Article
Nanoscience & Nanotechnology
Zhen Chen, Jing Liu, Yujie Chen, Xu Zheng, Hezhou Liu, Hua Li
Summary: A multi-stimulus-responsive and multifunctional hydrogel system was developed, showing good elasticity, flexibility, and stable conductivity. It can detect human motion, respond to physiological signals, and environmental temperature changes. The bilayer hydrogel system also functions as actuators and has thermoresponsive smart features for displaying and concealing information.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Polymer Science
Yuqing Deng, Jianfeng Xi, Liucheng Meng, Yanling Lou, Farzad Seidi, Weibing Wu, Huining Xiao
Summary: This review comprehensively discusses the latest developments in stimuli-responsive nanocellulose hydrogels, including their preparation, properties, and applications. These hydrogels exhibit specific responsiveness and detection capability to environmental stimuli, making them highly applicable in various fields such as biomedicine, bionic intelligent materials, and sensing detection.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Zexing Deng, Rui Yu, Baolin Guo
Summary: Stimuli-responsive conductive hydrogels, combining the advantages of conductive polymers, carbon nanomaterials, metals, and conductive ionic compounds, have emerged as a new concept in the field of hydrogel research. These hydrogels can respond to various stimuli such as temperature, pH, light, magnetic fields, and electrical fields, and have a wide range of applications in sensors, electronic devices, drug release, wound healing, photothermal therapy, tissue engineering, and cell delivery. Various issues still need to be addressed, and future directions for the development of new types of stimuli-responsive conductive hydrogels are proposed in this review.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Review
Biotechnology & Applied Microbiology
Mengmeng Chen, Yu Wang, Jingyang Zhang, Yuan Peng, Shuang Li, Dianpeng Han, Shuyue Ren, Kang Qin, Sen Li, Zhixian Gao
Summary: DNA hydrogels have rich structural and functional information, making them useful for various applications in bioanalysis and biomedicine. Stimuli-responsive DNA hydrogels, which can undergo reversible transitions from gel to sol under different triggers, have emerged as smart materials for sensing. This study provides a review on stimuli-responsive DNA hydrogels and their biosensing applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Yuyang Wang, Yu-Mo Zhang, Sean Xiao-An Zhang
Summary: Stimuli-responsive materials have great potential in novel photoelectric devices, but progress has been slow due to the lack of high-performance smart materials and limitations in available reaction mechanisms. Learning from nature by mimicking proton transfer processes can provide new insights and design strategies for developing advanced materials and devices.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Hao Sun, Shen Shen, Liangliang Zhu
Summary: Purely organic room-temperature phosphorescent (RTP) materials are gaining increasing interest due to their long lifetime, persistent luminescence, and potential applications. This review summarizes recent advances in photo-stimuli-responsive organic RTP materials and discusses their tunable properties, design mechanisms, and promising applications. It aims to provide guidance for future development in this field.
ACS MATERIALS LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Xiao Li, Minghao Li, Lisa Tang, Diwei Shi, Emily Lam, Jinhye Bae
Summary: This review explores the potential of stimuli-responsive hydrogels in mimicking the morphing behavior of living tissues or organisms, and discusses how functional additives can be combined with hydrogels to extend their functionalities. It also highlights the potential applications of stimuli-responsive composite hydrogels in various fields including soft robotics, information encryption/decryption, biomedical research, flexible electronics, and engineering living materials.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Fan Gu, Xiang Ma
Summary: This review summarizes recent advances in stimuli-responsive room-temperature phosphorescence materials, focusing on the frontier development in polymer systems. Various stimuli-responsive factors including light, oxygen, temperature, mechanical force and pH regulations are investigated. Potential applications and strategies for future studies in this area are deeply discussed.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Hamidreza Parsimehr, Ali Ehsani
Summary: Electrochemical energy storage devices that respond to external stimuli have been developed rapidly, enhancing performance and applications. The multi-responsive behaviors of these devices stem from their functionality and specific structure. Future research will focus on merging economic, environmental, and multi-responsiveness priorities to improve performance and address complex situations.
Review
Chemistry, Physical
Chenfang Sun, Tie Wang
Summary: The early determination of disease-related biomarkers can improve patient survival rate significantly. Therefore, explorations for new diagnosis technologies, such as optical and electrochemical methods, have been devoted to life and health monitoring. Organic thin-film transistor (OTFT), as a label-free, low-cost, facial, and rapid detection technology, has attracted significant attention. However, the reliability and accuracy of the biosensor need to be improved while ensuring sensitivity, selectivity, and stability.
Review
Chemistry, Multidisciplinary
Pedro Lavrador, Marco R. Esteves, Vitor M. Gaspar, Joao F. Mano
Summary: Recent advances in the design of stimuli-responsive nanocomposite hydrogels have expanded their potential for operating as advanced systems in various biomedical applications, benefitting from tailored single or multi-responsiveness. The combination of hydrogels and nanoparticles showcases an intrinsic ability to react to external or internal/physiological stimuli, developing intelligent systems with application-oriented features.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Hongyue Wang, Lin Wang, Shasha Guo, Zehao Liu, Luqing Zhao, Renzhong Qiao, Chao Li
Summary: An active flavonoid compound, rutin, was incorporated into a guanosine phenylborate hydrogel (GBR) for the treatment of inflammatory bowel disease (IBD). The hydrogel exhibited good stability and injectability, and achieved dual-responsive release in an acidic pH and excessive ROS-containing medium. In vivo studies showed that the GBR hydrogel had higher therapeutic efficacy than free rutin and could suppress the expression of inflammatory cytokines.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Yuhan Sun, Yan Lv, Yin Zhang, Zhouping Wang
Summary: A colorimetric aptasensor was developed in this study by combining catalytical metal-organic frameworks with polyacrylamide-DNA hydrogel. The aptasensor demonstrated remarkable selectivity and ease of use for detecting Fumonisin B1 in solution and food samples. The strategy could serve as a model for developing stimuli-responsive aptasensors targeting hazards in food safety.
Review
Chemistry, Multidisciplinary
Yanling Hu, Hui Li, Xinyi Lv, Yan Xu, Yannan Xie, Lihui Yuwen, Yingnan Song, Shengke Li, Jinjun Shao, Dongliang Yang
Summary: Diabetic wound infection is a common disease that poses challenges due to the diabetic wound environment and bacterial resistance. Nanobiomaterial-based therapeutic systems with stimuli-responsive performance can address these challenges by delivering therapeutic agents on demand.
Article
Chemistry, Analytical
Miaomiao Kong, Haojie Li, Yu Liang, Kang Cheng, Xin Zhou, Xiaojie Song, Zhihong Yang, Jianmei Xu, Ling Zhao
Summary: A smart actuator with multi-response behaviors was designed using low-cost materials and facile fabricating method. The bilayer actuators prepared with montmorillonite, graphene oxide, and their derivatives showed controlled and large deformation. The bilayer films exhibited good actuating performance under the external stimuli of humidity, organic solvent, and infrared light.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Sumon Pratihar, Ragini Agrawal, Virender Kumar Pal, Amit Singh, Thimmaiah Govindaraju
Summary: Identifying and characterizing a highly conserved antiparallel G-quadruplex (GQ)-forming DNA sequence within the SARS-CoV-2 genome, researchers developed a novel benzobisthiazole-based fluorogenic probe for specific target recognition. This probe, used in a cost-effective assay involving PCR amplification and endpoint fluorescence detection, demonstrates a potential diagnostic tool for SARS-CoV-2 clinical samples. The study suggests a general strategy that can be adapted for developing specific diagnostic assays targeting different noncanonical nucleic acid sequences.
Review
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Debasis Ghosh, Sumon Pratihar, Shuo Shi, Thimmaiah Govindaraju
Summary: Nucleic acid-based architectures have provided numerous opportunities for basic and applied research in DNA nanotechnology. By utilizing conventional and unconventional base pairing interactions, functional nucleic acid systems and devices that respond to changes in pH have been designed, offering biocompatibility and structural programmability. This Mini-Review highlights recent advancements in nucleic acid architectonics, particularly pH-driven molecular systems including nanoscale architectures, nanomachines, hydrogels, targeted bioimaging, and drug delivery architectures. The review concludes by emphasizing the challenges and opportunities for future developments.
Article
Chemistry, Medicinal
Dikshaa Padhi, Thimmaiah Govindaraju
Summary: This article discusses the potential and possibilities of drug repurposing and hybrid drug design in the treatment of AD, presenting several potential drug candidates and discussing their plausible mechanisms of action.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Pandeeswar Makam, Sharma S. R. K. C. Yamijala, Venkata S. Bhadram, Linda J. W. Shimon, Bryan M. Wong, Ehud Gazit
Summary: The study presents a simple and efficient single amino acid bionanozyme that can catalyze the rapid oxidation of phenolic contaminants and detect neurotransmitters. Compared to natural enzymes, this copper-coordinated bionanozyme is more cost-effective, efficient, and versatile.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Biswanath Maity, Shadab Alam, Sourav Samanta, Relekar G. Prakash, Thimmaiah Govindaraju
Summary: In this study, a composite hydrogel for rapid wound healing in diabetic condition is developed, which releases berberine slowly and has the ability to control oxidative stress and promote wound repair.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Madhu Ramesh, Chenikkayala Balachandra, Prayasee Baruah, Thimmaiah Govindaraju
Summary: Liquid-liquid phase separation (LLPS) is a complex physicochemical phenomenon mediated by multivalent transient weak interactions among macromolecules like polymers, proteins, and nucleic acids. It has implications in cellular physiology and disease conditions like cancer and neurodegenerative disorders. Limited chemical tools exist to modulate protein LLPS, and the development of small-molecule modulators (SMMs) could provide therapeutic potential for neurodegenerative disorders. Rationally designed cyclic dipeptide (CDP)-based SMMs have been shown to effectively inhibit and dissolve Zn-mediated tau LLPS condensates, as well as inhibit tau condensate-to-fibril transition, establishing a novel platform for the development of therapeutics for neurodegenerative disorders.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraju
Summary: This article presents a glucose-responsive smart hydrogel platform based on phenylboronic acid-functionalized natural silk fibroin protein for regulated insulin delivery. The platform provides controlled insulin release and restores blood glucose levels in diabetic conditions.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraju
Summary: Efficient delivery of bioactive ingredients into cells remains a challenge, and cell-penetrating peptides (CPPs) have emerged as promising delivery vehicles. In this study, novel CPPs derived from the flexible and disordered tail extensions of DNA-binding Ku proteins were developed. The lead CPP, Ku-P4, demonstrated high internalization efficacy and biocompatibility. The presence of proline residue was crucial for maintaining the intrinsically disordered state and biocompatibility. Biophysical and DNA binding studies revealed that Ku-P4 efficiently condensed DNA into positively charged polyplexes, which were then able to penetrate the cell membrane and deliver the plasmid DNA inside the cell. These findings suggest that these novel CPPs have the potential to enhance the cellular uptake and therapeutic efficacy of peptide-drug or gene conjugates.
ACS BIO & MED CHEM AU
(2023)
Article
Chemistry, Multidisciplinary
Sumon Pratihar, Mohamed Nabeel Mattath, Thimmaiah Govindaraju
Summary: Pathogenic genomes with noncanonical G-quadruplex (GQ) forming sequences are potential targets for diagnosis. The GQ-forming cDNA sequences of SARS-CoV-2 have been identified and validated as reliable diagnostic targets. High fidelity fluorescence detection of specific cDNA GQs derived from the SARS-CoV-2 RNA genome is demonstrated using small molecular probes.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Sumon Pratihar, Krithi K. Bhagavath, Thimmaiah Govindaraju
Summary: Theranostics, the integration of therapy and diagnostics, is crucial for monitoring disease progression and treatment response. Advancements in medicinal chemistry and technology have led to the development of targeted therapeutic drugs that also provide real-time updates on disease progression and treatment. The inclusion of imaging in therapy has significantly improved the prognosis of devastating diseases. Theranostic agents play important roles in early-stage drug development and clinical-stage therapeutic-containing drug candidates.
RSC CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Haibin Zhang, Debasis Ghosh, Thimmaiah Govindaraju, Shuo Shi
Summary: Biocomputing, using DNAs as its primary building blocks, is the most promising alternative for next-generation molecular computers. DNA nanoclusters (NCs) have unique self-assembly properties and programmability, making them promising candidates for biosensing applications. Thymine overhang-modified DNA-templated NCs are chemosensing ensembles capable of driving elementary and complex logic operations. These NCs can also be used for advanced DNA logic devices and error detection.
Article
Chemistry, Multidisciplinary
Madhu Ramesh, Thimmaiah Govindaraju
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that contributes significantly to global dementia cases. The pathology of AD is characterized by the accumulation of amyloid beta plaques and tau neurofibrillary tangles. Despite a lack of complete understanding and approved treatments, research has revealed the multifactorial nature of AD. Therefore, developing multipronged approaches targeting multiple biomarkers and targets is crucial for effective diagnosis and therapeutics.
Article
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Debasis Ghosh, Chunyan Dong, Thimmaiah Govindaraju, Shuo Shi
Summary: Boolean operations based on DNA have promising applications in biocomputing. By introducing parity generator and parity checker, bit errors can be effectively evaluated. In this study, a DNA hybrid architecture platform was constructed using a chemosensing ensemble and a binary to gray code encoder was used to convert the transmitted and received data into secure information.
MATERIALS HORIZONS
(2022)
Article
Chemistry, Multidisciplinary
Dikshaa Padhi, Chenikkayala Balachandra, Madhu Ramesh, Thimmaiah Govindaraju
Summary: A series of 2,2'-bipyridine derivatives with structurally unique biomolecular auxiliaries were synthesized and found to effectively ameliorate amyloid toxicity and oxidative stress observed in Alzheimer's disease (AD).
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Debasis Ghosh, Mouli Konar, Tanmay Mondal, Thimmaiah Govindaraju
Summary: The differential structures of designer peptidomimetics derived from amyloid beta (Aβ14-23) peptide were manipulated to stabilize distinct Cu oxidation states, which catalyzed different chemical reactions effectively. By incorporating cyclic dipeptide (CDP) and pyrene (Py) units, the Cu-chelation and self-assembly properties of Aβ14-23 peptide were tuned to form nanosheets and micelle-like core-shell structures. These structures demonstrated the ability to stabilize Cu-II and Cu-I states separately and catalyze tandem oxidative-hydrolysis and alkyne-azide cycloaddition reactions.
NANOSCALE ADVANCES
(2022)