ACSL4 promotes microglia-mediated neuroinflammation by regulating lipid metabolism and VGLL4 expression

ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression

(2022) Julia Grube et al.   Cell Death & Disease

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice

(2021) Yangping Shentu et al.   BEHAVIOURAL BRAIN RESEARCH

Myeloid-Specific Deficiency of Long-Chain Acyl CoA Synthetase 4 Reduces Inflammation by Remodeling Phospholipids and Reducing Production of Arachidonic Acid–Derived Proinflammatory Lipid Mediators

(2021) Andrew R. Reeves et al.   JOURNAL OF IMMUNOLOGY

The semantics of microglia activation: neuroinflammation, homeostasis, and stress

(2021) Samuel C. Woodburn et al.   Journal of Neuroinflammation

Glial Cells: Role of the Immune Response in Ischemic Stroke

(2020) Shenbin Xu et al.   Frontiers in Immunology

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

(2020) Clotilde Lauro et al.   Frontiers in Immunology

Multiple Roles of Vestigial-Like Family Members in Tumor Development

(2020) Noritaka Yamaguchi   Frontiers in Oncology

The Role of Metabolic Enzymes in the Regulation of Inflammation

(2020) Wesley H. Godfrey et al.   Metabolites

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway

(2020) Junru Chen et al.   CANCER LETTERS

VGLL4 plays a critical role in heart valve development and homeostasis

(2019) Wei Yu et al.   PLoS Genetics

Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages

(2019) Hiroshi Kuwata et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dual function of VGLL 4 in muscle regeneration

(2019) Xue Feng et al.   EMBO JOURNAL

NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis

(2019) Shu-zhen Zhang et al.   BMC Medicine

Cellular phenotypes as inflammatory mediators in Parkinson’s disease: Interventional targets and role of natural products

(2018) Xu Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer

(2018) Lisa Sevenich   Frontiers in Immunology

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

(2018) Irene Maeve Rea et al.   Frontiers in Immunology

The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors

(2018) Thijs J. Hagenbeek et al.   Science Signaling

A lincRNA-p21/miR-181 family feedback loop regulates microglial activation during systemic LPS- and MPTP- induced neuroinflammation

(2018) Yongyi Ye et al.   Cell Death & Disease

CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling

(2018) Fan Meng et al.   BRAIN

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

(2017) Henna Martiskainen et al.   Journal of Neuroinflammation

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

(2017) Shi Jiao et al.   Nature Communications

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

(2016) Annelies Quaegebeur et al.   Cell Metabolism

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

(2016) Li Du et al.   MOLECULAR NEUROBIOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

(2016) Richard Gordon et al.   NEUROBIOLOGY OF DISEASE

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease

(2015) N. Panicker et al.   JOURNAL OF NEUROSCIENCE

Long-chain acyl-CoA esters in metabolism and signaling: Role of acyl-CoA binding proteins

(2015) Ditte Neess et al.   PROGRESS IN LIPID RESEARCH

miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth

(2015) Marija Mihailovich et al.   Nature Communications

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

(2013) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

Neuroprotective effects of genistein in VSC4.1 motoneurons exposed to activated microglial cytokines

(2011) Misty L. McDowell et al.   NEUROCHEMISTRY INTERNATIONAL

SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB

(2011) Tsutomu Sasaki et al.   NEURON

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells

(2008) Qin Yuan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY