Article
Gastroenterology & Hepatology
Fabian Bartsch, Johannes Eberhard, Felix Rueckert, Moritz Schmelzle, Nadja Lehwald-Tywuschik, Stefan Fichtner-Feigl, Jochen Gaedcke, Karl J. Oldhafer, Felix Oldhafer, Markus Diener, Arianeb Mehrabi, Utz Settmacher, Thomas Becker, Tobias Keck, Helmut Friess, Benjamin Struecker, Sabine Opitz, Johannes Lemke, Andreas Schnitzbauer, Hauke Lang
Summary: Repeated resection of intrahepatic cholangiocarcinoma (ICC) shows acceptable morbidity and mortality rates, with improved long-term survival outcomes. Factors such as preoperative CA19-9 levels, R status of initial liver resection, and time to recurrence play significant roles in determining the feasibility of repeated resection. Structured follow-up post-ICC resection is crucial for early identification and management of recurrent cases.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Jiawei Zhang, Qiming Huang, Yi Yang, Jiahui Zhang, Xueting Fang, Yubin Yang, Huifang Liang, Wei Wang, Yanjun Wang
Summary: The role of carbonic anhydrase II (CAII) in intrahepatic cholangiocarcinoma (ICC) was investigated and a novel prognostic system combining CAII and preoperative carbohydrate antigen 19-9 (CA19-9) was established to predict the survival of patients with ICC after curative resection.
Article
Gastroenterology & Hepatology
Kenichiro Kodama, Tomokazu Kawaoka, Masanari Kosaka, Yusuke Johira, Yuki Shirane, Ryoichi Miura, Shigeki Yano, Serami Murakami, Kei Amioka, Kensuke Naruto, Yuwa Ando, Yumi Kosaka, Shinsuke Uchikawa, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Wataru Okamoto, Masami Yamauchi, Daiki Miki, Michio Imamura, Shintaro Kuroda, Tsuyoshi Kobayashi, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama
Summary: This study retrospectively evaluated the effects of calcium channel blockers (CCBs) on patients with intrahepatic cholangiocarcinoma. The results showed that the overall survival and recurrence-free survival of patients treated with CCBs were significantly higher, indicating that CCBs treatment might improve the prognosis of patients with intrahepatic cholangiocarcinoma.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Chongyu Zhao, Chaobin He, Jiawei Lu, Xin Huang, Cheng Chen, Xiaojun Lin
Summary: By investigating the progression patterns of recurrent intrahepatic cholangiocarcinoma patients and developing a nomogram for predicting post-progression survival, new evidence for precise postoperative and post-progression management of these patients can be provided.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sungeun Park, Youngeun Lee, Haeryoung Kim, Mi Hye Yu, Eun Sun Lee, Jeong Hee Yoon, Ijin Joo, Jeong Min Lee
Summary: Liver magnetic resonance imaging (MRI) can differentiate different subtypes of intrahepatic cholangiocarcinoma (iCCA) and predict patients' survival outcomes. Patients with MRI features suggestive of the large-duct (LD) type have poorer prognosis, and combining multiple features can better differentiate the LD type. Therefore, preoperative liver MRI is clinically significant in predicting the subtype of iCCA and the survival outcomes of patients.
Article
Oncology
Gaya Spolverato, Giulia Capelli, Giulia Lorenzoni, Dario Gregori, Jin He, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Oliver Soubrane, Guillaume Martel, Bas Groot Koerkamp, Endo Itaru, Yi Lv, Timothy M. Pawlik
Summary: The study aimed to develop a dynamic prognostic model for patients undergoing curative-intent resection for intrahepatic cholangiocarcinoma (ICC) using landmark analysis. The model incorporated selected variables and their interaction with time to predict overall survival (OS) over time. The model demonstrated good discrimination ability and accuracy in internal validation.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Hongxu Zhu, Longrong Wang, Miao Wang, Xigan He, Weiqi Xu, Weiping Zhu, Yiming Zhao, Lu Wang
Summary: This study suggests that a resection margin length >= 1.0 cm is associated with significantly improved survival in patients undergoing resection for intrahepatic cholangiocarcinoma (ICC). Therefore, achieving a clear margin of at least 1.0 cm during ICC resection is recommended for better outcomes.
AMERICAN JOURNAL OF SURGERY
(2021)
Review
Medicine, General & Internal
Ruslan Alikhanov, Anna Dudareva, Miguel Angel Trigo, Alejandro Serrablo
Summary: Intrahepatic cholangiocarcinoma (iCCA) usually requires surgical treatment, even in cases of macrovascular invasion, as surgery offers the only chance of cure. However, tumor recurrence is common post-surgery and long-term prognosis is poor, indicating the need for multimodal treatment to improve outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Li-Ming Deng, Yi Wang, Jin-Huan Yang, Jia-Liang Li, Zi-Yan Chen, Wen-Ming Bao, Kai-Yu Chen, Xin-Fei Yao, Chong-Ming Zheng, Jiu-Yi Zheng, Zheng-Ping Yu, Bin Jin, Gang Chen
Summary: Diffuse reduction of spleen density (DROSD) in intrahepatic cholangiocarcinoma (ICC) patients is associated with poorer overall survival (OS) and recurrence-free survival (RFS). A nomogram created with independent risk factors, including DROSD, was found to accurately predict the prognosis of ICC patients with good reliability.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhi-Peng Liu, Wei-Yue Chen, Yan-Qi Zhang, Yan Jiang, Jie Bai, Yu Pan, Shi-Yun Zhong, Yun-Ping Zhong, Zhi-Yu Chen, Hai-Su Dai
Summary: This study evaluated the impact of postoperative morbidity on tumor recurrence and mortality in patients with HCCA following curative resection. The results showed that postoperative morbidity is associated with decreased overall survival and recurrence-free survival, especially in cases of major morbidity.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Chaobin He, Chongyu Zhao, Jiawei Lu, Xin Huang, Cheng Chen, Xiaojun Lin
Summary: The study demonstrated that modified Glasgow Prognostic Score (mGPS) is significantly associated with survival outcomes in intrahepatic cholangiocarcinoma (iCCA) patients, with superior predictive accuracy compared to other inflammation-based scores. Therefore, mGPS can serve as an effective preoperative prognostic factor to guide subsequent treatment and surveillance for patients with iCCA.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tatsuo Matsuda, Yuzo Umeda, Tadakazu Matsuda, Yoshikatsu Endo, Daisuke Sato, Toru Kojima, Kenta Sui, Masaru Inagaki, Tetsuya Ota, Masayoshi Hioki, Masahiro Oishi, Masashi Kimura, Toshihiro Murata, Nobuhiro Ishido, Takahito Yagi, Toshiyoshi Fujiwara
Summary: The study identified the prognostic nutritional index (PNI) as a useful indicator for predicting postoperative complications and prognosis in patients with intrahepatic cholangiocarcinoma. Patients with a low PNI had higher rates of complications and worse overall survival outcomes.
Article
Oncology
So Jeong Yoon, Sunghae Park, Hongbeom Kim, Sang Hyun Shin, Jin Seok Heo, Jinsoo Rhu, Gyu-Seong Choi, Jong Man Kim, Jae -Won Joh, In Woong Han
Summary: This study aimed to investigate the risk factors for intrahepatic cholangiocarcinoma (IHCCC) and explore the prognostic significance of tumor multiplicity after surgical resection. The study found that patients with multiple tumors had poorer survival than patients with a single tumor. The oncologic significance of tumor multiplicity in IHCCC should be reconsidered in the next staging system update.
CANCER RESEARCH AND TREATMENT
(2023)
Review
Surgery
Nikolaos Machairas, Ioannis D. Kostakis, Dimitrios Schizas, Stylianos Kykalos, Nikolaos Nikiteas, Georgios C. Sotiropoulos
Summary: The study found that compared to open liver resection, laparoscopic surgery in the treatment of intrahepatic cholangiocarcinoma results in smaller tumors, less extensive resections, higher R0 resection rates, less blood loss, lower transfusion requirements, decreased overall morbidity, and shorter hospital stays. However, there were no significant differences between the two groups in terms of operative time, major complications, mortality, and long-term survival rates.
UPDATES IN SURGERY
(2021)
Review
Oncology
Woo Jin Choi, Phil J. Williams, Marco P. A. W. Claasen, Tommy Ivanics, Marina Englesakis, Steven Gallinger, Bettina Hansen, Gonzalo Sapisochin
Summary: This systematic review identifies prognostic factors for early recurrence and 24-month disease-free survival after curative-intent resection of intrahepatic cholangiocarcinoma (iCCA). Multiple tumors, microvascular invasion, macrovascular invasion, lymph node metastasis, and R1 resection were associated with increased risk for early recurrence or reduced 24-month disease-free survival. Receipt of adjuvant chemo/radiation therapy was associated with improved outcomes. Cirrhosis, sex, and HBV status were not associated with early recurrence or 24-month disease-free survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Laura Alaimo, Zorays Moazzam, Zachary J. Brown, Yutaka Endo, Andrea Ruzzenente, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Olivier Soubrane, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik
Summary: This study aimed to investigate the patterns of recurrence after surgery for intrahepatic cholangiocarcinoma (ICC) in relation to lymph node status, tumor extension, tumor burden score (TBS), and adjuvant chemotherapy. The results showed that the peak of recurrence typically occurred at 6.6 months after surgery. Among patients with negative lymph nodes, T4-category had a higher peak rate of recurrence compared to other T-categories, while high TBS was associated with an earlier peak of recurrence. Among patients with positive lymph nodes, T2-T4 categories had multiple peaks of recurrence with higher hazard rates during the first 3 years after surgery compared to the T1-category, and high TBS groups had an earlier and higher peak rate of recurrence. The administration of adjuvant chemotherapy was associated with delayed hazard rates of recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yutaka Endo, Zorays Moazzam, Laura Alaimo, Henrique A. Lima, Muhammad M. Munir, Chanza F. Shaikh, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Minoru Kitago, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas G. Koerkamp, Itaru Endo, Timothy M. Pawlik
Summary: The study developed a predictive model based on tumor characteristics to help identify which patients may benefit the most from adjuvant chemotherapy after resection of ICC. Results showed that patients receiving AC had a survival benefit in high/medium-risk categories but not in low-risk category.
Article
Surgery
Zorays Moazzam, Laura Alaimo, Yutaka Endo, Henrique A. Lima, Andrea Ruzzenente, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas Groot Koerkamp, Itaru Endo, Jordan Cloyd, Aslam Ejaz, Timothy M. Pawlik
Summary: This study investigated the roles of CA19-9 and TBS in intrahepatic cholangiocarcinoma, and found that both CA19-9 and TBS were associated with overall survival and recurrence. The combined use of CA19-9 and TBS, evaluated by the CTC grading system, can predict prognosis in these patients.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Article
Multidisciplinary Sciences
Friso Achterberg, Babs G. Sibinga Mulder, Quisette Janssen, Bas Groot A. Koerkamp, Lieke L. Hol, Rutger Quispel, Bert Bonsing, Alexander E. Vahrmeijer, Casper H. J. van Eijck, Daphne Roos, Lars Perk, Erwin van der Harst, Peter-Paul L. O. Coene, Michail Doukas, Frank M. M. Smedts, Mike Kliffen, Marie-Louise F. van Velthuysen, Valeska Terpstra, Arantza Farina Sarasqueta, Hans Morreau, J. Sven D. Mieog
Summary: This study investigates the incremental diagnostic value of Next-Generation Sequencing (NGS) in patients with inconclusive diagnosis, showing that NGS can speed up the diagnostic process, prevent repeated procedures, and significantly change the final diagnosis and treatment plan.
Article
Medicine, Research & Experimental
Nikki S. IJzerman, Wills F. Filipe, Peter de Bruijn, Florian E. Buisman, Leni van Doorn, Pascal G. Doornebosch, Jessica J. Holster, Cecile Grootscholten, Dirk J. Gruenhagen, Christian P. E. van Bommel, Marjolein Y. V. Homs, Niels F. M. Kok, Cornelis Verhoef, Bas Groot Koerkamp, Koert F. D. Kuhlmann, Ron H. J. Mathijssen, Stijn L. W. Koolen
Summary: This study aimed to quantify the systemic exposure of floxuridine and found that most patients had low concentrations of floxuridine, which decreased over time, indicating minimal systemic side-effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Surgery
Niccolo Napoli, Concetta Cacace, Emanuele F. Kauffmann, Leia Jones, Michael Ginesini, Cesare Gianfaldoni, Alice Salamone, Fabio Asta, Allegra Ripolli, Armando Di Dato, Olivier R. Busch, Marie L. Cappelle, Ying Jui Chao, Roeland F. de Wilde, Thilo Hackert, Jin-Young Jang, Bas Groot Koerkamp, Wooil Kwon, Daan Lips, Misha D. P. Luyer, Felix Nickel, Olivier Saint-Marc, Yan-Shen Shan, Baiyong Shen, Fabio Vistoli, Marc G. Besselink, Mohammad Abu Hilal, Ugo Boggi
Summary: This study developed a difficulty score for robotic pancreatoduodenectomy, which can predict severe postoperative complications. The score was validated in multiple cohorts and showed good performance in predicting complications. The score also predicted other surgical outcomes and is available online.
