Review
Gastroenterology & Hepatology
Tao Zhang, Guangqi Gao, Lai-Yu Kwok, Zhihong Sun
Summary: The advent of high-throughput 'omics' technologies has improved our understanding of the connection between gut microbiome and Alzheimer's disease (AD). Modulating the gut microbiota has emerged as a novel approach for clinical management of AD. This review provides an overview of the association between gut dysbiosis and AD, the mechanisms of gut microbiota in driving AD progression, and the success and challenges of gut microbiome-targeted therapies in AD studies.
Review
Gastroenterology & Hepatology
Mijra Koning, Hilde Herrema, Max Nieuwdorp, Abraham S. Meijnikman
Summary: Humans have a diverse gut microbiome, consisting of bacteria, fungi, viruses, and archaea. Patients with NAFLD have an altered gut microbiome and compromised gut barrier function. Preclinical studies suggest that adjusting the gut microbiome could be a promising therapeutic strategy for NAFLD. This overview summarizes the current information on both untargeted techniques (such as probiotics and fecal microbiota transplantation) and targeted microbiome-focused therapies (including engineered bacteria, prebiotics, postbiotics, and phages) for the treatment of NAFLD.
Review
Medicine, Research & Experimental
Yan Wang, Hui Li
Summary: The gut microbiota plays a crucial role in the development of colorectal cancer, and various strategies have been developed to modify the microbiota. However, the potential implications and long-term effects of these strategies in clinical settings need to be evaluated.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Karolina Kazmierczak-Siedlecka, Karolina Skonieczna-Zydecka, Jaroslaw Bilinski, Giandomenico Roviello, Luigi Francesco Iannone, Alessandro Atzeni, Bartosz Kamil Sobocki, Karol Polom
Summary: Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a recommended curative therapy for hematologic malignancies, but complications such as graft-versus-host disease, mucositis, and infections can disrupt gut microbiota balance and barrier integrity. Fecal microbiota transplantation (FMT) may be effective in restoring gut microbiota diversity, although caution is needed with the use of fungal probiotics due to the risk of fungemia/septicemia.
Review
Immunology
Hanghang Yuan, Ruirui Gui, Zhicheng Wang, Fang Fang, Hongguang Zhao
Summary: Colorectal cancer (CRC) is a common and deadly cancer that poses a major burden on human health. Gut microbiota regulate human immunity and metabolism through producing numerous metabolites, but the specific mechanisms by which gut microbiota interact with immunotherapy and radiotherapy remain incongruent. This review discusses recent advances and the potential of targeting gut microbiota to enhance the efficacy of radioimmunotherapy in CRC, providing references and fresh ideas for the clinical application of this novel strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Mong-Hong Lee
Summary: Research has shown that gut microbiota dysbiosis is linked to physiological changes and various diseases, including cancers. Advances in metagenome sequencing and multiomics studies have provided insights into the composition, taxonomic alterations, and host interactions of gut microbiota during tumorigenesis. However, the complexity of gut microbiota interactions still presents challenges in fully understanding the microbiota-cancer connections and their implications for cancer diagnosis, treatment, and prevention.
CANCER COMMUNICATIONS
(2021)
Review
Cell Biology
Xiaoqiang Qi, Yajun Liu, Samira Hussein, Grace Choi, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Guangfu Li
Summary: Modulation of gut microbiota is a promising strategy for enhancing antitumor immune responses and reducing resistance to immunotherapy in cancer. However, identifying gut bacteria species that are favorable or unfavorable for cancer therapy remains a major challenge.
Article
Nutrition & Dietetics
Bartosz Kamil Sobocki, Karolina Kazmierczak-Siedlecka, Marcin Folwarski, Viktoria Hawrylkowicz, Wojciech Makarewicz, Ewa Stachowska
Summary: Dysbiosis of gut microbiota may influence tumorigenic pathways, trigger pancreatic cancer development, and modulate tumor aggressiveness and microenvironment. Strategies such as prebiotics, probiotics, and next-generation probiotics can potentially enhance pancreatic cancer treatment outcomes and improve patients' quality of life.
