Identification of Four New Chemical Series of Small Drug‐Like Natural Products as Potential Neuropilin‐1 Inhibitors by Structure‐Based Virtual Screening: Pharmacophore‐Based Molecular Docking and Dynamics Simulation

Structure-Based Identification of Potential Drugs Against FmtA of Staphylococcus aureus: Virtual Screening, Molecular Dynamics, MM-GBSA, and QM/MM

(2021) Vikram Dalal et al.   PROTEIN JOURNAL

Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry

(2021) Samantha Perez-Miller et al.   ACS Chemical Neuroscience

Neuropilin-1 Assists SARS-CoV-2 Infection by Stimulating the Separation of Spike Protein Domains S1 and S2

(2021) Li Zhen-lu et al.   BIOPHYSICAL JOURNAL

Structure of dye-decolorizing peroxidase from Bacillus subtilis in complex with veratryl alcohol

(2021) Poonam Dhankhar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19)

(2020) Pere Domingo et al.   EBioMedicine

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability

(2019) Zhoutong Sun et al.   CHEMICAL REVIEWS

NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model

(2018) Wang-Qing Liu et al.   CANCER LETTERS

Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1

(2017) Dagmara Tymecka et al.   PEPTIDES

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy

(2017) Sohini Roy et al.   Frontiers in Immunology

Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1

(2016) Karolina Grabowska et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity

(2015) Gerald J Prud'homme et al.   Oncotarget

Discovery of novel inhibitors of vascular endothelial growth factor-A–Neuropilin-1 interaction by structure-based virtual screening

(2014) Anna Starzec et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and structure–activity relationship of non-peptidic antagonists of neuropilin-1 receptor

(2014) Wang-Qing Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors

(2014) Amita Patnaik et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model

(2014) Lucia Borriello et al.   CANCER LETTERS

A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors

(2014) Colin D. Weekes et al.   INVESTIGATIONAL NEW DRUGS

Drug-Like ProteinProtein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology

(2014) Bruno O. Villoutreix et al.   Molecular Informatics

Super Natural II—a database of natural products

(2014) Priyanka Banerjee et al.   NUCLEIC ACIDS RESEARCH

Neuropilin 1: function and therapeutic potential in cancer

(2013) Belal Chaudhary et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization

(2012) Nicholas G.M. Davies et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting VEGF signalling via the neuropilin co-receptor

(2012) Snezana Djordjevic et al.   DRUG DISCOVERY TODAY

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

(2012) Matthew W. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Good Are State-of-the-Art Docking Tools in Predicting Ligand Binding Modes in Protein–Protein Interfaces?

(2012) Dennis M. Krüger et al.   Journal of Chemical Information and Modeling

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Targeting the Proangiogenic VEGF-VEGFR Protein-Protein Interface with Drug-like Compounds by In Silico and In Vitro Screening

(2011) Benoit Gautier et al.   CHEMISTRY & BIOLOGY

Multifaceted Role of Neuropilins in Cancer

(2011) S. Rizzolio et al.   CURRENT MEDICINAL CHEMISTRY

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Neuropilins: A New Target for Cancer Therapy

(2011) Camille Grandclement et al.   Cancers

Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1

(2010) Alexandre Novoa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution

(2010) Jeremy R. Greenwood et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

(2010) Ashley Jarvis et al.   JOURNAL OF MEDICINAL CHEMISTRY

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The relationship between the solvent-accessible surface area of a protein and the number of native contacts in its structure

(2008) N. S. Bogatyreva et al.   MOLECULAR BIOLOGY

Radius of gyration as an indicator of protein structure compactness

(2008) M. Yu. Lobanov et al.   MOLECULAR BIOLOGY