Article
Optics
Shanggeng Li, Xiaolin Liu, Shuai Zhang, Yawen Zhou, Xiangyu Wan, Ning Li, Jing Li, Lin Zhang
Summary: This research designed and synthesized four conjugate-extended two-photon polymerization initiators with different alkane chain lengths, and demonstrated their ability as two-photon initiators and their performance in additive manufacturing. The study also found that a certain degree of conjugation extension can improve the initiation ability of molecules, and changing the alkane chain length can affect the solubility of molecules, which is helpful to adapt to different monomers.
Article
Chemistry, Organic
Pawel Kowalczyk, Mariusz Tasior, Shuhei Ozaki, Kenji Kamada, Daniel T. Gryko
Summary: An original approach has been developed for the insertion of formyl substituents at positions 2 and 5 of 1,4-dihydropyrrolo[3,2-b]pyrroles. The synthetic utility of these formyl groups was investigated, and a series of centrosymmetric A-pi-D-pi-A frameworks were constructed. One of the molecules with dicyanovinylidene flanking groups exhibited strong two-photon absorption and can be potentially applied in specific fields.
Article
Spectroscopy
Wenjun Wang, Xuesong Xu, Zijiang Yang
Summary: The photoinduced charge transfer mechanisms of two Donor-pi-Donor-pi-Acceptor conjugates are analyzed based on density functional theory calculations and visualization methods. The effects of the linkage between the two donors on the excitation characteristics are studied. The results show that the efficiency of superexchange charge transfer is affected by the change of bridge in one-photon absorption process, while the advantage of superexchange charge transfer is influenced by the linkage change in two-photon absorption process.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Rebekka Weber, Kerby Chok, Stephan Junek, Clemens Glaubitz, Alexander Heckel
Summary: This study presents the synthesis and photophysical characterization of a two-photon sensitive uncaging dyad based on rhodamine 101 as donor fluorophore and a redshifted BODIPY as acceptor photocage. The liberation of p-nitroaniline (PNA) upon one-photon photolysis was confirmed by HPLC analysis. The considerable change of the fluorescence properties of the chromophores indicated the occurrence of the photoreaction. The possibility of fluorescent read-out enabled the detection of two-photon induced uncaging by confocal fluorescence microscopy.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Wenqi Gong, Ke Qin, Xiaokang Yao, Qiuying Li, Anqi Lv, Wenpeng Ye, Huifang Shi, Zhongfu An, Huili Ma
Summary: Researchers established a pi-orbital model to investigate the substituent effect on the room temperature phosphorescence (RTP) of organic materials. By using the QM/MM model and NEVPT2 theory, they found that electron-donating groups (EDGs) can increase the pi-orbital energy level, leading to changes in the intersystem crossing process and suppressing nonradiative relaxation, thereby improving RTP performance.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Applied
Lei Sun, Xiaoyu Wang, Paul Fleurat-Lessard, Claude P. Gros, Frederic Bolze, Haijun Xu
Summary: The synthesis and spectroscopic characterization of a series of benzazole derivatives with different carbazole substituents were reported in this article. The photophysical properties of these molecules in different solvents were investigated using UV-vis absorption and fluorescence spectroscopy. The dyes exhibited strong absorption bands in the near ultraviolet region, fluorescence emission in the blue-green region, and large Stokes' shifts. Molecular modeling was utilized to explain their spectroscopic behavior, and they were found to possess high thermal stability.
Article
Multidisciplinary Sciences
Guanqun Han, Guodong Li, Jie Huang, Chuang Han, Claudia Turro, Yujie Sun
Summary: The study presents a group of ruthenium polypyridyl complexes with two-photon absorption capabilities, active with lower-energy (740 nm) light.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yanqi Ban, Linhong Hao, Zhenbo Peng, Lishui Sun, Lihua Teng, Yingjie Zhao
Summary: Two star-type push-pull chromophores (T1, T2) based on triphenylamine were designed and synthesized. The structures and molecular arrangement of the chromophores were confirmed by single-crystal X-ray diffraction. The photophysical research of T1 and T2 absorption characteristics and density functional theory (DFT) calculations verified their excellent two-photon absorption (TPA) properties. By adjusting the electronic structures of the chromophores, the TPA performance of the small organic molecule could be greatly enhanced, making them promising candidates for various two-photon applications.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Applied
Antonio Dominguez-Alfaro, Vania F. Pais, David B. Guzman-Rios, Daniel Collado, Francisco Najera, Ezequiel Perez-Inestrosa, Uwe Pischel
Summary: A bichromophoric dyad composed of a Prodan-derived moiety and a BODIPY dye was synthesized and characterized for multiphoton fluorescence microscopy of N13 microglial cells. The efficient energy transfer of the dyad was observed independent of solvent polarity, but in polar media, photoinduced electron transfer competed with energy transfer. The Prodan-derived chromophore also exhibited significant two-photon absorption, making it suitable as a sensitization antenna for BODIPY fluorescence.
Article
Chemistry, Organic
Jela Nociarova, Patrik Osusky, Erik Rakovsky, Dimitris Georgiou, Ioannis Polyzos, Mihalis Fakis, Peter Hrobarik
Summary: Direct iodination of benzothiazoles under strong oxidative/acidic conditions results in a mixture of iodinated heteroarenes with 1-2 major components, including 4,7-diiodobenzothiazoles with a rare substitution pattern as dominant products. These compounds have been utilized in the synthesis of a new class of highly efficient quasi-quadrupolar fluorophores, exhibiting large two-photon absorption cross sections in the near-infrared region.
Article
Chemistry, Physical
Xinyue Wang, Di Wang, Jia Li, Meixia Zhang, Peng Song
Summary: The theoretical study investigated the photoinduced charge transfer process of D-D-pi-A molecules, showing red shift in absorption spectrum and increased absorption intensity due to donor insertion. Visualization method was used to observe charge transfer in one- and two-photon absorption processes, with the thiazolo[5,4-d]thiazole donor insertion showing the largest TPA cross-section. This work contributes to understanding D-D-pi-A molecules and designing molecules with large cross-section TPA properties.
Article
Chemistry, Multidisciplinary
Bidyut Kumar Kundu, Guanqun Han, Yujie Sun
Summary: In this study, two novel two-photon-absorbing organic photosensitizers were reported, which can be driven by NIR light irradiation using inexpensive LED as the light source. By modulating the donor-pi-acceptor-pi-donor conjugated structure, excellent two-photon absorption capability in the NIR region was achieved. These organic photosensitizers exhibited superior performance in driving various O2-involved organic reactions under 850 nm light irradiation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Pengfei Li, Dan Sun, Ningchao Liu, Yuanyuan Fang, Claude P. Gros, Frederic Bolze, Hai-Jun Xu
Summary: A series of BODIPY derivatives with different thiophene and truxene substituents were synthesized and their photophysical and electrochemical properties were investigated. These conjugated dyes exhibited excellent one-photon photophysical properties in the red to near-infrared region and showed remarkable two-photon absorption cross section.
Article
Chemistry, Inorganic & Nuclear
Amir Sohel Bulbul, Nivedita Chaudhri, Mohd Shanu, Jitendra Nath Acharyya, G. Vijaya Prakash, Muniappan Sankar
Summary: Two new series of unsymmetrically beta-functionalized porphyrins were synthesized and characterized, showing notable red-shifted electronic spectral features and changes in nonlinear optical properties.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mukundam Vanga, Ashutosh Sahoo, Roger A. Lalancette, Frieder Jakle
Summary: The functionalization of polycyclic aromatic hydrocarbons via B <- N Lewis pair formation allows for the synthesis of a variety of compounds with advantageous properties, such as fluorinated derivatives showing lower HOMO and LUMO levels, strong fluorescence, and effective singlet oxygen sensitization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed Haider, Susan Bengs, Angela Portmann, Alexia Rossi, Hazem Ahmed, Dominik Etter, Geoffrey Warnock, Nidaa Mikail, Muriel Gramer, Alexander Meisel, Livio Gisler, Caitlin Jie, Claudia Keller, Sebastian Kozerke, Bruno Weber, Roger Schibli, Linjing Mu, Philipp A. Kaufmann, Vera Regitz-Zagrosek, Simon M. Ametamey, Catherine Gebhard
Summary: This study aimed to assess the impact of female and male sex hormones on myocardial perfusion and coronary flow reserve. The experimental data in mice indicate that testosterone plays a primary role in sex differences in myocardial perfusion.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mina Kim, Afroditi Eleftheriou, Luca Ravotto, Bruno Weber, Michal Rivlin, Gil Navon, Martina Capozza, Annasofia Anemone, Dario Livio Longo, Silvio Aime, Moritz Zaiss, Kai Herz, Anagha Deshmane, Tobias Lindig, Benjamin Bender, Xavier Golay
Summary: This article discusses the importance of advanced medical imaging technology in the early detection of cancer, and the sensitivity of dynamic glucose-enhanced MRI in cancer detection. The GLINT consortium is an important international collaboration project aimed at translating this technology into clinical practice.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Biochemical Research Methods
