Article
Cardiac & Cardiovascular Systems
Bernard De Bruyne, Nico H. J. Pijls, Emanuele Gallinoro, Alessandro Candreva, Stephane Fournier, Danielle C. J. Keulards, Jeroen Sonck, Marcel Van't Veer, Emanuele Barbato, Jozef Bartunek, Marc Vanderheyden, Eric Wyffels, Annemiek De Vos, Mohamed El Farissi, Pim A. L. Tonino, Olivier Muller, Carlos Collet, William F. Fearon
Summary: This study proposes microvascular resistance reserve (MRR) as a specific index for assessing coronary microvascular function, independent of autoregulation and myocardial mass, based on absolute values of coronary flow and pressure. The research found a strong correlation between continuous thermodilution-derived MRR and Doppler MRR, suggesting MRR as a specific, quantitative, and operator-independent metric for quantifying coronary microvascular dysfunction.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Joo Myung Lee, Ki Hong Choi, Jin-Oh Choi, Doosup Shin, Yoonjee Park, Juwon Kim, Seung Hun Lee, Darae Kim, Jeong Hoon Yang, Yang Hyun Cho, Kiick Sung, Ji Yeon Choi, Meesoon Park, Jung-Sun Kim, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Jae K. Oh, Eun-Seok Jeon
Summary: Assessing coronary microcirculatory dysfunction with IMR early after heart transplantation is significantly associated with the risk of acute cellular rejection, making IMR a valuable clinical tool for identifying high-risk patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chenguang Li, Yumeng Hu, Jingpu Wang, Congcong Pan, Hao Lu, Yizhe Wu, Zhangwei Chen, Zhiqiang Pei, Li Shen, Jingsong He, Xiaochang Leng, Jianping Xiang, Junbo Ge
Summary: This study compared the diagnostic performance of calculating angiography-derived IMR and FFR under baseline and hyperemic conditions. It found that calculating IMR under hyperemic conditions is more accurate, while calculating FFR under both conditions is accurate.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Medicine, General & Internal
Sylwia Iwanczyk, Patrycja Wozniak, Anna Smukowska-Gorynia, Aleksander Araszkiewicz, Alicja Nowak, Maurycy Jankowski, Aneta Konwerska, Tomasz Urbanowicz, Maciej Lesiak
Summary: Although the treatment and prognosis of patients after heart transplantation have improved significantly, late graft dysfunction, including acute allograft rejection and cardiac allograft vasculopathy, remains a critical problem. Studies have shown that assessing coronary microcirculation dysfunction, particularly by measuring the microcirculatory resistance index, can help predict graft dysfunction and optimize post-transplantation management. It is also an independent prognostic factor for transplant rejection and survival rate. However, more advanced studies are needed to fully understand the importance of microcirculatory dysfunction in patients after heart transplantation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Coen K. M. Boerhout, Guus A. de Waard, Joo Myung Lee, Hernan Mejia-Renteria, Seung Hun Lee, Ji-Hyun Jung, Masahiro Hoshino, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Ashkan Eftekhari, Mohamed A. Effat, Tadashi Murai, Koen Marques, Yolande Appelman, Joon-Hyung Doh, Evald Hoj Christiansen, Rupak Banerjee, Chang-Wook Nam, Giampaolo Niccoli, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Marcel A. M. Beijk, Paul Knaapen, Javier Escaned, Tsunekazu Kakuta, Bon -Kwon Koo, Jan J. Piek, Tim P. van de Hoef
Summary: The combined assessment of coronary flow reserve (CFR) and minimal microvascular resistance (MR) can identify two distinct subtypes of coronary microvascular dysfunction. In patients with angina and non-obstructive coronary arteries, abnormal CFR is associated with an increased risk of major adverse cardiac events (MACE) and target vessel failure (TVF) over a 5-year follow-up period. However, abnormal MR is not associated with adverse clinical events. There is no significant difference in the risk of MACE and TVF between the two subtypes of coronary microvascular dysfunction.
Article
Engineering, Multidisciplinary
M. M. Dobrolinska, P. Gasior, A. Blach, R. Gocol, D. Hudziak, W. Wojakowski
Summary: The aim of this study is to measure the acute and long-term changes in FFR, IMR, and CFR in patients undergoing TAVI procedure, and to compare the diagnostic accuracy of intracoronary indices with myocardial perfusion measured by CZT-SPECT, in order to find cut-off values defining significant stenosis.
Article
Cardiac & Cardiovascular Systems
Ashkan Eftekhari, Tim P. van de Hoef, Masahiro Hoshino, Joo Myung Lee, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Seung Hun Lee, Hernan Mejia-Renteria, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Mohamed A. Effat, Koen Marques, Joon-Hyung Doh, Rupak Banerjee, Chang-Wook Nam, Giampaolo Niccoli, Tadashi Murai, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Paul Knaapen, Niels van Royen, Javier Escaned, Bon Kwon Koo, Steven A. J. Chamuleau, Tsunekazu Kakuta, Jan J. Piek, Evald Hoj Christiansen
Summary: This study investigated the association between changes in microvascular resistance (MR) and target vessel failure (TVF) in patients undergoing percutaneous coronary intervention (PCI). The results showed that increased MR post-PCI was associated with lesions of less severe hemodynamic influence at baseline and higher rates of TVF at follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
Zhihua Yang, Yangxi Liu, Zhenzhen Li, Shaoling Feng, Shanshan Lin, Zhao Ge, Yujian Fan, Yi Wang, Xianliang Wang, Jingyuan Mao
Summary: Coronary microvascular dysfunction (CMD) is a high-risk factor for various cardiovascular events and is closely related to the occurrence and development of cardiovascular diseases. However, the pathophysiological mechanism of CMD is still limited, which hinders its clinical diagnosis and treatment. Promising strategies for the treatment of cardiovascular diseases include improving coronary microvascular remodelling and increasing myocardial perfusion.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Paolo Severino, Andrea D'Amato, Silvia Prosperi, Vincenzo Myftari, Lorenzo Colombo, Elisa Tomarelli, Alice Piccialuti, Gianluca Di Pietro, Lucia Ilaria Birtolo, Viviana Maestrini, Roberto Badagliacca, Gennaro Sardella, Francesco Fedele, Carmine Dario Vizza, Massimo Mancone
Summary: Ischemic heart disease (IHD) is the leading cause of death globally. The presence of myocardial infarction with non-obstructive coronary artery disease (MINOCA), which can be classified into atherosclerotic and non-atherosclerotic mechanisms, is increasingly recognized. Coronary microvascular dysfunction (CMD) is a leading factor for the pathophysiology and prognosis of MINOCA patients, and further research is needed to understand the genetic mechanisms underlying CMD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Bert Vandeloo, Daniele Andreini, Sofie Brouwers, Takuya Mizukami, Giovanni Monizzi, Stijn Lochy, Niya Mileva, Jean-Francois Argacha, Matthias De Boulle, Philip Muyldermans, Marta Belmonte, Jeroen Sonck, Emanuele Gallinoro, Daniel Munhoz, Bram Roosens, Daniela Trabattoni, Stefano Galli, Ruiko Seki, Martin Penicka, Eric Wyffels, Saima Mushtaq, Sakura Nagumo, Sofie Pardaens, Emanuele Barbato, Antonio L. Bartorelli, Bernard De Bruyne, Bernard Cosyns, Carlos Collet
Summary: This study aimed to assess the diagnostic performance of exercise stress tests in diagnosing coronary artery disease, and found that considering both epicardial and microvascular resistance indexes can reduce the false discovery rate.
Article
Cardiac & Cardiovascular Systems
Abdul-Quddus Mohammed, Fuad A. Abdu, Yang Su, Lu Liu, Guoqing Yin, Yundi Feng, Wen Zhang, Yawei Xu, Dachun Xu, Wenliang Che
Summary: This study investigated the prevalence and prognostic significance of coronary microvascular dysfunction (CMD) in heart failure with preserved ejection fraction (HFpEF) patients. CMD was found to be highly prevalent and independently predictive of adverse outcomes in HFpEF patients. Assessment of CMD may help identify high-risk patients early for intensified treatment and risk-factor management.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gilles Rioufol, Francois Derimay, Francois Roubille, Thibault Perret, Pascal Motreff, Denis Angoulvant, Yves Cottin, Ludovic Meunier, Laura Cetran, Guillaume Cayla, Brahim Harbaoui, Jean-Yves Wiedemann, Eric Van Belle, Christophe Pouillot, Nathalie Noirclerc, Jean-Francois Morelle, Francois-Xavier Soto, Christophe Caussin, Bernard Bertrand, Thierry Lefevre, Patrick Dupouy, Pierre-Francois Lesault, Franck Albert, Olivier Barthelemy, Rene Koning, Laurent Leborgne, Pierre Barnay, Philippe Chapon, Sebastien Armero, Antoine Lafont, Christophe Piot, Camille Amaz, Bernadette Vaz, Lakhdar Benyahya, Yvonne Varillon, Michel Ovize, Nathan Mewton, Gerard Finet
Summary: The FUTURE trial investigated whether a treatment strategy based on FFR was superior to a traditional strategy in the treatment of multivessel CAD, and found no significant difference in rates of major adverse cardiac events or death at 1-year follow-up between the two groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Masahiro Hoshino, Seokhun Yang, Tomoyo Sugiyama, Jinlong Zhang, Yoshihisa Kanaji, Rikuta Hamaya, Masao Yamaguchi, Masahiro Hada, Tomoki Horie, Kai Nogami, Hiroki Ueno, Toru Misawa, Taishi Yonetsu, Doyeon Hwang, Joo Myung Lee, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Bon-Kwon Koo, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study found that the prevalence of coronary microvascular dysfunction (CMD) in patients with intermediate epicardial stenosis is about one-third. CMD was significantly associated with greater lumen volume, fibrofatty and necrotic component volume, and epicardial fat volume.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Xuelian Gao, Rui Wang, Zhonghua Sun, Hongkai Zhang, Kairui Bo, Xiaofei Xue, Junjie Yang, Lei Xu
Summary: This study found that the CTP-FFR model has promising value in improving the diagnostic accuracy of CCTA in detecting coronary ischemia. The feasibility of using CTP-FFR to detect coronary artery ischemia in patients with suspected CAD was proven.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Yuji Nagatomo, Dries Belsack, Hannes Devos, Nico Buls, Bernard Cosyns, Jean-Francois Argacha, Michel De Maeseneer, Johan De Mey
Summary: This study found that in vessels with no apparent CAD, vessel length was the most influential factor on FFRCT, followed by the bifurcation angle.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Joo Myung Lee, Hyun Sung Joh, Ki Hong Choi, David Hong, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Seung-Hyuk Choi, Jin-Ok Jeong, Jong-Young Lee, Young Jin Choi, Jei-Keon Chae, Seung-Ho Hur, Jang-Whan Bae, Ju-Hyeon Oh, Kook-Jin Chun, Hyun-Joong Kim, Byung Ryul Cho, Doosup Shin, Seung Hun Lee, Doyeon Hwang, Hyun-Jong Lee, Ho-Jun Jang, Hyun Kuk Kim, Sang Jin Ha, Eun-Seok Shin, Joon-Hyung Doh, Joo-Yong Hahn, Hyeon-Cheol Gwon
Summary: This study evaluated the mid-term safety and efficacy of Absorb BVS with meticulous device optimization under intravascular imaging guidance. The results showed that BVS had comparable risks of target vessel failure and patient-oriented composite outcome with DES at 2 years. Meticulous device optimization and avoidance of implantation in small vessels improved the outcomes of BVS.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Yu Jin Chung, Ki Hong Choi, Seung Hun Lee, Doosup Shin, David Hong, Sugeon Park, Hyun Sung Joh, Hyun Kuk Kim, Sang Jin Ha, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo Myung Lee
