Review
Cardiac & Cardiovascular Systems
Jordi Alastruey, Peter H. Charlton, Vasiliki Bikia, Birute Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, Jonathan Mynard, Alun D. Hughes, Patrick Segers, Berend E. Westerhof
Summary: Arterial pulse waves (PWs), such as blood pressure and photoplethysmogram (PPG) signals, are rich sources of information for assessing vascular age and identifying individuals at elevated cardiovascular risk. This review explores the possibilities and limitations of reduced-order biophysical models and theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information. Detailed mathematical derivations are provided, demonstrating the relationships between these models and methods. Suggestions for future research are also outlined to fully utilize the potential of modeling and analyzing PW signals for accurate vascular age assessment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Peter H. Charlton, Birute Paliakait, Kristjan Pilt, Martin Bachler, Serena Zanelli, Daniel Kulin, John Allen, Magid Hallab, Elisabetta Bianchini, Christopher C. Mayer, Dimitrios Terentes-Printzios, Verena Dittrich, Bernhard Hametner, Dave Veerasingam, Dejan Zikic, Vaidotas Marozas
Summary: This review summarizes the research on assessing vascular age using the photoplethysmogram (PPG) signal. The methods can be divided into those using a single PPG signal, those using multiple PPG signals, and those using PPG in combination with other signals. The review presents evidence on the performance, repeatability and reproducibility, and clinical utility of PPG-derived parameters for assessing vascular age.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Fredrika Schill, Margaretha Persson, Gunnar Engstrom, Olle Melander, Sofia Enhorning
Summary: The study found that elevated copeptin levels are associated with increased markers of coronary atherosclerosis and arterial stiffness, indicating copeptin may be a useful marker in the assessment of cardiovascular risk.
Article
Peripheral Vascular Disease
Ramachandran S. Vasan, Stephanie Pan, Martin G. Larson, Gary F. Mitchell, Vanessa Xanthakis
Summary: Aging is associated with increased prevalence of subclinical atherosclerosis and arteriosclerosis, which can be mitigated by ideal cardiovascular health. The presence of subclinical atherosclerosis, arteriosclerosis, and poor cardiovascular health simultaneously is significantly associated with increased risk of cardiovascular disease, while their absence signifies low risk.
Article
Peripheral Vascular Disease
Tomoaki Murakami, Yoko Horibata, Shigeru Tateno, Yasutaka Kawasoe, Koichiro Niwa
Summary: The prevalence of early vascular aging is high in adult patients with congenital heart disease, with factors such as age, blood pressure, and blood lipids being closely related. Systolic blood pressure was identified as a significant determinant of early vascular aging. Careful monitoring of blood pressure and pulse wave velocity is crucial to prevent potential damage to the vulnerable hearts of these patients.
HYPERTENSION RESEARCH
(2021)
Article
Medicine, General & Internal
Zhiyuan Wu, Jinqi Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Yue Liu, Xinlei Miao, Ze Han, Xiaoping Kang, Xia Li, Xiuhua Guo, Lixin Tao, Wei Wang
Summary: This study investigates the association between remnant cholesterol (RC) and joint arteriosclerosis and atherosclerosis progression patterns. It finds that RC is independently associated with the progression of these conditions beyond LDL-C.
Article
Cardiac & Cardiovascular Systems
Xuan Deng, Yongjian Song, Xu Han, Xueyu Chen, Wenyi Yang, Shouling Wu, Yong Zhou
Summary: This study aimed to identify multiple brachial-ankle Pulse Wave Velocity (baPWV) trajectory phenotypes and assess their determinants. Four distinct baPWV trajectories were identified, mainly determined by mean arterial pressure and age. Additionally, several biochemical markers and body mass index were associated with the trajectory.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Naoto Katakami, Tomoya Mita, Hidenori Yoshii, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Yosuke Okada, Keiichi Torimoto, Yutaka Umayahara, Hideaki Kaneto, Takeshi Osonoi, Tsunehiko Yamamoto, Nobuichi Kuribayashi, Kazuhisa Maeda, Hiroki Yokoyama, Keisuke Kosugi, Kentaro Ohtoshi, Isao Hayashi, Satoru Sumitani, Mamiko Tsugawa, Kayoko Ryomoto, Hideki Taki, Tadashi Nakamura, Satoshi Kawashima, Yasunori Sato, Hirotaka Watada, Iichiro Shimomura
Summary: The study evaluated the effects of tofogliflozin on brachial-ankle pulse wave velocity in patients with type 2 diabetes without a history of apparent cardiovascular disease. Tofogliflozin significantly inhibited the increased baPWV, suggesting that it suppressed the progression of arterial stiffness in these patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Engineering, Biomedical
Yi Huang, Lingyu Zhao, Minkun Cai, Jiaqi Zhu, Liu Wang, Xinxing Chen, Yumin Zeng, Liqing Zhang, Jidong Shi, Chuan Fei Guo
Summary: A single-point strategy for assessing arteriosclerosis based on stable fingertip pulse monitoring using a flexible iontronic pressure sensor is presented. This technique allows for reliable and accurate measurement of heart-fingertip pulse wave velocity (hfPWV), providing a potential solution for wearable arteriosclerosis assessment systems.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Kaitlin A. Freeberg, Daniel H. Craighead, Christopher R. Martens, Zhiying You, Michel Chonchol, Douglas R. Seals
Summary: The study aims to investigate the effects of oral supplementation with nicotinamide riboside on reducing systolic blood pressure and arterial stiffness in midlife and older adults. The trial utilizes a randomized, double-blind, placebo-controlled design to evaluate the safety and efficacy of nicotinamide riboside in participants with above-normal systolic blood pressure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Seung-Jae Lee, Hyunah Kim, Byeong Kil Oh, Hyo-In Choi, Jong Young Lee, Sung Ho Lee, Byung Jin Kim, Bum Soo Kim, Jin Ho Kang, Jeonggyu Kang, Seong Hwan Kim, Ki-Chul Sung
Summary: This study investigated the distribution of inter-arm blood pressure differences (IADs) in a large cohort of apparently healthy people and their association with brachial-ankle pulse wave velocity (baPWV) and coronary artery calcium (CAC). The study found that the majority of participants had an IAD of 10 mmHg or less, and IAD was significantly associated with arterial stiffness, but not with the presence of CAC. The study suggests that IAD may be a valuable tool for the early detection of asymptomatic individuals with subclinical arterial disease.
Article
Peripheral Vascular Disease
Carlos A. Valencia-Hernandez, Joni Lindbohm, Martin J. Shipley, Ian B. Wilkinson, Carmel M. McEniery, Sara Ahmadi-Abhari, Archana Singh-Manoux, Mika Kivimaki, Eric J. Brunner
Summary: Aortic pulse wave velocity can predict the risk of major adverse cardiovascular events in elderly individuals and improve the performance of commonly used cardiovascular disease risk assessment tools.
Article
Physiology
Hiroyuki Oda, Mami Fujibayashi, Naoyuki Matsumoto, Masato Nishiwaki
Summary: This study aimed to examine the effects of low-intensity EMS of the lower limbs on segmental arterial stiffness, and the results showed that low-intensity EMS can reduce arterial stiffness, but only in the areas that received EMS.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zheng-Qiu Zhu, Ling-Shan Chen, Xue-Zhong Jiang, Yi-Yun Wu, Chong Zou, Yun Luan, Hui Gao, Ping Dai, Xue-Hui Ma, Lin-Lin Wu, Hui-Juan Sun, Yin-Ping Wang, Fei Zou, Fu-Ming Liu, Hui Huang
Summary: The study found that many individuals without conventional cardiovascular risk factors have carotid stiffening, with age, male sex, and body mass index being independently associated with carotid stiffening.
EUROPEAN RADIOLOGY
(2021)
Article
Geriatrics & Gerontology
T. Sun, Z. Ma, L. Gao, Y. Wang, Hui Xie
Summary: The study of 2511 elderly subjects found a positive correlation between sarcopenia and arteriosclerosis, with a higher prevalence of sarcopenia in subjects with high baPWV. Additionally, HGS was negatively correlated with baPWV. These findings suggest potential shared pathophysiological mechanisms between arteriosclerosis and sarcopenia, with implications for future interventions.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)