期刊
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
卷 27, 期 7, 页码 1285-1288出版社
SPRINGER
DOI: 10.1007/s13361-016-1397-x
关键词
Collision induced dissociation; Ion mobility spectrometry; rf Confinement; Ion optics; Peptide fragmentation; Manipulation; Conveyor
资金
- National Institutes of Health (NIH) NIGMS [5P41GM103493-13]
- Department of Energy, Office of Biological and Environmental Research Genome Sciences Program under the Pan-omics project
- Laboratory Directed Research and Development (LDRD) program at the Pacific Northwest National Laboratory
- DOE [DE-AC05-76RL0 1830]
A collision induced dissociation (CID) structure for lossless ion manipulations (SLIM) module is introduced and coupled to a quadrupole time-of-flight (QTOF) mass spectrometer. The SLIM CID module was mounted after an ion mobility (IM) drift tube to enable IM/CID/MS studies. The efficiency of CID was studied by using the model peptide leucine enkephalin. CID efficiencies (62%) compared favorably with other beam-type CID methods. Additionally, the SLIM CID module was used to fragment a mixture of nine peptides after IM separation. This work also represents the first application of SLIM in the 0.3 to 0.5 Torr pressure regime, an order of magnitude lower in pressure than previously studied.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据