Summary: Indeterminate diastolic function is associated with an increased risk of cardiovascular death or admission for heart failure, and is related to coronary microvascular dysfunction. Presence of coronary microvascular dysfunction and elevated left ventricular filling pressure are independent predictors of cardiovascular death or admission for heart failure among patients with indeterminate diastolic function.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Min Woo Lee, Jeong Min Lee, Young Hwan Koh, Jin Wook Chung
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ki Hong Choi, Jeong Hoon Yang, Jeong Hun Seo, David Hong, Taeho Youn, Hyun Sung Joh, Seung Hun Lee, Darae Kim, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Jin-Oh Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Eun-Seok Jeon
Summary: This study evaluated the discriminative and prognostic roles of invasive measured left ventricular end-diastolic pressure in the population with suspected HFpEF, particularly for patients with intermediate HFA-PEFF score. The results showed that HFA-PEFF score can predict adverse events in HFpEF to some extent, and invasive measured left ventricular end-diastolic pressure can provide additional information for patients with intermediate HFA-PEFF scores.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Ki Hong Choi, Jeong Hoon Yang, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Chul-Min Ahn, Cheol Woong Yu, Ik Hyun Park, Woo Jin Jang, Hyun-Joong Kim, Jang-Whan Bae, Sung Uk Kwon, Hyun-Jong Lee, Wang Soo Lee, Jin-Ok Jeong, Sang-Don Park, Tae-Soo Kang, Hyeon-Cheol Gwon
Summary: This study compared the clinical outcomes of culprit-only percutaneous coronary intervention (PCI) and immediate multivessel PCI in patients with acute myocardial infarction complicated by cardiogenic shock (CS) who underwent venoarterial-extracorporeal membrane oxygenation before revascularization. The results showed that immediate multivessel PCI was associated with lower incidences of 30-day mortality or renal replacement therapy and 12-month follow-up mortality, compared with culprit-only PCI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Oncology
Jeong Hee Yoon, Jin Young Park, Sang Min Lee, Eun Sun Lee, Jae Hyun Kim, Jeong Min Lee
Summary: This study investigated the effect of reduced iodinated contrast medium (CM) dose on contrast-enhanced liver computed tomography (CT). The results showed that image contrast and overall image quality caused by decreased CM can be restored using low monoenergetic imaging or DL-based iodine-boosting reconstruction.
Article
Oncology
Jae Hyun Kim, Hee Soo Kim, Jeong Hee Yoon, Ijin Joo, Jung-Hwan Yoon, Yoon Jun Kim, Su Jong Yu, Jeong Min Lee
Summary: The purpose of this study was to evaluate the technical feasibility and therapeutic outcomes of anatomical ablation using multiple radiofrequency applicators for peripherally-located small hepatocellular carcinomas (HCCs). The results showed a technical success rate of 98.2% and a low incidence of local tumor progression (3.7%) after treatment. Therefore, anatomical ablation using multiple RF applicators can provide excellent local tumor control in patients with peripherally-located small HCCs.
Article
Oncology
Sae-Jin Park, Jeong Hee Yoon, Ijin Joo, Jeong Min Lee
Summary: The calculation of muscle volume on abdominal CT scans can predict survival outcomes and the occurrence of diabetes for liver transplantation recipients.
