☆ 4.6 Article

Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex

CELLULAR SIGNALLING (2015)

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CELLULAR SIGNALLING
卷 27, 期 3, 页码 436-442

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2014.12.010

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ER stress; PERK inhibitors; PTEN; Vaults; MVP

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Cell Biology

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The high proliferation rate of cancer cells, together with environmental factors such as hypoxia and nutrient deprivation can cause Endoplasmic Reticulum (ER) stress. The protein kinase PERK is an essential mediator in one of the three ER stress response pathways. Genetic and pharmacological inhibition of PERK has been reported to limit tumor growth in xenograft models. Here we provide evidence that inactive PERK interacts with the nuclear pore-associated Vault complex protein and that this compromises Vault-mediated nuclear transport of PTEN. Pharmacological inhibition of PERK under ER stress results is abnormal sequestration of the Vault complex, leading to increased cytoplasmic PTEN activity and lower AKT activation. As the PI3K/PTEN/AKT pathway is crucial for many aspects of cell growth and survival, this unexpected effect of PERK inhibitors on ART activity may have implications for their potential use as therapeutic agents. (C) 2014 The Authors. Published by Elsevier Inc.

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