Article
Oncology
Waleed Abdelbag Almahi, K. N. Yu, Fathelrahman Mohammed, Peizhong Kong, Wei Han
Summary: The principle of radiotherapy is to kill cancer cells while minimizing harm to non-cancer cells. Ferroptosis has been proposed as a new mechanism of radiation-induced cell death. This study demonstrated that Hemin, an iron overload agent, enhances reactive oxygen species (ROS) generation induced by ionizing radiation in lung cancer cells, leading to ferroptosis. Hemin also protected normal lung cells against radiation-induced cell death.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Qi Zhang, Hang Qu, Yinghui Chen, Xueyang Luo, Chong Chen, Bing Xiao, Xiaowei Ding, Pengjun Zhao, Yanan Lu, Alex F. Chen, Yu Yu
Summary: This study discovered that ferroptosis, a programmed iron-dependent cell death mechanism, serves as a mechanism in statin-induced myopathy, and specifically identified atorvastatin as the statin that could lead to ferroptosis in human cardiomyocytes and murine skeletal muscle cells. The study highlights the importance of understanding the underlying pathophysiological mechanism of atorvastatin-induced myopathy and suggests that targeting ferroptosis could be a protective strategy for clinical application.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Hua Liu, Tian-ai Zhang, Wen-Yue Zhang, Si-Rui Huang, Yue Hu, Jia Sun
Summary: The study demonstrates that Rhein, a natural anthraquinone compound, attenuates ischemic stroke-induced damage by inhibiting ferroptosis through the NRF2/SLC7A11/GPX4 axis. Rhein suppresses oxidative stress and ferroptosis-related protein expression in both in vivo and in vitro models of oxygen-glucose deprivation/reperfusion and middle cerebral artery occlusion. These findings highlight Rhein as a potential therapeutic agent for ischemic stroke.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ruijin Xie, Wenjing Zhao, Scott Lowe, Rachel Bentley, Guoqin Hu, Huiya Mei, Xiaofan Jiang, Chenyu Sun, Yu Wu, Yueying Liu
Summary: The study examined the protective effects of quercetin against seizure-induced neuron death and the mechanisms by which it alleviates cognitive function impairment through regulating the SIRT1/Nrf2/SLC7A11/GPX4 pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shunv Cai, Shuang Fu, Weikang Zhang, Xiaohong Yuan, Yun Cheng, Jun Fang
Summary: This study found that silencing SIRT6 can overcome sorafenib resistance in gastric cancer by promoting ferroptosis. Mechanistically, SIRT6 inhibition leads to inactivation of the Keap1/Nrf2 pathway and downregulation of GPX4, while over-expression of GPX4 or activation of Keap1/Nrf2 can reverse the effects. Targeting the SIRT6/Keap1/Nrf2/GPX 4 pathway may be a potential strategy for overcoming sorafenib resistance in gastric cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Tao Yang, Haiqiong Liu, Chaobo Yang, Huaqiang Mo, Xianbao Wang, Xudong Song, Luping Jiang, Ping Deng, Ran Chen, Pengcui Wu, Aihua Chen, Jing Yan
Summary: This study aimed to investigate the pharmacological effects of Gal on myocardial ischemic reperfusion injury (MIRI). The results showed that Gal alleviates myocardial injury, enhances cardiac function, and reduces cell death by targeting the Nrf2/Gpx4 signaling pathway to prevent iron overload and lipid peroxidation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Minling Pan, Zhen Wang, Yiyi Wang, Xianqin Jiang, Yali Fan, Fanghua Gong, Yunpeng Sun, Dezhong Wang
Summary: Ferroptosis is a crucial process in AKI that can lead to CKD and ESRD. Celastrol, an active ingredient of Tripterygium wilfordii, has anti-inflammatory and anti-cancer effects. This study found that celastrol protected against cisplatin-induced AKI by reducing inflammation, oxidative stress, renal iron accumulation, and ferroptosis. Mechanistic analysis revealed that celastrol upregulated GPX4 via Nrf2, alleviating ferroptosis and reducing LDH release, intracellular iron accumulation, and lipid peroxidation. These findings suggest the potential use of celastrol for treating AKI associated with ferroptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Yong Liu, Zefan Du, Junbin Huang, Tianwen Li, Jing Zhang, Yixian Li, Wenfang Yi, Chun Chen
Summary: Ferroptosis, an iron-dependent programmed cell death, has been discovered in recent years. It is characterized by the accumulation of lipid reactive oxygen species in cells, leading to oxidative stress and cell death. It plays a pivotal role in normal physiology and the development of various diseases.
FRONTIERS IN ONCOLOGY
(2023)
Article
Environmental Sciences
Feng Lian, Dandan Dong, Jiaxi Pu, Guanghua Yang, Jing Yang, Shaofei Yang, Yijie Wang, Bin Zhao, Minhao Lu
Summary: This study revealed the function of USP10 in thyroid cancer, showing that it can promote malignancy by facilitating GPX4 and inhibiting ferroptosis. This provides a novel treatment target for thyroid cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhi Xu, Xiumei Wang, Wenbo Sun, Fan Xu, Hengyuan Kou, Weizi Hu, Yanyan Zhang, Qin Jiang, Jinhai Tang, Yong Xu
Summary: This study reveals the contribution of RelB-upregulated GPX4 in inhibiting ferroptosis to tamoxifen resistance in breast cancer.
Article
Biochemistry & Molecular Biology
Ping Han, Xia Wang, Tianqiu Zhou, Jinmei Cheng, Chengniu Wang, Fei Sun, Xi Zhao
Summary: Expression of Nrf2 in sperm is reduced in oligospermia patients, but the mechanism is unclear. This study found that Nrf2 and GPX4 protein expressions in sperm of oligospermia men were significantly decreased. Animal experiments showed that Nrf2 knockout in mice led to the occurrence of ferroptosis in spermatogenic cells, resulting in oligospermia. Treatment with a ferroptosis inhibitor reversed the decrease in sperm concentration and motility.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Shujuan Song, Zhenyi Su, Ning Kon, Bo Chu, Huan Li, Xuejun Jiang, Jianyuan Luo, Brent R. Stockwell, Wei Gu
Summary: ALOX5 plays a crucial role in mHTT-mediated ferroptosis, providing a new target for the treatment of Huntington's disease.
GENES & DEVELOPMENT
(2023)
Review
Biochemistry & Molecular Biology
Nadia Zaffaroni, Giovanni Luca Beretta
Summary: Lipid peroxidation-driven iron-dependent ferroptosis is a regulated cell death mechanism implicated in various diseases, such as neurological diseases, kidney injury, ischemia, and tumors, including prostate cancer. Ferroptosis inducers targeting iron, reactive oxygen species, and amino acid metabolic pathways show promise in effectively treating prostate cancer and combating the progression towards castration-resistant disease.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Ching-Yuan Wu, Yao-Hsu Yang, Yu-Shih Lin, Geng-He Chang, Ming-Shao Tsai, Cheng-Ming Hsu, Reming-Albert Yeh, Li-Hsin Shu, Yu-Ching Cheng, Hung-Te Liu
Summary: In this study, it was found that dihydroisotanshinone I extracted from danshen can inhibit the growth of lung cancer cells through inducing apoptosis and ferroptosis and blocking the protein expression of GPX4. Furthermore, the treatment with DT was able to inhibit metastasis of A549 cells in a nude mice model without any adverse effects. Further research is needed to validate these findings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Pu Xia, Gui-Min Wen, Xiao-Hui Zheng, Zhen-Ying Zhao
Summary: The study identified shared pathogenic genes linked to ferroptosis in liver cancer patients from diverse racial backgrounds. FDFT1, ACSL4, and EMC2 were found to induce ferroptosis in liver cancer cells by regulating ROS levels and GPX4. These findings suggest potential novel therapeutic approaches for liver cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wenzhe Ma, Senling Feng, Xiaojun Yao, Zhongwen Yuan, Liang Liu, Ying Xie
SCIENTIFIC REPORTS
(2015)
Article
Integrative & Complementary Medicine
Yantao Li, Jiajun Huang, Wanjun Lin, Zhongwen Yuan, Senling Feng, Ying Xie, Wenzhe Ma
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2016)
Article
Pharmacology & Pharmacy
Sen-Ling Feng, Zhong-Wen Yuan, Xiao-Jun Yao, Wen-Zhe Ma, Liang Liu, Zhong-Qiu Liu, Ying Xie
PHARMACOLOGICAL RESEARCH
(2016)
Article
Pharmacology & Pharmacy
Wanjun Lin, Jiajun Huang, Xiaolin Liao, Zhongwen Yuan, Senling Feng, Ying Xie, Wenzhe Ma
PHARMACOLOGICAL RESEARCH
(2016)
Article
Pharmacology & Pharmacy
Zhong-Wen Yuan, Ya-Zhuo Li, Zhong-Qiu Liu, Sen-ling Feng, Hua Zhou, Chang-Xiao Liu, Liang Liu, Ying Xie
PHARMACOLOGICAL RESEARCH
(2018)
Article
Multidisciplinary Sciences
Wanjun Lin, Jiajun Huang, Zhongwen Yuan, Senling Feng, Ying Xie, Wenzhe Ma
SCIENTIFIC REPORTS
(2017)
Article
Plant Sciences
Sen-Ling Feng, Hai-Bin Luo, Liang Cai, Jie Zhang, Dan Wang, Ying-Jiang Chen, Huan-Xing Zhan, Zhi-Hong Jiang, Ying Xie
JOURNAL OF GINSENG RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Senling Feng, Huifang Zhou, Deyan Wu, Dechong Zheng, Biao Qu, Ruiming Liu, Chen Zhang, Zhe Li, Ying Xie, Hai-Bin Luo
ACTA PHARMACEUTICA SINICA B
(2020)
Article
Plant Sciences
Feng Sen-Ling, Tian Yun, Huo Shuai, Qu Biao, Liu Rui-Ming, Xu Peng, Li Ya-Zhuo, Xie Ying
Article
Plant Sciences
Rui-Ming Liu, Peng Xu, Qi Chen, Sen-ling Feng, Ying Xie
Article
Plant Sciences
Ying Xie, Sen-Ling Feng, Chu-Tian Mai, Yan-Fang Zheng, Hui Wang, Zhong-Qiu Liu, Hua Zhou, Liang Liu
Summary: The study demonstrates that silybin can ameliorate dyslipidemia and arthritis in AIA rats through modulating lipid metabolism and suppressing the up-regulated LXR alpha, highlighting the potential of LXR alpha inhibition as a therapeutic target for rheumatoid arthritis.
Article
Plant Sciences
Ying Xie, Chu-Tian Mai, De-Chong Zheng, Yu-Fei He, Sen-Lin Feng, Ya-Zhou Li, Chang-Xiao Liu, Hua Zhou, Liang Liu
Summary: The study revealed the synergistic anti-arthritic effects of the five herbs in WTD, with Radix Aconite (AC) as the principal anti-inflammatory component. Assistant herbs Herba Ephedrae (EP) and Radix Astragali (AS) intensified the anti-arthritic effects of AC by regulating NF-kappa B and Nrf2 pathways. WTD achieved the best effects in alleviating the symptoms of rheumatoid arthritis through these pathways.
Article
Medicine, Research & Experimental
Sen Ling Feng, Jing Zhang, Hongliu Jin, Wen Ting Zhu, Zhongwen Yuan
Summary: This network pharmacology study identified quercetin, kaempferol, and tetramethoxyluteolin as the main active compounds in Hypericum japonicum, which showed potential in promoting recovery from cholestatic hepatitis. Key targets associated with the effects included PTGS2, BCL2, CYP7A1, and FXR genes.
MEDICAL SCIENCE MONITOR
(2021)