Review
Biochemistry & Molecular Biology
Aja Badgeley, Hina Anwar, Karan Modi, Paige Murphy, Ashakumary Lakshmikuttyamma
Summary: Studies have shown that probiotics, particularly Lactobacillus and Bifidobacterium, induce anti-cancer action and decrease cancer-producing microorganisms. Gut microbes not only enhance the action of chemotherapy drugs but also reduce the side effects of these medications.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Biology
Martina Takacova, Alojz Bomba, Csilla Tothova, Alena Michal'ova, Hana Turna
Summary: Alterations in intestinal microbiome composition, known as dysbiosis, can be influenced by diet, antibiotics, stress, and diseases. There are various methods to modulate the microbiome, including dietary changes, antimicrobials, prebiotics, probiotics, postbiotics, and synbiotics. Faecal microbiota transplantation (FMT) is a new method used to reconstruct the recipient's intestinal microbiome and has been successfully used in cases of recurrent Clostridium difficile infection (CDI) in human medicine. FMT has been used in large animal medicine for several years, but is not common in small animal medicine.
Review
Pharmacology & Pharmacy
Xiumiao Zhao, Zhaoxia Liu, Tingtao Chen
Summary: Ovarian cancer is a challenging gynecologic cancer with unknown pathogenesis. Vaginal microbiota has been identified as a potential factor in ovarian cancer, with studies showing microbial dysbiosis in cancer cases. The correlation between vaginal microbes and ovarian cancer carcinogenesis, progression, and treatment is increasingly recognized. However, research on the role of vaginal microbiota in ovarian cancer remains limited. This review aims to summarize the potential mechanisms and applications of vaginal microbiota in ovarian cancer and shed light on its involvement in gynecologic cancer treatment.
Review
Oncology
Wenyu Li, Xiaorong Deng, Tingtao Chen
Summary: In recent years, the gut microbiota has gained attention for its role in human health and disease. It plays a crucial role in maintaining homeostasis in the human body and an altered composition can lead to pathogenic conditions and potentially cancer development. Recent research has focused on the interplay between gut microbiota and anticancer therapies, highlighting the potential for manipulating microbiota to improve therapeutic outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Qin Xu, Dan Li, Jing Chen, Ju Yang, Jiai Yan, Yanping Xia, Feng Zhang, Xuesong Wang, Hong Cao
Summary: This paper reviews the relationship between the gut microbiota and postmenopausal osteoporosis (PMO), exploring the underlying mechanisms and potential role of the gut microbiota in the prevention and treatment of PMO. It discusses the therapeutic effects of diet, prebiotics, probiotics, and fecal microbiota transplantation on the gut microbiota.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Yunxia Li, Siting Xia, Xiaohan Jiang, Can Feng, Saiming Gong, Jie Ma, Zhengfeng Fang, Jie Yin, Yulong Yin
Summary: Diarrhea is closely linked to gut microbiota, and reshaping gut microbiota through dietary probiotics or fecal bacteria transplantation can help prevent or treat diarrhea.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Food Science & Technology
Chen Wang, Junying Bai, Xiaoyong Chen, Jiajia Song, Yu Zhang, Hongwei Wang, Huayi Suo
Summary: Host health and disease are affected by changes in intestinal flora. Strategies such as probiotics, prebiotics, diet, fecal microbiota transplantation, antibiotics, and phages can regulate the structure and abundance of microflora. Diets and prebiotics have reduced risk and high security, while phages have high specificity for targeted regulation. Individual variability in microflora and metabolic response should be considered, and future studies should use artificial intelligence and multi-omics to develop personalized intervention strategies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Immunology
Richa Sharma, Asmita Das
IMMUNOLOGIC RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Pratyusa Das, Sunil Kumar Chaudhari, Asmita Das, Somashree Kundu, Chabita Saha
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2019)
Review
Oncology
Sanghamitra Mylavarapu, Asmita Das, Monideepa Roy
FRONTIERS IN ONCOLOGY
(2018)
Article
Cell Biology
Madhuri Chaurasia, Swapnil Gupta, Asmita Das, B. S. Dwarakanath, Anne Simonsen, Kulbhushan Sharma
Article
Oncology
Sanghamitra Mylavarapu, Harsh Kumar, Smita Kumari, L. S. Sravanthi, Misti Jain, Aninda Basu, Manjusha Biswas, Sivaram V. S. Mylavarapu, Asmita Das, Monideepa Roy
FRONTIERS IN ONCOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Neeraj Kumari, Asmita Das, Anant Narayan Bhatt
JOURNAL OF BIOCHEMISTRY
(2020)
Review
Medicine, Research & Experimental
Karanpreet Bhatia, Bhumika, Asmita Das
Review
Immunology
Muskaan Dhingra, Shayon Mahalanobis, Asmita Das
Summary: Breast cancer is the most common cancer in females worldwide, and women with Hashimoto's thyroiditis are more likely to develop it. The thyroid receptor beta has been found to act as a tumor suppressor in various cancers, including breast cancer, through regulating cell growth and proliferation. The dysregulation of these pathways may be caused by Hashimoto's thyroiditis. Therefore, targeting TR-beta could be a novel therapeutic approach for breast cancer.
