Review
Biochemical Research Methods
YuWei Zhang, Wei Liu, Qian Wang
Summary: In dermatology, photodynamic therapy (PDT) is widely used for its killing effect on skin tumors and infections through the production of toxic reactive oxygen species (ROS). Low-dose PDT, on the other hand, has shown potential in improving aging and wound healing by promoting fibroblast proliferation, blocking DNA damage, counteracting oxidative stress, inhibiting melanogenesis, and remodeling lymphatic vessels. However, further research is needed to thoroughly investigate the positive effects of low-dose PDT in dermatology.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Pharmacology & Pharmacy
Shijie Luan, Ngoc T. Tran, Hui-Yi Xue, Ho-Lun Wong
Summary: A new liposomal MAL formulation (lipMAL) designed for systemic or intraperitoneal administration was developed in this study to expand the application of MAL to dual intraoperative PDD and PDT of peritoneal carcinomatosis. LipMALs demonstrated controlled MAL release behavior, achieved strong fluorescence in cancer cells, and led to significantly higher fluorescence levels than free MAL groups, showing promising anticancer PDT effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Rupesh Jain, Milan Paul, Sri Ganga Padaga, Sunil Kumar Dubey, Swati Biswas, Gautam Singhvi
Summary: The study introduces lipidic nanoparticles loaded with curcumin and chlorin e6 that generate reactive oxygen species (ROS) upon activation by near-infrared light, which show promise for treating aggressive cutaneous melanomas. The optimized nanoparticle formulation exhibited a small particle size and high entrapment efficiency. Co-delivery of curcumin and chlorin e6 enhanced cellular uptake, inhibited cancer growth, and induced apoptosis compared to free drug. The nanoparticles also achieved better skin permeation and retention, demonstrating their potential synergy.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Joanna Bartosinska, Paulina Szczepanik-Kulak, Dorota Raczkiewicz, Marta Niewiedziol, Agnieszka Gerkowicz, Dorota Kowalczuk, Miroslaw Kwasny, Dorota Krasowska
Summary: The study evaluated the efficacy and cosmetic outcome of different photosensitizers in AK patients, indicating that ALA-P may have better effects and lower pain intensity compared to ALA-HCl and MAL-HCl.
Article
Biochemistry & Molecular Biology
Martin Kiening, Norbert Lange
Summary: Most cancer research focuses on targeting specific types of cancer, but this can be limiting as not all cancers or patients express the necessary antigens for certain therapies. Combination therapies are promising but require personalized treatment and can be expensive. In this study, the researchers investigated the use of aminolevulinate-based photodynamic diagnosis and therapy for breast cancer and found that a novel derivative showed potential in accumulating the fluorescent protoporphyrin IX, which could aid in guided resection and destruction of cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Optics
K. T. Efendiev, P. M. Alekseeva, I. R. Bikmukhametova, L. S. Piterskova, K. F. Orudzhova, U. D. Agabekova, E. K. Slovokhodov, V. B. Loschenov
Summary: HAL showed better diagnostic and therapeutic effects for cervical dysplasia compared to ALA. Continuous PDT did not induce intraepithelial changes in cervical dysplasia patients, while repeated PDT was needed for vulvar leukoplakia patients after pulsed light irradiation.
