期刊
CEPHALALGIA
卷 36, 期 3, 页码 279-283出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102415586064
关键词
Migraine; MRI; cerebral blood flow; pH; familial hemiplegic migraine; genetics; chemical exchange saturation transfer
资金
- Danish Ministry of Science, Technology and Innovation's University Investment Grant MINDLab
Introduction To investigate tissue flow disturbance and hypoxia during migraine aura, we studied a case of familial hemiplegic migraine (FHM) using novel magnetic resonance imaging (MRI) techniques. Case results A 44-year-old male was admitted with suspected stroke because of confusion and aphasia. Initial gadolinium-based perfusion MRI showed a decrease in cerebral blood flow and an increase in capillary flow disturbances within the left hemisphere. Later during the prolonged aura phase, chemical exchange saturation transfer MRI indicated a drop in pH in the affected area. The patient was diagnosed with an R908Q mutation in the ATP1A2 gene causing FHM type 2. Discussion During prolonged aura in FHM, MRI shows reduced CBF, capillary flow disturbances and a possible pH drop that could indicate tissue hypoxia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据