IMMUNOLOGIC RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Namit Dey, Deenan Santhiya, Asmita Das
Summary: We report a surfactant-free method for the synthesis of hollow mesoporous bioactive glass nanoparticles at ambient atmospheric conditions. The hollow core is achieved by gently removing calcium carbonate nanoparticles used as a template. The removal of the template is confirmed by FTIR and XRD analysis, and the spherical morphology and sub-100 nm size of the particles are observed by TEM. Furthermore, N2 adsorption and desorption analysis confirm the hollow and mesoporous nature of the bioactive glass shell. Interestingly, the post-template removal particles show increased surface area, pore volume, and pore diameter, along with a decrease in surface charge. The deposition of hydroxyapatite on the hollow bioactive glass in Simulated Buffer Fluid (SBF) is observed from Day 7 of immersion, with well-developed hydroxyapatite depositions observed by Day 30. This demonstrates the bioactivity of the material, and cytotoxicity analysis on the Human Osteosarcoma cell line (U2OS) through MTT assay confirms the biocompatible nature of the hollow bioactive glass particles.
Article
Chemistry, Multidisciplinary
Namit Dey, Deenan Santhiya, Asmita Das
Summary: In this study, a novel hybrid nanoparticle formulation of doxorubicin with bioactive glass-ceramic was prepared. The synthesis was carried out through a bio-inspired route using different precursors of bioactive glass added to a Tris(hydroxymethyl)aminomethane buffer with slightly alkaline pH. The doxorubicin-bioactive glass-ceramic nanoparticles showed superior cytotoxic behavior towards osteosarcoma cells compared to free drug, without the use of surfactant or high temperature. The nanoparticles also exhibited hydroxyapatite deposition when immersed in simulated body fluid.
Article
Biology
Sunil Kumar, Asmita Das
Summary: The incidence and mortality rate of breast cancer increase annually. Biopsies of tumors are expensive, invasive, and risky. Early detection biomarkers are variable and may be undetectable at an early stage. This study used XGBoost and XAI to identify potential diagnostic biomarkers for breast cancer, discovering ten genes that could serve as early, non-invasive markers.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2023)
Review
Oncology
Bharmjeet, Asmita Das
Summary: Advancements in cancer research have led to significant reductions in mortality globally. However, there are still disparities in cancer care, including diagnosis, treatment, and palliative care, among different populations. These disparities are influenced by social determinants, discrimination, and biases in the implementation of new treatments. A comprehensive evaluation of these issues is necessary to design better strategies for cancer management and reduce mortality.
Review
Oncology
Saksham Garg, Nikita Sharma, Asmita Bharmjeet, Asmita Das
Summary: The microbiome plays a significant role in shaping the human immune system and impacting cancer development. Microbes interact with immune cells and can modulate immune responses as well as enhance the effectiveness of immunotherapies.
Article
Multidisciplinary Sciences
Asmita Das, Pangwan M. Konyak, Argha Das, Subrata Kumar Dey, Chabita Saha