LASER PHYSICS LETTERS
(2021)
Article
Pharmacology & Pharmacy
Aishwarya Shivashankarappa, K. R. Sanjay, Dhruvi Shah, Aishwarya Tagat
Summary: This study demonstrates the use of gold nanoparticles as an effective drug delivery vehicle for photodynamic cancer therapy targeting skin melanoma cells. Gold nanoparticles were synthesized from the medicinal plant Decalepis hamiltonii and conjugated with an anti-cancer drug 5-aminolevulinic acid (5-ALA). The activated gold-5ALA conjugates showed a deleterious effect on cancer cells with no significant effect on normal cells, indicating specific targeting towards cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Oncology
P. O'Mahoney, I. D. W. Samuel, E. Eadie, S. Ibbotson
Summary: The study found a correlation between fluorescence and skin surface temperature during photodynamic therapy, but the factors influencing treatment outcomes are likely to be multifactorial.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Dermatology
Mark S. Nestor, Haowei Han, Francesca M. Ceci, Alec Lawson, Anita Gade
Summary: This study evaluated the safety, tolerability, and efficacy of ALA-PDL-PDT for facial cutaneous squamous cell carcinoma in situ (isSCC). The results showed that the protocol was safe and well-tolerated, with a high clearance rate of the tumor.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Oncology
Hiroki Kurumi, Takuki Sakaguchi, Keiichi Hashiguchi, Taro Yamashita, Masashi Fujii, Yuichiro Ikebuchi, Akira Yoshida, Hajime Isomoto
Summary: Gastric cancer is a common disease in Japan, and endoscopy plays an important role in its early diagnosis. In this study, the diagnostic yield of 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) was investigated for gastric cancers and high-grade adenomas. The results showed that 5-ALA PDD had a high detection rate and could provide additional diagnostic yields for multiple lesions. Further studies are needed to confirm the usefulness of 5-ALA PDD in identifying early gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
William J. Nahm, John Shen, Patrick M. Zito, Adrianna M. Gonzalez, Nicole Nagrani, Kevin Moore, Evangelos Badiavas, Robert S. Kirsner, Anna J. Nichols
Summary: This study assessed the efficacy of varying combinations of anti-tumor agents with cryotherapy in treating non-melanoma skin cancers. It found that the combination of imiquimod/5-fluorouracil/tretinoin with cryotherapy had high clearance rates and was the most effective treatment regimen.
JOURNAL OF DRUGS IN DERMATOLOGY
(2021)
Article
Biochemical Research Methods
Chunlan Xu, Dan Yuan, Shi Cheng, Xiaoling Lan, Qian Wang, Xinyu Lin, Wei Liu
Summary: This study observed the fluorescence characteristics of acne inflammatory skin lesions in ALA-PDD and discussed its viability in evaluating these lesions and predicting subclinical skin lesions. The results showed that ALA-PDD is a feasible method for recognizing and evaluating inflammatory skin lesions, with advantages in predicting subclinical skin lesions.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Oncology
Qingyu Zeng, Chengqian Chen, Diyan Chen, Guolong Zhang, Xiuli Wang
Summary: Non-melanoma skin cancer (NMSC) is a prevalent global skin disease, mainly consisting of basal cell carcinoma and squamous cell carcinoma. Non-surgical therapies, such as physical therapy and photodynamic therapy, have become alternatives to surgical excision, especially for low-risk NMSC cases. Radiotherapy plays an important role in comprehensive treatment strategies, particularly for patients who are ineligible for surgery. Immunotherapy is also a viable solution for advanced NMSC cases.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Review
Dermatology
Yanci A. Algarin, Anokhi Jambusaria-Pahlajani, Emily Ruiz, Vishal A. Patel
Summary: This review evaluated and summarized evidence-based recommendations for topical treatments of various skin malignancies. Photodynamic therapy, 5-fluorouracil, and imiquimod showed high clearance rates in the treatment of different conditions.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Oncology
Aijia Ding, Chenxin Li, Jianglin Zhang
Summary: Flat warts, caused by human papillomavirus, are common skin infections affecting children and young adults. This study shows that 10% 5-aminolevulinic acid-based photodynamic therapy is an effective treatment for flat warts, with long-lasting results in some cases.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Letter
Dermatology
Martin Gillstedt, Ella Hedlund, John Paoli, Sam Polesie
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Caroline Stenman, Martin Gillstedt, Lykke Barck, Helena Gonzalez, Christina Halldin, Andreas Wallinder, John Paoli, Amra Osmancevic, Magdalena Claeson
Summary: Organ transplant recipients reported less sun exposure than non-transplant patients, and specialized dermatological follow-up appears to improve sun protection behavior among OTRs. Specialized OTR clinics should be more widely implemented.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Siekkeri Vandikas, Kerstin Landin-Wilhelmsen, Martin Gillstedt, Amra Osmancevic
Summary: In patients with psoriasis, high levels of vitamin D-binding protein (DBP) may serve as a new inflammatory biomarker. Total 25(OH)D is a reliable measure for vitamin D status in psoriasis patients, but evaluation of free 25(OH)D levels should be considered in patients with multiple co-morbidities and/or undergoing biologic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Sam Polesie, Martin Gillstedt
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Oscar M. Moreno-Arrones, Carlota Garcia-Hoz, Rosa del Campo, Garbine Roy, David Saceda-Corralo, Juan Jimenez-Cauhe, Manuel Ponce-Alonso, Sergio Serrano-Villar, Pedro Jaen, John Paoli, Sergio Vano-Galvan
Summary: By studying the follicular microbiota and immune response of patients with folliculitis decalvans, it was found that the affected hair follicles have a distinct bacterial composition and the patients have an impaired immune response. These findings contribute to understanding the etiology and pathogenesis of folliculitis decalvans.
