Article
Pharmacology & Pharmacy
Zhiyi Wang, Xinxing Wang, Zhonghou Rong, Longfei Dai, Chengkun Qin, Shikang Wang, Wenmao Geng
Summary: This study investigated the role of LINC01134 in DNA damage response (DDR) and discovered its involvement in radioresistance of hepatocellular carcinoma (HCC) cells through modulation of the miR-342-3p/MAPK1 axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Weiqi Wu, Yanyan Zhang, Caixia Xu, Hongwei Yang, Siyi Liu, Guofu Huang
Summary: This study aimed to investigate the function of long non-coding RNA (LncRNA) LOXL1-AS1 in retinoblastoma (RB) cell proliferation and metastasis. LOXL1-AS1 was found to be overexpressed in RB tissues and cells. Knockdown of LOXL1-AS1 decreased cell viability, colony formation potential, migration, and invasion, while increasing the proportion of cells in the G2/M phase. In a xenograft model, tumors in the sh-LOXL1-AS1 group grew slower compared to the control group. LOXL1-AS1 was found to regulate RB cell progression through the MAPK signaling pathway. These findings suggest that LOXL1-AS1 may serve as a potential biomarker and therapeutic target for RB.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Yongzhi Han, Jing Fang, Zhiwei Xiao, Jian Deng, Minghui Zhang, Lixiong Gu
Summary: The study found that TSLNC8 is significantly downregulated in BRAF inhibitor-resistant melanoma tissues and cells. Downregulation of TSLNC8 reduces the toxicity response to BRAF inhibitor and inhibits apoptosis of melanoma cells treated with PLX4720. TSLNC8 can bind with PP1α to regulate its distribution, and downregulation of TSLNC8 results in PP1α cytoplasmic accumulation, reactivating the MAPK signaling pathway.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Li Zhang, Ting Liu, Haoyu Chen, Qi Zhao, Hongsheng Liu
Summary: In this study, a semi-supervised interactome network-based approach was applied to explore and predict the interaction between lncRNAs and miRNAs. The results showed that the model had reliability and good generalizability, indicating its potential in forecasting interactions between lncRNAs and miRNAs.
Article
Biochemistry & Molecular Biology
Fang Ma, Jiangyong Shen, Hui Zhang, Zhenghao Zhang, Anning Yang, Jiantuan Xiong, Yun Jiao, Zhigang Bai, Shengchao Ma, Huiping Zhang, Yideng Jiang
Summary: This study identifies a downregulated lncRNA called FPASL in hypertrophic scars and finds that its knockdown promotes fibroblast proliferation, while its overexpression inhibits fibroblast proliferation. Furthermore, the target genes of differentially expressed lncRNAs in hypertrophic scars are enriched in fibroblast proliferation signaling pathways. These findings contribute to a better understanding of the role of lncRNAs in hypertrophic scars and suggest that FPASL may act as a potential therapeutic target.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Developmental Biology
Hui Zhao, Yali Li, Nana Dong, Lei Zhang, Xi Chen, Huihui Mao, Samed Ahmed Al-Ezzi Al-Ameri, Xiaoling Wang, Qun Wang, Lutao Du, Chuanxin Wang, Haiting Mao
Summary: The long noncoding RNA LINC01088 plays a crucial role in the pathogenesis of recurrent pregnancy loss (RPL) by affecting the production of nitric oxide (NO) and activating the JNK and p38 MAPK signaling pathways in trophoblast cells.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Oncology
Wenfei Li, Chuanfeng Ke, Cuiyan Yang, Jiyao Li, Qikui Chen, Zhongsheng Xia, Jihao Xu
Summary: This study aimed to determine the function of lncRNA DICER1 antisense RNA 1 (DICER1-AS1) in colorectal cancer (CRC) and confirm its potential regulatory mechanisms. DICER1-AS1 was significantly upregulated in CRC tissue and its overexpression promoted CRC proliferation, migration, and invasion. Mechanistically, DICER1-AS1 acted as a competitive endogenous RNA (ceRNA) by sponging miR-650 to upregulate MAPK1 and activate the MAPK/ERK signaling pathway.
Article
Cell Biology
Lei Jiang, Bing Zhou, Dongjie Fu, Bo Cheng
Summary: This study demonstrated the significant roles of lncRNA TUG1, miR-593-3p, and MAPK signaling pathway in oral squamous cell carcinoma (OSCC). The findings suggest that targeting the TUG1/miR-593-3p/MAPK axis can potentially identify diagnostic biomarkers and therapies for OSCC.
Article
Biochemistry & Molecular Biology
Irina V. Pronina, Leonid A. Uroshlev, Alexey A. Moskovtsev, Danila M. Zaichenko, Elena A. Filippova, Marina V. Fridman, Alexey M. Burdennyy, Vitaly I. Loginov, Tatiana P. Kazubskaya, Nikolay E. Kushlinskii, Alexey A. Dmitriev, Eleonora A. Braga, Olga I. Brovkina
Summary: This study aimed to identify lncRNA-miRNA-mRNA competing triplets that promote ovarian tumorigenesis. Through analysis of tumor samples and experimental validation, multiple RNA triplets related to ovarian cancer were identified. Some triplets showed direct binding sites between lncRNA, mRNA, and miRNA. Transfection of miRNA into cells confirmed novel connections between miRNA and OC-related genes. These findings provide potential biomarkers for early detection of metastasis.
Article
Cell Biology
Cecilia Cattelani, Dominik Lesiak, Gudrun Liebscher, Isabel I. Singer, Taras Stasyk, Moritz H. Wallnoefer, Alexander M. Heberle, Corrado Corti, Michael W. Hess, Kristian Pfaller, Marcel Kwiatkowski, Peter P. Pramstaller, Andrew A. Hicks, Kathrin Thedieck, Thomas Muller, Lukas A. Huber, Mariana Eca Guimaraes de Araujo
Summary: The study reveals the role of SZT2 in the amino acid-sensing branch of mTORC1, with mutations in this gene causing severe neurodevelopmental and epileptic encephalopathy. Further analysis indicates enhanced mTORC1 signaling activation and higher levels of autophagic components in SZT2 ablated cells.
Review
Biochemistry & Molecular Biology
Tongjun Sun, Yuelin Zhang
Summary: This review summarizes the functions of MAPK cascades in plant development and innate immunity, as well as recent findings on the molecular links connecting surface receptors to MAPK cascades and the mechanisms underlying MAPK signaling specificity.
Review
Biochemistry & Molecular Biology
Emma Marie Wilber Hepworth, Shanta D. Hinton
Summary: MAPK signaling pathways are crucial regulators of eukaryotic cell function, with kinases and phosphatases controlling the activation and inhibition of MAPK. Pseudoenzymes also play a significant role in regulating these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yu-xi Liu, Yan Ke, Pin Qiu, Jie Gao, Gao-pi Deng
Summary: Anomalies in long non-coding RNA (lncRNA) cause early ovarian failure. The down-regulation of lncRNA nuclear enriched abundant transcript 1 (NEAT1) is connected to premature ovarian failure (POF) mice, but the mechanism is unclear. NEAT1 reduced apoptosis and autophagy in cyclophosphamide-treated ovarian granulosa cells (OGCs) by suppressing the expression of miR-654. Inhibition of NEAT1 overexpression on apoptosis and autophagy in OGCs was reversed by miR-654 mimics. NEAT1 modulated the STC2/MAPK pathway to decrease apoptosis and autophagy in POF.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yihao Wei, Tiantian Qi, Siyang Cao, Weifei Zhang, Fei Yu, Hui Zeng, Jian Weng
Summary: In recent years, studies have shown that lncRNAs play important roles in myogenic differentiation. This study identified a specific lncRNA XLOC_015548 and constructed gene editing cell models to explore its mechanism of action. The results demonstrated that XLOC_015548 promotes myoblast proliferation and differentiation, and regulates the expression of myogenic differentiation regulators. Moreover, XLOC_015548 was found to be correlated with the phosphorylation level of MAPK/MEK/ERK pathway proteins. These findings provide a laboratory foundation for the clinical application of lncRNAs in the treatment of disuse muscle atrophy.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Fan Zhang, Long Li, Wen-tao Huang, Jun-hua Liao, Ye-jun Huang, Jing-xin Huang, Yu-hui Zeng
Summary: In this study, it was found that the long noncoding RNA AFAP1-AS1 in serum exosomes of patients with septic shock plays an important regulatory role in activating the MAPK signaling pathway, thereby promoting the inflammatory response of leukocytes.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Wyatt B. Potter, Trina Basu, Kenneth J. O'Riordan, Allison Kirchner, Paul Rutecki, Corinna Burger, Avtar Roopra
Review
Neurosciences
Allison Kirchner, Fabien Dachet, Jeffrey A. Loeb
Article
Dermatology
Allison Kirchner, Artem Sergeyenko, Janice Keane, Kenneth Belinski, Wenhua Liu
Summary: MSP is a non-neoplastic condition characterized by spindle-shaped histiocytes colonized by mycobacteria, commonly diagnosed in the immunocompromised. It most frequently affects the lymph nodes and skin. Proper diagnosis through histopathological analysis and antibiotic therapy can lead to almost complete resolution of symptoms.
JOURNAL OF CUTANEOUS PATHOLOGY
(2021)
Letter
Dermatology
Allison Kirchner, Vishnutheertha Kulkarni, Jeffrey Rajkumar, Ahmed Usman, Shahzeb Hassan, Ernest Y. Lee
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Melissa A. Nickles, Vishnutheertha Kulkarni, Swati P. Garg, Mit M. Patel, Allison Kirchner, Arpan V. Prabhu
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Allison Kirchner, Mit Patel, Vishnutheertha Kulkarni, Ahmed Usman, Ernest Y. Lee
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Mit M. Patel, Allison Kirchner, Sripadh Sharma, Swati Garg, Torin Kovach, Brandon Park, Peter A. Lio
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
A. Kirchner, S. Hoyer
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Allison Kirchner, Isabelle M. Sanchez, Alice Zalan, Gifty Bhat, Michelle Bain
Summary: IPEX syndrome is a rare genetic disorder characterized by severe diarrhea, autoimmune endocrine disorder, and eczematous dermatitis. This case report highlights the importance of relating clinical symptoms to genetic results, as whole genome sequencing was used to diagnose a severe case of IPEX syndrome in a 2-week-old boy.
PEDIATRIC DERMATOLOGY
(2022)
Article
Dermatology
Allison Kirchner, Eden Lake
Summary: Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by itching and dryness. Recent studies have identified genetic risk factors, guiding the treatment options for AD. Current treatments include topical agents, systemic biologics, and Janus kinase inhibitors.
JOURNAL OF THE DERMATOLOGY NURSES ASSOCIATION
(2022)
Article
Dermatology
Allison Kirchner, Joanna Jaros, Marylee Braniecki, Gerard Nuovo, Shilpa Mehta
Summary: This case report highlights the importance of proper histopathological diagnosis and HPV viral testing when clinical presentations may vary or mimic other diseases. In this case, the patient presented with morphologically distinct lesions consistent with epidermodysplasia verruciformis (EDV), but further analysis confirmed the lesions as HPV-57-positive verruca vulgaris (VV).
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Dermatology
Allison Kirchner, Maureen Riegert, Eden Lake
Article
Neurosciences
A. Kirchner, S. Bagla, F. Dachet, J. A. Loeb
NEUROBIOLOGY OF DISEASE
(2020)