Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Effects of sugars, fatty acids and amino acids on cytosolic and mitochondrial hydrogen peroxide release from liver cells

(2022) Jingqi Fang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice

(2021) Hoi-Shan Wong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Controlled power: how biology manages succinate-driven energy release

(2021) Shona A. Mookerjee et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Acute sources of mitochondrial NAD+ during respiratory chain dysfunction

(2020) Christos Chinopoulos   EXPERIMENTAL NEUROLOGY

Production of superoxide and hydrogen peroxide in the mitochondrial matrix is dominated by site IQ of complex I in diverse cell lines

(2020) Jingqi Fang et al.   Redox Biology

Cellpose: a generalist algorithm for cellular segmentation

(2020) Carsen Stringer et al.   NATURE METHODS

Defining the mechanism of action of S1QELs, specific suppressors of superoxide production in the quinone-reaction site in mitochondrial complex I

(2019) Atsushi Banba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of S1QELs and S3QELs to link mitochondrial sites of superoxide and hydrogen peroxide generation to physiological and pathological outcomes

(2019) Mark A. Watson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

S1QELs suppress mitochondrial superoxide/hydrogen peroxide production from site IQ without inhibiting reverse electron flow through Complex I

(2019) Hoi-Shan Wong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physiologic Implications of Reactive Oxygen Species Production by Mitochondrial Complex I Reverse Electron Transport

(2019) John O. Onukwufor et al.   Antioxidants

The use of site-specific suppressors to measure the relative contributions of different mitochondrial sites to skeletal muscle superoxide and hydrogen peroxide production

(2019) Renata L.S. Goncalves et al.   Redox Biology

Control of mitochondrial superoxide production by reverse electron transport at complex I

(2018) Ellen L. Robb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial and cytosolic sources of hydrogen peroxide in resting C2C12 myoblasts

(2018) Hoi-Shan Wong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

(2017) Shona A. Mookerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease

(2017) Filippo Scialò et al.   Frontiers in Physiology

Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I

(2016) Judy Hirst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Suppressors of superoxide production from mitochondrial complex III

(2015) Adam L Orr et al.   Nature Chemical Biology

Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessedex Vivounder Conditions Mimicking Rest and Exercise

(2014) Renata L. S. Goncalves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Novel Inhibitors of Mitochondrial sn-Glycerol 3-phosphate Dehydrogenase

(2014) Adam L. Orr et al.   PLoS One

Sources of superoxide/H2O2 during mitochondrial proline oxidation

(2014) Renata L.S. Goncalves et al.   Redox Biology

Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria

(2013) Irina V. Perevoshchikova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening

(2013) Adam L. Orr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters

(2012) Casey L. Quinlan et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Refined Analysis of Superoxide Production by Mitochondrialsn-Glycerol 3-Phosphate Dehydrogenase

(2012) Adam L. Orr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Model of the Proton Translocation Mechanism of Complex I

(2011) Jason R. Treberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I

(2011) Kenneth R. Pryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Two Sites of Superoxide Production by Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)

(2011) Jason R. Treberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production - a correction using glutathione depletion

(2010) Jason R. Treberg et al.   FEBS Journal

elastix: A Toolbox for Intensity-Based Medical Image Registration

(2009) S. Klein et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Dissociation of superoxide production by mitochondrial complex I from NAD(P)H redox state

(2008) Adrian J. Lambert et al.   FEBS LETTERS