Article
Dermatology
Eva Backman, Maria Oxelblom, Martin Gillstedt, Johan Dahlen Gyllencreutz, John Paoli
Summary: This study reveals the significant impact of clinically diagnosed BCCs on official disease statistics, suggesting that the burden of BCC in Sweden may be 70% higher than reported.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andrea Elmelid, Maria Siekkeri Vandikas, Martin Gillstedt, Amra Osmancevic, Mikael Alsterholm
Summary: Vitamin D plays an important role in skin inflammation in psoriasis, and UVB phototherapy can increase vitamin D levels. This study aimed to measure free serum 25(OH)D levels in psoriasis patients before and after phototherapy and determine if free 25(OH)D correlates stronger to disease severity than total 25(OH)D. The results showed that both total and free 25(OH)D levels increased after phototherapy and were positively correlated. However, no correlations between disease severity and vitamin D levels were found.
Article
Dermatology
Theofanis Zagoras, Rahime Inci, Despoina Kantere, Peter Holmstroem, Jenny Brostroem, Martin Gillstedt, Sam Polesie, Sirkku Peltonen
Summary: This retrospective registry-based cohort study aimed to estimate the incidence and prevalence of genodermatoses in the Swedish population and analyse healthcare usage. The study identified 73 unique genodermatosis diagnoses from the patient registry and verified the diagnoses using medical records. The incidence and prevalence of each diagnosis were calculated based on the nationwide cohort.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
J. Fougelberg, E. Backman, E. Hasselquist, A. Sjoholm, M. Claeson, J. Paoli
Summary: This study compared the effectiveness of cryosurgery and curettage for treating IEC and found that cryosurgery had a higher overall clearance rate at the 1-year follow-up, while curettage may result in shorter wound healing times.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Meeting Abstract
Dermatology
Rahime Inci, Theofanis Zagoras, Despoina Kantere, Jenny Brostrom, Peter Holmstrom, Martin Gillstedt, Sam Polesie, Sirkku Peltonen
ACTA DERMATO-VENEREOLOGICA
(2022)
Meeting Abstract
Dermatology
Karolina Wojewoda, Martin Gillstedt, Jonatan Tovi, Louai Salah, Ann-Marie Wennberg Larko, Alexandra Sjoholm, Carin Sandberg
ACTA DERMATO-VENEREOLOGICA
(2022)
Meeting Abstract
Dermatology
Eva Johansson Backman, Sam Polesie, Sofia Berglund, Martin Gillstedt, Alexandra Sjoholm, Maja Modin, John Paoli
ACTA DERMATO-VENEREOLOGICA
(2022)
Meeting Abstract
Dermatology
Sofia Berglund, John Paoli, Petra Svensson, Karin Terstappen, Martin Gillstedt, Johan Dahlen Gyllencreutz
ACTA DERMATO-VENEREOLOGICA
(2022)
Meeting Abstract
Dermatology
Andrea Elmelid, Martin Gillstedt, Mikael Alsterholm, Amra Osmancevic
ACTA DERMATO-VENEREOLOGICA
(2022)
Meeting Abstract
Dermatology
Martin Gillstedt, Sam Polesie
ACTA DERMATO-VENEREOLOGICA
(2022)