Article
Dermatology
Marco Vecchiato, Stefano Piaserico, Giulia Biolo, Anna Chiara Frigo, Monica Loy, Federico Rea, Irene Russo, Mauro Alaibac
Summary: This study aimed to determine the incidence and risk factors of skin cancers in lung transplant recipients, finding that age, gender, phototype, and voriconazole use were significant predictors for squamous cell carcinoma development. Male gender and phototype were identified as independent risk factors for basal cell carcinoma.
DERMATOLOGIC THERAPY
(2021)
Review
Dermatology
Brittany Urso, Andrew Kelsey, Jenna Bordelon, Patricia Sheiner, Justin Finch, Joel L. Cohen
Summary: Organ transplant recipients are at an increased risk of developing skin cancer, requiring a multidisciplinary approach for management. Dedicated transplant dermatology clinics provide specialized and frequent screenings for this high-risk population.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Surgery
Jonathan Kentley, Rina Allawh, Swati Rao, Alden Doyle, Amar Ahmad, Kumar Nadhan, Charlotte Proby, Catherine A. Harwood, Christina L. Chung
Summary: Organ transplant recipients, especially white OTRs, have a higher risk of developing skin cancer, while black OTRs are more prone to inflammatory skin diseases and ME/M individuals are more susceptible to fungal infections. The data indicates the necessity of implementing targeted dermatology surveillance programs for all OTRs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Dermatology
Mirit Gluck, Emmilia Hodak, Batya Davidovici
Summary: Immunosuppressants are crucial for graft survival in solid-organ transplant recipients, but they can lead to an increased incidence of nonmelanoma skin cancers. A retrospective study showed that mammalian target of rapamycin inhibitors (mTORi) have a sustained effectiveness in reducing the occurrence of nonmelanoma skin cancers.
DERMATOLOGIC THERAPY
(2022)
Article
Oncology
Robert P. Carroll, Michael Boyer, Val Gebski, Bronwyn Hockley, Julie K. Johnston, Svjetlana Kireta, Hsiang Tan, Anne Taylor, Kate Wyburn, John RZalcberg
Summary: Maintaining baseline immunosuppression before treatment with an immune checkpoint inhibitor in kidney transplant recipients might not affect expected efficacy and might reduce the risk of allograft rejection mediated by immune checkpoint inhibitors.
Article
Dermatology
Zeeshaan-Ul Hasan, Ikhlaaq Ahmed, Rubeta N. Matin, Victoria Homer, John T. Lear, Ferina Ismail, Tristan Whitmarsh, Adele C. Green, Jason Thomson, Alan Milligan, Sarah Hogan, Vanessa Van-de-Velde, Liza Mitchell-Worsford, Jonathan Kentley, Claire Gaunt, Yolande Jefferson-Hulme, Sarah J. Bowden, Piers Gaunt, Keith Wheatley, Charlotte M. Proby, Catherine A. Harwood
Summary: This study aimed to evaluate the feasibility, activity, and evaluation outcomes of topical chemoprevention of cSCC in OTRs, and the results support further investigation of 5-FU-based treatments in future phase III trials.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Medicine, General & Internal
Simona Granata, Gianpaolo Tessari, Giovanni Stallone, Gianluigi Zaza
Summary: In the last two decades, advancements in organ preservation, surgical techniques, and personalised immunosuppression have reduced the occurrence of acute rejections and early post-transplant complications. However, long-term graft survival rates have remained stagnant, possibly due to chronic calcineurin inhibitor toxicity. Skin cancer, particularly non-melanoma skin cancer (squamous cell carcinoma and basal cell carcinoma), is the most common malignancy among Caucasian solid organ transplant recipients. Various factors, including immunosuppression, contribute to the susceptibility to skin cancers, which have higher mortality rates compared to the general population. Early identification and treatment, along with patient education on sun protection and self-diagnosis, are crucial preventive measures. Collaboration between transplant clinicians, dermatologists, and surgeons is essential for effective management of these complications.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Jennifer R. Dusendang, Ekama Carlson, David S. Lee, Sangeeta Marwaha, Shabnam Madani, Stacey E. Alexeeff, Allison Webber, Nelson B. Goes, Lisa J. Herrinton
Summary: This study aimed to evaluate the risk of cutaneous squamous cell carcinoma (cSCC) in solid organ transplant recipients (SOTRs) using immunosuppressive medications. The results showed that the annual incidence of cSCC was higher in SOTRs compared to persons without transplantation. Lung transplant and the use of voriconazole were associated with an increased risk of cSCC, while belatacept and other immunosuppressive medications were not.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Efrat Solomon-Cohen, Shiran Reiss-Huss, Emmilia Hodak, Batya Davidovici
Summary: Low-dose acitretin treatment in SOTRs has shown to significantly reduce the number of new keratinocyte carcinomas, including both SCC and basal cell carcinoma, indicating its positive effect as a chemoprevention method in this population.
Article
Immunology
Isadora Zago Miotto, Bruno de Castro e Souza, Stephen K. Tyring, Walmar Roncalli Pereira de Oliveira
Summary: This study examined the prevalence of cutaneous adverse reactions to immunosuppressants in solid organ transplant recipients in a Brazilian tertiary center. Acneiform eruption and diffuse non-scarring alopecia were the most common drug reactions found, highlighting the importance of adequate immunosuppression for successful transplantation.
TRANSPLANT IMMUNOLOGY
(2021)
Article
Dermatology
Nirmala Pandeya, Nancy Huang, Zainab Jiyad, Elsemieke Plasmeijer, Mandy Way, Nicole Isbel, Scott Campbell, Daniel C. Chambers, Peter Hopkins, H. Peter Soyer, David C. Whiteman, Catherine M. Olsen, Adele C. Green
Summary: Organ transplant recipients (OTRs) have a higher risk of basal cell carcinomas (BCCs) compared to the general population. There are some differences in the clinicopathologic features of BCCs between OTRs and the general population. Although aggressive subtypes of BCCs are less common in OTRs, BCCs that invade beyond the dermis are almost twice as prevalent in OTRs compared to the general population.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Alexis H. Lerner, Elizabeth J. Klein, Anna Hardesty, Orestis A. Panagiotou, Chelsea Misquith, Dimitrios Farmakiotis
Summary: This study aims to evaluate the association between COVID-19 patients and history of organ transplantation, affecting disease severity and mortality. Methods include literature search, meta-analysis, and meta-regression analysis. The findings may hold implications for clinical practice and resource allocation.
SYSTEMATIC REVIEWS
(2021)
Article
Immunology
Emily Ximin Shao, Brigid Betz-Stablein, Kiarash Khosrotehrani, Scott Campbell, Nicole Isbel, Adele C. Green
Summary: Kidney transplant recipients have more than 20 times higher mortality risk from keratinocyte cancer compared to the general population. Most keratinocyte cancer deaths are caused by cutaneous squamous cell carcinoma, but basal cell carcinoma can also be fatal. Education in skin cancer prevention is crucial for kidney transplant recipients.
Article
Dermatology
John A. G. Gibson, Andrea Cordaro, Thomas D. Dobbs, Rowena Griffiths, Ashley Akbari, Sairan Whitaker, Hayley A. Hutchings, Ronan A. Lyons, Iain S. Whitaker
Summary: This study found a higher incidence of skin cancer in solid organ transplant recipients, with age, male gender, and azathioprine use being associated with increased risk. Contemporary immunomodulators such as tacrolimus and mycophenolate were found to reduce skin cancer risk when compared to older medications like cyclosporin and azathioprine. Different organ transplant recipients had varying levels of risk for skin cancer.
EUROPEAN JOURNAL OF DERMATOLOGY
(2021)
Article
Transplantation
David Massicotte-Azarniouch, Randal K. Detwiler, Yichun Hu, Ronald J. Falk, Manish K. Saha, Susan L. Hogan, Vimal K. Derebail
Summary: This study found that kidney transplant patients who received pre-transplant immunosuppression (PTI) for glomerulonephritis (GN) had a higher risk of developing malignancy. Compared with kidney transplant patients without PTI, those with GN and PTI had a significantly increased risk of malignancy.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Letter
Dermatology
Jacqueline G. Berliner, Joshua M. Schulman, Zelmira Lazarova, Edit Olasz, Sarah T. Arron
DERMATOLOGIC SURGERY
(2019)
Article
Otorhinolaryngology
Melody J. Xu, Ann A. Lazar, Adam A. Garsa, Sarah T. Arron, William R. Ryan, Ivan H. El-Sayed, Jonathan R. George, Alain P. Algazi, Chase M. Heaton, Patrick K. Ha, Sue S. Yom
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2018)
Article
Dermatology
Daniel Winchester, Julia Lehman, Tiffany Tello, Nicolette Chimato, Thomas Hocker, Sunhee Kim, Joseph Chang, Jeffrey Markey, Sue S. Yom, William Ryan, Thaddeus Mully, David Hodge, Clark Otley, Sarah T. Arron
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2018)
Article
Dermatology
Giorgia L. Garrett, Joyce T. Yuan, Thuzar M. Shin, Sarah T. Arron
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2018)
Letter
Dermatology
Yi Gao, Sarah T. Arron, Eleni Linos, Ingrid Polcari, Matthew D. Mansh
Article
Dermatology
Ethan C. Levin, Conroy Chow, Zaineb Makhzoumi, Chengshi Jin, Stephen C. Shiboski, Sarah T. Arron
DERMATOLOGIC SURGERY
(2019)
Article
Dermatology
Melissa Dodds, Sarah T. Arron, Eleni Linos, Ingrid Polcari, Matthew D. Mansh
Letter
Dermatology
S. L. Soon, S. F. Ibrahim, S. T. Arron
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Editorial Material
Dermatology
R. Motley, S. Arron
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Letter
Dermatology
L. D. Crow, J. T. Yuan, C. S. Aroyan, A. R. Twigg, J. P. Singer, G. R. Roll, A. A. Lazar, S. T. Arron
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Review
Oncology
Priyadharsini Nagarajan, Maryam M. Asgari, Adele C. Green, Samantha M. Guhan, Sarah T. Arron, Charlotte M. Proby, Dana E. Rollison, Catherine A. Harwood, Amanda Ewart Toland
CLINICAL CANCER RESEARCH
(2019)
Article
Rheumatology
Michael E. Johnson, Jennifer M. Franks, Guoshuai Cai, Bhaven K. Mehta, Tammara A. Wood, Kimberly Archambault, Patricia A. Pioli, Robert W. Simms, Nicole Orzechowski, Sarah Arron, Michael L. Whitfield
ARTHRITIS RESEARCH & THERAPY
(2019)
Review
Dermatology
S. E. Lowenstein, G. Garrett, A. E. Toland, A. Jambusaria-Pahlajani, M. M. Asgari, A. Green, E. A. Engels, S. T. Arron
BRITISH JOURNAL OF DERMATOLOGY
(2017)
Article
Dermatology
L. Wei, D. C. Allain, M. N. Bernhardt, J. L. Gillespie, S. B. Peters, O. H. Iwenofu, H. H. Nelson, S. T. Arron, A. E. Toland
BRITISH JOURNAL OF DERMATOLOGY
(2017)
Review
Dermatology
M. Blomberg, S. Y. He, C. Harwood, S. T. Arron, S. Demehri, A. Green, M. M. Asgari
BRITISH JOURNAL OF DERMATOLOGY
(2017)