Editorial Material
Cardiac & Cardiovascular Systems
Xuan Jiang, Jinduo Liu, Tianxiang Gu
Summary: This case report describes a patient with a lipoma in the posterior tricuspid leaflet, which was successfully excised with no recurrence during follow-up. The autologous pericardium repair was effective in treating the lesion.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander A. Brescia, Tessa M. F. Watt, Liza M. Rosenbloom, Shannon L. Murray, Xiaoting Wu, Matthew A. Romano, Steven F. Bolling
Summary: The study found no differences in long-term survival or reoperation rates between anterior and posterior repairs for degenerative mitral valve disease. Surgeons at centers of excellence should aim for repair of both anterior and posterior leaflet pathology with the same decision-making threshold over valve replacement.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Cardiac & Cardiovascular Systems
David I. Blusztein, Rebecca T. Hahn
Summary: The tricuspid valve is a complex structure and tricuspid regurgitation is a complex disease process. Transcatheter devices are being investigated as a treatment option with lower morbidity and mortality. This review discusses different types of transcatheter device therapy, who to treat, and the future of device and surgical therapy trials.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Devin W. Laurence, Colton J. Ross, Ming-Chen Hsu, Arshid Mir, Harold M. Burkhart, Gerhard A. Holzapfel, Chung-Hao Lee
Summary: The study presents the experimental characterization of pre-strains in tricuspid valve leaflets for the first time and calculates the strains of different leaflets. The results show that the leaflets shrink after being explanted, with the septal leaflet experiencing the most compressive changes. The computed pre-strains are mainly due to the release of in situ annulus and chordae connections. The study also compares biomechanically oriented metrics in different stress-free reference configurations, finding smaller tissue stretches and material anisotropies compared to post-preconditioning configuration.
ACTA BIOMATERIALIA
(2022)
Article
Cardiac & Cardiovascular Systems
Atsushi Sugiura, Tetsu Tanaka, Refik Kavsur, Can Ozturk, Johanna Vogelhuber, Nihal Wilde, Marc Ulrich Becher, Sebastian Zimmer, Georg Nickenig, Marcel Weber
Summary: This study aimed to assess leaflet variation in patients undergoing transcatheter tricuspid repair and found that a 4-leaflet configuration was associated with an increased risk of residual TR and adverse clinical outcomes compared to a 3-leaflet configuration.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Lucas Burke, Magdi Hassanin, Geraldine Ong, Neil Fam
Summary: Concomitant tricuspid regurgitation is common in patients with mitral regurgitation. Though guidelines recommend repairing both valves during surgery when possible, high-risk patients are often undertreated. Advances in transcatheter edge-to-edge repair have provided new options for managing heart failure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Susheel K. Kodali, Rebecca T. Hahn, Charles J. Davidson, Akhil Narang, Adam Greenbaum, Patrick Gleason, Samir Kapadia, Rhonda Miyasaka, Firas Zahr, Scott Chadderdon, Robert L. Smith, Paul Grayburn, Robert M. Kipperman, Leo Marcoff, Brian Whisenant, Mike Gonzales, Raj Makkar, Moody Makar, William O'Neill, Dee Dee Wang, William A. Gray, Sandra Abramson, James Hermiller, Lucas Mitchel, D. Scott Lim, Dale Fowler, Mathew Williams, Sorin V. Pislaru, Abdellaziz Dahou, Michael J. Mack, Martin B. Leon, Mackram F. Eleid
Summary: The PASCAL system has shown promising results in reducing mortality and heart failure hospitalization rates, as well as improving TR severity, functional status, and quality of life in patients with severe TR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wang Wei, Li Ning, Ning Xiaoping, Xu Zhiyun, Li Bailing, Cai Chengliang, Yang Fan, Zhou Guangwei, Bai Yifan, Han Lin, Qiao Fan, Lu Fanglin
Summary: This paper reports the hemodynamic profiles of LuX-Valve, which show that the procedure improves cardiac output and right atrium pressure without significant effect on pulmonary artery pressure. Invasive right atrium pressure may be a potential indicator for evaluating and guiding the procedure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Juliano Lentz Carvalho, Hartzell V. Schaff, Rick A. Nishimura, Steve R. Ommen, Jeffrey B. Geske, Brian D. Lahr, Darrell B. Newman, Joseph A. Dearani
Summary: This study investigated the mitral valve leaflet length and outcomes of patients undergoing septal myectomy for obstructive hypertrophic cardiomyopathy. The results showed that patients with hypertrophic cardiomyopathy have slightly elongated mitral valve leaflets. However, the length of the leaflets is not significantly associated with left ventricular outflow tract gradient relief or postoperative outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Ythan H. Goldberg, Edwin Ho, Mei Chau, Azeem Latib
Summary: Severe tricuspid regurgitation is common in the elderly and associated with poor survival. Transcatheter tricuspid valve interventions show promise in improving quality of life and mortality, with valve replacement emerging as a potential preferred treatment option.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biology
Kyriakos Dimitriadis, Nikolaos Pyrpyris, Konstantinos Aznaouridis, Panagiotis Iliakis, Aggeliki Valatsou, Panagiotis Tsioufis, Eirini Beneki, Emmanouil Mantzouranis, Konstantina Aggeli, Eleftherios Tsiamis, Konstantinos Tsioufis
Summary: Tricuspid regurgitation (TR) is a commonly neglected valve pathology, but recent advancements in transcatheter interventions offer promising potential for its treatment. Percutaneously delivered devices for either valve repair or replacement have shown echocardiographic reduction in TR, symptom relief, and functional improvement in clinical trials. Personalized device selection, considering valve anatomy and available options at each heart center, as well as appropriate patient selection and timing, are crucial for successful procedures.
Article
Cardiac & Cardiovascular Systems
Eladio Sanchez, Kambiz Rezaei, Belen Ramos, Mariano Garcia-Borbolla, Jose-Miguel Borrego
Summary: A new technique for repairing the anteroseptal tricuspid valve commissure in a patient with left-sided infective endocarditis is presented in this study. The technique involves a sliding plasty of septal and posterior leaflets, with the aid of De-Vega like annuloplasty, to reach the anteroseptal commissure.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Keshav Kohli, Zhenglun Alan Wei, Vahid Sadri, Andrew W. Siefert, Philipp Blanke, Emily Perdoncin, Adam B. Greenbaum, Jaffar M. Khan, Robert J. Lederman, Vasilis C. Babaliaros, Ajit P. Yoganathan, John N. Oshinski
Summary: This study is the first to quantitatively and individually compare LVOT hemodynamics after TMVR. LAMPOON procedure can improve LVOT hemodynamics, especially for patients with a small neo-LVOT.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Valeria Cammalleri, Myriam Carpenito, Maria Caterina Bono, Simona Mega, Gian Paolo Ussia, Francesco Grigioni
Summary: Severe symptomatic tricuspid regurgitation (TR) affects millions of people globally, with surgical correction remaining controversial due to increased risks. Novel transcatheter tricuspid valve interventions (TTVI) have been developed to address this, with specific imaging protocols needed to assess anatomical feasibility and predict procedural success. Different TTVI methods have varying selection criteria, demonstrating the need for individualized approaches for patients with TR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Fang-Lin Lu, Zhao An, Ye Ma, Zhi-Gang Song, Cheng-Liang Cai, Bai-Ling Li, Guang-Wei Zhou, Lin Han, Jun Wang, Yi-Fan Bai, Xiao-Hong Liu, Jia-Feng Wang, Xu Meng, Hai-Bo Zhang, Jian Yang, Nian-Guo Dong, Sheng-Shou Hu, Xiang-Bin Pan, Anson Cheung, Fan Qiao, Zhi-Yun Xu
Summary: The study demonstrates that transcatheter tricuspid valve replacement (TTVR) is a feasible and safe treatment option with low complication rates for high-risk patients with severe tricuspid regurgitation (TR).
Article
Engineering, Biomedical
Monica Emendi, Francesco Sturla, Ram P. Ghosh, Matteo Bianchi, Filippo Piatti, Francesca R. Pluchinotta, Daniel Giese, Massimo Lombardi, Alberto Redaelli, Danny Bluestein
Summary: This study successfully reproduced the hemodynamics of congenital bicuspid aortic valve using a fully coupled fluid-structure interaction model and MRI data, providing new insights into the risk of BAV patients and revealing information not directly attainable from MRI.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Michal Jaworek, Andrea Mangini, Edoardo Maroncelli, Federico Lucherini, Rubina Rosa, Eleonora Salurso, Emiliano Votta, Carlo Antona, Gianfranco Beniamino Fiore, Riccardo Vismara
Summary: The study investigated the feasibility of using deer hearts as a pathological model for functional mitral regurgitation treatment and demonstrated the potential of deer hearts in simulating dynamic heart structures with pathological conditions.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Giordano Tasca, Michal Jaworek, Federico Lucherini, Francesco Trinca, Paola Redaelli, Carlo Antona, Riccardo Vismara
Summary: The study compared the effects of the Florida-sleeve technique and the Yacoub technique on aortic leaflet kinematics, showing significant differences in the slow closing phase. The Florida-sleeve technique exhibited notable changes in slow closing time and velocity, while the Yacoub technique showed greater leaflet displacement before rapid closing.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Engineering, Biomedical
Silvia Pozzi, Maurizio Domanin, Laura Forzenigo, Emiliano Votta, Paolo Zunino, Alberto Redaelli, Christian Vergara
Summary: A surrogate model for blood dynamics in carotid arteries with plaque was proposed, integrating numerical modeling, subject-specific data, and clinical imaging. By adjusting elastic parameters to characterize plaque and surrounding tissues, the model showed improved accuracy compared to rigid models. The validity of the proposed model was confirmed through comparisons with in vivo measurements and gold standard FSI models.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Roberta Visone, Giovanni S. Ugolini, Daniela Cruz-Moreira, Simona Marzorati, Stefano Piazza, Enrico Pesenti, Alberto Redaelli, Matteo Moretti, Paola Occhetta, Marco Rasponi
Summary: Cardiac toxicity is a common adverse outcome in drug development that can lead to withdrawal of drugs from the market. Recent advancements in developing in vitro models resembling the human heart have allowed for more accurate detection of drug-induced cardiac toxicity early in the drug development process. Organs-on-chip are considered promising tools to replicate key aspects of in vivo cardiac physiology and provide a means for direct analysis of functional outputs.
Article
Engineering, Biomedical
Silvia Bozzi, Yana Roka-Moiia, Tatiana Mencarini, Federica Vercellino, Ilenia Epifani, Kaitlyn R. Ammann, Filippo Consolo, Marvin J. Slepian, Alberto Redaelli
Summary: The study found that both mechanical stimulation and polymer surface-contact significantly contribute to platelet activation, with the latter playing a more prominent role. Platelet activation increases with increasing shear stress magnitude and has a non-linear, time-dependent relationship to exposure time. Different biomaterials have varying effects on platelet activation, with PE and PEEK having the lowest and highest prothrombotic potential, respectively.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2021)
Article
Biophysics
Alessandra Riva, Francesco Sturla, Alessandro Caimi, Silvia Pica, Daniel Giese, Paolo Milani, Giovanni Palladini, Massimo Lombardi, Alberto Redaelli, Emiliano Votta
Summary: Blood is commonly modeled as a Newtonian fluid, but this assumption may not hold true for the complex flow dynamics in the left ventricle. This study investigated the impact of different viscosity models on quantifying blood energetics, showing that accounting for non-Newtonian behavior can enhance the accuracy of intracardiac energetics assessment. The findings suggest that individualized consideration of non-Newtonian blood behavior may serve as a non-invasive index to distinguish between healthy and pathological left ventricles.
