期刊
CELLULAR SIGNALLING
卷 27, 期 4, 页码 777-788出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2014.12.014
关键词
Cysteine oxidation; Tyrosine phosphorylation; Inflammation; T cells; Kinases & phosphatases; Syk inhibitors
类别
资金
- Bank of Sardinia Foundation (Fondazione Banco di Sardegna) [U712.2013/AI.636.MGB]
Reactive Oxygen Species (ROS) are crucial to multiple biological processes involved in the pathophysiology of inflammation, and are also involved in redox signaling responses. Although previous reports have described an association between oxidative events and the modulation of innate immunity, a role for redox signaling in T cell mediated adaptive immunity has not been described yet. This work aims at assessing if T cells can sense redox stress through protein sulfhydryl oxidation and respond with tyrosine phosphorylation changes. Our data show that Jurkat T cells respond to -SH group oxidation with specific tyrosine phosphorylation events. The release of T cell cytokines TNF, IFN gamma and 112 as well as the expression of a number of receptors are affected by those changes. Additionally, experiments with spleen tyrosine kinase (Syk) inhibitors showed a major involvement of Syk in these responses. The experiments described herein show a link between cysteine oxidation and tyrosine phosphorylation changes in T cells, as well as a novel mechanism by which Syk inhibitors exert their anti-inflammatory activity through the inhibition of a response initiated by ROS. (C) 2014 Elsevier Inc. All rights reserved.
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