traits are more strongly associated with the choice of contraceptive type rather than the choice between hormonal and non-hormonal options. Current users of IUDs show higher agreeableness and extraversion compared to current users of oral contraceptives.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Medical Laboratory Technology
Omer Ozcan, Wendy P. J. den Elzen, Jacquelien J. J. Hillebrand, Martin den Heijer, Laura L. van Loendersloot, Johan Fischer, Henrike Hamer, Robert de Jonge, Annemieke C. C. Heijboer
Summary: This review evaluates the effects of hormonal contraceptives (HC) on various chemistry tests and finds that different parameters are affected based on the dosage, duration, composition, and route of administration of the HCs. The use of HC in women mainly stimulates the liver production of binding proteins. Therefore, biochemical test results of women using HC should be carefully assessed and unexpected test results should be further evaluated.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Clinical Neurology
Roberto De Icco, Laura Cucinella, Irene De Paoli, Silvia Martella, Grazia Sances, Vito Bitetto, Giorgio Sandrini, Giuseppe Nappi, Cristina Tassorelli, Rossella E. Nappi
JOURNAL OF HEADACHE AND PAIN
(2016)
Review
Geriatrics & Gerontology
Rossella E. Nappi, Laura Cucinella, Silvia Martella, Margherita Rossi, Lara Tiranini, Ellis Martini
Review
Obstetrics & Gynecology
R. E. Nappi, L. Cucinella, E. Martini, M. Rossi, L. Tiranini, S. Martella, D. Bosoni, C. Cassani
Review
Endocrinology & Metabolism
Rossella E. Nappi, Ellis Martini, Laura Cucinella, Silvia Martella, Lara Tiranini, Alessandra Inzoli, Emanuela Brambilla, David Bosoni, Chiara Cassani, Barbara Gardella
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Geriatrics & Gerontology
Rossella E. Nappi, Costantino Di Carlo, Laura Cucinella, Marco Gambacciani
Article
Endocrinology & Metabolism
Rossella E. Nappi, Laura Cucinella, Ellis Martini, Chiara Cassani
Summary: Menopause presents challenges to urogenital health due to hormonal changes, leading to tissue degeneration. Genitourinary syndrome of menopause (GSM) is a clinical condition involving vaginal atrophy that negatively impacts quality of life.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Obstetrics & Gynecology
Rossella E. Nappi, Laura Cucinella
Summary: This article summarizes key points for approaching sexual symptoms in midlife women, providing principles for diagnosing and managing hypoactive sexual desire disorder and genitourinary syndrome of menopause/vulvovaginal atrophy, as well as managing contraceptive needs.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rossella E. Nappi, Lara Tiranini, Laura Cucinella, Ellis Martini, David Bosoni, Alessandra Righi, Chiara Cassani, Barbara Gardella
Summary: Female sexual dysfunctions (FSDs) are common and have a significant impact on quality of life and relationships. Current pharmacotherapies for FSDs are limited and safety is a concern. Recent research suggests that psychoactive agents and hormonal compounds are effective treatment options. However, there is a need for further research and a multimodal approach.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Fabio Sirchia, Elisa Giorgio, Laura Cucinella, Enza Maria Valente, Rossella E. Nappi
Summary: This case report reveals the presence of compound heterozygous variants in the PSMC3IP gene in a patient with secondary amenorrhea and her sister. It highlights the importance of including PSMC3IP in designed POI NGS panels or sequencing studies in patients with amenorrhea.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Urology & Nephrology
Rossella E. Nappi, Lara Tiranini, Ellis Martini, David Bosoni, Alessandra Righi, Laura Cucinella
UROLOGIC CLINICS OF NORTH AMERICA
(2022)
Article
Geriatrics & Gerontology
Federica Barbagallo, Laura Cucinella, Lara Tiranini, Ellis Martini, David Bosoni, Pietro Molinaro, Federica Battista, Francesca Albani, Aldo E. Calogero, Rossella E. Nappi
Summary: This study found that personality traits are related to sexual function and mood in symptomatic postmenopausal women, with harm avoidance playing a mediating role. This suggests that in clinical practice, it may be useful to use psychometric tools to screen for mood disorders and assess personality traits in order to improve the diagnosis and treatment of sexual disorders in menopausal women.
Article
Endocrinology & Metabolism
F. Barbagallo, G. Pedrielli, D. Bosoni, L. Tiranini, L. Cucinella, A. E. Calogero, F. Facchinetti, R. E. Nappi
Summary: This study aimed to compare sexual function and distress in women with functional hypothalamic amenorrhea (FHA) and women with FHA and an underlying polycystic ovary syndrome (PCOS)-phenotype, considering their psychometric variables. The results showed that the psychometric profiles were similar in both groups, but women with typical FHA had more severe sexual impairment. Further studies should investigate the role of sex hormones in women's sexual functioning.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Clinical Neurology
Lara Tiranini, Laura Cucinella, Silvia Martella, David Bosoni, Ellis Martini, Rossella E. Nappi
Summary: Estrogen fluctuations affect pain threshold and have a significant role in menstrually related migraine (MRM). Exogenous estrogens can help manage MRM, but the use of combined hormonal contraception (CHC) should be carefully considered due to the increased risk of stroke. Different regimens and supplementation with estrogens during the hormone-free interval may have benefits for women with MRM.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Review
Obstetrics & Gynecology
Laura Cucinella, Ellis Martini, Lara Tiranini, Federica Battista, Pietro Molinaro, Arianna Casiraghi, Selene Cominotti, Manuela Piccinino, Roberta Rossini, Rossella E. Nappi
Summary: Biological and psycho-relational factors contribute equally to the development of sexual symptoms and associated distress in menopausal women. Consultation during midlife is crucial for discussing sexual health, and healthcare providers should be proactive in addressing sexual concerns. An accurate sexual history is necessary to understand symptoms, assess their impact on quality of life, and identify risk factors. Hypoactive sexual desire disorder and genitourinary syndrome of menopause are common sexual dysfunctions in midlife. A multidimensional approach that considers patient characteristics, goals, and expectations is essential and should involve educational counseling and addressing modifiable risk factors. Specific treatments for FSDs should include non-pharmacological and pharmacological options to address both biological and psychosocial components.
MINERVA OBSTETRICS AND GYNECOLOGY
(2022)