Mycobacterium avium Infection of Multinucleated Giant Cells Reveals Association of Bacterial Survival to Autophagy and Cholesterol Utilization

Monocyte progenitors give rise to multinucleated giant cells

(2021) Anne Kathrin Lösslein et al.   Nature Communications

The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini

(2020) Ajitesh Lunge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early cell-autonomous accumulation of neutral lipids during infection promotes mycobacterial growth

(2020) Colleen M. McClean et al.   PLoS One

An Overview of the Derivation and Function of Multinucleated Giant Cells and Their Role in Pathological Processes

(2019) Patricia Joyce Brooks et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor Necrosis Factor-Alpha Antagonist Interferes With the Formation of Granulomatous Multinucleated Giant Cells: New Insights Into Mycobacterium tuberculosis Infection

(2019) Soraya Mezouar et al.   Frontiers in Immunology

A Comprehensive Review on the Manipulation of the Sphingolipid Pathway by Pathogenic Bacteria

(2019) Monica Rolando et al.   Frontiers in Cell and Developmental Biology

Lipid metabolism and its implication in mycobacteria–host interaction

(2018) Gabriela Gago et al.   CURRENT OPINION IN MICROBIOLOGY

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

(2018) Matthew Knight et al.   PLoS Pathogens

Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesis

(2018) Kaley M Wilburn et al.   Pathogens and Disease

Genome analysis of Mycobacterium avium subspecies hominissuis strain 109

(2018) William M. Matern et al.   Scientific Data

Comparative analysis of the genomes of clinical isolates of Mycobacterium avium subsp. hominissuis regarding virulence-related genes

(2017) Brendan Jeffrey et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Clinical Mycobacterium abscessus strain inhibits autophagy flux and promotes its growth in murine macrophages

(2017) Seong-Woo Kim et al.   Pathogens and Disease

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

(2016) Mark R. Cronan et al.   IMMUNITY

Nontuberculous mycobacterial pulmonary disease mimicking lung cancer

(2016) Su Jin Hong et al.   MEDICINE

Identification of Bicarbonate as a Trigger and Genes Involved with Extracellular DNA Export in Mycobacterial Biofilms

(2016) Sasha J. Rose et al.   mBio

Epidemiology of Human Pulmonary Infection with Nontuberculous Mycobacteria

(2015) D. Rebecca Prevots et al.   CLINICS IN CHEST MEDICINE

Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome

(2015) Qiuchan Deng et al.   INFECTION AND IMMUNITY

Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication ofMycobacterium tuberculosisin macrophages

(2015) Alexander Speer et al.   MOLECULAR MICROBIOLOGY

The autophagic machinery ensures nonlytic transmission of mycobacteria

(2015) Lilli Gerstenmaier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction

(2015) Ronny Milde et al.   Cell Reports

Mycobacterium-Host Cell Relationships in Granulomatous Lesions in a Mouse Model of Latent Tuberculous Infection

(2015) Elena Ufimtseva   Biomed Research International

Drug treatment of pulmonary nontuberculous mycobacterial disease in HIV-negative patients: the evidence

(2013) Jakko van Ingen et al.   Expert Review of Anti-Infective Therapy

Aberrant Expression of Beclin-1 and LC3 Correlates with Poor Prognosis of Human Hypopharyngeal Squamous Cell Carcinoma

(2013) Juan Wang et al.   PLoS One

Francisella tularensis Harvests Nutrients Derived via ATG5-Independent Autophagy to Support Intracellular Growth

(2013) Shaun Steele et al.   PLoS Pathogens

The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes

(2012) Delphine Milhas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The CD40-CD40L axis and IFN-  play critical roles in Langhans giant cell formation

(2011) H. Sakai et al.   INTERNATIONAL IMMUNOLOGY

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Mycobacterium avium uses apoptotic macrophages as tools for spreading

(2010) Julie Early et al.   MICROBIAL PATHOGENESIS

Mycobacterium tuberculosis Eis Regulates Autophagy, Inflammation, and Cell Death through Redox-dependent Signaling

(2010) Dong-Min Shin et al.   PLoS Pathogens

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

(2009) J. Muse Davis et al.   CELL

Novel mechanism of U18666A-induced tumour necrosis factor-α production in RAW 264·7 macrophage cells

(2009) I. Iftakhar-E-Khuda et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Giant cell formation and function

(2008) William G Brodbeck et al.   CURRENT OPINION IN HEMATOLOGY

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY