Article
Critical Care Medicine
Sung-Min Cho, Lavienraj Premraj, Jonathon Fanning, Samuel Huth, Adrian Barnett, Glenn Whitman, Rakesh C. Arora, Denise Battaglini, Diego Bastos Porto, HuiMahn Choi, Jacky Suen, Gianluigi Li Bassi, John F. Fraser, Chiara Robba, Matthew Griffee
Summary: In an international cohort of ICU patients with coronavirus disease 2019, stroke was infrequent. Hemorrhagic stroke, but not ischemic stroke, was associated with increased mortality. Further, both hemorrhagic stroke and ischemic stroke were associated with traditional vascular risk factors.
CRITICAL CARE MEDICINE
(2021)
Article
Pediatrics
Mariha Khan, Samhita Bhattarai, Thomas G. Boyce, Reyaad A. Hayek, Sergey Zhadanov, Elisabeth E. Hooper, Edward G. Fernandez, Monica A. Koehn
Summary: A 5-week-old infant born at term was diagnosed with acute necrotizing encephalopathy associated with severe acute respiratory syndrome coronavirus 2 based on clinical presentation, neuroimaging, and cerebrospinal fluid studies. The patient received high-dose intravenous methylprednisolone, tocilizumab, and intravenous immunoglobulin treatment, which resulted in significant short-term clinical improvement but long-term sequelae.
JOURNAL OF PEDIATRICS
(2022)
Article
Anesthesiology
Vinh Pham, Le Nguyen, Riley J. Hedin, Courtney Shaver, Kendall A. P. Hammonds, William C. Culp
Summary: This study found that in the absence of waste anesthesia gas suction systems, anesthesia machines may deliver inadvertent increases in airway pressure, and these increases can be mitigated by recommended modifications by the manufacturer.
ANESTHESIA AND ANALGESIA
(2021)
Article
Clinical Neurology
M. Mehrpour, A. Shuaib, M. Farahani, H. R. Hatamabadi, Z. Fatehi, M. Ghaffari, N. B. Moghadam, S. H. Aghamiri, B. Mansouri, F. Assarzadegan, B. S. Lima, O. Hesami
Summary: The COVID-19 pandemic resulted in a significant decrease in acute stroke admissions, but did not significantly impact the treatment plans and care of patients. Stroke cases with COVID-19 had higher age, more large vessel ischemic strokes, and more severe strokes compared to those without COVID-19.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Review
Ophthalmology
Kateki Vinod, Paul A. Sidoti
Summary: The COVID-19 pandemic has significantly impacted the delivery of ophthalmic care, leading to enhanced infection control measures, increased use of telemedicine in glaucoma practices, and research on home monitoring tools for intraocular pressure and virtual visual field testing. Glaucoma specialists are innovating modifications to reduce viral transmission and optimize patient and staff safety, while teleglaucoma is expanding with advancements in remote diagnostic devices.
CURRENT OPINION IN OPHTHALMOLOGY
(2021)
Article
Geriatrics & Gerontology
Emily B. Fessler, Theresa Soriano, Christina R. Whitehouse, Rachel K. Miller
Summary: Ms. H, a 78-year-old woman with a history of congestive heart failure, COPD, and recent stroke, was discharged from a subacute rehabilitation facility a month ago. She moved in with her son due to her mobility issues, but developed a low-grade fever and mild shortness of breath one evening, causing concern for her son who knows she does not want to go back to the hospital.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Clinical Neurology
Claudio Baracchini, Alessio Pieroni
Summary: The COVID-19 pandemic has had a significant impact on stroke care, leading to a decline in stroke presentations and delays in treatment. Further studies are needed to monitor COVID-19 patients undergoing procedures and develop more effective therapies. Efforts to maintain stroke teams and provide timely treatments should be prioritized through telestroke networks and stroke awareness programs.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Critical Care Medicine
Francesco Santoro, Ivan J. Nunez-Gil, Maria C. Viana-Llamas, Charbel Maroun Eid, Rodolfo Romero, Inmaculada Fernandez Rozas, Alvaro Aparisi, Victor Manuel Becerra-Munoz, Marcos Garcia Aguado, Jia Huang, Ludovica Maltese, Enrico Cerrato, Emilio Alfonso-Rodriguez, Alex Fernando Castro Mejia, Francisco Marin, Sergio Raposeiras Roubin, Martino Pepe, Victor H. Moreno Munguia, Gisela Feltes, Jesus Varas Navas, Bernardo Cortese, Luis Buzon, Cristoph Liebetrau, Raquel Ramos-Martinez, Antonio Fernandez-Ortiz, Vicente Estrada, Natale Daniele Brunetti
Summary: In general population with coronavirus disease 2019, anticoagulation therapy was not associated with better survival rates but with higher bleeding risk. Better outcomes were observed in patients admitted with respiratory failure and requiring invasive ventilation.
CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Joan Marti-Fabregas, Daniel Guisado-Alonso, Raquel Delgado-Mederos, Alejandro Martinez-Domeno, Luis Prats-Sanchez, Marina Guasch-Jimenez, Pere Cardona, Ana Nunez-Guillen, Manuel Requena, Marta Rubiera, Marta Olive, Alejandro Bustamante, Meritxell Gomis, Sergio Amaro, Laura Llull, Xavier Ustrell, Gislaine Castilho de Oliveira, Laia Sero, Manuel Gomez-Choco, Luis Mena, Joaquin Serena, Saima Bashir Viturro, Francisco Purroy, Mikel Vicente, Ana Rodriguez-Campello, Angel Ois, Esther Catena, Maria Carmen Garcia-Carreira, Oriol Barrachina, Ernest Palomeras, Jerzky Krupinski, Marta Almeria, Josep Zaragoza, Patricia Esteve, Dolores Cocho, Antia Moreira, Cecile van Eendenburg, Javier Emilio Codas, Natalia Perez de la Ossa, Merce Salvat, Pol Camps-Renom
Summary: The study evaluated the impact of COVID-19 infection on patients with ischemic stroke, finding that infected patients had more severe strokes and higher mortality rates, but similar functional outcomes compared to the non-infected group.
Article
Public, Environmental & Occupational Health
Yu Zhang, Yan-li Wang, Shu-qin Wang, Chun-yan Zhang, Na Wan, Yan-rui Jia, Feng-li Gao
Summary: This study investigated the training experiences and needs of ICU general nurses under regular COVID-19 prevention and control. Through interviews with 10 nurses, five themes were identified from their experiences: broadening their thinking, discovering personal shortcomings, gaining self-confidence, calmly facing frontline work, and experiencing high assessment pressure. The nurses expressed a need for increased training time, improved assessment mechanisms, a normal rotating-shift training system, and balanced teaching levels. There is a practical significance and value in ICU training for general nurses, and efforts should be made to establish perfect training and assessment mechanisms for these nurses.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Kevin Roedl, Dominik Jarczak, Olaf Boenisch, Geraldine de Heer, Christoph Burdelski, Daniel Frings, Barbara Sensen, Axel Nierhaus, Stefan Kluge, Dominic Wichmann
Summary: More than half of critically ill patients with COVID-19 suffer from chronic critical illness (CCI). Patients with CCI have higher short and long-term survival rates compared to patients without CCI, and prolonged therapy should be provided when resources permit.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Chaorui C. Huang, Hong Xu
Summary: This study aimed to evaluate the risk factors and develop a precision diagnostic method for COVID-19 related severe outcome in New York State. Age was identified as the greatest risk factor, and by considering other variables, the predictive accuracy of the model improved to 0.85.
SCIENTIFIC REPORTS
(2023)
Article
Peripheral Vascular Disease
Anne G. Raafs, Mohammed A. Ghossein, Yentl Brandt, Michiel T. H. M. Henkens, M. Eline Kooi, Kevin Vernooy, Marc E. A. Spaanderman, Suzanne Gerretsen, Susanne van Santen, Rob G. H. Driessen, Christian Knackstedt, Iwan C. C. van der Horst, Bas C. T. van Bussel, Stephane R. B. Heymans, Chahinda Ghossein-Doha
Summary: A follow-up study on COVID-19 patients 6 months after discharge reveals that one out of five mechanically ventilated survivors had coronary artery disease (CAD), a quarter had subclinical left ventricular dysfunction, and 42% had cardiac abnormalities on cardiac magnetic resonance imaging (CMR). Long-term cardiovascular follow-up is strongly recommended for all post-ICU COVID-19 patients based on these findings.
JOURNAL OF HYPERTENSION
(2022)
Article
Immunology
Michael A. Hansen, Rodrigo Hasbun
Summary: Herpes simplex encephalitis (HSE) readmissions are relatively common, particularly among older and sicker individuals. Early signs and symptoms of neurological disease at index were correlated with encephalopathic specific readmissions.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Seon Jin Lee, Jeong Min Kim, Ha Rim Keum, Sang Won Kim, Hee Sun Baek, Jun Chul Byun, Yu Kyung Kim, Saeyoon Kim, Jae Min Lee
Summary: This study investigated the relationship between the incidence of encephalitis and viral infections in all age groups from 2015 to 2019. The results showed that respiratory syncytial virus (HRSV), coronavirus (HCoV), influenza virus (IFV), and norovirus tended to precede encephalitis by 1 month. Further research is needed to confirm the association between these viruses and encephalitis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Virginia F. J. Newcombe, Nicholas J. Ashton, Jussi P. Posti, Ben Glocker, Anne Manktelow, Doris A. Chatfield, Stefan Winzeck, Edward Needham, Marta M. Correia, Guy B. Williams, Joel Simren, Riikka S. K. Takala, Ari J. Katila, Henna-Riikka Maanpaa, Jussi Tallus, Janek Frantzen, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, David K. Menon
Summary: Newcombe et al. found that serum levels of GFAP and neurofilament light remain elevated for months to years after traumatic brain injury and are correlated with microstructural injury and atrophy. These biomarkers may be able to identify survivors at risk of late neurological damage after traumatic brain injury.
Article
Critical Care Medicine
Marjolein van der Vlegel, Ana Mikolic, Quentin Lee Hee, Z. L. Rana Kaplan, Isabel R. A. Retel Helmrich, Ernest van Veen, Nada Andelic, Nicole V. Steinbuechel, Anne Marie Plass, Marina Zeldovich, Lindsay Wilson, Andrew I. R. Maas, Juanita A. Haagsma, Suzanne Polinder
Summary: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults, and it poses a growing public health problem. However, there is a lack of research on TBI in older adults. This study provides an overview of healthcare utilization and outcomes after TBI in older adults, and identifies the determinants of these outcomes. The findings indicate that the rate of impairment and disability following TBI is substantial in older adults, and poorer outcomes are associated with worse pre-injury health. However, a considerable number of patients are able to return to their pre-injury functioning.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Correction
Biochemistry & Molecular Biology
Baptiste Vasey, Myura Nagendran, Bruce Campbell, David A. Clifton, Gary S. Collins, Spiros Denaxas, Alastair K. Denniston, Livia Faes, Bart Geerts, Mudathir Ibrahim, Xiaoxuan Liu, Bilal A. Mateen, Piyush Mathur, Melissa D. McCradden, Lauren Morgan, Johan Ordish, Campbell Rogers, Suchi Saria, Daniel S. W. Ting, Peter Watkinson, Wim Weber, Peter Wheatstone, Peter McCulloch
Article
Clinical Neurology
David Fischer, Virginia Newcombe, Davinia Fernandez-Espejo, Samuel B. Snider
Summary: Disorders of consciousness (DoC) after severe brain injury are challenging for clinicians due to uncertainties in diagnosis, prognosis, and management. Advanced MRI technology, including diffusion MRI and functional MRI, has the potential to improve understanding of DoC pathophysiology, aid in identifying patient consciousness, and enhance clinical prognostication. This article reviews emerging evidence for the application of advanced MRI in patients with DoC.
SEMINARS IN NEUROLOGY
(2022)
Article
Critical Care Medicine
Lennart Riemann, Ana Mikolic, Andrew Maas, Andreas Unterberg, Alexander Younsi
Summary: We investigated the relationship between the presence of intracranial traumatic CT pathologies and the global functional outcome one year after mTBI in young patients. The study included all patients with mTBI (GCS: 13-15) aged <=24 years from the CENTER-TBI study. The results showed that patients with CT abnormalities were less likely to achieve complete recovery 12 months post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Rebecca E. Woodrow, Stefan Winzeck, Andrea Luppi, Isaac R. Kelleher-Unger, Lennart R. B. Spindler, J. T. Lindsay Wilson, Virginia F. J. Newcombe, Jonathan P. Coles, David K. Menon, Emmanuel A. Stamatakis
Summary: Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. The study found acute thalamic hyperconnectivity in mTBI, even without structural changes. These acute changes in thalamic connectivity can serve as early markers for persistent symptoms and have associations with specific emotional and cognitive symptoms.
Article
Critical Care Medicine
Maira Siqueira Pinto, Stefan Winzeck, Evgenios N. Kornaropoulos, Sophie Richter, Roberto Paolella, Marta M. Correia, Ben Glocker, Guy Williams, Anne Vik, Jussi P. Posti, Asta Haberg, Jonas Stenberg, Pieter-Jan Guns, Arnold J. den Dekker, David K. Menon, Jan Sijbers, Pieter Van Dyck, Virginia F. J. Newcombe
Summary: Predicting functional outcome after mild traumatic brain injury (mTBI) is challenging. Conventional MRI is not effective in explaining outcome variance, while more advanced techniques like dMRI can detect microstructural changes and improve prediction. This study explores the potential of linearSVCs and the harmonization of dMRI biomarkers for predicting recovery after mTBI.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Ana Mikolic, Ewout W. Steyerberg, Suzanne Polinder, Lindsay Wilson, Marina Zeldovich, Nicole von Steinbuechel, Virginia F. J. Newcombe, David K. Menon, Joukje van der Naalt, Hester F. Lingsma, Andrew I. R. Maas, David van Klaveren
Summary: This study aimed to develop prognostic models for the Glasgow Outcome Scale Extended (GOSE) and persistent post-concussion symptoms (PPCS) at 6 months after mild traumatic brain injury (mTBI). Various predictors were evaluated, including clinical variables, questionnaires, computed tomography (CT), and blood biomarkers. The models showed moderate performance for predicting GOSE and poor performance for predicting PPCS, indicating that additional factors, such as symptoms assessed at 2-3 weeks, are necessary for better predictive ability.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Medicine, General & Internal
Fatima Nasrallah, Judith Bellapart, James Walsham, Esther Jacobson, Xuan Vinh To, Silvia Manzanero, Nathan Brown, Jason Meyer, Janine Stuart, Tracey Evans, Shekhar S. Chandra, Jason Ross, Lewis Campbell, Siva Senthuran, Virginia Newcombe, James McCullough, Jennifer Fleming, Clifford Pollard, Michael Reade
Summary: This study aims to develop a machine learning predictive model for neurological outcomes at 6 months in patients with moderate-to-severe TBI, incorporating longitudinal clinical, multimodal neuroimaging and blood biomarker predictor variables.
Article
Clinical Neurology
Toni J. U. Niiranen, Anne-Cecile Chiollaz, Riikka S. K. Takala, Miko Voutilainen, Olli Tenovuo, Virginia F. J. Newcombe, Henna-Riikka Maanpaa, Jussi Tallus, Mehrbod Mohammadian, Iftakher Hossain, Mark van Gils, David K. Menon, Peter J. Hutchinson, Jean-Charles Sanchez, Jussi P. Posti
Summary: This study aimed to investigate the blood levels of interleukin 10 (IL-10) and heart fatty acid-binding protein (H-FABP) in patients with moderate-to-severe traumatic brain injury (TBI), and their correlations with inflammation/infection markers and cardiac injury markers. The results showed that increased IL-10 levels were associated with the inflammatory/infection status, while elevated H-FABP levels were related to cardiac injury in TBI patients.
FRONTIERS IN NEUROLOGY
(2023)
Review
Emergency Medicine
Virginia Newcombe, Sophie Richter, Daniel P. Whitehouse, Benjamin Michael Bloom, Fiona Lecky
Summary: Mild traumatic brain injury is a common presentation in the emergency department, and current management focuses on determining the need for CT scans and neurosurgical intervention. However, a significant number of patients, even with normal CT results, experience ongoing symptoms known as post-concussion syndrome. The use of blood biomarkers and advanced MRI techniques has shown potential in improving diagnostic pathways and predicting outcomes for these patients.
EMERGENCY MEDICINE JOURNAL
(2023)
Editorial Material
Critical Care Medicine
Virginia Newcombe, Susanne Muehlschlegel, Romain Sonneville
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Lennart Riemann, Ana Mikolic, Andrew Maas, Andreas Unterberg, Alexander Younsi
Summary: The study investigated the relationship between traumatic intracranial computed tomography (CT) pathologies and global functional outcome in young patients one year after mild traumatic brain injury (mTBI). It found that the presence of intracranial traumatic CT pathologies was predictive of outcome 12 months after mTBI in young patients.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Neuroimaging
Kamen A. Tsvetanov, Lennart R. B. Spindler, Emmanuel A. Stamatakis, Virginia F. J. Newcombe, Victoria C. Lupson, Doris A. Chatfield, Anne E. Manktelow, Joanne G. Outtrim, Anne Elmer, Nathalie Kingston, John R. Bradley, Edward T. Bullmore, James B. Rowe, David K. Menon
Summary: This study investigates the long-term impact of COVID-19 on cerebrovascular health and finds that severe acute COVID-19 is associated with chronic cerebrovascular impairment, which is related to cognitive function and mental wellbeing.
NEUROIMAGE-CLINICAL
(2022)