Both selenium deficiency and excess impair male reproductive system via inducing oxidative stress-activated PI3K/AKT-mediated apoptosis and cell proliferation signaling in testis of mice

Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis

(2022) Qianhui Dou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclophilin A inhibits A549 cell oxidative stress and apoptosis by modulating the PI3K/Akt/mTOR signaling pathway

(2021) Zhenling Ma et al.   BIOSCIENCE REPORTS

Dietary Selenium Requirement for the Prevention of Glucose Intolerance and Insulin Resistance in Middle-Aged Mice

(2021) Ying-Chen Huang et al.   JOURNAL OF NUTRITION

PI3K/mTOR Dual Inhibitor PF-04691502 Is a Schedule-Dependent Radiosensitizer for Gastroenteropancreatic Neuroendocrine Tumors

(2021) Zeta Chow et al.   Cells

The Roles of Luteinizing Hormone, Follicle-Stimulating Hormone and Testosterone in Spermatogenesis and Folliculogenesis Revisited

(2021) Olayiwola O. Oduwole et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential protein expression due to Se deficiency and Se toxicity in rat liver

(2021) Barbara Rita Cardoso et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Modular Characteristics and Mechanism of Action of Herbs for Endometriosis Treatment in Chinese Medicine: A Data Mining and Network Pharmacology–Based Identification

(2020) Weilin Zheng et al.   Frontiers in Pharmacology

Selenium Anticancer Properties and Impact on Cellular Redox Status

(2020) Lolita Kuršvietienė et al.   Antioxidants

Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice

(2020) Baolian Hou et al.   JOURNAL OF HAZARDOUS MATERIALS

Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells

(2020) Wei Chen et al.   Biomed Research International

Luteolin Ameliorates Testis Injury and Blood‐Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Up‐Regulating Cx43

(2019) Bo Ma et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice

(2019) Noriyuki Akahoshi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Selenium deficiency inhibits micRNA-146a to promote ROS-induced inflammation via regulation of the MAPK pathway in the head kidney of carp

(2019) Xue-jiao Gao et al.   FISH & SHELLFISH IMMUNOLOGY

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

(2019) Izhar Hyder Qazi et al.   Antioxidants

Aflatoxin B1 promotes autophagy associated with oxidative stress-related PI3K/AKT/mTOR signaling pathway in mice testis

(2019) Wanyue Huang et al.   ENVIRONMENTAL POLLUTION

Effect of long-term selenium supplementation on mortality: Results from a multiple-dose, randomised controlled trial

(2018) Margaret P. Rayman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Beneficial and paradoxical roles of selenium at nutritional levels of intake in healthspan and longevity

(2018) Li Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Five threads: How U-shaped thinking weaves together dogs, men, selenium, and prostate cancer risk

(2018) David J. Waters et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenium – a fascinating antioxidant of protective properties

(2018) Małgorzata Kiełczykowska et al.   Advances in Clinical and Experimental Medicine

Effect of Fe and Cd Co-Exposure on Testicular Steroid Metabolism, Morphometry, and Spermatogenesis in Mice

(2018) Sunny O. Abarikwu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Selenium, Selenoproteins, and Female Reproduction: A Review

(2018) Izhar Qazi et al.   MOLECULES

Venlafaxine and carvedilol ameliorate testicular impairment and disrupted spermatogenesis in rheumatoid arthritis by targeting AMPK/ERK and PI3K/AKT/mTOR pathways

(2018) Ahmed H. Eid et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Analyses of Selenotranscriptomes and Selenium Concentrations in Response to Dietary Selenium Deficiency and Age Reveal Common and Distinct Patterns by Tissue and Sex in Telomere-Dysfunctional Mice

(2017) Lei Cao et al.   JOURNAL OF NUTRITION

Dietary Selenium Deficiency or Excess Reduces Sperm Quality and Testicular mRNA Abundance of Nuclear Glutathione Peroxidase 4 in Rats

(2017) Ji-Chang Zhou et al.   JOURNAL OF NUTRITION

Oxidative stress and male infertility

(2017) Shilpa Bisht et al.   Nature Reviews Urology

Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant

(2017) Ning Wang et al.   Oxidative Medicine and Cellular Longevity

Restricting the induction of NGF in ovarian stroma engenders selective follicular activation through the mTOR signaling pathway

(2017) Yuanlin He et al.   Cell Death & Disease

Response of Selenium and Selenogenome in Immune Tissues to LPS-Induced Inflammatory Reactions in Pigs

(2016) Lv-Hui Sun et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Excessive Selenium Supplementation Induced Oxidative Stress and Endoplasmic Reticulum Stress in Chicken Spleen

(2016) Yachao Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Effects of Dietary Selenium Supplementation on Seminiferous Tubules and SelW, GPx4, LHCGR, and ACE Expression in Chicken Testis

(2016) Ahmed Khalid et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Selenium Deficiency-Induced Apoptosis of Chick Embryonic Vascular Smooth Muscle Cells and Correlations with 25 Selenoproteins

(2016) Qingyu Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Selenoprotein Gene Nomenclature

(2016) Vadim N. Gladyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR/P70S6K promotes spermatogonia proliferation and spermatogenesis in Sprague Dawley rats

(2016) Hao Xu et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Deficient and excess dietary selenium levels affect growth performance, blood cells apoptosis and liver HSP70 expression in juvenile yellow catfish Pelteobagrus fulvidraco

(2015) Jun-Ru Hu et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Selenoproteins protect against avian nutritional muscular dystrophy by metabolizing peroxides and regulating redox/apoptotic signaling

(2015) Jia-Qiang Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Persistent DNA Damage in Spermatogonial Stem Cells After Fractionated Low-Dose Irradiation of Testicular Tissue

(2015) Angelika Grewenig et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Prevention of Aflatoxin B1 Hepatoxicity by Dietary Selenium Is Associated with Inhibition of Cytochrome P450 Isozymes and Up-Regulation of 6 Selenoprotein Genes in Chick Liver

(2015) Lv-Hui Sun et al.   JOURNAL OF NUTRITION

Integrated Transcriptional and Proteomic Analysis of Growth Hormone Suppression Mediated by Trichothecene T-2 Toxin in Rat GH3 Cells

(2015) Dan Wan et al.   TOXICOLOGICAL SCIENCES

Role of selenium in male reproduction—A review

(2014) U. Ahsan et al.   ANIMAL REPRODUCTION SCIENCE

Selenium and selenoprotein function in brain disorders

(2014) Roshan Pillai et al.   IUBMB LIFE

Roles of Reactive Oxygen Species in the Spermatogenesis Regulation

(2014) Giulia Guerriero et al.   Frontiers in Endocrinology

A high-selenium diet induces insulin resistance in gestating rats and their offspring

(2012) Min-Shu Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenium and human health

(2012) Margaret P Rayman   LANCET

Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents

(2011) Anna M Raines et al.   BMC GENOMICS

Glutathione Peroxidases at Work on Epididymal Spermatozoa: An Example of the Dual Effect of Reactive Oxygen Species on Mammalian Male Fertilizing Ability

(2011) A. Noblanc et al.   JOURNAL OF ANDROLOGY

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diminished reproductive potential of male mice in response to selenium-induced oxidative stress: Involvement of HSP70, HSP70-2, and MSJ-1

(2009) Naveen Kaushal et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Apoptosis induced by modulation in selenium status involves p38 MAPK and ROS: implications in spermatogenesis

(2009) Pavitra Ranawat et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Oxidative Stress: A Common Factor in Testicular Dysfunction

(2008) T. T. Turner et al.   JOURNAL OF ANDROLOGY

Hormonal regulation of spermatogenesis and spermiogenesis

(2008) Nikolaos Sofikitis et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY