期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 37, 期 5, 页码 1869-1880出版社
KARGER
DOI: 10.1159/000438548
关键词
MicroRNA; Cisplatin; Lung cancer; Chemo resistance; Post-transcriptional regulation
资金
- National Natural Science Foundation of China [81172335, 81472266]
- Excellent Youth Foundation of Jiangsu Province, China [BK20140032]
Cisplatin (CDDP) is one of the most effective broad-spectrum anticancer drugs, which has been employed for the treatment of lung cancer. The development of CDDP resistance is a major problem of tumor chemotherapy. MicroRNAs (miRNAs) are an abundant class of small nonprotein- coding RNAs, involved in the initiation and progression of human cancer. Increasing evidence has shown that dysregulation of miRNAs is involved in chemo resistance of tumor cells to anti-cancer drugs, including CDDP. This article summarizes current research involving miRNAs as regulators of key target genes for CDDP resistance in lung cancer. Potential use of targeting miRNAs can lead to miRNA-based therapies, which will be helpful for overcoming drug resistance and developing more effective personalized anti-cancer treatment strategies in human lung cancers. Copyright (C) 2015 S. Karger AG, Basel
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