Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2

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Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

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Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function

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Caveolae and lipid sorting: Shaping the cellular response to stress

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Caveolae: Formation, dynamics, and function

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In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation

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Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers

(2020) Bowen Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Lymph protects metastasizing melanoma cells from ferroptosis

(2020) Jessalyn M. Ubellacker et al.   NATURE

Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture

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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

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Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

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Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

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The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

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Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells

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Caveolae: Structure, Function, and Relationship to Disease

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Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

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Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane

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A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease

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Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

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Activation of apoptosis signalling pathways by reactive oxygen species

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SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis

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PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges

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Caveolae protect endothelial cells from membrane rupture during increased cardiac output

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The caveolin–cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle

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Caveolin-1 and CDC42 mediated endocytosis of silica-coated iron oxide nanoparticles in HeLa cells

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PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Structural Insights into the Organization of the Cavin Membrane Coat Complex

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C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair

(2014) Suhong Xu et al.   DEVELOPMENTAL CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

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Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

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Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

(2014) Yann Gambin et al.   eLife

Causal analysis approaches in Ingenuity Pathway Analysis

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Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

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Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration

(2013) Nick R. Love et al.   NATURE CELL BIOLOGY

Caveolae as plasma membrane sensors, protectors and organizers

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PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer

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Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed

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The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Vitamin E Protects against Lipid Peroxidation and Rescues Tumorigenic Phenotypes in Cowden/Cowden-like Patient-Derived Lymphoblast Cells with Germline SDHx Variants

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Structure-Based Reassessment of the Caveolin Signaling Model: Do Caveolae Regulate Signaling through Caveolin-Protein Interactions?

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Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish

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The Nuclear Receptor, Nor-1, Markedly Increases Type II Oxidative Muscle Fibers and Resistance to Fatigue

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NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif?

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Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

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Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

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The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

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Apoptotic Cells Provide an Unexpected Source of Wnt3 Signaling to Drive Hydra Head Regeneration

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The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

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MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

(2009) Michele Bastiani et al.   JOURNAL OF CELL BIOLOGY

Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy

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A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

(2008) Michelle M. Hill et al.   CELL

Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

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