Article
Geriatrics & Gerontology
G. C. -K. Chan, J. K. -C. Ng, K. -M. Chow, P. M. -S. Cheng, M. -C. Law, C. -B. Leung, P. K. -T. Li, C. -C. Szeto
Summary: The interaction between polypharmacy, frailty, nutrition, hospitalization, and survival in peritoneal dialysis patients was examined in this study. The results showed that medication number significantly predicted the onset and progression of frailty, malnutrition, fall, hospitalization, and mortality, while daily pill load did not have the same predictive value.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Geriatrics & Gerontology
Li Yuan, Xiaoming Zhang, Na Guo, Zhen Li, Dongmei Lv, Hui Wang, Jingfen Jin, Xianxiu Wen, Shengxiu Zhao, Tao Xu, Jing Jiao, Xinjuan Wu
Summary: This study investigated the prevalence of cognitive impairment among older inpatients in China and found a significant relationship between cognitive impairment and 1-year adverse health outcomes (death, frailty, and decreased HRQoL), particularly among elderly patients over 75 years old.
Review
Cell Biology
Janice Jia Yun Toh, Hui Zhang, Yang Yue Soh, Zeyu Zhang, Xi Vivien Wu
Summary: This review analyzes the prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty. The overall prevalence of polypharmacy and hyperpolypharmacy in frail older adults was 59% and 22% respectively. Older adults with polypharmacy were less likely to improve their frailty state, had higher mortality risks, experienced adverse hospital-related outcomes, and required additional assistance compared to those without polypharmacy.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Bader Alqahtani
Summary: This study aimed to examine the association between number of medications, polypharmacy, and frailty in community-dwelling older adults. A cross-sectional analysis was performed using data of 328 individuals aged between 65 and 85 years. The results showed that number of medications and polypharmacy were associated with frailty.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Medicine, General & Internal
Aparna Verma, Sanjib Saha, Johan Jarl, Ellen Conlon, Bernadette McGuinness, Dominic Trepel
Summary: Frailty, a lack of resilience and decreased ability to recover following a health problem, is a challenging aspect of ageing populations. Medication reviews have been successful in managing polypharmacy in the general population, but their impact on frail older adults is uncertain. This overview of systematic reviews found that medication reviews can reduce the use of inappropriate medications in frail older adults, but there is insufficient evidence regarding frailty score and hospital admissions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Mostafa R. Mohamed, Supriya G. Mohile, Katherine M. Juba, Hala Awad, Megan Wells, Kah Poh Loh, Marie Flannery, Eva Culakova, Rachael G. Tylock, Erika E. Ramsdale
Summary: Polypharmacy and potential drug-drug interactions (PDIs) are associated with an increased risk of adverse treatment outcomes in older adults with advanced cancer receiving systemic therapy.
Article
Pharmacology & Pharmacy
Yi Song, Lihua Chen, Ying Liu, Xin Xia, Lisha Hou, Jinhui Wu, Li Cao, Li Mo
Summary: This study aimed to determine whether a geriatrician-led multidisciplinary team (MDT) management mode could reduce medications use among older inpatients. The results showed that MDT management significantly reduced the number of medications used in older inpatients at discharge. This indicates that implementing MDT mode in hospitals can reduce medication burden for older patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lvliang Lu, Shuang Wang, Jiaqi Chen, Yujie Yang, Kai Wang, Jing Zheng, Pi Guo, Yunpeng Cai, Qingying Zhang
Summary: Chronic polypharmacy and potentially inappropriate medication use are prevalent among older adults with diabetes in Chinese communities, and are associated with a higher incidence of adverse health outcomes. Patient-centered medication reviews and caution in polypharmacy, especially potentially inappropriate medication use, are necessary for older adults with diabetes in primary care facilities in China.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Z. M. Lobato, A. C. Almeida da Silva, S. M. Lima Ribeiro, M. M. Biella, A. Santos Silva Siqueira, T. Correa de Toledo Ferraz Alves, R. Machado-Vieira, M. K. Borges, R. C. Oude Voshaar, Ivan Aprahamian
Summary: The study aims to evaluate the prevalence of malnutrition in depressed older inpatients and determine which indices of malnutrition predict adverse health outcomes in late-life depression.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Geriatrics & Gerontology
Alejandro Alvarez-Bustos, Jose Antonio Carnicero-Carreno, Juan Luis Sanchez-Sanchez, Francisco Javier Garcia-Garcia, Cristina Alonso-Bouzon, Leocadio Rodriguez-Manas
Summary: By examining and analyzing the evolution of different frailty trajectories, it was found that prospective increases in frailty levels among older adults are associated with an increased risk of adverse events.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Yan-Zuo Chen, Shih-Tsung Huang, Yu-Wen Wen, Liang-Kung Chen, Fei-Yuan Hsiao
Summary: The study indicates that both frailty and polypharmacy modify the risks of mortality and hospital admissions in older people, but the combined effects vary in distinct groups.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
J. J. Li, S. Jiang, M. L. Zhu, X. H. Liu, X. H. Sun, S. Q. Zhao
Summary: The study compared the predictive ability of three frailty scales (FP, FRAIL, FI) and found that they had similar predictive value for adverse outcomes. Among the three scales, FRAIL may be the most practical choice due to its simplicity. Multidimensional measures of frailty were found to be more effective for predicting adverse outcomes among older adults compared to unidimensional measures.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Oncology
Tomohiro F. Nishijima, Taito Esaki, Masaru Morita, Yasushi Toh
Summary: In older adults with cancer, the Robinson Frailty Score (RFS) was found to be significantly predictive of postoperative adverse events, while the Edmonton Frail Scale (EFS) and the G8 tool showed no significant associations.
Article
Geriatrics & Gerontology
Suey S. Y. Yeung, Ruth S. M. Chan, Timothy Kwok, Jenny S. W. Lee, Jean Woo
Summary: The study showed that malnutrition classified according to GLIM criteria was significantly associated with sarcopenia, frailty, and mortality in community-dwelling Chinese older adults. However, there was no significant association found for falls, mobility limitation, and hospitalization.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Kinda Ibrahim, Natalie J. Cox, Jennifer M. Stevenson, Stephen Lim, Simon D. S. Fraser, Helen C. Roberts
Summary: This systematic review summarizes the current evidence for deprescribing among older people living with frailty. The included studies suggest that deprescribing could be safe, feasible, well tolerated, and can lead to important benefits. Further research should focus on understanding the impact of deprescribing on frailty status in high-risk populations.
Article
Public, Environmental & Occupational Health
Shakti Shrestha, Arjun Poudel, Emily Reeve, Amy M. Linsky, Kathryn J. Steadman, Lisa M. Nissen
Summary: This study developed and validated a survey tool for assessing healthcare professionals' attitudes towards deprescribing in older adults with limited life expectancy. The 23-itemed tool showed valid descriptive statistics and reasonable reliability.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2022)
Article
Nursing
Amanda Fox, Fiona Crawford-Williams, Joseph Ria, Cardiff Lynda, Thoms Debra, Yates Patsy, Nissen Lisa, Raymond Javan Chan
Summary: The study found that the majority of Australian nurses are prepared to embrace the role of prescribing under supervision. Motivations for prescribing include enhancing patient care and job satisfaction. Nurses with less than 10 years of experience, a bachelor's degree, or higher qualification are more likely to desire to prescribe.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Nursing
Amanda Fox, Carla Thamm, Fiona Crawford-Williams, Ria Joseph, Lynda Cardiff, Debra Thoms, Lisa Nissen, Patsy Yates, Raymond Javan Chan
Summary: This study explores nurses' preferences for educational preparation and support in expanding nursing practice to include prescribing. The survey results indicate that most nurses prefer education delivered through a blended approach by health services and universities, along with support from authorized prescribers and multidisciplinary collaboration. Course accreditation and formal qualification are identified as the major factors influencing nurses' desire to undertake a specific program.
Article
Geriatrics & Gerontology
Julie D. Henry, Sarah P. Coundouris, Jessica Mead, Brielle Thompson, Ruth E. Hubbard, Sarah A. Grainger
Summary: This study examines the relationship between social cognitive difficulties and social frailty, as well as the correlation between social frailty and psychological well-being. The findings show that social cognitive difficulties and social behavior can predict increased social frailty, with social behavior being the only significant predictor. Furthermore, social frailty is also associated with various aspects of psychological well-being, with significant effects on demoralization, resilience, and life satisfaction even after adjusting for covariates.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Marea Patounas, Esther T. L. Lau, Deborah Rigby, Vincent Chan, Lisa M. Nissen
Summary: This study aimed to develop and test an evaluation instrument for clinical Home Medicines Review (HMR) reports in Australia. The results showed that the HMR reports aligned with practice guidelines for some criteria, but there were still areas that did not meet the standards. Future research should be conducted on a larger scale to further investigate adherence to practice guidelines in clinical HMR report writing.
JOURNAL OF PHARMACY PRACTICE AND RESEARCH
(2023)
Article
Geriatrics & Gerontology
Kenji Fujita, Sarita Y. Y. Lo, Ruth E. Hubbard, Danijela Gnjidic, Sarah N. Hilmer
Summary: This study compared two frailty assessment tools (eFI-AH and HFRS) in terms of their characteristics and predictive ability for hospitalized patients. The results showed that both tools were associated with adverse outcomes and had comparable ability to predict prolonged hospitalization. However, they did not consistently identify the same frail inpatients.
AUSTRALASIAN JOURNAL ON AGEING
(2023)
Review
Pharmacology & Pharmacy
Shakti Shrestha, Arjun Poudel, Ayda S. Forough, Kathryn J. Steadman, Lisa M. Nissen
Summary: This study reviewed deprescribing tools for older adults with limited life expectancy and assessed the rigor of their development and validation. The findings indicate that there is a limited number of consensus-validated deprescribing tools available for use in this population. These tools target specific disease medications or medication classes guided by the GRADE framework, or a list of medications irrespective of disease, developed using various approaches and validated using the Delphi method.
INTERNATIONAL JOURNAL OF PHARMACY PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Shakti Shrestha, Arjun Poudel, Kathryn J. Steadman, Lisa M. Nissen
Summary: Developed and validated a Deprescribing Tool for Older People with Limited-life Expectancy (De-TOPPLE) through expert consensus and feedback. The tool addresses risk and benefit evaluation, distinguishing medication types, following deprescribing process, and stepwise approach. Version 1 of De-TOPPLE was developed after two rounds of the Delphi process.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Olivia P. P. Demichelis, Sarah A. A. Grainger, Ruth E. E. Hubbard, Julie D. D. Henry
Summary: Social frailty, defined as an inability to meet basic social needs, is considered a threat to both physical and mental health. This study examined whether emotion regulation mediates the relationship between social frailty and important well-being outcomes (stress, anxiety, and depression). The results showed that higher social frailty predicted increased stress, anxiety, and depression, and these relationships were partially mediated by emotion regulation capacity. These findings suggest that emotion regulation abilities may serve as a protective factor against the negative consequences of social frailty.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Judith A. A. Singleton, Esther T. -L. Lau, Lisa M. M. Nissen
Summary: This study aimed to investigate waste disposal behaviors in a hospital pharmacy department. Bin audits revealed recyclable waste percentages ranging from 4.9% to 36.1% in the clinical waste stream, and from 14.3% to 44.4% in the general waste stream. Lack of recycling bins in the main dispensing areas and confusion over the correct disposal of original containers and non-contaminated packaging waste were identified as reasons for poor waste segregation. Provision of commingled recycling bins and education on waste segregation processes can improve waste management in hospital pharmacy departments.
JOURNAL OF PHARMACY PRACTICE AND RESEARCH
(2023)
Article
Medicine, General & Internal
Jean Spinks, Richard Violette, Douglas I. R. Boyle, Dennis Petrie, Laura Fanning, Kerry K. Hall, Fiona Kelly, Amanda J. Wheeler, Robert S. Ware, Joshua Byrnes, Esa Chen, Andrew Donald, Nicolette Ellis, Megan DelDot, Lisa Nissen
Summary: The ACTMed program aims to use information technology and financial incentives to encourage collaboration between pharmacists and general practitioners, thereby reducing the risk of medication-related problems and improving the quality and efficiency of healthcare services.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Medicine, General & Internal
E. H. Gordon, N. M. Peel, R. E. Hubbard, N. Reid
Summary: This study aimed to measure frailty in younger adult inpatients and compare it with middle-aged and older adult inpatients. The results showed a high prevalence of frailty among younger patients and that frailty was associated with longer length of stay.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Danielle Mazza, Anisa Rojanapenkul Assifi, Safeera Yasmeen Hussainy, Deborah Bateson, Stefanie Johnston, Jane Tomnay, Jessica Kasza, Jody Church, Luke E. Grzeskowiak, Lisa Nissen, Sharon Tracey Cameron
Summary: The ALLIANCE trial aims to compare the subsequent uptake of effective contraception in women seeking emergency contraceptive pills or medical abortion medicines who receive the ALLIANCE community pharmacy-based intervention with those who do not receive the intervention.