Correction
Medicine, Research & Experimental
F. L. Vissers, A. Balduzzi, E. A. van Bodegraven, J. van Hilst, S. Festen, M. Abu Hilal, H. J. Asbun, J. S. D. Mieog, B. Groot Koerkamp, O. R. Busch, F. Daams, M. Luyer, M. De Pastena, G. Malleo, G. Marchegiani, J. Klaase, I. Q. Molenaar, R. Salvia, H. C. van Santvoort, M. Stommel, D. Lips, M. Coolsen, C. Bassi, C. van Eijck, M. G. Besselink
Article
Surgery
Yutaka Endo, Zorays Moazzam, Selamawit Woldesenbet, Henrique Araujo Lima, Laura Alaimo, Muhammad Musaab Munir, Chanza F. Shaikh, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Minoru Kitago, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik
Summary: The prognostic impact of major postoperative complications (POCs) for intrahepatic cholangiocarcinoma (ICC) remains unclear. This study analyzed the relationship between POCs and outcomes relative to lymph node metastases (LNM) and tumor burden score (TBS). The results showed that the presence of POCs was associated with an increased risk of recurrence and death in low TBS/N0 patients, but not in high TBS and/or N1 patients.
WORLD JOURNAL OF SURGERY
(2023)
Article
Oncology
Kevin C. Soares, Joshua S. Jolissaint, Sarah M. McIntyre, Kenneth P. Seier, Mithat Gonen, Carlie Sigel, Naaz Nasar, Andrea Cercek, James J. Harding, Nancy E. Kemeny, Louise C. Connell, Bas Groot Koerkamp, Vinod P. Balachandran, Michael I. D'Angelica, Jeffrey A. Drebin, T. Peter Kingham, Alice C. Wei, William R. Jarnagin
Summary: The role of locoregional therapy versus systemic chemotherapy for unresectable intrahepatic cholangiocarcinoma remains controversial. This study compared overall survival in patients treated with resection, hepatic arterial infusion pump chemotherapy, or systemic chemotherapy, and evaluated the efficacy of locoregional salvage therapy. The findings highlight the importance of hepatic disease control and the potential benefits of liver-directed therapy.
Article
Surgery
Simone Augustinus, Tara M. Mackay, Bodil Andersson, Joal D. Beane, Olivier R. Busch, Elizabeth M. Gleeson, Bas G. Koerkamp, Tobias Keck, Hjalmar C. van Santvoort, Bobby Tingstedt, Ulrich F. Wellner, Caroline Williamsson, Marc G. Besselink, Henry A. Pitt
Summary: The study defines and assesses Ideal Outcome in the national or multicenter registries of North America, Germany, the Netherlands, and Sweden. The composite outcome measure, Ideal Outcome, can be used for auditing and comparing outcomes after pancreatoduodenectomy. The observed differences can guide collaborative initiatives to improve the outcomes of pancreatic surgery.
Article
Oncology
Tao Wei, Jianfeng Lu, Xue-Lian Xiao, Matthew Weiss, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Oliver Soubrane, Guillaume Martel, Bas Groot Koerkamp, Endo Itaru, Yi Lv, Xu-Feng Zhang, Timothy M. Pawlik
Summary: Intrahepatic cholangiocarcinoma (ICC) can be classified into two subtypes based on the anatomical origin of tumors, and these subtypes have distinct clinicopathological features and survival outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Letter
Oncology
Florian E. Buisman, Dirk J. Gruenhagen, Cornelis Verhoef, Bas Groot Koerkamp
EUROPEAN JOURNAL OF CANCER
(2023)
Meeting Abstract
Oncology
Stijn Franssen, Lydi M. J. W. Van Driel, Adriaan Moelker, Bas Groot Koerkamp
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Immunology
Eveline E. Vietsch, Diba Latifi, Maaike Verheij, Elise W. A. van der Oost, Roeland F. de Wilde, Roel Haen, Anne Loes van den Boom, Bas Groot Koerkamp, Pascal G. Doornebosch, Victorien M. T. van Verschuer, Ariadne H. A. G. Ooms, Farzana Mohammad, Marcella Willemsen, Joachim G. J. V. Aerts, Ricki T. Krog, Noel F. C. C. de Miranda, Thierry P. P. van den Bosch, Yvonne M. Mueller, Peter D. Katsikis, Casper H. J. van Eijck
Summary: This study analyzed the healthy appendix tissue of PDAC patients and found increased inflammation and cytotoxic activity in the GALT. Additionally, the appendix microbiome of PDAC patients had higher levels of certain pathogenic bacteria and lower levels of commensal bacteria.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
J. Chen, S. Augustinus, A. Engelsman, B. Bonsing, Groot B. Koerkamp, C. van Eijck, I de Hingh, S. Bouwense, M. Besselink, Nieveen E. van Dijkum
JOURNAL OF NEUROENDOCRINOLOGY
(2023)