Article
Nutrition & Dietetics
Bernadette Leser, Nina Dalkner, Adelina Tmava-Berisha, Frederike T. Fellendorf, Human-Friedrich Unterrainer, Tatjana Stross, Alexander Maget, Martina Platzer, Susanne A. Bengesser, Alfred Haussl, Ina Zwigl, Armin Birner, Robert Queissner, Katharina Stix, Linda Wels, Elena M. D. Schonthaler, Melanie Lenger, Andreas R. Schwerdtfeger, Sieglinde Zelzer, Markus Herrmann, Eva Z. Reininghaus
Summary: Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. This study aimed to investigate the association between vitamin D metabolites and cognitive ability in individuals with bipolar disorder. The results showed no significant association between vitamin D metabolites and cognitive domains. Therefore, this study does not support the role of vitamin D metabolism as a modulating factor of cognitive function in euthymic bipolar disorder patients.
Article
Physiology
Anna Ksiazek, Aleksandra Zagrodna, Giovanni Lombardi, Malgorzata Slowinska-Lisowska
Summary: Novel markers of vitamin D status, such as free 25-(OH)D and the vitamin D metabolite ratio, show seasonal rhythms in athletes, while markers of psychophysical stress and free 25-(OH)D do not exhibit clear rhythmicity. Additionally, strong correlations exist between vitamin D metabolites in different training periods.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Tomozumi Takatani, Yuzuka Kunii, Mamoru Satoh, Akifumi Eguchi, Midori Yamamoto, Kenichi Sakurai, Rieko Takatani, Fumio Nomura, Naoki Shimojo, Chisato Mori
Summary: The correlation between maternal vitamin D concentrations and birth outcomes is conflicting. This study found that the maternal vitamin D metabolite ratio, specifically VMR2, is associated with neonatal anthropometric data regardless of 25(OH)D concentrations. Accurate measurement of vitamin D metabolites can help understand the effects of vitamin D on birth outcomes.
Article
Nutrition & Dietetics
Seunghye Lee, Hye Jin Chung, Sehyun Jung, Ha Nee Jang, Se-Ho Chang, Hyun-Jung Kim, Min-Chul Cho
Summary: Appropriate management of vitamin D deficiency and hyperparathyroidism is essential in preventing metabolic bone disorder and cardiovascular diseases in chronic kidney disease. The study found that the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (VMR) can serve as a useful biomarker for evaluating metabolic bone disorder in CKD patients. The study concluded that 24,25-dihydroxyvitamin D and VMR have the potential to be reliable vitamin D biomarkers in CKD patients.
Article
Medical Laboratory Technology
Anna Ksiazek, Aleksandra Zagrodna, Giovanni Lombardi, Malgorzata Slowinska-Lisowska
Summary: The main objective of this study was to assess 25-(OH)DF, vitamin D metabolites, and VMRs in inactive men and athletes. The results showed that regular long-term physical activity had no effect on the concentration of vitamin D metabolites at rest. Furthermore, free vitamin D did not correlate more strongly with vitamin D metabolites and VMRs compared to total.
CLINICA CHIMICA ACTA
(2023)
Article
Medical Laboratory Technology
Etienne G. Cavalier, Callum G. Fraser, Harjit Pal C. Bhattoa, Annemieke C. Heijboer, Konstantinos Makris, Samuel Vasikaran, Loreen Huyghebaert, Stephanie Peeters, Caroline Le Goff, Markus Herrmann, Anna Carobene
Summary: The study evaluated the biological variation (BV) of 24,25-dihydroxyvitamin D (24,25(OH)2D) in the European Biological Variation Study (EuBIVAS) cohort samples to determine the analytical performance specifications (APS) for 24,25(OH)2D. The results showed that the variation of 24,25(OH)2D concentration over a 10-week period was 34.6%, and methods for detecting significant changes in 24,25(OH)2D production would need relative measurement uncertainties of less than 14.9% or 10.5%, depending on the level of significance.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Fisheries
S. Rider, V. Verlhac-Trichet, D. Constant, E. Chenal, S. Etheve, B. Riond, H. Schmidt-Posthaus, R. Schoop
Summary: The vitamin D endocrine system is essential for regulating the expression of various genes in vertebrates, including those related to bone health, growth, nutrient metabolism, and immunity. Salmonids have high requirements for vitamin D compared to other aquaculture species. However, factors such as aquafeed composition, growth in seawater, and production challenges may lead to suboptimal activation of vitamin D hormone in fish.
Article
Medicine, General & Internal
P. G. Vaughan-Shaw, G. Grimes, J. P. Blackmur, M. Timofeeva, M. Walker, L. Y. Ooi, Victoria Svinti, Kevin Donnelly, F. V. N. Din, S. M. Farrington, M. G. Dunlop
Summary: This study found that oral vitamin D supplementation can induce beneficial gene expression effects in human rectal epithelium, leading to anti-tumour effects. However, only a minority of participants showed significant responses to vitamin D supplementation. Changes in HIPK2 and PPP1CC expression serve as blood biomarkers of mucosal transcriptomic response.
Article
Dermatology
Maria Siekkeri Vandikas, Kerstin Landin-Wilhelmsen, Sam Polesie, Martin Gillstedt, Amra Osmancevic
Summary: Higher levels of serum vitamin D-binding protein have been found in patients with psoriasis compared to healthy controls, suggesting a potential role in inflammation. Treatment with etanercept for 24 weeks resulted in improvements in psoriasis and a decrease in highly sensitive C-reactive protein levels. Higher baseline levels of vitamin D were associated with faster and greater improvement in psoriasis, indicating a potential predictive value for treatment outcomes.
ACTA DERMATO-VENEREOLOGICA
(2021)
Editorial Material
Immunology
Cihan Bedel, Mustafa Korkut, Hamit Hakan Armagan
Summary: The article discusses the diagnostic and predictive roles of NLR, d-NLR and PLR in COVID-19 patients, with an emphasis on NLR as an independent prognostic biomarker. While acknowledging the authors' valuable contribution to the literature, attention is also drawn to cases that require more attention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dae-Hyun Ko, Sun-Hee Jun, Youngwon Nam, Sang H. Song, Minje Han, Yeo-Min Yun, Kyunghoon Lee, Junghan Song
Summary: A multiplex LC-MS/MS method was developed to determine bioavailable vitamin D and VMR, showing differences in bioavailable vitamin D levels among different ethnicities. The new method was robust and reliable, suitable for routine clinical samples.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Food Science & Technology
Chao Lu, Weihua Zhou, Xinjue He, Xinxin Zhou, Chaohui Yu
Summary: The study found that patients with celiac disease have lower Vitamin D levels compared to controls, which improve after treatment, but there is no difference in Vitamin D Receptor genotypes between the two groups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Multidisciplinary Sciences
Pavel Dusek, Ales Kopal, Michaela Brichova, Jan Roth, Olga Ulmanova, Jiri Klempir, Jana Lizrova Preiningerova, Andreas Neueder, Alfred S. Lewin
Summary: This study aimed to compare retinal parameters in Huntington's disease and evaluate their value as markers of disease progression. The study found small retinal changes in patients with Huntington's disease, but these changes are not suitable as biomarkers for disease progression.
Article
Biotechnology & Applied Microbiology
Jiaye Liu, Junyi Shen, Chunyang Mu, Yang Liu, Dongsheng He, Han Luo, Wenshuang Wu, Xun Zheng, Yi Liu, Sunrui Chen, Qiuwei Pan, Yiguo Hu, Yinyun Ni, Yang Wang, Yong Liu, Zhihui Li
Summary: The study demonstrates a new method involving the one-step self-assembly of calcitriol and amphiphilic cholesterol-based conjugates to form a stable minimalist micellar nanosystem for anticancer treatment, which shows promising efficacy and biocompatibility.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Alexandra M. Sparks, Susan E. Johnston, Ian Handel, Jill G. Pilkington, Jacqueline Berry, Josephine M. Pemberton, Daniel H. Nussey, Richard J. Mellanby
Summary: This study reveals that vitamin D levels in wild Soay sheep are genetically influenced and positively associated with female survival and fecundity. It provides evidence for the potential response of vitamin D levels to natural selection and offers new insights into the association between vitamin D metabolism and fitness in wild environments.