Loic Duffet, Seher Kosar, Mariangela Panniello, Bianca Viberti, Edward Bracey, Anna D. Zych, Arthur Radoux-Mergault, Xuehan Zhou, Jan Dernic, Luca Ravotto, Yuan-Chen Tsai, Marta Figueiredo, Shiva K. Tyagarajan, Bruno Weber, Miriam Stoeber, Nadine Gogolla, Markus H. Schmidt, Antoine R. Adamantidis, Tommaso Fellin, Denis Burdakov, Tommaso Patriarchi
Summary: This study developed a genetically encoded orexin sensor called OxLight1, which enables sensitive and direct optical detection of orexin neuropeptides in living animals with high spatiotemporal resolution. The sensor was used in mouse experiments to show that orexin release is associated with behaviors such as running, stress, and sleep-to-wake transitions.
Article
Chemistry, Physical
Ramees K. Rahman, Jacklyn Higgs, Erik Ninnemann, Jessica Baker, Artem E. Masunov, Subith S. Vasu
Summary: In this study, the thermal decomposition reaction rate of DIMP at high temperatures was investigated and the rate parameters were obtained. The obtained rates extend the temperature range of previous measurements and are important for studying the reaction kinetics of DIMP combustion.
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
(2022)
Correction
Biochemical Research Methods
Loic Duffet, Seher Kosar, Mariangela Panniello, Bianca Viberti, Edward Bracey, Anna D. Zych, Arthur Radoux-Mergault, Xuehan Zhou, Jan Dernic, Luca Ravotto, Yuan-Chen Tsai, Marta Figueiredo, Shiva K. Tyagarajan, Bruno Weber, Miriam Stoeber, Nadine Gogolla, Markus H. Schmidt, Antoine R. Adamantidis, Tommaso Fellin, Denis Burdakov, Tommaso Patriarchi
Article
Clinical Neurology
Nadine Felizitas Binder, Chaim Glueck, William Middleham, Michael Alasoadura, Nikolete Pranculeviciute, Matthias Tasso Wyss, Julien Chuquet, Bruno Weber, Susanne Wegener, Mohamad El Amki
Summary: This study found that different types of spontaneous vasodilation occur after ischemia. Depending on the shape and distribution of vasodilation, the severity of stroke injury and outcome can be predicted. The study also suggests that modulating the hemodynamic response to cortical spreading depolarization (CSD) may be a promising therapeutic strategy.
Article
Chemistry, Inorganic & Nuclear
S. Panteleev, S. K. Ignatov, S. N. Belyaev, A. G. Razuvaev, Artem E. Masunov
Summary: Global structure optimizations were performed for the clusters Mg-n (n = 2-32) using DFT method. The study analyzed the binding energies, structural parameters, and their relationship with cluster size and morphology. The results revealed the existence of more energetically stable structures and the discovery of tube-like isomers previously unknown. Additionally, the relationship between cluster nuclearity and morphology parameters, as well as mechanical hardness/softness, was discussed.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Endocrinology & Metabolism
Jillian L. Stobart, Eva Erlebach, Chaim Glueck, Sheng-Fu Huang, Matthew Jp Barrett, Max Li, Sergei A. Vinogradov, Jan Klohs, Yvette Zarb, Annika Keller, Bruno Weber
Summary: This study found that deleting the PDGFB retention motif results in severe pericyte deficiency in the vascular network, leading to reduced cerebral vasodilation capacity and impaired oxygen delivery to the tissue. Pdgfb(ret/ret) mice also showed abnormal blood oxygen extraction, indicating a state of hypoxia. These findings suggest that severe pericyte deficiency can cause vascular abnormalities and altered cerebral blood flow, resembling arteriovenous malformations.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neurosciences
Afroditi Eleftheriou, Luca Ravotto, Matthias T. Wyss, Geoffrey Warnock, Anita Siebert, Moritz Zaiss, Bruno Weber
Summary: Glucose is a crucial energy source for the brain, and monitoring its uptake and utilization can provide valuable information about pathological brain function. GlucoCEST and DGE are promising techniques for non-radioactive monitoring of glucose and tumor detection. However, the specific contributions of vascular, extracellular, and intracellular glucose to the DGE signal are still unclear.
Article
Chemistry, Multidisciplinary
Stanislav K. Ignatov, Artem E. Masunov
Summary: The isotropic electrostatic polarizability of sub-nanosized magnesium clusters was studied, and a linear correlation was found between the polarizability of the most favorable isomers and the cluster nuclearity. Furthermore, the most stable cluster isomers demonstrated minimal polarizability values. These observations are independent of the cluster structures and may be related to the energetic favorability of the cluster structure. The significance of these trends for cluster structure prediction and practical applications is discussed.
Article
Neurosciences
Vyara Todorova, Mia Fee Stauffacher, Luca Ravotto, Sarah Notzli, Duygu Karademir, Lynn J. A. Ebner, Cornelia Imsand, Luca Merolla, Stefanie. M. M. Hauck, Marijana Samardzija, Aiman. S. S. Saab, L. Felipe Barros, Bruno Weber, Christian Grimm
Summary: This study investigates the pathological mechanisms of photoreceptor (PR) degeneration during chronic activation of hypoxia-inducible factors (HIFs). The results show that PR cells have an exceptionally high glycolytic flux and the activation of HIFs slows down the cellular anabolism, leading to the shortening of rod outer segments before cell degeneration.
MOLECULAR NEURODEGENERATION
(2023)
Article
Thermodynamics
Ramees K. Rahman, Chun-Hung Wang, Artem E. Masunov, Subith Vasu
Summary: In this study, the high-temperature oxidation of diisopropyl methylphosphonate (DIMP) was investigated, and the rate parameters for its reactions with oxygen and hydroxyl radicals were determined using molecular simulations. The developed model was validated with experimental data, confirming its reliability in predicting the formation of carbon monoxide (CO) during DIMP oxidation.
COMBUSTION AND FLAME
(2023)
Article
Materials Science, Multidisciplinary
Gavin S. Mohammad-Pour, Yovan de Coene, Meryl Wiratmo, Aditya Maan, Koen Clays, Artem E. Masunov, Kaitlyn E. Crawford
Summary: This study investigates the design, synthesis, and application of a new class of push-pull chromophores for non-linear electro-optic (EO) applications. The chromophores demonstrate a significant potential for improving non-linear EO systems and exhibit large hyperpolarizability values (beta), stability, and modifiable functional groups.
MATERIALS ADVANCES
(2022)
Article
Biochemical Research Methods
Eva Erlebach, Luca Ravotto, Matthias T. Wyss, Jacqueline Condrau, Thomas Troxler, Sergei A. Vinogradov, Bruno Weber
Summary: This article presents a protocol for imaging oxygen distributions in the tissue and vasculature of the cerebral cortex in mice, both under anesthesia and awake. The protocol uses a two-photon phosphorescence lifetime microscopy (2PLM) approach with the probe Oxyphor 2P. This minimally invasive method outperforms existing approaches in terms of accuracy, resolution, and imaging depth. For a complete understanding of the protocol, please refer to Esipova et al. (2019).
Article
Chemistry, Multidisciplinary
Yury V. Matveychuk, Artem S. Yurchenko, Artem E. Masunov, Ekaterina V. Bartashevich
Summary: This study focused on the mechanical behavior and structural changes of three polymorphic forms of 6-chloro-2,4-dinitroaniline crystals, revealing their distinct anisotropy in mechanical properties. The findings suggest that it is necessary to employ multiple analysis methods to accurately predict the mechanical properties of molecular crystals.
CRYSTAL GROWTH & DESIGN
(2022)