Article
Cardiac & Cardiovascular Systems
Seokhun Yang, Doyeon Hwang, Jinlong Zhang, Jiesuck Park, Jun Pil Yun, Joo Myung Lee, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Shao-Liang Chen, Tsunekazu Kakuta, Gabor G. Toth, Zsolt Piroth, Nils P. Johnson, Abdul Hakeem, Barry F. Uretsky, Yohei Hokama, Nobuhiro Tanaka, Hong-Seok Lim, Tsuyoshi Ito, Akiko Matsuo, Lorenzo Azzalini, Massoud A. Leesar, Tara Neleman, Nicolas M. van Mieghem, Roberto Diletti, Joost Daemen, Damien Collison, Carlos Collet, Bernard De Bruyne, Bon-Kwon Koo
Summary: This study aimed to identify adverse clinical and vessel characteristics related to hard outcomes after percutaneous coronary intervention (PCI) and investigate their individual and combined prognostic implications. The study found that adverse clinical characteristics such as age 65 and older, diabetes, chronic kidney disease, and left ventricular ejection fraction less than 50%, as well as adverse vessel characteristics such as post-PCI fractional flow reserve less than or equal to 0.80 and total stent length greater than or equal to 54 mm, were independently predictive of cardiac death or target-vessel myocardial infarction. Assessing the combination of adverse clinical and vessel characteristics can optimize post-PCI risk stratification.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyo-Jin Kang, Jeong Min Lee, Chulkyun Ahn, Jae Seok Bae, Seungchul Han, Se Woo Kim, Jeong Hee Yoon, Joon Koo Han
Summary: This study investigated the image quality and lesion conspicuity of a deep-learning-based contrast-boosting algorithm on double-low-dose CT in high-risk participants for HCC. The results showed that the algorithm improved the visibility of the aorta and portal vein and did not significantly affect the detection rate of HCC.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jae Hyun Kim, Jeong Hee Yoon, Se Woo Kim, Junghoan Park, Seong Hwan Bae, Jeong Min Lee
Summary: This study evaluated the efficacy of a vendor-specific deep learning reconstruction algorithm (DLRA) in enhancing image quality and focal lesion detection in gadoxetic acid-enhanced liver MRI. The results showed that DLRA significantly improved image quality and had higher sensitivity for focal lesion detection compared to conventional methods.
ABDOMINAL RADIOLOGY
(2023)
Article
Oncology
Dong Ho Lee, Seung Soo Lee, Jeong Min Lee, Jin-Young Choi, Chang Hee Lee, Hong Il Ha, Bo-Kyeong Kang, Mi Hye Yu, Won Chang, Sae Jin Park
Summary: The assessment of tumor vascular contact is crucial for evaluating the resectability of pancreatic ductal adenocarcinoma (PDAC). This study compared the image quality and diagnostic performance of high-resolution (HR) pancreas computed tomography (CT) using 80 kVp with 1 mm slice thickness (ST) with the standard protocol CT using 120 kVp. The results showed that HR-CT had better contrast and tumor visibility, but it was not significantly different from standard CT in predicting resectability.
Correction
Radiology, Nuclear Medicine & Medical Imaging
Kathryn J. Fowler, Mustafa R. Bashir, David T. Fetzer, Azusa Kitao, Jeong Min Lee, Hanyu Jiang, Ania Z. Kielar, Maxime Ronot, Aya Kamaya, Robert M. Marks, Khaled M. Elsayes, An Tang, Claude B. Sirlin, Victoria Chernyak
Article
Radiology, Nuclear Medicine & Medical Imaging
Taehee Lee, Jeong Hee Yoon, Jin Young Park, Jihyuk Lee, Jae Won Choi, Chulkyun Ahn, Jeong Min Lee
Summary: Low-contrast-dose liver CT using a deep learning based iodine contrast-augmenting algorithm (DLICA) improves image quality and diagnostic performance for hypovascular hepatic metastases.
ABDOMINAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
So Hyun Park, Jeong Hee Yoon, Jin Young Park, Young Sup Shim, Sang Min Lee, Seung Joon Choi, Marcel Dominik Nickel, Jeong Min Lee
Summary: In this study evaluating free-breathing T1W dynamic imaging in patients who underwent gadoxetic acid-enhanced liver MRI, both XD-VIBE and SG-GRASP sequences provided sufficient image quality without significant differences in image quality or the lesion detection rate between sequences.
EUROPEAN RADIOLOGY
(2023)