Human iPSC-derived brain organoids: A 3D mini-brain model for studying HIV infection

Microglia innate immune response contributes to the antiviral defense and blood–CSF barrier function in human choroid plexus organoids during HSV‐1 infection

(2023) Haowen Qiao et al.   JOURNAL OF MEDICAL VIROLOGY

Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids

(2023) Pelin Saglam-Metiner et al.   Communications Biology

Combination anti-HIV antibodies provide sustained virological suppression

(2022) Michael C. Sneller et al.   NATURE

Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against HIV-1: a phase 1 clinical trial

(2022) Boris Julg et al.   NATURE MEDICINE

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

(2022) Stephanie B. H. Gumbs et al.   Viruses-Basel

Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells

(2022) Jérémy Dufloo et al.   Nature Communications

Generation of vascularized brain organoids to study neurovascular interactions

(2022) Xin-Yao Sun et al.   eLife

Modeling the Human Brain With ex vivo Slices and in vitro Organoids for Translational Neuroscience

(2022) Giovanna O. Nogueira et al.   Frontiers in Neuroscience

Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV

(2022) Giovanni Di Liberto et al.   BRAIN

The role of CCR5 in HIV-associated neurocognitive disorders

(2022) Cecile Riviere-Cazaux et al.   Heliyon

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

(2022) Samudyata et al.   MOLECULAR PSYCHIATRY

Parallels Between NeuroHIV and NeuroCOVID-19

(2021) David E. Vance et al.   JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE

Human immunodeficiency virus‐1/simian immunodeficiency virus infection induces opening of pannexin‐1 channels resulting in neuronal synaptic compromise: A novel therapeutic opportunity to prevent NeuroHIV

(2021) Anna Maria Gorska et al.   JOURNAL OF NEUROCHEMISTRY

Quality of life in people living with HIV-associated neurocognitive disorder: A scoping review study

(2021) Kate Alford et al.   PLoS One

Novel Scalable and Simplified System to Generate Microglia-Containing Cerebral Organoids From Human Induced Pluripotent Stem Cells

(2021) Brittany Bodnar et al.   Frontiers in Cellular Neuroscience

Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology

(2021) Ranjie Xu et al.   Stem Cell Reports

Human Blood Vessel Organoids Penetrate Human Cerebral Organoids and Form a Vessel-Like System

(2021) Yujin Ahn et al.   Cells

Productive HIV infection in astrocytes can be established via a non-classical mechanism

(2020) Guan-Han Li et al.   AIDS

Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity

(2020) Julia Niessl et al.   NATURE MEDICINE

Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection

(2020) Sean K. Ryan et al.   Stem Cell Reports

HIV Neuropathogenesis in the Presence of a Disrupted Dopamine System

(2020) E. A. Nickoloff-Bybel et al.   Journal of Neuroimmune Pharmacology

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Inflammasomes in HIV-1 and Drug Abuse Mediated Neuroinflammaging

(2020) Susmita Sil et al.   Cells

Opioid and neuroHIV Comorbidity – Current and Future Perspectives

(2020) Sylvia Fitting et al.   Journal of Neuroimmune Pharmacology

Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia

(2020) Roberta S. dos Reis et al.   Scientific Reports

Comparative analysis of human microglial models for studies of HIV replication and pathogenesis

(2020) Mohammad A. Rai et al.   Retrovirology

Human Brain Slice Culture: A Useful Tool to Study Brain Disorders and Potential Therapeutic Compounds

(2019) Xin-Rui Qi et al.   Neuroscience Bulletin

HIV-1 and Compromised Adult Neurogenesis: Emerging Evidence for a New Paradigm of HAND Persistence

(2019) Raj Putatunda et al.   AIDS REVIEWS

Sex-specific neurogenic deficits and neurocognitive disorders in middle-aged HIV-1 Tg26 transgenic mice

(2019) Raj Putatunda et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain organoids: advances, applications and challenges

(2019) Xuyu Qian et al.   DEVELOPMENT

Role of T Lymphocytes in HIV Neuropathogenesis

(2019) Caroline Subra et al.   Current HIV/AIDS Reports

The Emergence of Stem Cell‐Based Brain Organoids: Trends and Challenges

(2019) Jay Gopalakrishnan   BIOESSAYS

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Microglial Cells: The Main HIV-1 Reservoir in the Brain

(2019) Clementine Wallet et al.   Frontiers in Cellular and Infection Microbiology

Cross-talk between microglia and neurons regulates HIV latency

(2019) David Alvarez-Carbonell et al.   PLoS Pathogens

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer’s disease-associated Aβ oligomers

(2018) Niele D. Mendes et al.   JOURNAL OF NEUROSCIENCE METHODS

The human microglial HMC3 cell line: where do we stand? A systematic literature review

(2018) Cinzia Dello Russo et al.   Journal of Neuroinflammation

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Methamphetamine increases HIV infectivity in neural progenitor cells

(2017) Marta Skowronska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

(2017) Richard J. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Neurobehavioral Disturbances During Acute and Early HIV Infection

(2016) Rujvi Kamat et al.   Cognitive and Behavioral Neurology

Astrocytes as an HIV Reservoir: Mechanism of HIV Infection

(2016) Guan-Han Li et al.   CURRENT HIV RESEARCH

Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4

(2015) Guan-Han Li et al.   AIDS

HIV-associated neurocognitive disorder

(2013) David B Clifford et al.   LANCET INFECTIOUS DISEASES

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

HIV-1 alters neural and glial progenitor cell dynamics in the central nervous system: Coordinated response to opiates during maturation

(2012) Yun Kyung Hahn et al.   GLIA

Heparan Sulfate Facilitates FGF and BMP Signaling to Drive Mesoderm Differentiation of Mouse Embryonic Stem Cells

(2012) Daniel C. Kraushaar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

A two-culture method for exposure of human brain organotypic slice cultures to replicating human immunodeficiency virus type 1

(2011) Ricardo Martinez et al.   JOURNAL OF NEUROSCIENCE METHODS

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE