期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 64, 期 4, 页码 788-797出版社
WILEY
DOI: 10.1111/jgs.14077
关键词
potentially inappropriate medications; Beers criteria; older adults; database study; pharmacoepidemiology; Medicare
资金
- Pharmacoepidemiology Gillings Innovation Lab for the Population-Based Evaluation of Drug Benefits and Harms in Older U.S. Adults [GIL 200811.0010]
- Center for Pharmacoepidemiology, Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina (UNC)
- CER Strategic Initiative, UNC Clinical Translational Science Award [UL1TR001111]
- Cecil G. Sheps Center for Health Services Research, UNC
- UNC School of Medicine
- MECESUP Chile [UCH0811]
- National Institute on Aging (NIA) [R01 AG023178]
ObjectivesTo estimate the prevalence and determinants of the use of potentially inappropriate medications (PIMs) in older U.S. adults using the 2012 Beers criteria. DesignRetrospective cohort study in a random national sample of Medicare beneficiaries. SettingFee-for-service Medicare beneficiaries from 2007 to 2012. ParticipantsU.S. population aged 65 and older with Parts A, B, and D enrollment in at least 1month during a calendar year (N=38,250 individuals; 1,308,116 observations). MeasurementsThe 2012 Beers criteria were used to estimate the prevalence of the use of PIMs in each calendar month and over a 12-month period using data on diagnoses or conditions present in the previous 12months. Generalized estimating equations were used to account for the dependence of multiple monthly observations of a single person when estimating 95% confidence intervals (CIs), and logistic regression was used to identify independent determinants of PIM use. ResultsThe point prevalence of the use of PIMs decreased from 37.6% (95% CI=37.0-38.1) in 2007 to 34.2% (95% CI=33.6-34.7) in 2012, with a statistically significant 2% (95% CI=1-3%) decline per year assuming a linear trend. The 1-year period prevalence declined from 64.9% in 2007 to 56.6% in 2012. The strongest predictor of PIM use was the number of drugs dispensed. Individuals aged 70 and older and those seen by a geriatrician were less likely to receive a PIM. ConclusionFrom 2007 to 2012, the prevalence of PIM use in older U.S. adults decreased according to the 2012 Beers criteria, although it remains high, still affecting one-third each month and more than half over 12months. The number of dispensed prescriptions could be used to target future interventions.
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