JOURNAL OF BIOMECHANICS
(2021)
Article
Biotechnology & Applied Microbiology
Daniela Cruz-Moreira, Roberta Visone, Francisco Vasques-Novoa, Antonio S. Barros, Adelino Leite-Moreira, Alberto Redaelli, Matteo Moretti, Marco Rasponi
Summary: Heart-on-chip technology can recapitulate key signals in cardiac pathophysiology, and the new platform allows precise fluid control to improve microtissue performance. Different flow patterns impact the structure and gene expression of microtissues.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Maria C. Palumbo, Alberto Redaelli, Matthew Wingo, Katherine A. Tak, Jeremy R. Leonard, Jiwon Kim, Lisa Q. Rong, Christine Park, Hannah W. Mitlak, Richard B. Devereux, Mary J. Roman, Arindam RoyChoudury, Christopher Lau, Mario F. L. Gaudino, Leonard N. Girardi, Jonathan W. Weinsaft
Summary: Prosthetic graft replacement of the ascending aorta increases downstream aortic wall shear stress and strain, which may lead to adverse aortic remodeling.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Roberto Lorusso, Samuel Heuts, Federica Jiritano, Roberto Scrofani, Carlo Antona, Guglielmo Actis Dato, Paolo Centofanti, Sandro Ferrarese, Matteo Matteuci, Antonio Miceli, Mattia Glauber, Enrico Vizzardi, Sandro Sponga, Igor Vendramin, Andrea Garatti, Carlo de Vincentis, Michele De Bonis, Silvia Ajello, Giovanni Troise, Margherita Dalla Tomba, Filiberto Serraino
Summary: This study aimed to evaluate the predictors of early mortality and complication rates in cardiac surgery patients supported by an intra-aortic balloon pump (IABP). The results showed that the use of perioperative IABP support was safe and associated with relatively low complication rates.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Editorial Material
Engineering, Biomedical
Alberto Redaelli, Mian Long
APL BIOENGINEERING
(2022)
Article
Engineering, Biomedical
Eleonora Salurso, Michal Jaworek, Francesca Perico, Matteo Frigelli, Claudia Romagnoni, Monica Contino, Guido Gelpi, Gianfranco Beniamino Fiore, Riccardo Vismara
Summary: Fresh and defrosted porcine heart samples were investigated as pathological models for tricuspid valve regurgitation. Freezing resulted in worsening of the regurgitation, indicating that frozen samples can simulate severe pathological conditions. Fresh samples were found to be a reliable ex-vivo model for mild tricuspid regurgitation.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Alice Caldiroli, Sara Cappelletti, Giovanni Birarda, Alberto Redaelli, Stefania Adele Riboldi, Chiaramaria Stani, Lisa Vaccari, Federica Piccirilli
Summary: In this study, infrared scattering-type scanning near-field optical microscopy (IR s-SNOM) and imaging, attenuated total reflection (ATR) IR imaging, and scanning electron microscopy (SEM) were used to analyze the chemical composition of fibers in hybrid electrospun meshes. The research focused on a bio-hybrid material named Silkothane®, which is a nanofibrous matrix produced from a silk fibroin-polyurethane (SFPU) blend through electrospinning for vascular tissue engineering applications. The nanoscale resolution of IR s-SNOM allowed for successful characterization of the morphology and chemistry of single fibers at both surface and subsurface levels. The findings revealed that SF and PU do not co-aggregate to form hybrid fibers at the length scale of hundreds of nanometers and suggested the presence of subdomains other than fibrillar structures. This study demonstrated the potential of IR s-SNOM as a valuable technique for understanding the chemistry of nanostructured materials and supporting their production and engineering.
Article
Cardiac & Cardiovascular Systems
Claudia Romagnoni, Monica Contino, Michal Jaworek, Rubina Rosa, Eleonora Salurso, Francesca Perico, Guido Gelpi, Riccardo Vismara, Gianfranco Beniamino Fiore, Andrea Mangini, Carlo Antona
Summary: The study showed that reorienting the commissures to 180 degrees did not improve the aortic valve gradient at rest, but could have potential benefits under stress conditions. Despite being more complex and time-consuming, this approach may be a good strategy for improving long-term outcomes, especially in young patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
